1.1.1.91: aryl-alcohol dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about aryl-alcohol dehydrogenase (NADP+), go to the full flat file.
Reaction
Synonyms
AAD, AAD1, AAD14, Aad14p, Aad1p, AAD4, Aad4p, ADH, aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate) coniferyl alcohol dehydrogenase, aryl-alcohol dehydrogenase, coniferyl alcohol dehydrogenase, NADPH-linked benzaldehyde reductase, PcAad1p, ScAad14p protein, ScAad4p protein, SDR A5, SDR B3, short-chain dehydrogenase/reductase
ECTree
1.1.1.91 aryl-alcohol dehydrogenase (NADP+)Advanced search results
results (
results (Substrates Products
Substrates Products on EC 1.1.1.91 - aryl-alcohol dehydrogenase (NADP+)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-butanol + NADP+
butyraldehyde + NADPH + H+
56% activity compared to crotyl alcohol
-
-
?
1-propanol + NADP+
propionaldehyde + NADPH + H+
17.4% activity compared to crotyl alcohol
-
-
?
2,4-dimethoxybenzyl alcohol + NADP+
2,4-dimethoxybenzyl aldehyde + NADPH + H+
-
-
-
?
2-fluorobenzaldehyde + NADPH
2-fluorobenzyl alcohol + NADP+
-
relative activity: 27% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
2-hydroxyacetophenone + NADPH + H+
(S)-1,2-phenylethanediol + NADP+
-
-
-
?
2-methoxybenzaldehyde + NADPH
2-methoxybenzyl alcohol + NADP+
-
relative activity: 58% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
2-nitrobenzaldehyde + NADPH
2-nitrobenzyl alcohol + NADP+
-
relative activity: 57% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
3,4,5-trimethoxybenzaldehyde + NADPH
3,4,5-trimethoxybenzyl alcohol + NADP+
-
-
-
-
?
3,4-dihydroxybenzaldehyde + NADPH
3,4-dihydroxybenzyl alcohol + NADP+
-
-
-
-
?
3,4-dimethoxybenzaldehyde + NADH
3,4-dimethoxybenzyl alcohol + NAD+
-
-
-
-
r
3,4-dimethoxybenzyl alcohol + NADP+
veratraldehyde + NADPH + H+
-
-
-
r
3-chlorobenzaldehyde + NADPH
3-chlorobenzyl alcohol + NADP+
-
relative activity: 73% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
3-fluorobenzaldehyde + NADPH
3-fluorobenzyl alcohol + NADP+
-
relative activity: 69% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
3-hydroxy-4-methoxy-benzaldehyde + NADPH
3-hydroxy-4-methoxy-benzyl alcohol + NADP+
-
relative activity: 17% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
3-hydroxy-4-methoxybenzaldehyde + NADPH + H+
3-hydroxy-4-methoxybenzyl alcohol + NADP+
-
-
-
-
?
3-methoxybenzaldehyde + NADPH
3-methoxybenzyl alcohol + NADP+
-
relative activity: 117% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
3-nitrobenzaldehyde + NADPH
3-nitrobenzyl alcohol + NADP+
-
relative activity: 25% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
3-phenylpropionaldehyde + NADPH + H+
3-phenylpropionyl alcohol + NADP+
-
-
-
-
r
4-benzyloxy-3-methoxybenzaldehyde + NADPH + H+
4-benzyloxy-3-methoxybenzyl alcohol + NADP+
-
-
-
-
?
4-chlorobenzaldehyde + NADPH
4-chlorobenzyl alcohol + NADP+
-
relative activity: 61% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
4-fluorobenzaldehyde + NADPH
4-fluorobenzyl alcohol + NADP+
-
relative activity: 29% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
4-hydroxy-3-methoxy-benzaldehyde + NADPH
4-hydroxy-3-methoxy-benzyl alcohol + NADP+
-
relative activity: 19% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
4-hydroxy-3-methoxybenzaldehyde + NADPH + H+
4-hydroxy-3-methoxybenzyl alcohol + NADP+
-
-
-
-
?
4-hydroxybenzaldehyde + NADPH
4-hydroxybenzyl alcohol + NADP+
-
relative activity: 34% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
4-hydroxybenzaldehyde + NADPH + H+
4-hydroxybenzyl alcohol + NADP+
-
-
-
-
?
4-methoxybenzaldehyde + NADPH
4-methoxybenzyl alcohol + NADP+
-
relative activity: 110% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
4-methoxybenzaldehyde + NADPH + H+
4-methoxybenzyl alcohol + NADP+
-
-
-
-
?
