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1.1.1.B3: (S)-specific secondary alcohol dehydrogenase

This is an abbreviated version!
For detailed information about (S)-specific secondary alcohol dehydrogenase, go to the full flat file.

Reaction

(S)-R-CHOH-R'
+
NAD+
=
R-CO-R'
 +
NADH
 +
H+

Synonyms

(S)-1-phenylethanol dehydrogenase, (S)-1-phenylethanolsynthase, acetophenone reductase, ADH, ADH-A, ADH1, ADH2, ADHTt, APRD, carbonyl reductase (NADH, specific for (S)-configuration of alcohol), CRII, More, NAD+-dependent (S)-stereospecific alcohol dehydrogenase, NAD+-dependent ADH, PED, S-ADH, SADH, Scr2, SDR, short chain dehydrogenase, short-chain NAD(H)-dependent alcohol dehydrogenase, SOU1, SPES, TtADH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B3 (S)-specific secondary alcohol dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.B3 - (S)-specific secondary alcohol dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(R)-1-phenylethanol
-
-
(S)-1-phenylethanol
-
strong substrate inhibition, 50% of maximum activity at 0.1 mM
1-butyl-3-methylimidazolium tetrafluoroborate
-
65% inhibition at 2 mM
4-hydroxy mercuribenzoate
-
2 mM, 5% residual activity
acetophenone
-
inhibitory above 0.02 mM, 75% of maximum activity at 1 mM
Ag+
1 mM, no residual activity
AgNO3
Ca2+
-
10% inhibition at 1 mM and 30% at 100 mM
CdCl2
Nocardia fusca AKU 2123
-
2 mM, 6.6% residual activity
citrate
-
2 mM, 28% residual activity
Co(NO3)2
-
2 mM, 59% residual activity
CuSO4
-
2 mM, complete inhibition
D-cysteine
-
2 mM, 8% residual activity
diethyldicarbonate
-
2 mM, 30% residual activity
Fe2+
1 mM, 2.5% residual activity
Fe3+
1 mM, 44% residual activity
FeCl3
-
2 mM, 2% residual activity
glutathione
-
2 mM, 31% residual activity
guanidinium hydrochloride
-
1 M, 1.5% residual activity
Hg2+
-
67% inhibition at 1 mM
HgCl2
Nocardia fusca AKU 2123
-
2 mM, no residual activity
hydroxylamine
-
2 mM, 23% residual activity
Hydroxyquinoline
-
2 mM, 18% residual activity
iodoacetate
L-cysteine
-
2 mM, 12% residual activity
MgCl2
-
2 mM, 75% residual activity
MnSO4
-
2 mM, 53% residual activity
N-ethylmaleimide
-
2 mM, 5% residual activity
NiCl2
-
2 mM, 24% residual activity
o-phenanthroline
oxalate
-
2 mM, 26% residual activity
Pb(OAc)2
-
2 mM, 8% residual activity
phenyl methyl sulfonylfluoride
5 mM, 49% residual activity
potassium iodide
-
1 M, 1.4% residual activity
SDS
1%, no residual activity
Sodium azide
-
2 mM, 35% residual activity
sodium dodecylsulfate
tartarate
-
2 mM, 21% residual activity
Triton X-100
-
1% w/v, 67% residual activity
trypaflavine
Nocardia fusca AKU 2123
-
1 mM, 7.7% residual activity
Tween 80
-
1% w/v, 26.5% residual activity
Urea
-
1 M, 5.8% residual activity
Zn2+
1 mM, 79% residual activity
ZnSO4
-
2 mM, 2% residual activity
additional information
-