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1.1.1.B40: 11beta-hydroxysteroid dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about 11beta-hydroxysteroid dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.1.1.B40

Reaction

an 11beta-hydroxysteroid
+
NAD+
=
an 11-oxosteroid
+
NADH
+
H+

Synonyms

11 beta-hydroxysteroid dehydrogenase, 11 beta-hydroxysteroid dehydrogenase type 2, 11-beta hydroxysteroid dehydrogenase type 1, 11-beta hydroxysteroid dehydrogenase type 2, 11-beta-HSD2, 11beta hydroxysteroid dehydrogenase type 2, 11beta-HSD, 11beta-HSD 2, 11beta-HSD type 2, 11beta-HSD1, 11beta-HSD2, 11beta-HSD2 (oxidase) NAD+, 11beta-HSD2/HSD11B2, 11beta-hydroxysteroid dehydrogenase 2, 11beta-hydroxysteroid dehydrogenase isoforms 2, 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase type-2, 11beta-hydroxysteroid dehydrogenases type 2, 11beta-OHSD, 11betaHSD2, 11HSD1, 7-alpha-HCD, 7-alpha-hydroxycholesterol dehydrogenase, corticosteroid 11-beta-dehydrogenase isozyme 1, HSD 2, HSD11B type 1, HSD11B type 2, Hsd11B2, isozyme 11beta-HSD2, More, NAD(+)-dependent 11beta-dehydrogenase, NAD+-dependent 11beta-hydroxysteroid dehydrogenase 2, type 2 11beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B40 11beta-hydroxysteroid dehydrogenase (NAD+)

Reference

Reference on EC 1.1.1.B40 - 11beta-hydroxysteroid dehydrogenase (NAD+)

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Latif, S.A.; Sheff, M.F.; Ribeiro, C.E.; Morris, D.J.
Selective inhibition of sheep kidney 11beta-hydroxysteroid dehydrogenase isoform 2 activity by 5alpha-reduced (but not 5beta) derivates of adrenocorticosteroids
Steroids
62
230-237
1997
Ovis aries aries
Manually annotated by BRENDA team
Ferrari, P.; Smith, R.E.; Funder, J.W.; Krozowski, Z.S.
Substrate and inhibitor specificity of the clones human 11beta-hydroxysteroid dehydrogenase type 2 isoform
Am. J. Physiol.
270
E900-904
1996
Homo sapiens
Manually annotated by BRENDA team
Alfaidy, N.; Blot-Chabaud, M.; Robic, D.; Kenouch, S.; Bourbouze, R.; Bonvalet, J.P.; Farman, N.
Characteristics and regulation of 11beta-hydroxysteroid dehydrogenase of proximal and distal nephron
Biochim. Biophys. Acta
1243
461-468
1995
Rattus norvegicus
Manually annotated by BRENDA team
Blum , S.; Buhler, H.
Characterization of human placental 11beta-hydroxysteroid dehydrogenase, a key enzyme of cortocosteroid metabolism
Cell. Physiol. Biochem.
5
167-175
1995
Homo sapiens
-
Manually annotated by BRENDA team
Albiston, A.L.; Obeyesekere, V.R.; Smith, R.E.; Krozowski, Z.S.
Cloning and tissue distribution of the human 11beta-hydroxysteroid dehydrogenase type 2 enzyme
Mol. Cell. Endocrinol.
105
R11-R17
1994
Homo sapiens
Manually annotated by BRENDA team
Zhang, Y.D.; Lorenzo, B.; Reidenberg, M.M.
Inhibition of 11beta-hydroxysteroid dehydrogenase obtained from guinea pig kidney by furosemide, naringenin and some other compounds
J. Steroid Biochem. Mol. Biol.
49
81-85
1994
Cavia porcellus
Manually annotated by BRENDA team
Lakshim, V.; Nath, N.; Muneyyirci-Delale, O.