4-nitrobenzaldehyde + NADPH
4-nitrobenzyl alcohol + NADP+
-
relative activity: 31% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
5-(hydroxymethyl)-2-furaldehyde + NADPH + H+
(furan-2,5-diyl)dimethanol + NADP+
-
relative activity: 36% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
benzyl alcohol + NAD+
benzaldehyde + NADPH + H+
oxidation of benzyl alcohol at pH 9.6 is NAD+-dependent while NADP+ did not yield detectable activity under the same conditions
-
-
r
coniferyl aldehyde + NADH + H+
coniferyl alcohol + NAD+
-
-
-
-
r
crotonyl alcohol + NADP+
crotonaldehyde + NADPH + H+
highest oxidative activity with crotyl alcohol
-
-
r
decanal + NADPH
decanol + NADP+
-
relative activity: 2% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
heptaldehyde + NADPH
?
-
relative activity: 26% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
hexanal + NADPH
hexanol + NADP+
-
relative activity: 47% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
m-hydroxybenzaldehyde + NADPH + H+
m-hydroxybenzyl alcohol + NADP+
-
-
-
-
r
nonanal + NADPH
nonanol + NADP+
-
relative activity: 3% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
octanal + NADPH
octanol + NADP+
-
relative activity: 37% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
p-aminobenzyl alcohol + NADP+
p-aminobenzaldehyd + NADPH
-
-
-
-
r
p-hydroxybenzaldehyde + NADPH + H+
p-hydroxybenzyl alcohol + NADP+
-
-
-
-
r
pentanal + NADPH
pentanol + NADP+
-
relative activity: 8% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
phenylacetaldehyde + NADPH
phenylethanol + NADP+
-
relative activity: 109 (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
salicyl alcohol + NADP+
p-hydroxybenzaldehyde + NADPH
-
i.e. p-hydroxybenzyl alcohol
-
-
r
trans-cinnamaldehyde + NADPH
?
-
relative activity: 39% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
veratraldehyde + NADPH + H+
3,4-dimethoxybenzyl alcohol + NADP+
-
-
-
r
veratryl alcohol + NADP+
veratraldehyde + NADPH
-
i.e. 3,4-dimethoxybenzyl alcohol
-
-
r
(R)-1-phenylethanol + NAD+
1-phenylacetaldehyde + NADH + H+
-
-
-
?
(S)-1-phenylethanol + NADP+
1-phenylacetaldehyde + NADPH + H+
-
-
-
?
2-methyl-propanol + NADPH + H+
?
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
-
-
-
-
?
3,4-dimethoxybenzaldehyde + NADPH
3,4-dimethoxybenzyl alcohol + NADP+
-
-
-
-
?
3,4-dimethoxybenzaldehyde + NADPH
3,4-dimethoxybenzyl alcohol + NADP+
-
relative activity: 100% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
3,4-dimethoxybenzaldehyde + NADPH + H+
3,4-dimethoxybenzol + NADP+
-
-
-
-
r
3,4-dimethoxybenzaldehyde + NADPH + H+
3,4-dimethoxybenzol + NADP+
-
-
-
r
3,4-dimethoxybenzaldehyde + NADPH + H+
3,4-dimethoxybenzol + NADP+
-
-
-
r
3,4-dimethoxybenzaldehyde + NADPH + H+
3,4-dimethoxybenzol + NADP+
-
-
-
r
3,5-dimethoxybenzaldehyde + NADPH
3,5-dimethoxybenzyl alcohol + NADP+
-
-
-
-
?
3,5-dimethoxybenzaldehyde + NADPH
3,5-dimethoxybenzyl alcohol + NADP+
-
relative activity: 110% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
4-methoxybenzyl alcohol + NADP+
4-methoxybenzaldehyde + NADPH
-
i.e. anisic alcohol
-
-
r
4-methoxybenzyl alcohol + NADP+
4-methoxybenzaldehyde + NADPH
-
i.e. anisic alcohol
-
-
r
4-nitrobenzaldehyde + NADPH + H+
4-nitrobenzylalcohol + NADP+
-
-
-
r
4-nitrobenzaldehyde + NADPH + H+
4-nitrobenzylalcohol + NADP+
-
-
-
r
4-nitrobenzaldehyde + NADPH + H+
4-nitrobenzylalcohol + NADP+
-
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
relative activity: 42% (reference substrate: 3,4-dimethoxybenzaldehyde)
-
-
r
benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
reduction of benzaldehyde at pH 6.0 is NADPH-dependent while NADH does not yield detectable activity under the same conditions
-
-
r
benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
highest reductive activity with benzaldehyde
-
-
r
benzyl alcohol + NADP+
benzaldehyde + NADPH
-
enzyme participates in benzoate reduction
-
-
r
benzyl alcohol + NADP+
benzaldehyde + NADPH
-
enzyme participates in benzoate reduction
-
-
r
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
41.7% activity compared to crotyl alcohol
-
-
r
coniferyl alcohol + NADP+
coniferylaldehyde + NADPH + H+
-
-
-
-
r
coniferyl alcohol + NADP+
coniferylaldehyde + NADPH + H+
-
i.e. 4-hydroxy-3-methoxycinnamic alcohol
-
-
r
heptanal + NADPH + H+
heptanol + NADP+
-
-
-
r
hexanal + NADPH + H+
hexanol + NADP+
-
-
-
r
additional information
?
