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1.1.1.42: isocitrate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about isocitrate dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.1.1.42

Reaction

isocitrate
+
NADP+
=
2-oxoglutarate
+
CO2
+
NADPH
+
H+

Synonyms

AbIDH1, AfIDH, CgIDH, cICDH, CtIDP1, CtIDP2, cytosolic isocitrate dehydrogenase 1, cytosolic NADP(+)-dependent isocitrate dehydrogenase, cytosolic NADP+-dependent isocitrate dehydrogenase, cytosolic NADP-dependent isocitrate dehydrogenase, cytosolic NADPH-dependent isocitrate dehydrogenase, DpIDH, EcIDH, HICDH, ICD, ICD1, ICD2, icdA, ICDH, ICDH-1, IDH, IDH-90, IDH-I, IDH-IIa, IDH-IIb, IDH1, IDH2, IDH3, IDHP, IDP, IDP1, IDP2, IDP3, IDPA, IDPc, IDPm, isocitrate dehydrogenase, isocitrate dehydrogenase (NADP), isocitrate dehydrogenase (NADP-dependent), isocitrate dehydrogenase (nicotinamide adenine dinucleotide phosphate), isocitrate dehydrogenase 1, isocitrate dehydrogenase 2, isocitrate dehydrogenase-1, isocytrate deyhdrogenase, mICDH, mitochondrial NADP+-dependent isocitrate dehydrogenase, NAD+-dependent isocitrate dehydrogenase, NADP isocitric dehydrogenase, NADP+ dependent isocitrate dehydrogenase, NADP+-dependent Ds-threo-isocitrate dehydrogenase, NADP+-dependent Ds-threo-isocitrate:NADP+ oxidoreductase, NADP+-dependent ICDH, NADP+-dependent IDH, NADP+-dependent isocitrate dehydrogenase, NADP+-ICDH, NADP+-IDH, NADP+-isocitrate dehydrogenase, NADP+-linked isocitrate dehydrogenase, NADP+-specific ICDH, NADP+-specific IDH, NADP+-specific isocitrate dehydrogenase, NADP-dependent IDH, NADP-dependent isocitrate dehydrogenase, NADP-dependent isocitric dehydrogenase, NADP-ICDH, NADP-IDH, NADP-IDH Idp1p, NADP-isocitrate dehydrogenase, NADP-linked isocitrate dehydrogenase, NADP-specific isocitrate dehydrogenase, NADPH-dependent isocitrate dehydrogenase, NADPH-IDH, oxalosuccinate decarboxylase, oxalsuccinic decarboxylase, perICDH, PS-NADP-IDH, TaIDH, TM1148, YlIDP

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.42 isocitrate dehydrogenase (NADP+)

Temperature Stability

Temperature Stability on EC 1.1.1.42 - isocitrate dehydrogenase (NADP+)

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
10 - 15
110
the Tm-value is 109.9°C
15
-
isoenzyme II
20
-
isoenzyme II
30 - 50
-
after incubation at 25°C and 30°C, the enzyme activity loses 31% and 69% of ist activity, respectively, and no activity is detected after incubation at 50°C
35
-
isoenzyme C, half-life 20 min
35 - 39
the enzyme is stable below 35°C. The enzyme sustains 50% activity after incubation at 39°C for 20 min with Mn2+ and 38°C with Mg2+
35 - 42
-
the enzyme is stable below 35°C, but its activity decreases rapidly above 35°C. The enzyme is almost inactivated after incubation at 42.5°C for 20 min
36.5
melting temperature
38 - 50
about 50% of IDH activity is preserved at 38°C after 20 min of incubation, the enzyme is inactive at 50°C
40 - 70
-
after incubation at temperatures up to 40°C, the wild type enzyme maintains its activity, but its residual activity is decreased by incubation at over 45°C and is lost after incubation at 70°C
45 - 55
purified recombinant enzyme, stable up to 45°C, enzyme activity drops quickly above this temperature, incubation at 50°C for 20 min causes a 40% loss of activity, while incubation at 55°C almost inactivates the enzyme
47
-
purified enzyme, 20 min, loss of 50% activity
49
-
isoenzyme A, half-life 20 min
49.1
melting temperature
50 - 75
the enzyme retains full activity at 50°C and loses ca. 50% of its activity after 1 h of incubation at 75°C
52
-
isoenzyme C, half-life 20 min, presence of isocitrate
58
-
isoenzyme A, T50-value, presence of isocitrate
69
-
isoenzyme B, T50-value, presence of isocitrate
74
10 min, 50% loss of activity, mutant enzyme A336F
75
half-life: 24 min
82
melting temperature at pH 7.5 is 82.2°C
85
melting temperature at pH 5.8 is 84.5°C
89
10 min, 50% loss of activity, mutant enzyme I321L
90
half life of 22 min in 50 mM tricine-KOH buffer, pH 8
91
10 min, 50% loss of activity, mutant enzyme A325P/G326S
98
the Tm-value is 98.3°C
additional information