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1.1.1.49: glucose-6-phosphate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about glucose-6-phosphate dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.1.1.49

Reaction

D-glucose 6-phosphate
+
NADP+
=
6-phospho-D-glucono-1,5-lactone
 +
NADPH
 +
H+

Synonyms

6-phosphoglucose dehydrogenase, beta-D-glucose-6-phosphate; NADP oxidoreductase, beta-D-glucose-6-phosphate;NADP oxido-reductase, D-glucose 6-phosphate dehydrogenase, D-glucose 6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate:NADP oxidoreductase, Entner-Doudoroff enzyme, G-6-PD, G-6-PDH, G-6PD, G6PD, G6PD1, G6PD2, G6PD3, G6PD4, G6PD5, G6PD6, G6PDH, G6PDH-1, G6PDH-2, G6PDH1, G6PDH2, G6PDH3, G6PDH4, G6PDH5, G6PDH6, Glc6PDH, glucose 6-phosphate dehydrogenase, glucose 6-phosphate dehydrogenase (NADP), glucose-6-phosphate 1-dehydrogenase, glucose-6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase Zwf, glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, GPD, KlZWF1, NADP-dependent glucose 6-phophate dehydrogenase, NADP-glucose-6-phosphate dehydrogenase, P2-G6PDH, PF14_0511, PfGluPho, plastidial glucose 6-phosphate dehydrogenase, VEG11, Vegetative protein 11, Zwf, zwf-1, Zwf-2, Zwf1p, Zwischenferment

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+)

Specific Activity

Specific Activity on EC 1.1.1.49 - glucose-6-phosphate dehydrogenase (NADP+)

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.007 - 0.009
-
cellular extract
0.025
-
cells grown on a phosphate-deficient medium TRP
0.0286
-
crude extract, at pH 8.0 temperature not specified in the publication
0.0374
-
crude extract, at pH 8.0, temperature not specified in the publication
0.0443
crude extract, at pH 8.0 and 37°C
0.045
-
cells grown on a phosphate-deficient medium TRP
0.077
-
nephridic enzyme
0.09
-
cells grown on a phosphate-sufficient minimal medium M9
0.098
-
cells grown on a phosphate-sufficient minimal medium M9
0.2282
purified enzyme, at pH 8.0 and 37°C
0.327
-
hepatic enzyme
0.346
-
crude extract, pH 8.0, 25°C
0.64
-
crude enzyme in optimized culture
0.916
-
isoform G6PD1, after 24.49fold purification, at pH 8.0, temperature not specified in the publication
1.804
-
after 63.09fold purification, at pH 8.0 temperature not specified in the publication
1.83
-
purified enzyme
100
-
25°C, pH 8.0, high-level glucose-6-phosphate dehydrogenase strain DF82
1033
-
cofactor: NADP+, G6PDH-2
104
-
25°C, pH 8.0, wild-type strain K-10
1077
-
cofactor: NAD+, G6PDH-2
11.23
purified G6PDH1 upon reduction by reduced DTT
135
-
purified recombinant mutant R393E
139.5
purified G6PDH1 upon oxidation by diamide
14
-
purified enzyme
15.43
-
purified enzyme
16.24
-
purified enzyme
16.7
-
purified enzyme
166
-
purified recombinant mutant R393V
176
-
purified recombinant mutant R393L
178
-
purified recombinant mutant R393G
181
-
purified recombinant mutant R393I
2.221
-
isoform G6PD2, after 59.38fold purification, at pH 8.0, temperature not specified in the publication
20.3
purified G6PDH1
201
-
purified isoenzyme II
210
-
purified isoenzyme I
22.2
-
untreated fruits
220
-
purified enzyme
222.8
-
recombinant from Escherichia coli
269.7
-
mutant enzyme A117S/F277I/Q324H/M381I/V443I/S470I, pH 7.5, 30°C
27.5
-
purified wild-type enzyme
27.69
-
purified kidney cortex enzyme
289.6
purified recombinant His-tagged enzyme, pH 7.5, 25°C
2890
-
cofactor: NADP+, G6PDH-1
298.6
-
mutant enzyme L99I/A117S/G225S/F277I/Q324H/M381I/V443I/S470I/A476V, pH 7.5, 30°C
3078
-
cofactor: NAD+, G6PDH-1
314.2
-
mutant enzyme A117S/Q324H/M381I/V443I/S470I, pH 7.5, 30°C
316.2
-
wild-type enzyme, pH 7.5, 30°C
32
-
purified enzyme, pH and temperature not specified in the publication
326.9
-
mutant enzyme A117S/Q324H/V443I/S470I, pH 7.5, 30°C
33.6
pH 7.6, and temperature not specified in the publication
33.8
-
25°C, pH 7.8, substrates: D-glucose 6-phosphate and NADP+
36.25
-
purified enzyme, pH 6.0, 25°C
36.3
-
fruits treated with benzo-thiadiaziole-7-carbothioic acid S-methyl ester
4.64
-
purified enzyme
44.16
-
purified enzyme
480
-
purified enzyme
5.7
-
pH 8.0, temperature not specified in the publication
52
-
purified isoenzyme II
53.8
-
purified enzyme
54.1
-
purified enzyme
67.6
-
39°C, pH 7.8, substrates: D-glucose 6-phosphate and NADP+
741
-
mutant enzyme A117S/F277I/Q324H/M381I/V443I/S470I, pH 7.5, 60°C
745
-
purified enzyme
76
-
purified recombinant enzyme, development of a coupled continuous thermostable assay method, determination at 85°C
772
-
mutant enzyme A117S/Q324H/V443I/S470I, pH 7.5, 60°C
790
-
purified enzyme
8.35
-
pH 8.5, 25°C
847
-
mutant enzyme L99I/A117S/G225S/F277I/Q324H/M381I/V443I/S470I/A476V, pH 7.5, 60°C
850
-
mutant enzyme A117S/Q324H/M381I/V443I/S470I, pH 7.5, 60°C
852
-
wild-type enzyme, pH 7.5, 60°C
additional information