-
-
no activity is detected for isoform SDR A5 with isobutyraldehyde, isovaleraldehyde, 2-heptanone, 2-phenylacetaldehyde, 1-phenyl-1-butanone, 1-phenyl-1-pentanone, 1-phenyl-1-hexanone, 1-phenyl-2-propanone, 2-hydroxyacetophenone, 2'-hydroxyacetophenone, 1-phenylpropane-1,2-dione, benzophenone, (R)-(-)-benzoin, propanol, butanol, rac-2-propanol, 2-methylpropanol, 3-methylbutanol, rac-3-methyl-2-butanol, (S)-4-methyl-2-pentanol, (R)-4-methyl-2-pentanol, (R)-2-hexanol, (R)-2-octanol, rac-1-amino-2-propanol, rac-1-bromo-2-propanol, butan-2,3-diol, rac-decan-1,2-diol, 3-hydroxybutanoic acid, 2-hexyn-1-ol, (R)-1-phenylethanol, 2-phenylethanol, rac-benzoin, meso-hydrobenzoin, (S,S)-hydrobenzoin, and (R,R)-hydrobenzoin. No activity is detected for isoform SDR B3 with isobutyraldehyde, 2-hexanone, 2-heptanone, 2-octanone, ethyl acetoacetate, acetophenone, 1-phenyl-1-butanone, 1-phenyl-1-pentanone, 1-phenyl-1-hexanone, 1-phenyl-2-propanone, 2-hydroxyacetophenone, 2'-hydroxyacetophenone, 4-(4-hydroxyphenyl)-2-butanone, 1-phenylpropane-1,2-dione, benzophenone, rac-benzoin, (R)-benzoin, propanol, butanol, rac-2-propanol, 2-methylpropanol, 3-methylbutanol, (R)-4-methyl-2-pentanol, (R)-2-hexanol, rac-1-amino-2-propanol, rac-1-bromo-2-propanol, butan-2,3-diol, 3-hydroxybutanoic acid, 2-hexyn-1-ol, (R)-1-phenylethanol, 2-phenylethanol, rac-benzoin, meso-hydrobenzoin, (S,S)-hydrobenzoin, and (R,R)-hydrobenzoin
-
-
?
additional information
?
-
-
the enzyme accepts both NAD+ and NADP+. However, purified enzyme shows strong preference for NADP+
-
-
?
additional information
?
-
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
-
no activity is detected for isoform SDR A5 with isobutyraldehyde, isovaleraldehyde, 2-heptanone, 2-phenylacetaldehyde, 1-phenyl-1-butanone, 1-phenyl-1-pentanone, 1-phenyl-1-hexanone, 1-phenyl-2-propanone, 2-hydroxyacetophenone, 2'-hydroxyacetophenone, 1-phenylpropane-1,2-dione, benzophenone, (R)-(-)-benzoin, propanol, butanol, rac-2-propanol, 2-methylpropanol, 3-methylbutanol, rac-3-methyl-2-butanol, (S)-4-methyl-2-pentanol, (R)-4-methyl-2-pentanol, (R)-2-hexanol, (R)-2-octanol, rac-1-amino-2-propanol, rac-1-bromo-2-propanol, butan-2,3-diol, rac-decan-1,2-diol, 3-hydroxybutanoic acid, 2-hexyn-1-ol, (R)-1-phenylethanol, 2-phenylethanol, rac-benzoin, meso-hydrobenzoin, (S,S)-hydrobenzoin, and (R,R)-hydrobenzoin. No activity is detected for isoform SDR B3 with isobutyraldehyde, 2-hexanone, 2-heptanone, 2-octanone, ethyl acetoacetate, acetophenone, 1-phenyl-1-butanone, 1-phenyl-1-pentanone, 1-phenyl-1-hexanone, 1-phenyl-2-propanone, 2-hydroxyacetophenone, 2'-hydroxyacetophenone, 4-(4-hydroxyphenyl)-2-butanone, 1-phenylpropane-1,2-dione, benzophenone, rac-benzoin, (R)-benzoin, propanol, butanol, rac-2-propanol, 2-methylpropanol, 3-methylbutanol, (R)-4-methyl-2-pentanol, (R)-2-hexanol, rac-1-amino-2-propanol, rac-1-bromo-2-propanol, butan-2,3-diol, 3-hydroxybutanoic acid, 2-hexyn-1-ol, (R)-1-phenylethanol, 2-phenylethanol, rac-benzoin, meso-hydrobenzoin, (S,S)-hydrobenzoin, and (R,R)-hydrobenzoin
-
-
?