Characterization of 11beta-hydroxysteroid dehydrogenase of human placenta: Evidence for the existence of two species of 11beta-hydroxysteroid dehydrogenases
J. Steroid Biochem. Mol. Biol.
45
391-397
1993
Homo sapiens
Manually annotated by BRENDA team
Monder, C.
The forms and functions of 11beta-hydroxysteroid dehydrogenase
J. Steroid Biochem. Mol. Biol.
45
161-165
1993
Rattus norvegicus
Manually annotated by BRENDA team
Naray-Fejes-Toth, A.; Rusvai, E.; Denault, D.L.; Germain, D.L.St.; Fejes-Toth, G.
Expression and characterization of a new species of 11beta-hydroxysteroid dehydrogenase in Xenopus oocytes
Am. J. Physiol.
265
F896-900
1993
Oryctolagus cuniculus
Manually annotated by BRENDA team
Hundertmark, S.; Ragosch, V.; Schein, B.; Buhler, H.; Fromm, M.; Lorenz, U.; Weitzel, H.K.
11-beta-Hydroxysteroid dehydrogenase of rat lung: Enzyme kinetic, oxidase-reductase ration, electrolyte and trace element dependence
Enzyme Protein
47
83-91
1993
Rattus norvegicus
Manually annotated by BRENDA team
Gomez-Sanchez, E.P.; Ganjam, V.; Chen, Y.J.; Liu, Y.; Zhou, M.Y.; Toroslu, C.; Romero, D.G.; Hughson, M.D.; de Rodriguez, A.; Gomez-Sanchez, C.E.
Regulation of 11beta-hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol
Am. J. Physiol.
285
E272-279
2003
Rattus norvegicus
Manually annotated by BRENDA team
Holmes, M.C.; Yau, J.L.W.; Kotelevtsev, Y.; Mullins, J.J.; Seckl, J.R.
11beta-Hydroxysteroid dehydrogenases in the brain: two enzymes two roles
Ann. N. Y. Acad. Sci.
1007
357-366
2003
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Schipper, L.; Spee, B.; Rothuizen, J.; Woutersen-van Nijnanten, F.; Fink-Gremmels, J.
Characterisation of 11beta-hydroxysteroid dehydrogenases in feline kidney and liver
Biochim. Biophys. Acta
1688
68-77
2004
Felis catus
Manually annotated by BRENDA team
Zbankova, S.; Bryndova, J.; Kment, M.; Pacha, J.
Expression of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in colorectal cancer
Cancer Lett.
210
95-100
2004
Homo sapiens
Manually annotated by BRENDA team
Waddell, B.J.; Hisheh, S.; Krozowski, Z.S.; Burton, P.J.
Localization of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in the male reproductive tract
Endocrinology
144
3101-3106
2003
Rattus norvegicus
Manually annotated by BRENDA team
Zallocchi, M.L.; Matkovic, L.; Calvo, J.C.; Damasco, M.C.
Adrenal gland involvement in the regulation of renal 11beta-hydroxysteroid dehydrogenase 2
J. Cell. Biochem.
92
591-602
2004
Rattus norvegicus
Manually annotated by BRENDA team
Burton, P.J.; Waddell, B.J.
Myometrial expression of 11beta-hydroxysteroid dehydrogenase type 2 in rat pregnancy
J. Endocrinol.
172
519-526
2002
Rattus norvegicus
Manually annotated by BRENDA team
Gomez-Sanchez, E.P.; Venkataseshu, G.; Chen, Y.J.; Liu, Y.; Zhou, M.Y.; Toroslu, C.; Romero, D.G.; Hughson, M.D.; de Rodriguez, A.; Gomez-Sanchez, C.E.
Regulation of 11beta-hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol
Am. J. Physiol. Endocrinol. Metab.
285
E272-E279
2003
Rattus norvegicus
Manually annotated by BRENDA team
Kossintseva, I.; Wong, S.; Johnstone, E.; Guilbert, L.; Olson, D.M.; Mitchell, B.F.
