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1.1.1.67: mannitol 2-dehydrogenase

This is an abbreviated version!
For detailed information about mannitol 2-dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.67

Reaction

D-mannitol
+
NAD+
=
D-fructose
+
NADH
+
H+

Synonyms

alcohol dehydrogenase, zinc-containing, D-mannitol dehydrogenase, M2DH, mannitol 2-dehydrogenase, mannitol dehydrogenase, mannitol-2-dehydrogenase, MDH, mt-dh, MtDH, MtlD, NAD+-dependent mannitol dehydrogenase, NADH-dependent mannitol dehydrogenase, pfMDH, polyol dehydrogenase, PsM2DH, TM0298, TM_0298

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.67 mannitol 2-dehydrogenase

Temperature Stability

Temperature Stability on EC 1.1.1.67 - mannitol 2-dehydrogenase

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20
-
not stable above
25
half-life 3.6 h
30
half-life 0.42 h
30 - 40
-
The enzyme is very stable at 30°C. The half life time at 40°C is 35 min for D-mannitol oxidation.
50
-
heat inactivation, 50% loss of activity after 30 min incubation
75 - 90
-
the enzyme records 85%, 50% and 10% of its initial activity after 4 h of exposure to 75, 80, 85 and 90°C, respectively. The enzyme almost does not lose the activity after 1 h of incubation at 75°C and still has half of initial activity after incubated at 90°C for 1 h