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low level
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low mRNA expression
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low level
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no sex differences in enzyme expression
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moderate expression
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cultured cells, enzyme expression is stimulated with all-trans and 9-cis retinoic acid
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cultured cells, expresses 17beta-HSD isoforms 1-4
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EpiskinTM is a cultured human epidermis. 17beta-hydroxysteroid dehydrogenase and 3alpha-hydroxysteroid dehdyrogenase activities are present at moderate levels in EpiskinTM, while 3beta-hydroxysteroid dehdyrogenase activity is low
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ovarian surface epithelial cell
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association of 17HSD1 with extravillous cells indicates that the enzyme perhaps plays a role in trophoblast invasion
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epithelial cells. Increased expression of 17HSD1 in epithelial cells of fallopian tube may lead to a local estradiol supply sufficient for maintenance of tubal pregnancy
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high expression
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cultured cells, expresses 17beta-HSD isoforms 1-4
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cultured cells, expresses 17beta-HSD isoforms 1-4
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transfected with type 1 cDNA, high activity
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no sex differences in enzyme expression
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a T-lymphoma cell line
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choriocarcinoma JAr cell
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Jurkat acute T cell leukemia cell line
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3beta- and 17beta-hydroxysteroid dehydrogenase are not altered in metyrapone-treated cells
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HSD17B2 expression is significantly higher in invasive lobular carcinoma (ILC) than in invasive ductal carcinoma
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cultured cells, expresses 17beta-HSD isoforms 1-4
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HSD17B2 expression is significantly higher in invasive lobular carcinoma (ILC) than in invasive ductal carcinoma
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high levels of 17betaHSD1 transcript are detected. Downregulation during follicular luteinization
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moderate expression
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cultured muscle cell
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moderate expression
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NSCLC, immunihostichemic enzyme analysis: higher 17betaHSD1 immunoreactivity tends to be positively associated with aromatase and tumor stage. A higher 17betaHSD1 immunoreactivity is also significantly associated with lower intratumoral estrone concentration and a higher intratumoral estradiol/estrone concentration ratio. On the other hand a higher 17betaHSD2 immunoreactivity is significantly associated with higher intratumoral estrone concentration
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cultured cells
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a B-lymphoma cell line
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normal and tubal pregancies possess identical expression of 17HSD1 in syncytiotrophoblast cells and therefore, similar estradiol production in the placenta
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breast cancer cell, 7beta-HSD type 1
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isozyme AKR1B15.2
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low mRNA expression
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endometriotic epithelial cell line
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epidermoid tumor of the vulva, A431
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isozymes AKR1B15.1 and AKR1B15.2
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retroperitonea, high mRNA expression
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high expression
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expression of type 7 17beta-hydroxysteroid dehydrogenase in zona fasciculata and reticularis in the cortex
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in the three zones of the cortex, not in the medulla
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low mRNA expression
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fetal, very low expression of isozyme AKR1B15.2
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HSD17B4 mRNA and activity are detectable in the early developing and adult brain
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HSD17B4 mRNA is expressed more in the song regions of males compared to females throughout development. Females have significantly higher levels of HSD17B4 mRNA in auditory (caudomedial nidopallium) and visual (hyperpalliumapicale)regions than does males at day 25
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17beta-HSD1 is overexpressed in many breast tumors
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the inhibition of the enzyme (17beta-HSD7) constitutes the basis of breast cancer cell proliferation
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17beta-HSD type 12 in 83% of the breast cancer specimen. The expression of 17beta-HSD type 12 is significantly higher in breast carcinoma specimen than in normal tissues
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17beta-HSD type 7 activity is detected in 47% of the breast cancer specimen
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the 17beta-HSD type 1 can be detected only in one tumor
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breast cells, activity is far greater in epithelial cells than in fibroblasts
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enzyme type 2 from ovarian tumor: CAOV-3
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high expression
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type 7 17beta-hydroxysteroid dehydrogenase is expressed in epithelial cells of both acini and small ducts
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high mRNA expression
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HSD17B2 is normally expressed in the epithelial cells of the colon lumen, and to a lesser extent in the crypt epithelium small intestine endometrium
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type 7 17beta-hydroxysteroid dehydrogenase is restricted to epithelial cells of the mucosa
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low mRNA expression
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detectable throughout the luteal phase of the ovarian cycle and during pregnancy
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ubiquitously expressed in all tissues analyzed, with higher levels in organs with high metabolic rates, such as kidney and digestive gland
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of fallopian tube. Increased expression of 17HSD1 in epithelial cells of fallopian tube may lead to a local estradiol supply sufficient for maintenance of tubal pregnancy
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granulosa cells, Leydig cells and Sertoli cells