Proinflammatory cytokines inhibit human placental 11beta-hydroxysteroid dehydrogenase type 2 activity through Ca2+ and cAMP pathways
Am. J. Physiol. Endocrinol. Metab.
290
E282-E288
2006
Homo sapiens
Manually annotated by BRENDA team
Garbrecht, M.R.; Schmidt, T.J.; Krozowski, Z.S.; Snyder, J.M.
11beta-Hydroxysteroid dehydrogenase type 2 and the regulation of surfactant protein A by dexamethasone metabolites
Am. J. Physiol. Endocrinol. Metab.
290
E653-E660
2006
Homo sapiens
Manually annotated by BRENDA team
Denari, D.; Ceballos, N.R.
Seasonal changes in the activity of 11 beta-hydroxysteroid dehydrogenase in toad testes
Ann. N. Y. Acad. Sci.
1040
297-300
2005
Rhinella arenarum
Manually annotated by BRENDA team
Zhang, J.; Osslund, T.D.; Plant, M.H.; Clogston, C.L.; Nybo, R.E.; Xiong, F.; Delaney, J.M.; Jordan, S.R.
Crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetes
Biochemistry
44
6948-6957
2005
Mus musculus
Manually annotated by BRENDA team
Xiang, J.; Ipek, M.; Suri, V.; Massefski, W.; Pan, N.; Ge, Y.; Tam, M.; Xing, Y.; Tobin, J.F.; Xu, X.; Tam, S.
Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I
Bioorg. Med. Chem. Lett.
15
2865-2869
2005
Homo sapiens
Manually annotated by BRENDA team
Olson, S.; Aster, S.D.; Brown, K.; Carbin, L.; Graham, D.W.; Hermanowski-Vosatka, A.; LeGrand, C.B.; Mundt, S.S.; Robbins, M.A.; Schaeffer, J.M.; Slossberg, L.H.; Szymonifka, M.J.; Thieringer, R.; Wright, S.D.; Balkovec, J.M.
Adamantyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
Bioorg. Med. Chem. Lett.
15
4359-4362
2005
Mus musculus (P51661), Homo sapiens (P80365)
Manually annotated by BRENDA team
Jang, C.; Obeyesekere, V.R.; Dilley, R.J.; Alford, F.P.; Inder, W.J.
11beta Hydroxysteroid dehydrogenase type 1 is expressed and is biologically active in human skeletal muscle
Clin. Endocrinol. (Oxf.)
65
800-805
2006
Homo sapiens
Manually annotated by BRENDA team
Basu, R.; Edgerton, D.S.; Singh, R.J.; Cherrington, A.; Rizza, R.A.
Splanchnic cortisol production in dogs occurs primarily in the liver: evidence for substantial hepatic specific 11beta hydroxysteroid dehydrogenase type 1 activity
Diabetes
55
3013-3019
2006
Canis lupus familiaris
Manually annotated by BRENDA team
Groyer, G.; Eychenne, B.; Girard, C.; Rajkowski, K.; Schumacher, M.; Cadepond, F.
Expression and functional state of the corticosteroid receptors and 11 beta-hydroxysteroid dehydrogenase type 2 in Schwann cells
Endocrinology
147
4339-4350
2006
Rattus norvegicus
Manually annotated by BRENDA team
Ozaki, Y.; Higuchi, M.; Miura, C.; Yamaguchi, S.; Tozawa, Y.; Miura, T.
Roles of 11beta-hydroxysteroid dehydrogenase in fish spermatogenesis
Endocrinology
147
5139-5146
2006
Anguilla japonica (Q05KC1)
Manually annotated by BRENDA team
Ohshima, M.; Ohno, S.; Nakajin, S.
Inhibitory effects of some possible endocrine-disrupting chemicals on the isozymes of human 11beta-hydroxysteroid dehydrogenase and expression of their mRNA in gonads and adrenal glands
Environ. Sci.
12
219-230
2005
Homo sapiens
Manually annotated by BRENDA team
Claus, R.; Wagner, A.; Lambert, T.
