1.1.1.47: glucose 1-dehydrogenase [NAD(P)+] This is an abbreviated version! For detailed information about glucose 1-dehydrogenase [NAD(P)+], go to the full flat file .
Reaction
D-glucose +
NAD(P)+ =
D-glucono-1,5-lactone +
NAD(P)H +
H+
Synonyms alkali-resistant glucose 1-dehydrogenase, beta-D-glucose:NAD(P)+ 1-oxido-reductase, beta-D-glucose:NAD(P)+ 1-oxidoreductase, BmGlcDH-III, BmGlcDH-IV, bzgdh, D-glucose dehydrogenase (NAD(P)), EC 1.1.5.2, GDH, gdh-2, GDHB, general stress protein 74, GlcDH, GlcDH-I, GlcDH-II, GlcDH-IWG3, glucose 1-dehydrogenase, glucose 1-dehydrogenase 3, glucose 1-dehydrogenase B, glucose 1-dehydrogenase III, glucose 1-dehydrogenase IV, glucose dehydrogenase, glucose1-dehydrogenase, GluDH, GSP74, hexose phosphate dehydrogenase, hexose-6-phosphate dehydrogenase, LsGDH, More, NAD(P)-dependent glucose 1-dehydrogenase, NAD(P)-dependent glucose dehydrogenase, NAD(P)-dependent glucose-1-dehydrogenase, NAD-GDH, nicotinamide adenine dinucleotide (NAD)-linked glucose dehydrogenase, SsGDH, SSO3204
ECTree
pH Range
pH Range on EC 1.1.1.47 - glucose 1-dehydrogenase [NAD(P)+]
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4.5 - 11
-
50% of maximal activity at pH 4.5 and pH 11.0
5 - 8
-
when incubated for 6 h at 37°C, the enzyme is highly stable in acidic conditions (pH 5.0-6.0) but is completely inactivated at pH values above 8.0
5.5 - 10.5
-
the enzyme's activity is more than 60% of its maximum at pH values ranging from 5.5 to 10.5
6 - 9.5
-
pH 6.0: about 40% of maximal activity, pH 9.5: about 45% of maximal activity
7 - 8.5
-
pH 7.0: 70% of maximal activity with glucose and NAD+ and about 55% of the activity with glucose and NADP+, pH 8.5: about 55% of maximal activity with glucose and NAD+ and about 75% of the activity with glucose and NADP+
7.5 - 10.5
-
at pH 7.5 and 10.0 respectively 75% and 50% activity compared to optimal pH
8 - 11
-
about 45% of maximal activity at pH 8.0 and pH 11.0
8.5 - 12
-
pH 8.5: about 35% of maximal activity, pH 12.0: about 65% of maximal activity
additional information
-
sharp drop in activity at alkaline pH of wild-type and mutant Q252L activities, not mutant Q252L/E170K
7 - 10
pH 7.0: about 40% of maximal activity, pH 10.0: about 45% of maximal activity
7 - 10
-
more than 60% activity between pH 7.0 and 10.0