1.1.1.71: alcohol dehydrogenase [NAD(P)+]
This is an abbreviated version!
For detailed information about alcohol dehydrogenase [NAD(P)+], go to the full flat file.
Word Map on EC 1.1.1.71
-
1.1.1.71
-
retinoids
-
thermoanaerobacter
-
all-trans-retinaldehyde
-
retinyl
-
ethanolicus
-
all-trans-retinol
-
r-1-phenylethanol
-
cyp26a1
-
akr1b10
- 1.1.1.71
-
retinoids
- thermoanaerobacter
- all-trans-retinaldehyde
-
retinyl
-
ethanolicus
- all-trans-retinol
-
r-1-phenylethanol
-
cyp26a1
- akr1b10
Reaction
Synonyms
ADH, ADH12, ADH2, Adh319, AdhA, AdhE, alcohol dehydrogenase, aldehyde reductase (NADPH/NADH), DHRS3, HvADH2, HVO_B0071, NAD(P)+-dependent alcohol dehydrogenase, NAD(P)H-dependent ADH, NAD(P)H-dependent aldehyde reductase, NADPH-dependent ADHA, NADPH-dependent alcohol dehydrogenase, PH0743, PhADH, RADH, retinal reductase, retinal short-chain dehydrogenase/reductase member 3, retinaldehyde reductase, Retinol dehydrogenase, retinol-active alcohol dehydrogenase, retSDR1, TeSADH, TsAdh319, Tsib_0319, VNG_2617G, YqhD
ECTree
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Substrates Products
Substrates Products on EC 1.1.1.71 - alcohol dehydrogenase [NAD(P)+]
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REACTION DIAGRAM
(1R)-1-hydroxy-1-phenylpropan-2-one + NADPH + H+
(1R)-1-phenylpropane-1,2-diol + NADP+
-
-
-
-
?
(2R)-2-hydroxy-1-(4-methoxyphenyl)propan-1-one + NADPH + H+
(2R)-1-(4-methoxyphenyl)propane-1,2-diol + NADP+
-
-
-
-
?
(2S)-2-hydroxy-1-(4-methoxyphenyl)propan-1-one + NADPH + H+
(2S)-1-(4-methoxyphenyl)propane-1,2-diol + NADP+
-
-
-
-
?
(4R,6S)-6-(chloromethyl)oxane-2,4-diol + NAD+
(4R,6S)-6-(chloromethyl)-4-hydroxyoxan-2-one + NADH + H+
-
-
-
-
?
(4R,6S)-6-(chloromethyl)oxane-2,4-diol + NADP+
(4R,6S)-6-(chloromethyl)-4-hydroxyoxan-2-one + NADPH + H+
-
-
-
-
?
(RS)-1-phenylethanol + NAD+
1-phenylethanone + NADH + H+
-
100% activity
-
-
?
(RS)-1-phenylethanol + NADP+
1-phenylethanone + NADPH + H+
-
100% activity
-
-
?
(S)-2-butanol + NADP+
butanone + NADPH
196% relative activity as compared to 2-propanol
-
-
?
(S)-2-butanol + NADP+
butanone + NADPH + H+
196% of the activity with 2-propanol, 2fold preference for (S)-2-butanol over (RS)-2-butanol
-
-
?
1,3-butanediol + NADP+
? + NADPH + H+
91% relative activity as compared to 2-propanol
-
-
?
1-(2-bromophenyl)ethanol + NAD(P)+
1-(2-bromophenyl)ethanone + NAD(P)H + H+
-
11.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-(2-chlorophenyl)ethanol + NAD(P)+
1-(2-chlorophenyl)ethanone + NAD(P)H + H+
-
16.4% activity compared to (RS)-1-phenylethanol
-
-
?
1-(3-bromophenyl)ethanol + NAD(P)+
1-(3-bromophenyl)ethanone + NAD(P)H + H+
-
315% activity compared to (RS)-1-phenylethanol
-
-
?