Characterization of 11beta-hydroxysteroid dehydrogenase activity in testicular tissue of control and GnRH-immunized boars as a possible regulator of spermatogenesis
Exp. Clin. Endocrinol. Diabetes
113
262-267
2005
Sus scrofa (Q8MKG1)
Manually annotated by BRENDA team
Carvajal, C.A.; Romero, D.G.; Mosso, L.M.; Gonzalez, A.A.; Campino, C.; Montero, J.; Fardella, C.E.
Biochemical and genetic characterization of 11 beta-hydroxysteroid dehydrogenase type 2 in low-renin essential hypertensives
J. Hypertens.
23
71-77
2005
Homo sapiens
Manually annotated by BRENDA team
Arampatzis, S.; Kadereit, B.; Schuster, D.; Balazs, Z.; Schweizer, R.A.; Frey, F.J.; Langer, T.; Odermatt, A.
Comparative enzymology of 11beta-hydroxysteroid dehydrogenase type 1 from six species
J. Mol. Endocrinol.
35
89-101
2005
Canis lupus familiaris, Mus musculus, Rattus norvegicus, Homo sapiens (P28845), Homo sapiens (P80365), Cavia porcellus (Q6QLL4), Mesocricetus auratus (Q6R0J2)
Manually annotated by BRENDA team
Mazancova, K.; Kopecky, M.; Miksik, I.; Pacha, J.
11beta-Hydroxysteroid dehydrogenase in the heart of normotensive and hypertensive rats
J. Steroid Biochem. Mol. Biol.
94
273-277
2005
Rattus norvegicus
Manually annotated by BRENDA team
Latif, S.A.; Pardo, H.A.; Hardy, M.P.; Morris, D.J.
Endogenous selective inhibitors of 11beta-hydroxysteroid dehydrogenase isoforms 1 and 2 of adrenal origin
Mol. Cell. Endocrinol.
243
43-50
2005
Ovis aries
Manually annotated by BRENDA team
Temkin, S.; Nacharaju, V.L.; Hellman, M.; Lee, Y.C.; Abulafia, O.
Type 2 11beta-hydroxysteroid dehydrogenase activity in human ovarian cancer
Steroids
7
1019-1023
2006
Homo sapiens
-
Manually annotated by BRENDA team
Sadosky, P.W.; Scammell, J.G.
Increased production of 11beta-hydroxysteroid dehydrogenase type 2 in the kidney microsomes of squirrel monkeys (Saimiri spp.)
Comp. Med.
58
180-187
2008
Saimiri, Sus scrofa, Oryctolagus cuniculus (P51976)
Manually annotated by BRENDA team
Balazs, Z.; Schweizer, R.A.; Frey, F.J.; Rohner-Jeanrenaud, F.; Odermatt, A.
DHEA induces 11 -HSD2 by acting on CCAAT/enhancer-binding proteins
J. Am. Soc. Nephrol.
19
92-101
2008
Rattus norvegicus
Manually annotated by BRENDA team
Ito-Kobayashi, M.; Aoyagi, A.; Tanaka, I.; Muramatsu, Y.; Umetani, M.; Takatsu, T.
Sterenin A, B, C and D, novel 11beta-hydroxysteroid dehydrogenase type 1 inhibitors from Stereum sp. SANK 21205
J. Antibiot.
61
128-135
2008
Homo sapiens
Manually annotated by BRENDA team
Jang, C.; Obeyesekere, V.R.; Dilley, R.J.; Krozowski, Z.; Inder, W.J.; Alford, F.P.
Altered activity of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in skeletal muscle confers metabolic protection in subjects with type 2 diabetes
J. Clin. Endocrinol. Metab.
92
3314-3320
2007
Homo sapiens
Manually annotated by BRENDA team
Sloboda, D.M.; Moss, T.J.; Li, S.; Matthews, S.G.; Challis, J.R.; Newnham, J.P.