additional information
?
-
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
-
the enzyme accepts both NAD+ and NADP+. However, purified enzyme shows strong preference for NADP+
-
-
?
additional information
?
-
-
broad substrate specificity towards both aromatic and to a lesser extent aliphatic aldehydes
-
-
?
additional information
?
-
-
substrate specificity, overview. PcAad1p is active on a broader spectrum of aryl-aldehyde substrates. PcAad1p can also act as an oxidase against several aliphatic and aromatic alcohols (at pH 10.3, with NADP+ as a cofactor)
-
-
-
additional information
?
-
substrate specificity, overview. ScAad14p exhibits its highest activity on aryl-aldehydes substituted at position 2. No activity with cinnamaldehyde
-
-
-
additional information
?
-
substrate specificity, overview. ScAad14p exhibits its highest activity on aryl-aldehydes substituted at position 2. No activity with cinnamaldehyde
-
-
-
additional information
?
-
substrate specificity, overview. ScAad4p is more active on aryl-aldehyde-bearing substituents at positions 3, 4, and 5, or even those bearing double and triple substitutions on the aromatic ring, while ScAad4p is inactive on aryl-aldehydes that have position 2 substitutions. No activity with 4-nitrobenzaldehyde
-
-
-
additional information
?
-
substrate specificity, overview. ScAad4p is more active on aryl-aldehyde-bearing substituents at positions 3, 4, and 5, or even those bearing double and triple substitutions on the aromatic ring, while ScAad4p is inactive on aryl-aldehydes that have position 2 substitutions. No activity with 4-nitrobenzaldehyde
-
-
-
additional information
?
-
substrate specificity, overview. ScAad14p exhibits its highest activity on aryl-aldehydes substituted at position 2. No activity with cinnamaldehyde
-
-
-
additional information
?
-
substrate specificity, overview. ScAad14p exhibits its highest activity on aryl-aldehydes substituted at position 2. No activity with cinnamaldehyde
-
-
-
additional information
?
-
substrate specificity, overview. ScAad4p is more active on aryl-aldehyde-bearing substituents at positions 3, 4, and 5, or even those bearing double and triple substitutions on the aromatic ring, while ScAad4p is inactive on aryl-aldehydes that have position 2 substitutions. No activity with 4-nitrobenzaldehyde
-
-
-
additional information
?
-
substrate specificity, overview. ScAad4p is more active on aryl-aldehyde-bearing substituents at positions 3, 4, and 5, or even those bearing double and triple substitutions on the aromatic ring, while ScAad4p is inactive on aryl-aldehydes that have position 2 substitutions. No activity with 4-nitrobenzaldehyde
-
-
-
additional information
?
-
substrate specificity, overview. ScAad14p exhibits its highest activity on aryl-aldehydes substituted at position 2. No activity with cinnamaldehyde
-
-
-
additional information
?
-
substrate specificity, overview. ScAad14p exhibits its highest activity on aryl-aldehydes substituted at position 2. No activity with cinnamaldehyde
-
-
-
additional information
?
-
substrate specificity, overview. ScAad4p is more active on aryl-aldehyde-bearing substituents at positions 3, 4, and 5, or even those bearing double and triple substitutions on the aromatic ring, while ScAad4p is inactive on aryl-aldehydes that have position 2 substitutions. No activity with 4-nitrobenzaldehyde
-
-
-
additional information
?
-
substrate specificity, overview. ScAad4p is more active on aryl-aldehyde-bearing substituents at positions 3, 4, and 5, or even those bearing double and triple substitutions on the aromatic ring, while ScAad4p is inactive on aryl-aldehydes that have position 2 substitutions. No activity with 4-nitrobenzaldehyde
-
-
-