1-(3-chlorophenyl)ethanol + NAD(P)+
1-(3-chlorophenyl)ethanone + NAD(P)H + H+
-
205% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-bromophenyl)ethanol + NAD(P)+
1-(4-bromophenyl)ethanone + NAD(P)H + H+
-
167% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-chlorophenyl)ethanone + NAD(P)+
1-(4-chlorophenyl)ethanone + NAD(P)H + H+
-
151% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-fluorophenyl)ethanol + NAD(P)+
1-(4-fluorophenyl)ethanol + NAD(P)H + H+
-
119% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-methylphenyl)ethanone + NAD(P)+
1-(4-methylphenyl)ethanol + NAD(P)H + H+
-
189% activity compared to (RS)-1-phenylethanol
-
-
?
1-butanol + NAD(P)+
butanal + NAD(P)H + H+
-
2.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-butanol + NADP+
butanal + NADPH
80% relative activity as compared to 2-propanol
-
-
?
1-heptanol + NAD(P)+
heptanal + NAD(P)H + H+
-
3.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-hexanol + NAD(P)+
hexanal + NAD(P)H + H+
-
2.8% activity compared to (RS)-1-phenylethanol
-
-
?
1-octanol + NAD(P)+
octanal + NAD(P)H + H+
-
2.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-pentanol + NAD(P)+
pentanal + NAD(P)H + H+
-
2.8% activity compared to (RS)-1-phenylethanol
-
-
?
1-phenyl-1,2-ethanediol + NAD(P)+
?
-
3.4% activity compared to (RS)-1-phenylethanol
-
-
?
1-phenyl-1-propanol + NAD(P)+
1-phenylpropionaldehyde + NAD(P)H + H+
-
13.1% activity compared to (RS)-1-phenylethanol
-
-
?
1-phenyl-2-propanol + NAD(P)+
1-phenylpropan-2-one + NAD(P)H + H+
-
39.1% activity compared to (RS)-1-phenylethanol
-
-
?
1-phenylethanol + NADP+
1-phenylethanone + NADPH + H+
35% of the activtiy with 1-propanol
-
-
?
1-phenylethanol + NADP+
acetophenone + NADPH + H+
35% compared to activity with 1-propanol
-
-
?
1-phenylmethanol + NADP+
benzaldehyde + NADPH + H+
180% relative activity as compared to 2-propanol
-
-
?
1-propanol + NAD(P)+
propionaldehyde + NAD(P)H + H+
-
1.2% activity compared to (RS)-1-phenylethanol
-
-
?
2,2,2-trifluoroacetophenone + NAD(P)H + H+
2,2,2-trifluoro-1-phenylethan-1-ol + NAD(P)+
-
180% activity compared to acetoin
-
-
?
2-bromoacetophenone + NAD(P)H + H+
1-(2-bromophenyl)ethanone + NAD(P)+
-
8.7% activity compared to acetoin
-
-
?
2-butanol + NAD(P)+
butan-2-one + NAD(P)H + H+
-
22.3% activity compared to (RS)-1-phenylethanol
-
-
?
2-butanol + NADP+
2-butanone + NADPH + H+
43% of the activity compared to ethanol
-
-
?
2-chloro-1-phenylethanol + NAD(P)+
2-chloro-1-phenylethan-1-one + NAD(P)H + H+
-
0.3% activity compared to (RS)-1-phenylethanol
-
-
?
2-heptanol + NAD(P)+
heptan-2-one + NAD(P)H + H+
-
61.6% activity compared to (RS)-1-phenylethanol
-
-
?
2-hexanol + NAD(P)+
hexan-2-one + NAD(P)H + H+
-
38.7% activity compared to (RS)-1-phenylethanol
-
-
?
2-hexanone + NAD(P)H + H+
hexan-2-ol + NAD(P)+
-
3.6% activity compared to acetoin
-
-
?
2-hydroxy-2-methyl-1-phenylpropan-1-one + NADPH + H+
2-methyl-1-phenylpropan-1,2-diol + NADP+
-
-
-
-
?
2-hydroxy-3-methoxybenzaldehyde + NADPH + H+
2-hydroxy-3-methoxybenzyl alcohol + NADP+
-
-
-
?
2-octanol + NAD(P)+
octan-2-one + NAD(P)H + H+
-
45.8% activity compared to (RS)-1-phenylethanol
-
-
?