Expression of glucocorticoid receptor, mineralocorticoid receptor, and 11beta-hydroxysteroid dehydrogenase 1 and 2 in the fetal and postnatal ovine hippocampus: ontogeny and effects of prenatal glucocorticoid exposure
J. Endocrinol.
197
213-220
2008
Ovis aries
Manually annotated by BRENDA team
Gong, R.; Morris, D.J.; Brem, A.S.
Human renal 11beta-hydroxysteroid dehydrogenase 1 functions and co-localizes with COX-2
Life Sci.
82
631-637
2008
Homo sapiens
Manually annotated by BRENDA team
Garbrecht, M.R.; Klein, J.M.; McCarthy, T.A.; Schmidt, T.J.; Krozowski, Z.S.; Snyder, J.M.
11-beta Hydroxysteroid dehydrogenase type 2 in human adult and fetal lung and its regulation by sex steroids
Pediatr. Res.
62
26-31
2007
Homo sapiens
Manually annotated by BRENDA team
Chandras, C.; Harris, T.E.; Bernal, A.L.; Abayasekara, D.R.; Michael, A.E.
PTGER1 and PTGER2 receptors mediate regulation of progesterone synthesis and type 1 11beta-hydroxysteroid dehydrogenase activity by prostaglandin E2 in human granulosa-lutein cells
J. Endocrinol.
194
595-602
2007
Homo sapiens
Manually annotated by BRENDA team
Johansson, L.; Fotsch, C.; Bartberger, M.D.; Castro, V.M.; Chen, M.; Emery, M.; Gustafsson, S.; Hale, C.; Hickman, D.; Homan, E.; Jordan, S.R.; Komorowski, R.; Li, A.; McRae, K.; Moniz, G.; Matsumoto, G.; Orihuela, C.; Palm, G.; Veniant, M.; Wang, M.; Williams, M.; Zhang, J.
2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice
J. Med. Chem.
51
2933-2943
2008
Homo sapiens
Manually annotated by BRENDA team
Milagro, F.I.; Campion, J.; Martinez, J.A.
11-Beta hydroxysteroid dehydrogenase type 2 expression in white adipose tissue is strongly correlated with adiposity
J. Steroid Biochem. Mol. Biol.
104
81-84
2007
Rattus norvegicus
Manually annotated by BRENDA team
Honda, Y.; Ohno, S.; Nakajin, S.
Leydig cells from neonatal pig testis abundantly express 11beta-hydroxysteroid dehydrogenase (11beta-HSD) type 2 and effectively inactivate cortisol to cortisone
J. Steroid Biochem. Mol. Biol.
108
91-101
2008
Sus scrofa
Manually annotated by BRENDA team
Sakumoto, R.; Ito, S.; Okuda, K.
Changes in expression of 11beta-hydroxysteroid dehydrogenase type-1, type-2 and glucocorticoid receptor mRNAs in porcine corpus luteum during the estrous cycle
Mol. Reprod. Dev.
75
925-930
2008
Sus scrofa
Manually annotated by BRENDA team
Sharp, V.; Thurston, L.M.; Fowkes, R.C.; Michael, A.E.
11Beta-hydroxysteroid dehydrogenase enzymes in the testis and male reproductive tract of the boar (Sus scrofa domestica) indicate local roles for glucocorticoids in male reproductive physiology
Reproduction
134
473-482
2007
Sus scrofa
Manually annotated by BRENDA team
Klusonova, P.; Kucka, M.; Miksik, I.; Bryndova, J.; Pacha, J.
Chicken 11beta-hydroxysteroid dehydrogenase type 2: partial cloning and tissue distribution
Steroids
73
348-355
2008
Gallus gallus
Manually annotated by BRENDA team
Henschkowski, J.; Stuck, A.E.; Frey, B.M.; Gillmann, G.; Dick, B.; Frey, F.J.; Mohaupt, M.G.
Age-dependent decrease in 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) activity in hypertensive patients
Am. J. Hypertens.
