1.1.1.60: 2-hydroxy-3-oxopropionate reductase

This is an abbreviated version!
For detailed information about 2-hydroxy-3-oxopropionate reductase, go to the full flat file.

Reaction

Synonyms

beta-hydroxyacid dehydrogenase, GarR, More, tartronate semialdehyde reductase, TSAR, TSR, TSR1, UM02592

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.60 2-hydroxy-3-oxopropionate reductase

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Results	in table
8012	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
23	Cofactor
4	Crystallization (Commentary)
1	General Information
16	Inhibitors
25	KM Value [mM]
7	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
14	Organism
7	Pathway
4	PDB ID
5	pH Optimum
3	pH Stability
6	Purification (Commentary)
1	Reaction
3	Reaction Type
13	Reference
3	Specific Activity [micromol/min/mg]
4	Storage Stability
32	Substrates and Products (Substrate)
2	Subunits
12	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Substrates Products

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of the Enzyme Summary Page.

Substrates Products on EC 1.1.1.60 - 2-hydroxy-3-oxopropionate reductase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(R)-beta-hydroxybutyrate + NAD+

?

Haemophilus influenzae

-

-

287167

-

-

?

(R)-glycerate + NAD(P)+

tartronate semialdehyde + NAD(P)H

5 entries

2-hydroxy-3-oxopropanoate + NADH + H+

D-glycerate + NAD+

Ustilago maydis

A0A0D1DYW4

-

726270

-

-

?

D-glycerate + NADP+

2-hydroxy-3-oxopropanoate + NADPH + H+

Ustilago maydis

A0A0D1DYW4

enzyme shows strong specificity and enantioselectivity for D-glycerate

726270

-

-

?

D-threonine + NAD+

?

Haemophilus influenzae

-

-

287167

-

-

?

hydroxypyruvate + NAD(P)H + H+

glycerate + NAD(P)+

3 entries

L-glycerate + NAD+

?

Escherichia coli

-

-

287167

-

-

r

L-glycerate + NADP+

2-hydroxy-3-oxopropanoate + NADPH + H+

Ustilago maydis

A0A0D1DYW4

enzyme shows strong specificity and enantioselectivity for D-glycerate

726270

-

-

?

malonic semialdehyde + NADH

3-hydroxypropanoate + NAD+

2 entries

mesoxalic semialdehyde + NADH

hydroxypyruvate + NAD+

2 entries

tartronate semialdehyde + NAD(P)H

(R)-glycerate + NAD(P)+

11 entries

tartronate semialdehyde + NADH

(R)-glycerate + NAD+

Salmonella enterica subsp. enterica serovar Typhimurium

-

as cofactor in the final stage of D-glycerate biosynthesis

699856

-

-

?

tartronate semialdehyde + NADH + H+

(R)-glycerate + NAD+

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

699856

-

-

?

additional information

?

-

2 entries

(R)-glycerate + NAD(P)+

tartronate semialdehyde + NAD(P)H

Escherichia coli

-

-

287168

-

287168

?

(R)-glycerate + NAD(P)+

tartronate semialdehyde + NAD(P)H

Escherichia coli

-

-

287167

-

287167

r

(R)-glycerate + NAD(P)+

tartronate semialdehyde + NAD(P)H

Haemophilus influenzae

-

-

287168

-

287168

?

(R)-glycerate + NAD(P)+

tartronate semialdehyde + NAD(P)H

Haemophilus influenzae

-

-

287167

-

287167

r

(R)-glycerate + NAD(P)+

tartronate semialdehyde + NAD(P)H

Hyphomicrobium sp.

-

-

287162

-

287162

r

hydroxypyruvate + NAD(P)H + H+

glycerate + NAD(P)+

Pseudomonas putida

-

-

287164

-

287164

r

hydroxypyruvate + NAD(P)H + H+

glycerate + NAD(P)+

Pseudomonas putida

-

-

287165

-

287165

r

hydroxypyruvate + NAD(P)H + H+

glycerate + NAD(P)+

Pseudomonas putida

-

-

287166

-

287166

r

malonic semialdehyde + NADH

3-hydroxypropanoate + NAD+

Pseudomonas putida

-

-

287165

-

287165

?

malonic semialdehyde + NADH

3-hydroxypropanoate + NAD+

Pseudomonas putida

-

-

287166

-

287166

?

mesoxalic semialdehyde + NADH

hydroxypyruvate + NAD+

Pseudomonas putida

-

-

287165

-

287165

?

mesoxalic semialdehyde + NADH

hydroxypyruvate + NAD+

Pseudomonas putida

-

-

287166

-

287166

?

tartronate semialdehyde + NAD(P)H

(R)-glycerate + NAD(P)+

Cupriavidus oxalaticus

-

-

4589

-

4589

?

tartronate semialdehyde + NAD(P)H

(R)-glycerate + NAD(P)+

Cupriavidus oxalaticus OX1

-

-

4589

-

4589

?

tartronate semialdehyde + NAD(P)H

(R)-glycerate + NAD(P)+

Escherichia coli

-

-

287168

-

287168

?

tartronate semialdehyde + NAD(P)H

(R)-glycerate + NAD(P)+

Escherichia coli

-

-

287167

-

287167

r

tartronate semialdehyde + NAD(P)H

(R)-glycerate + NAD(P)+

Haemophilus influenzae

-

-

287168

-

287168

?

tartronate semialdehyde + NAD(P)H

(R)-glycerate + NAD(P)+

Haemophilus influenzae

-

-

287167

-

287167

r

tartronate semialdehyde + NAD(P)H

(R)-glycerate + NAD(P)+

Hyphomicrobium sp.

-

-

287162

-

287162

r

tartronate semialdehyde + NAD(P)H

(R)-glycerate + NAD(P)+

Hyphomicrobium sp.

-

NADH 3 times more effective than NADPH

287162

-

287162

r

tartronate semialdehyde + NAD(P)H

(R)-glycerate + NAD(P)+

Pseudomonas putida

-

-

287164

-

287164

?

tartronate semialdehyde + NAD(P)H

(R)-glycerate + NAD(P)+

Pseudomonas putida

-

-

287165

-

287165

?

tartronate semialdehyde + NAD(P)H

(R)-glycerate + NAD(P)+

Pseudomonas putida

-

-

287166

-

287166

?

additional information

?

-

Ustilago maydis

A0A0D1DYW4

poor activity towards 6-phosphogluconic acid, beta-hydroxybutyric acid and D-threonine

726270

-

-

?

additional information

?

-

Ustilago maydis

-

poor activity towards 6-phosphogluconic acid, beta-hydroxybutyric acid and D-threonine

726270

-

-

?