2-pentanol + NAD(P)+
pentan-2-one + NAD(P)H + H+
-
30.2% activity compared to (RS)-1-phenylethanol
-
-
?
2-pentanol + NADP+
2-pentanone + NADPH + H+
67% relative activity as compared to 2-propanol
-
-
?
2-pentanol + NADP+
pentan-2-one + NADPH + H+
67% of the activity with 2-propanol
-
-
?
2-phenylethanol + NAD(P)+
phenylacetaldehyde + NAD(P)H + H+
-
0.3% activity compared to (RS)-1-phenylethanol
-
-
?
2-propanol + NAD(P)+
propan-2-one + NAD(P)H + H+
-
5.3% activity compared to (RS)-1-phenylethanol
-
-
?
3,4-dimethoxybenzaldehyde + NADPH + H+
3,4-dimethoxybenzyl alcohol + NADP+
-
-
-
?
3-methyl-2-pentanone + NADPH + H+
? + NADP+
13% relative activity as compared to pyruvaldehyde
-
-
?
3-methylbutanal + NADP+
? + NADPH + H+
about% of the activity with 1-butanol
-
-
?
acetoin + NAD(P)+
butan-2,3-dione + NAD(P)H + H+
-
100% activity
-
-
?
acetoin + NAD(P)H + H+
2,3-butanediol + NAD(P)+
-
4.5% activity compared to (RS)-1-phenylethanol
-
-
?
acetoin + NADPH + H+
?
-
1.9% activity compared to 3-hydroxypropionaldehyde
-
-
?
acetone + NAD(P)H + H+
propan-2-ol + NAD(P)+
-
4.1% activity compared to acetoin
-
-
?
acrolein + NADPH + H+
prop-2-en-1-ol + NADP+
-
41.8% activity compared to 3-hydroxypropionaldehyde
-
-
?
butan-1,4-diol + NADP+
butandialdehyde + NADPH
-
29% of activity with hexan-1-ol
-
r
butanal + NADPH + H+
1-butanol + NAD(P)+
44% activity compared to pentanal
-
-
?
cis-4-cyclopentene-1,3-diol + NADP+
(R)-4-hydroxy-2-cyclopentenone + NADPH + H+
-
-
-
-
?
cis-hex-3-en-1-ol + NADP+
cis-hex-3-en-1-al + NADPH
-
18.7% of activity with hexan-1ol
-
r
cyclohexanol + NAD(P)+
cyclohexanone + NAD(P)H + H+
-
52.3% activity compared to (RS)-1-phenylethanol
-
-
?
cyclohexanone + NAD(P)H + H+
cyclohexanol + NAD(P)+
-
19.1% activity compared to acetoin
-
-
?
D-arabinose + NAD(P)+
?
-
21.4% activity compared to (RS)-1-phenylethanol
-
-
?
D-arabinose + NADP+
? + NADPH + H+
200% relative activity as compared to 2-propanol
-
-
?
D-arabinose + NADP+
D-arabitol + NADPH + H+
200% of the activity with 2-propanol. D-arabinose is preferred over L-arabinose
-
-
?
D-mannose + NADP+
? + NADPH + H+
48% relative activity as compared to 2-propanol
-
-
?
D-ribose + NADP+
? + NADPH + H+
35% relative activity as compared to 2-propanol
-
-
?
decan-1-ol + NADP+
decanal + NADPH
-
decrease in enzyme activity with increase in chain length
-
r
dihydroxyacetone + NAD(P)H + H+
?
-
34.8% activity compared to acetoin
-
-
?
dodecan-1-ol + NADP+
dodecanal + NADPH
-
decrease in enzyme activity with increase in chain length
-
r
ethanol + NAD(P)+
acetaldehyde + NAD(P)H + H+
-
0.5% activity compared to (RS)-1-phenylethanol
-
-
?
ethyl pyruvate + NAD(P)H + H+
?
-
294% activity compared to acetoin
-
-
?
furfural + NADPH + H+
(furan-2-yl)methanol + NAD(P)+
5% activity compared to pentanal
-
-
?
glycerol + NADP+
glyceraldehyde + NADPH + H+
16% relative activity as compared to 2-propanol
-
-
?
glycoaldehyde + NADPH + H+
?