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very low expression of isozymes AKR1B15.1 and AKR1B15.2
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moderate expression
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low mRNA expression
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stable expressing 17beta-HSD12
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isozymes AKR1B15.1 and AKR1B15.2
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high activity
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cultured cells, enzyme expression is stimulated with all-trans and 9-cis retinoic acid
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high expression
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epithelial cells of proximal convoluted tubules
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low mRNA expression
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ubiquitously expressed in all tissues analyzed, with higher levels in organs with high metabolic rates, such as kidney and digestive gland
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proximal tubuli
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high activity
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high activity
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17beta-HSD8
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isozyme 17beta-HSD4
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moderate expression
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type 7 17beta-hydroxysteroid dehydrogenase is found in all the hepatocytes
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all hepatocytes
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low mRNA expression
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high expression
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17betaHSD gene expression in liver, but not in testis, varies negatively with fat androstenone concentration. Immunocastrated and surgically castrated male pigs show significant increase of 3betaHSD expression. Fat androstenone is negatively correlated with liver 17betaHSD gene expression. The mRNA expression is generally much greater from the 3betaHSD than from the 17betaHSD gene
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male pigs with high androstenone concentrations in fat have low 3betaHSD gene expression in liver and testis. Immunocastrated and surgically castrated male pigs shows significant increase of 3betaHSD expression. Fat androstenone is negatively correlated with liver 3betaHSD gene expression. The mRNA expression is generally much greater from the 3betaHSD than from the 17betaHSD gene
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bronchial epithelial cells and walls of pulmonary arteries
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bronchial epithelium
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moderate expression. Strong labeling expression is observed in epithelial cells and stromal cells
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type 7 17beta-hydroxysteroid dehydrogenase is expressed in stromal cells surrounding the duct
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ductal epithelial cells and stromal cells
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low mRNA expression
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breast cancer cell line MCF-7
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modulation of local synthesis of estradiol is one potential mechanism through which genistein, enterolactone and enterodiol may protect against breast cancer
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MCF-7.8H cell derived from MCF-7 via transfection, high enzyme activity
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weak activity
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breast cancer cell line MDA-MB-231
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enzyme type 2 from ovarian tumors: OVCAR-3, CAOV-3 and epidermoid tumor of the vulva, A431
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cultured granulosa cells, detectable in large follicles, very weak in medium follicles
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high expression in granulosa cells of growing follicles
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enzyme type 2 from ovarian tumors: OVCAR-3, CAOV-3
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ovarian surface epithelial cell
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type 12 17beta-hydroxysteroid dehydrogenase is most highly expressed in ovary and mammary gland
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17beta-HSD8 in cumulus cells, not in granulosa and luteal cells, vice versa for isozymes 17beta-HSD1 and 17beta-HSD7
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isozyme 17beta-HSD1
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low expression of isozymes AKR1B15.1 and AKR1B15.2
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the enzyme is primarily expressed in the placenta and ovarian granulose cells
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moderate expression
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type 7 17beta-hydroxysteroid dehydrogenase is restricted to corpus luteum cells
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low mRNA expression
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enzyme type 2 from ovarian tumor: OVCAR-3
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moderate expression
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in three lobes
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low mRNA expression
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285977, 285981, 287172, 287173, 287174, 287176, 287181, 287182, 287183, 287184, 287186, 287187, 287188, 287190, 287191, 655219, 656371, 658489, 669797, 670265, 688956, 700183 brenda
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high expression
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isoform 8 is highly expressed, low level of isoform 5
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normal and tubal pregancies possess identical expression of 17HSD1 in syncytiotrophoblast cells and therefore, similar estradiol production in the placenta
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organotin compounds are potent stimulators of 17beta-estradiol biosynthesis to enhance 17beta-HSD I activity in placenta
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isozyme 17beta-HSD1
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17beta-HSD1
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17beta-HSD2
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isozymes AKR1B15.1 and AKR1B15.2
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the enzyme is primarily expressed in the placenta and ovarian granulose cells
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type 7 17beta-hydroxysteroid dehydrogenase
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high mRNA expression
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high expression
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expressed in estrogen receptor beta-positive epithelial cells of the human prostate
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isozyme AKR1B15.1
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only in epithelial cells
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moderate expression
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epithelial cells of the acini and stromal cells
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isozymes AKR1B15.1 and AKR1B15.2
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diaphragm
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moderate expression
