1.1.1.86: ketol-acid reductoisomerase (NADP+)
This is an abbreviated version!
For detailed information about ketol-acid reductoisomerase (NADP+), go to the full flat file.
Word Map on EC 1.1.1.86
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1.1.1.86
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branched-chain
-
5-phosphate
-
karis
-
1-deoxy-d-xylulose
-
fosmidomycin
-
isoprenoids
-
methylerythritol
-
1-deoxy-d-xylulose-5-phosphate
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deoxyxylulose
-
l-valine
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isobutanol
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2-c-methyl-d-erythritol
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non-mevalonate
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dihydroxyacid
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2-keto
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isoleucine-valine
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ilvbnce
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drug development
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biofuel production
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industry
- 1.1.1.86
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branched-chain
- 5-phosphate
-
karis
- 1-deoxy-d-xylulose
- fosmidomycin
-
isoprenoids
- methylerythritol
- 1-deoxy-d-xylulose-5-phosphate
- deoxyxylulose
- l-valine
- isobutanol
-
2-c-methyl-d-erythritol
-
non-mevalonate
-
dihydroxyacid
-
2-keto
-
isoleucine-valine
-
ilvbnce
- drug development
- biofuel production
- industry
Reaction
Synonyms
2-hydroxy-3-keto acid reductoisomerase, acetohydroxy acid isomeroreductase, acetohydroxy acid reductoisomerase, acetohydroxy-acid isomeroreductase
ECTree
1.1.1.86 ketol-acid reductoisomerase (NADP+)Advanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.1.1.86 - ketol-acid reductoisomerase (NADP+)
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
(2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+
(S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
2-aceto-2-hydroxybutyrate + NADPH
2,3-dihydroxy-3-methylvalerate + NADP+
-
-
-
-
?
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+ + H+
-
the enzyme is the second of the valine pathway
-
-
r
NADPH + alpha-aceto-alpha-hydroxybutyrate
NADP+ + ?
-
enzyme of isoleucine biosynthesis
-
-
?
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
(2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
-
-
-
-
r
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
(2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
-
-
-
-
r
(2S)-2-acetolactate + NADPH
(2R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
?
(2S)-2-acetolactate + NADPH
(2R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
?
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+
(S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
-
-
-
-
r
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+
(S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
-
-
-
r
(S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
-
-
-
r
(S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
-
-
-
r
(S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
-
-
-
r
(S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
-
-
-
r
(S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
-
-
-
r
(S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
-
-
-
r
(S)-2-acetolactate + NADPH + H+
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
?
(S)-2-acetolactate + NADPH + H+
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
-
?
(S)-2-acetolactate + NADPH + H+
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
?
(S)-2-acetolactate + NADPH + H+
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
?
(S)-2-acetolactate + NADPH + H+
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
?
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
r
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
r
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
r
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
r
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
r
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
r
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
second enzyme in the branched-chain amino acid biosynthesis pathway
-
-
?
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
r
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
second enzyme in the branched-chain amino acid biosynthesis pathway
-
-
?
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
r
2-aceto-2-hydroxybutyrate + NADPH + H+
? + NADP+
-
-
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
second common reaction in the biosynthesis of the branched chain amino acids
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of valine synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
not reversible at pH 7.5, reversible at pH 9-10
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH + H+
3-hydroxy-3-methyl-2-oxobutyrate + NADP+
-
-
-
?
2-acetolactate + NADPH + H+
3-hydroxy-3-methyl-2-oxobutyrate + NADP+
-
-
-
?
additional information
?
-
-
the enzyme is involved in biosynthesis of branched amino acids valine, isoleucine, and leucine, pathway overview
-
-
?
additional information
?
-
-
the enzyme catalyses the second reaction in the biosynthesis of the branched-chain amino acids
-
-
?
additional information
?
-
-
the enzyme is involved in the biosynthesis of the branched-chain amino acids
-
-
?
additional information
?
-
-
structure-biological activity relationship, overview
-
-
?
additional information
?
-
-
structure-biological activity relationship, overview
-
-
?
additional information
?
-
-
enzyme expression is up-regulated in germinating cysts developing appressoria, which are important for interaction of pathogen and host plants tomato and potato
-
-
?
additional information
?
-
-
the enzyme is involved in biosynthesis of branched chain amino acids valine, isoleucine, and leucine, effects of KARI inhibition effects on other enzymes, such as alcohol dehydrogenase, EC 1.1.1.1, pyruvate dehydrogenase, EC 4.1.1.1, lactate dehydrogenase, EC 1.1.1.27, and alanine aminotransferase, EC 2.6.1.2, overview
-
-
?
additional information
?
-
-
the enzyme is involved in the biosynthesis of the branched-chain amino acids
-
-
?
additional information
?
-
-
the enzyme is involved in the biosynthesis of the branched-chain amino acids
-
-
?
additional information
?
-
-
structure-biological activity relationship, overview
-
-
?