5% activity compared to pentanal
-
-
?
glyoxylic acid + NADPH + H+
? + NADP+
36% relative activity as compared to pyruvaldehyde
-
-
?
heptanal + NADPH + H+
1-heptanol + NAD(P)+
56% activity compared to pentanal
-
-
?
hexanal + NAD(P)H + H+
hexan-1-ol + NAD(P)+
-
12.9% activity compared to acetoin
-
-
?
hexanal + NADPH + H+
1-hexanol + NAD(P)+
62% activity compared to pentanal
-
-
?
hydrocinnamaldehyde + NADPH + H+
hydrocinnamyl alcohol + NADP+
-
-
-
?
isoamyl alcohol + NADP+
? + NADPH + H+
about 80% of the activity with 1-butanol
-
-
?
L-arabinose + NAD(P)+
?
-
5.2% activity compared to (RS)-1-phenylethanol
-
-
?
L-arabinose + NADP+
? + NADPH + H+
17% relative activity as compared to 2-propanol
-
-
?
mannitol + NADP+
D-mannose + NADPH
-
6.5% of activity with hexan-1-ol
-
r
meso-2,3-butanediol + NAD+
?
-
272% activity compared to (RS)-1-phenylethanol
-
-
?
meso-2,3-butanediol + NADP+
?
-
272% activity compared to (RS)-1-phenylethanol
-
-
?
methanol + NAD(P)+
formaldehyde + NAD(P)H + H+
-
0.2% activity compared to (RS)-1-phenylethanol
-
-
?
methyl benzoylformate + NAD(P)H + H+
?
-
67% activity compared to acetoin
-
-
?
methylglyoxal + NADPH + H+
?
29% activity compared to pentanal
-
-
?
octan-1-ol + NADP+
octanal + NADPH
-
decrease in enzyme activity with increase in chain length
-
r
octanal + NADPH + H+
1-octanol + NAD(P)+
55% activity compared to pentanal
-
-
?
pentanal + NADPH + H+
1-pentanol + NAD(P)+
100% activity
-
-
?
phenylacetaldehyde + NAD(P)H + H+
2-phenylethan-1-ol + NAD(P)+
-
18.6% activity compared to acetoin
-
-
?
propanal + NADPH + H+
1-propanol + NAD(P)+
14% activity compared to pentanal
-
-
?
pyruvic aldehyde + NAD(P)H + H+
?
-
328% activity compared to acetoin
-
-
?
rac-1-nonen-4-ol + NADP+
(S)-1-nonen-4-ol + 1-nonen-4-one + NADPH + H+
-
-
-
-
?
rac-1-phenylethanol + NAD(P)+
acetophenone + (R)-1-phenylethanol + NAD(P)H + H+
-
-
-
-
?
rac-1-phenylethanol + NADP+
(R)-1-phenylethanol + (S)-1-phenylethanol + NADPH + H+
-
-
-
-
?
ribitol + NADP+
D-ribose + NADPH
-
4% of activity with hexan-1-ol
-
r
trans-2,cis-6-nonadienal + NAD(P)+
trans-2,cis-6-nonadienol + NAD(P)H
-
-
-
?
trans-2,cis-6-nonadienal + NADPH + H+
trans-2,cis-6-nonadienol + NADP+
-
-
-
?
trans-2-pentenol + NAD(P)+
trans-2-pentenal + NAD(P)H
-
-
-
?
trans-trans-2,4-decadienal + NADPH + H+
trans-trans-2,4-decadienol + NADP+
-
-
-
?
(2S,5S)-2,5-hexanediol + NADP+
? + NADPH + H+
-
-
-
?
(4R,6R)-6-butyl-4-hydroxyoxan-2-one + NADH + H+
-
-
-
-
?
(4R,6R)-6-butyloxane-2,4-diol + NAD+
(4R,6R)-6-butyl-4-hydroxyoxan-2-one + NADH + H+
Starmerella magnoliae DSMZ 70638
-
-
-
-
?
(4R,6R)-6-butyl-4-hydroxyoxan-2-one + NADPH + H+
-
-
-
-
?