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detectable in sebaceous glands, absent in epidermis, stroma, hair follicles and sweat glands
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high expression
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low mRNA expression
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low mRNA expression
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high activity
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cultured cells
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17beta-hydroxysteroid dehydrogenase has a pivotal role in regulating the synthesis of estradiol within breast tumours
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T47D breast cancer cell line
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isozyme AKR1B15.1, very low expression of isozyme AKR1B15.2
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moderate expression
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only in germ cells, absent in seminiferous tubules and Leydig cells
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Immunocastrated and surgically castrated male pigs shows significant increase of 17betaHSD expression. The mRNA expression is generally much greater from the 3betaHSD than from the 17betaHSD gene
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male pigs with high androstenone concentrations in fat have low 3betaHSD gene expression in liver and testis. Immunocastrated and surgically castrated male pigs shows significant increase of 3betaHSD expression. The mRNA expression is generally much greater from the 3betaHSD than from the 17betaHSD gene
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isozymes AKR1B15.1 and AKR1B15.2
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low mRNA expression
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proliferative
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secretory
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endometrial carcinoma
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moderate expression, epithelial cells and stromal cells
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endometrial 17beta-hydroxysteroid dehydrogenase activity is decreased on days 15-16 in pregnant and cyclic pigs compared with the preceding days
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very low expression of isozymes AKR1B15.1 and AKR1B15.2
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in epithelial, luminal and glandular, and in stromal cells
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low mRNA expression
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luminal and glandular epithelium
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additional information
not detectable in brain, colon, jejunum, pancreas, kidney, liver, adrenal, prostate, testis, uterus, lung, and spleen
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additional information
not detectable in brain, colon, jejunum, pancreas, kidney, liver, adrenal, prostate, testis, uterus, lung, and spleen
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additional information
not detectable in brain, lung and spleen
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additional information
not detectable in brain, lung and spleen
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additional information
enzyme identified from transcriptomic analysis. Lack of correlation of Ea17beta-hsd 14 transcript levels with the coral's reproductive cycle. Ea17beta-hsd 14 transcript and protein are detected in all tissues examined, such as the tentacles, mesenterial filaments, and gonads, at similar levels in both sexes, as determined by quantitative RT-PCR analysis and Western blotting with an anti-Ea17beta-Hsd 14 antibody. Immunohistochemical analysis reveals that Ea17beta-Hsd 14 is mainly distributed in the endodermal regions of the polyps, but the protein is also observed in all tissues examined. Seasonal variation in the levels of Ea17beta-hsd 14 transcripts, overview
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additional information
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enzyme identified from transcriptomic analysis. Lack of correlation of Ea17beta-hsd 14 transcript levels with the coral's reproductive cycle. Ea17beta-hsd 14 transcript and protein are detected in all tissues examined, such as the tentacles, mesenterial filaments, and gonads, at similar levels in both sexes, as determined by quantitative RT-PCR analysis and Western blotting with an anti-Ea17beta-Hsd 14 antibody. Immunohistochemical analysis reveals that Ea17beta-Hsd 14 is mainly distributed in the endodermal regions of the polyps, but the protein is also observed in all tissues examined. Seasonal variation in the levels of Ea17beta-hsd 14 transcripts, overview
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additional information
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no expression in villous cytotrophoblast cells
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additional information
in prostate cancers of Gleason grade higher than 3, both estrogen receptor beta and isoform 17betaHSD6 are undetectable
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additional information
17beta-HSD1 is highly expressed in breast and ovary tissues and represents a prognostic marker for the tumor progression and survival of patients with breast cancer and other estrogen-dependent tumors
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additional information
isozyme tissue-specific expression analysis, overview
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additional information
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not detectable in corpora lutea, interstitial cells, anterior and posterior lobes, mammary gland, uterus, vagina, adrenal gland, kidney, liver, brain, and lung
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additional information
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tissue distribution, in situ hybridization, overview
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additional information
ubiquitously expressed in all tissues analyzed, with higher levels in organs with high metabolic rates, such as kidney and digestive gland
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additional information
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ubiquitously expressed in all tissues analyzed, with higher levels in organs with high metabolic rates, such as kidney and digestive gland
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additional information
NlHsd17b12 is ubiquitously expressed in all tissues analyzed, with higher levels in organs with high metabolic rates, such as kidney and digestive gland, a pattern consistent with an involvement in lipid metabolism, detailed tissue distribution through quantitative PCR
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additional information
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NlHsd17b12 is ubiquitously expressed in all tissues analyzed, with higher levels in organs with high metabolic rates, such as kidney and digestive gland, a pattern consistent with an involvement in lipid metabolism, detailed tissue distribution through quantitative PCR
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additional information
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weak expression in the tissues examined, except for gastrointestinal tract and liver. No expression in lung
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additional information
co-localization of HSD17B4 and androgen receptor mRNA
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