1.1.1.83: D-malate dehydrogenase (decarboxylating)

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For detailed information about D-malate dehydrogenase (decarboxylating), go to the full flat file.

Reaction

Synonyms

D-malate dehydrogenase, D-malic enzyme, dehydrogenase, D-malate (decarboxylating), dmlA

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.83 D-malate dehydrogenase (decarboxylating)

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Results	in table
1	Activating Compound
10241	AA Sequence
1	Application
1	CAS Registry Number
8	Cofactor
3	Expression
2	General Stability
21	Inhibitors
6	KM Value [mM]
11	Metals/Ions
8	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
23	Organism
3	Pathway
1	PDB ID
4	pH Optimum
1	pH Range
1	pH Stability
4	Purification (Commentary)
1	Reaction
4	Reaction Type
15	Reference
3	Specific Activity [micromol/min/mg]
4	Storage Stability
17	Substrates and Products (Substrate)
5	Subunits
4	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
6	Temperature Stability [°C]

Expression

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Expression on EC 1.1.1.83 - D-malate dehydrogenase (decarboxylating)

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

addition of nitrate during anaerobic growth represses the expression of dmlA-lacZ about 2.2fold, but the expression is still higher than the expression under aerobic conditions. The presence of glucose during anaerobic growth represses dmlA expression to levels similar to those observed after nitrate addition, suggesting that there is some glucose repression (2.4fold)

Escherichia coli

P76251

712297

in a wild-type background, D-malate and meso- and L-tartrate cause high levels of induction of dmlA-lacZ expression (up to 12.3fold). With L-malate, succinate, and D-tartrate there is only weak induction. Induction of dmlA encoding DmlA requires an intact dmlR gene, which encodes DmlR, a LysR-type transcriptional regulator

Escherichia coli

P76251

712297

the expression of dmlA-lacZ at high levels is induced under anaerobic conditions in the presence of D-malate and is more than 5fold greater than the expression under aerobic conditions

Escherichia coli

P76251

712297