(4R,6R)-6-butyloxane-2,4-diol + NADP+
(4R,6R)-6-butyl-4-hydroxyoxan-2-one + NADPH + H+
Starmerella magnoliae DSMZ 70638
-
-
-
-
?
(4R,6R)-4-hydroxy-6-pentyloxan-2-one + NADH + H+
-
-
-
-
?
(4R,6R)-6-pentyloxane-2,4-diol + NAD+
(4R,6R)-4-hydroxy-6-pentyloxan-2-one + NADH + H+
Starmerella magnoliae DSMZ 70638
-
-
-
-
?
(4R,6R)-4-hydroxy-6-pentyloxan-2-one + NADPH + H+
-
-
-
-
?
(4R,6R)-6-pentyloxane-2,4-diol + NADP+
(4R,6R)-4-hydroxy-6-pentyloxan-2-one + NADPH + H+
Starmerella magnoliae DSMZ 70638
-
-
-
-
?
butanal + NADPH + H+
117% of the activity compared to ethanol
-
-
?
1-butanol + NADP+
butanal + NADPH + H+
80% compared to activity with 1-propanol
-
-
?
1-butanol + NADP+
butanal + NADPH + H+
80% compared to activity with 1-propanol
-
-
?
1-butanol + NADP+
butanal + NADPH + H+
80% of the activtiy with 1-propanol
-
-
?
1-butanol + NADP+
butanal + NADPH + H+
80% of the activtiy with 1-propanol
-
-
?
pentanal + NADPH + H+
74% of the activity compared to ethanol
-
-
?
1-pentanol + NADP+
pentanal + NADPH + H+
about 75% of the activity with 1-butanol
-
-
?
1-pentanol + NADP+
pentanal + NADPH + H+
about 75% of the activity with 1-butanol
-
-
?
propanal + NADH + H+
dual cofactor dependency, NAD+ shows 60% of the activity with NADP+
-
-
?
1-propanol + NAD+
propanal + NADH + H+
dual cofactor dependency, NAD+ shows 60% of the activity with NADP+
-
-
?
propanal + NADPH + H+
137% of the activity compared to ethanol
-
-
?
1-propanol + NADP+
propanal + NADPH + H+
dual cofactor dependency, NAD+ shows 60% of the activity with NADP+
-
-
?
1-propanol + NADP+
propanal + NADPH + H+
about 60% of the activity with 1-butanol
-
-
?
1-propanol + NADP+
propanal + NADPH + H+
about 60% of the activity with 1-butanol
-
-
?
butanone + NADPH + H+
30% compared to activity with 1-propanol
-
-
?
2-butanol + NADP+
butanone + NADPH + H+
30% of the activtiy with 1-propanol
-
-
?
2-butanol + NADP+
butanone + NADPH + H+
about 25% of the activity with 1-butanol
-
-
?
2-methoxybenzaldehyde + NADPH + H+
2-methoxybenzyl alcohol + NADP+
-
-
-
-
?
2-methoxybenzaldehyde + NADPH + H+
2-methoxybenzyl alcohol + NADP+
highest activity
-
-
?
acetone + NADPH + H+
25% compared to activity with 1-propanol
-
-
?
2-propanol + NADP+
acetone + NADPH + H+
25% compared to activity with 1-propanol
-
-
?
propan-1,3-diol + NADP+
-
100% activity
-
-
?
3-hydroxypropionaldehyde + NADPH + H+
propan-1,3-diol + NADP+
-
100% activity
-
-
?
4-methoxybenzaldehyde + NADPH + H+
4-methoxybenzyl alcohol + NADP+
-
-
-
-
?
4-methoxybenzaldehyde + NADPH + H+
4-methoxybenzyl alcohol + NADP+
-
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
2.2% activity compared to 3-hydroxypropionaldehyde
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
2.2% activity compared to 3-hydroxypropionaldehyde
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
?
acrylaldehyde + NADPH
-
28% of activity with hexan-1-ol
-
r
allyl alcohol + NADP+
acrylaldehyde + NADPH
-
-
-
r
benzaldehyde + NADPH + H+
20% compared to activity with 1-propanol
-
-
?
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
about% of the activity with 1-butanol
-
-
?
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
about% of the activity with 1-butanol
-
-
?
