1.1.1.B38: hydroxymethylglutaryl-CoA reductase [NAD(P)H]

This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA reductase [NAD(P)H], go to the full flat file.

+ 2 NAD(P)+ =

+ 2 NAD(P)H + 2 H+

3-hydroxy-3-methylglutaryl coenzyme A reductase, AF1736, class II HMG-CoA reductase, HGMR, HMG-CoA reductase

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Results	in table
1	AA Sequence
2	Cloned(Commentary)
6	Cofactor
1	Crystallization (Commentary)
1	General Information
1	IC50 Value
1	Inhibitors
6	kcat/KM [mM/s]
7	KM Value [mM]
2	Natural Substrates/ Products (Substrates)
2	Organism
2	Pathway
4	pH Optimum
2	Purification (Commentary)
1	Reaction
2	Reference
4	Substrates and Products (Substrate)
1	Subunits
5	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Turnover Number [1/s]

pH Optimum on EC 1.1.1.B38 - hydroxymethylglutaryl-CoA reductase [NAD(P)H]

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reductive deacylation of 3-hydroxy-3-methylglutaryl-CoA to mevalonate with NADPH

6.8

oxidative acylation of mevalonate to 3-hydroxy-3-methylglutaryl-CoA with NADP+

reductive deacylation of 3-hydroxy-3-methylglutaryl-CoA to mevalonate with NADH

9.5 - 10

oxidative acylation of mevalonate to 3-hydroxy-3-methylglutaryl-CoA with NAD+