1.1.1.85: 3-isopropylmalate dehydrogenase

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For detailed information about 3-isopropylmalate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.85

1.1.1.85

thermus

thermophilus

thiobacillus

homoisocitrate

ferrooxidans

alpha-isopropylmalate

analysis

Reaction

Synonyms

2-hydroxy-4-methyl-3-carboxyvalerate:NAD+ oxidoreductase, 2R,3S-isopropylmalate:NAD+ oxidoreductase (decaboxylating), 3-IPM dehydrogenase, 3-IPM-DH, 3-isopropylmalate dehydrogenase, 3-isopropylmalateDH, APS IPMDH, beta-IPM dehydrogenase, beta-IPMDH, beta-isopropylmalate dehydrogenase, beta-isopropylmalic enzyme, Bs3-isopropylmalateDH, dehydrogenase, 3-isopropylmalate, IMDH, IPMDH, IPMDH1, IPMDH2, IPMDH3, isopropylmalate dehydrogenase, leuB, NAD-dependent isopropylmalate dehydrogenase, Saci_0600, SbIPMDH, SoIPMDH, threo-Ds-3-isopropylmalate dehydrogenase, Tt-beta-3-isopropylmalateDH, two-domain 3-isopropylmalate dehydrogenase, Ydr417cp

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.85 3-isopropylmalate dehydrogenase

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Results	in table
1	Activating Compound
36146	AA Sequence
5	Application
1	CAS Registry Number
61	Cloned(Commentary)
108	Cofactor
27	Crystallization (Commentary)
2	Expression
23	General Information
8	General Stability
44	Inhibitors
66	kcat/KM [mM/s]
2	Ki Value [mM]
293	KM Value [mM]
3	Localization
73	Metals/Ions
30	Molecular Weight [Da]
34	Natural Substrates/ Products (Substrates)
3	Organic Solvent Stability
236	Organism
7	Pathway
116	PDB ID
24	pH Optimum
2	pH Range
2	pH Stability
1	pI Value
2	Posttranslational Modification
156	Protein Variants
32	Purification (Commentary)
2	Reaction
3	Reaction Type
164	Reference
4	Renatured (Commentary)
7	Source Tissue
26	Specific Activity [micromol/min/mg]
4	Storage Stability
197	Substrates and Products (Substrate)
54	Subunits
170	Synonyms
1	Systematic Name
26	Temperature Optimum [°C]
4	Temperature Range [°C]
37	Temperature Stability [°C]
224	Turnover Number [1/s]

Purification

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Purification on EC 1.1.1.85 - 3-isopropylmalate dehydrogenase

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11 entries

DE52 column chromatography, phenyl Sepharose column chromatography, and Superdex 200 gel filtration

Sulfolobus acidocaldarius

Q4JB37

738195

gene cloned in Escherichia coli

Thermus thermophilus

639131, 639157

Ni Sepharose 6 column chromatography

2 entries

Ni-NTA column chromatography and Superdex 200 gel filtration

Arabidopsis thaliana

P93882

738685

overexpression in Escherichia coli

Acidithiobacillus ferrooxidans

639161

partial

Thermus thermophilus

639146

purified by heat treatment followed by nickel affinity chromatography

Methanocaldococcus jannaschii

680494

recombinant enzyme

Escherichia coli

696778

recombinant enzyme expressed in Escherichia coli

3 entries

recombinant wild-type and mutant enzymes from Escherichia coli strain MA153 by anion exchange and hydrophobic interaction chromatography

Sulfurisphaera tokodaii

P50455

701046

recombinant wild-type and mutants from Escherichia coli strain MA153 by anion exchange and adsorption chromatography

Thermus thermophilus

Q5SIY4

668635

using a HisTrap HP column

2 entries

using Ni-NTA chromatography

Thermus thermophilus

Q5SIY4

710765