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
180% of the activity with 2-propanol
-
-
?
butanal + NADPH
-
36.3% of activity with hexan-1-ol
-
r
butanol + NADP+
-
118.4% activity compared to 3-hydroxypropionaldehyde
-
-
?
butyraldehyde + NADPH + H+
butanol + NADP+
-
118.4% activity compared to 3-hydroxypropionaldehyde
-
-
?
? + NADPH + H+
71% relative activity as compared to 2-propanol
-
-
?
cellobiose + NADP+
? + NADPH + H+
71% of the activity with 2-propanol
-
-
?
cis-2-butenol + NAD(P)H
trans-2-butenal + NAD(P)+
-
-
-
?
? + NADPH + H+
146% relative activity as compared to 2-propanol
-
-
?
D-glucose + NADP+
? + NADPH + H+
146% of the activity with 2-propanol
-
-
?
? + NADPH + H+
246% relative activity as compared to 2-propanol
-
-
?
D-xylose + NADP+
? + NADPH + H+
246% of the activity with 2-propanol
-
-
?
? + NADP+
270% relative activity as compared to pyruvaldehyde
-
-
?
dimethylglyoxal + NADPH + H+
? + NADP+
270% of the activity with pyruvaldehyde
-
-
?
glyoxal + NADPH
-
8.5% of activity with hexan-1-ol
-
r
acetaldehyde + NADH + H+
enzyme appears to preferentially catalyze the reductive reaction. Activity with NAD+ is 75% less than that detected with NADP+
-
-
?
acetaldehyde + NADPH + H+
enzyme appears to preferentially catalyze the reductive reaction. Activity with NAD+ is 75% less than that detected with NADP+
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
85% compared to activity with 1-propanol
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
85% compared to activity with 1-propanol
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
84% of the activtiy with 1-propanol
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
84% of the activtiy with 1-propanol
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
about 50% of the activity with 1-butanol
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
about 50% of the activity with 1-butanol
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
36% relative activity as compared to 2-propanol
-
-
?
ethanal + NADPH + H+
-
8.5% of activity with hexan-1-ol
-
r
ethanol + NADP+
ethanal + NADPH + H+
-
oxidation rate at 5% of reduction rate
-
r
pentanal + NADPH
-
4% of activity with hexan-1-ol
-
r
propanal + NADPH
-
28% of activity with hexan-1-ol
-
r
propan-1-ol + NADP+
propanal + NADPH
-
oxidation rate at 5% of reduction rate
-
r
propanol + NADP+
-
37.1% activity compared to 3-hydroxypropionaldehyde
-
-
?
propionaldehyde + NADPH + H+
propanol + NADP+
-
37.1% activity compared to 3-hydroxypropionaldehyde
-
-
?
pyruvaldehyde + NADPH + H+
lactaldehyde + NADP+
-
-
-
?
retinaldehyde + NADH
retinol + NAD+
-
the enzyme is involved in retinol and vitamin A metabolism, retinoic acid is important in intestinal epithelial cell proliferation and differentiation, the enzyme also plays a role in dietary conversion of beta-carotene to retinol via retinaldehyde
-
-
r
?
-
in wild-type strains, NADH is the preferred cofactor for both aldehyde dehydrogenase ALDH and alcohol dehydrogenase ADH activities. The AdhE protein of the ethanologenic strain of Clostridium thermocellum has acquired high NADPH-linked ADH activity while maintaining NADH-linked ALDH and ADH activities at wild-type levels
-
-
?
additional information
?
-
the enzyme does not accept methanol, 2-propanol, glycerol or glucose as substrates
-
-
?
additional information
?
-
-
the enzyme does not accept methanol, 2-propanol, glycerol or glucose as substrates
-
-
?
additional information
?
-
preference for short-chain alcohol substrates, particularly for 1-propanol (100%) and ethanol (84%), no activity with glycerol or methanol
-
-
?
additional information
?
-
preference for short-chain alcohol substrates, particularly for 1-propanol (100%) and ethanol (84%), no activity with glycerol or methanol
-
-
?
additional information
?
-
no substrates: methanol, glycerol
-
-
?
additional information
?
-
HvADH2 accepts a broad range of substrates, no activity with methanol
-
-
?
additional information
?