21
644-649
2008
Homo sapiens
Manually annotated by BRENDA team
Hong, D.; Li, X.W.; Lian, Q.Q.; Lamba, P.; Bernard, D.J.; Hardy, D.O.; Chen, H.X.; Ge, R.S.
Mono-(2-ethylhexyl) phthalate (MEHP) regulates glucocorticoid metabolism through 11beta-hydroxysteroid dehydrogenase 2 in murine gonadotrope cells
Biochem. Biophys. Res. Commun.
389
305-309
2009
Mus musculus
Manually annotated by BRENDA team
Zhao, B.; Chu, Y.; Huang, Y.; Hardy, D.O.; Lin, S.; Ge, R.S.
Structure-dependent inhibition of human and rat 11beta-hydroxysteroid dehydrogenase 2 activities by phthalates
Chem. Biol. Interact.
183
79-84
2010
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Mericq, V.; Medina, P.; Kakarieka, E.; Marquez, L.; Johnson, M.C.; Iniguez, G.
Differences in expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 and 2 in human placentas of term pregnancies according to birth weight and gender
Eur. J. Endocrinol.
161
419-425
2009
Homo sapiens
Manually annotated by BRENDA team
Chen, B.B.; Lin, H.; Hu, G.X.; Su, Y.; Zhou, H.Y.; Lian, Q.Q.; Cai, H.; Hardy, D.O.; Gu, D.Y.; Ge, R.S.
The (+)- and (-)-gossypols potently inhibit human and rat 11beta-hydroxysteroid dehydrogenase type 2
J. Steroid Biochem. Mol. Biol.
113
177-181
2009
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Classen-Houben, D.; Schuster, D.; Da Cunha, T.; Odermatt, A.; Wolber, G.; Jordis, U.; Kueenburg, B.
Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alpha-glycyrrhetinic acid but not 18beta-glycyrrhetinic acid
J. Steroid Biochem. Mol. Biol.
113
248-252
2009
Homo sapiens
Manually annotated by BRENDA team
Sharp, V.; Thurston, L.M.; Fowkes, R.C.; Michael, A.E.
Expression and activities of 11betaHSD enzymes in the testes and reproductive tracts of sexually immature male pigs
J. Steroid Biochem. Mol. Biol.
115
98-106
2009
Sus scrofa
Manually annotated by BRENDA team
Chapman, K.E.; Coutinho, A.E.; Gray, M.; Gilmour, J.S.; Savill, J.S.; Seckl, J.R.
The role and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in the inflammatory response
Mol. Cell. Endocrinol.
301
123-131
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Gong, R.; Morris, D.J.; Brem, A.S.
Variable expression of 11beta Hydroxysteroid dehydrogenase (11beta-HSD) isoforms in vascular endothelial cells
Steroids
73
1187-1196
2008
Bos taurus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Stanetty, C.; Czollner, L.; Koller, I.; Shah, P.; Gaware, R.; Cunha, T.D.; Odermatt, A.; Jordis, U.; Kosma, P.; Classen-Houben, D.
Synthesis of novel 3-amino and 29-hydroxamic acid derivatives of glycyrrhetinic acid as selective 11beta-hydroxysteroid dehydrogenase 2 inhibitors
Bioorg. Med. Chem.
18
7522-7541
2010
Homo sapiens
Manually annotated by BRENDA team
Kim, C.H.; Cho, Y.S.
Selection and optimization of MCF-7 cell line for screening selective inhibitors of 11beta-hydroxysteroid dehydrogenase 2
Cell Biochem. Funct.
28
440-447
2010
Homo sapiens
Manually annotated by BRENDA team
Xu, D.; Sheng, Y.; Zhou, Z.Y.; Liu, R.; Leng, Y.; Liu, J.K.
Sesquiterpenes from cultures of the basidiomycete Clitocybe conglobata and their 11 beta-hydroxysteroid dehydrogenase inhibitory activity
Chem. Pharm. Bull.
