1.1.1.B4: (R)-specific secondary alcohol dehydrogenase (NADH)
This is an abbreviated version!
For detailed information about (R)-specific secondary alcohol dehydrogenase (NADH), go to the full flat file.
Reaction
Synonyms
(R)-1-phenylethanolsynthase, (R)-epinephrine dehydrogenase, ADH, ADH1, ADH2, ADHTt, carbonyl reductase, carbonyl reductase (NADH, specific for (S)-configuration of alcohol), CHY1186, CpCR, mLDH, More, RPES, SADH, SDR, secondary alcohol dehydrogenase, short chain dehydrogenase, short-chain NAD(H)-dependent alcohol dehydrogenase
ECTree
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Reaction
Reaction on EC 1.1.1.B4 - (R)-specific secondary alcohol dehydrogenase (NADH)
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kinetic mechanism is ordered bi-bi with the cofactor binding first and releasing last. The enzyme transfers the pro-R hydride of NADH to the si face of carbonyl compounds to yield (R)-alcohols
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(R)-R-CHOH-R' + NAD+ = R-CO-R' + NADH + H+
kinetic mechanism is ordered bi-bi with the cofactor binding first and releasing last. The enzyme transfers the pro-R hydride of NADH to the si face of carbonyl compounds to yield (R)-alcohols
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