-
HvADH2 accepts a broad range of substrates, no activity with methanol
-
-
?
additional information
?
-
-
4-nitroacetophenone, benzyl, cortisone and progesterone are no substrates
-
-
?
additional information
?
-
-
no activity with dihydroxyacetone, hydroxyacetone, and acetone
-
-
?
additional information
?
-
-
no activity with dihydroxyacetone, hydroxyacetone, and acetone
-
-
?
additional information
?
-
no activity with glyoxal, methanal, and ethanal
-
-
?
additional information
?
-
the enzyme shows no oxidative activities towards alcoholic compounds
-
-
?
additional information
?
-
-
no activity with glyoxal, methanal, and ethanal
-
-
?
additional information
?
-
-
the enzyme shows no oxidative activities towards alcoholic compounds
-
-
?
additional information
?
-
no activity with glyoxal, methanal, and ethanal
-
-
?
additional information
?
-
the enzyme shows no oxidative activities towards alcoholic compounds
-
-
?
additional information
?
-
substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol
-
-
-
additional information
?
-
substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol
-
-
-
additional information
?
-
substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol
-
-
-
additional information
?
-
substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol
-
-
-
additional information
?
-
substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol
-
-
-
additional information
?
-
substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol
-
-
-
additional information
?
-
-
no activity with methanol and ethanol
-
-
?
additional information
?
-
the enzyme plays an important role in potato defence response to Erwinia carotovora
-
-
?
additional information
?
-
not: conferyl aldehyde and sinapaldehyde, the enzyme exhibits an absolute requirement for NADPH as cofactor and can not be substituted by NADH
-
-
?
additional information
?
-
-
lactol substrates (4R,6S)-6-(chloromethyl)oxane-2,4-diol and (4R,6R)-6-butyloxane-2,4-diol for the biocatalytic oxidations are obtained from 2-deoxy-D-ribose 5-phosphate aldolase (DERA) catalyzed reactions of the corresponding acceptor aldehydes chloroacetaldehyde and pentanal, respectively and at least two equivalents of acetaldehyde as described previously. Development of an efficient biocatalytic process on pilot plant scale to oxidize the aliphatic hydroxylactol substrate (4R,6R)-6-butyloxane-2,4-diol to the corresponding lactone product (4R,6R)-6-butyl-4-hydroxyoxan-2-one employing the wild-type alcohol dehydrogenase ADHA
-
-
-
additional information
?
-
Starmerella magnoliae DSMZ 70638
-
lactol substrates (4R,6S)-6-(chloromethyl)oxane-2,4-diol and (4R,6R)-6-butyloxane-2,4-diol for the biocatalytic oxidations are obtained from 2-deoxy-D-ribose 5-phosphate aldolase (DERA) catalyzed reactions of the corresponding acceptor aldehydes chloroacetaldehyde and pentanal, respectively and at least two equivalents of acetaldehyde as described previously. Development of an efficient biocatalytic process on pilot plant scale to oxidize the aliphatic hydroxylactol substrate (4R,6R)-6-butyloxane-2,4-diol to the corresponding lactone product (4R,6R)-6-butyl-4-hydroxyoxan-2-one employing the wild-type alcohol dehydrogenase ADHA
-
-
-
additional information
?
-
in wild-type strains, NADH is the preferred cofactor for both aldehyde dehydrogenase ALDH and alcohol dehydrogenase ADH activities. In high-ethanol-producing (ethanologen) strains of Thermoanaerobacterium saccharolyticum, both ALDH and ADH activities show increased NADPH-linked activity
-
-
?
additional information
?
-
-
no activity with D-arabinose, L-arabinose, acetophenone, and 4-chloroacetophenone
-
-
?
additional information
?
-
no oxidation of methanol, methoxyethanol, ethylene glycol, or D-galactose. No reduction of acetone, cyclopentanone, D-arabinose, D-xylose, D-glucose or cellobiose
-
-
?
additional information
?
-
-
no oxidation of methanol, methoxyethanol, ethylene glycol, or D-galactose. No reduction of acetone, cyclopentanone, D-arabinose, D-xylose, D-glucose or cellobiose
-
-
?