57
433-435
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Zhang, L.; Shen, Y.; Zhu, H.J.; Wang, F.; Leng, Y.; Liu, J.K.
Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11beta-hydroxysteroid dehydrogenases inhibitory activity
J. Antibiot.
62
239-242
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Zhang, L.; Shen, Y.; Wang, F.; Leng, Y.; Liu, J.K.
Rare merosesquiterpenoids from basidiomycete Craterellus odoratus and their inhibition of 11beta-hydroxysteroid dehydrogenases
Phytochemistry
71
100-103
2010
Homo sapiens
Manually annotated by BRENDA team
Kratschmar, D.V.; Vuorinen, A.; Da Cunha, T.; Wolber, G.; Classen-Houben, D.; Doblhoff, O.; Schuster, D.; Odermatt, A.
Characterization of activity and binding mode of glycyrrhetinic acid derivatives inhibiting 11beta-hydroxysteroid dehydrogenase type 2
J. Steroid Biochem. Mol. Biol.
125
129-142
2011
Homo sapiens (P80365)
Manually annotated by BRENDA team
Zhao, B.; Lian, Q.; Chu, Y.; Hardy, D.O.; Li, X.K.; Ge, R.S.
The inhibition of human and rat 11beta-hydroxysteroid dehydrogenase 2 by perfluoroalkylated substances
J. Steroid Biochem. Mol. Biol.
125
143-147
2011
Rattus norvegicus, Homo sapiens (P80365)
Manually annotated by BRENDA team
Hu, G.; Lin, H.; Lian, Q.; Zhou, S.; Guo, J.; Zhou, H.; Chu, Y.; Ge, R.
Curcumin as a potent and selective inhibitor of 11beta-hydroxysteroid dehydrogenase 1: improving lipid profiles in high-fat-diet-treated rats
PLoS ONE
8
e49976
2013
Homo sapiens (P80365)
Manually annotated by BRENDA team
Guan, H.; Sun, K.; Yang, K.
The ERK1/2 signaling pathway regulates 11beta-hydroxysteroid dehydrogenase type 2 expression in human trophoblast cells through a transcriptional mechanism
Biol. Reprod.
89
92
2013
Homo sapiens (P80365)
Manually annotated by BRENDA team
Green, B.B.; Armstrong, D.A.; Lesseur, C.; Paquette, A.G.; Guerin, D.J.; Kwan, L.E.; Marsit, C.J.
The role of placental 11-beta hydroxysteroid dehydrogenase type 1 and type 2 methylation on gene expression and infant birth weight
Biol. Reprod.
92
149
2015
Homo sapiens (P28845), Homo sapiens (P80365)
Manually annotated by BRENDA team
Ergang, P.; Kuzelova, A.; Sotak, M.; Klusonova, P.; Makal, J.; Pacha, J.
Distinct effect of stress on 11beta-hydroxysteroid dehydrogenase type 1 and corticosteroid receptors in dorsal and ventral hippocampus
Physiol. Res.
63
255-261
2014
Rattus norvegicus (P16232)
Manually annotated by BRENDA team
Heussner, K.; Ruebner, M.; Huebner, H.; Rascher, W.; Menendez-Castro, C.; Hartner, A.; Fahlbusch, F.B.; Rauh, M.
Species differences of 11beta-hydroxysteroid dehydrogenase type 2 function in human and rat term placenta determined via LC-MS/MS
Placenta
37
79-84
2016
Homo sapiens (P80365), Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Huebner, H.; Heussner, K.; Ruebner, M.; Schmid, M.; Nadal, J.; Woelfle, J.; Hartner, A.; Menendez-Castro, C.; Rauh, M.; Beckmann, M.W.; Kehl, S.; Fahlbusch, F.B.
Influence of labor on direct and indirect determinants of placental 11beta-hydroxysteroid dehydrogenase activity
Arch. Gynecol. Obstet.
303
401-408
2021
Homo sapiens (P80365)
Manually annotated by BRENDA team