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(2R,3S)-isocitrate + NAD+
2-oxoglutarate + CO2 + NADH
(2R,3S)-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
2-oxoglutarate + CO2 + NADPH
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
isocitrate + NADP+
2-oxoglutarate + NADPH + H+
2-hydroxyglutarate + NADP+
the reaction is catalyzed by mutant enzymes R153H and R153C
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?
2-oxoglutarate + NADPH + H+
D-2-hydroxyglutarate + NADP+
3-fluoroisocitrate + NADP+
3-fluoro-2-oxoglutarate + NADPH + CO2
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-
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?
3-hydroxyisocitrate + NADP+
3-hydroxy-2-oxoglutarate + NADPH + CO2
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-
-
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?
D-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
D-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
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-
-
?
DL-isocitrate + NAD+
2-oxoglutarate + CO2 + NADH
DL-isocitrate + NAD+
2-oxoglutarate + CO2 + NADH + H+
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
Ds-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
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-
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?
isocitrate + APADP+
2-oxoglutarate + CO2 + APADPH
isocitrate + NAD+
2-oxoglutarate + CO2 + NADH + H+
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
isocitrate + NADP+
oxalosuccinate + NADPH + H+
isocitrate + NHDP+
2-oxoglutarate + CO2 + NHDPH
isopropylmalate + NADP+
?
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-
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?
oxalosuccinate
2-oxoglutarate + CO2
threo-Ds-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
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?
additional information
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(2R,3S)-isocitrate + NAD+
2-oxoglutarate + CO2 + NADH
slow reaction
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?
(2R,3S)-isocitrate + NAD+
2-oxoglutarate + CO2 + NADH
slow reaction
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?
(2R,3S)-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
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-
-
-
?
(2R,3S)-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
-
-
-
?
(2R,3S)-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
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-
-
?
(2R,3S)-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
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-
-
?
(2R,3S)-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
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-
-
?
(2R,3S)-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
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-
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?
2-oxoglutarate + CO2 + NADPH
isocitrate + NADP+
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-
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r
2-oxoglutarate + CO2 + NADPH
isocitrate + NADP+
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-
-
-
r
2-oxoglutarate + CO2 + NADPH
isocitrate + NADP+
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-
-
-
r
2-oxoglutarate + CO2 + NADPH + H+
isocitrate + NADP+
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-
-
r
2-oxoglutarate + CO2 + NADPH + H+
isocitrate + NADP+
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-
-
r
2-oxoglutarate + NADPH + H+
D-2-hydroxyglutarate + NADP+
the reaction is catalyzed by diverse R132 mutant enzymes
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r
2-oxoglutarate + NADPH + H+
D-2-hydroxyglutarate + NADP+
the reaction is catalyzed by mutant enzyme R132H
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r
D-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
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-
r
D-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
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?
D-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
-
enzyme is an integral part of the mitochondrial TCA cycle, and it is involved in providing NADPH for reductive reactions in the cell
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?
D-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
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?
D-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
-
-
-
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?
D-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
-
the reaction is reversible for isozyme IDP2
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r
DL-isocitrate + NAD+
2-oxoglutarate + CO2 + NADH
Q8X277
NAD+ is only substrate for mutant R291S/K343D/Y344I/V350A/Y390P
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?
DL-isocitrate + NAD+
2-oxoglutarate + CO2 + NADH
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?
DL-isocitrate + NAD+
2-oxoglutarate + CO2 + NADH + H+
-
low activityy with NAD+
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?
DL-isocitrate + NAD+
2-oxoglutarate + CO2 + NADH + H+
-
low activityy with NAD+
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?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
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-
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?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
Q8X277
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?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
Q8X277
NAD+ is not substrate for mutant R291S/K343D/Y344I/V350A/Y390P
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?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
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-
-
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?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
-
-
-
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?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
-
-
-
?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
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-
-
-
?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
-
-
-
-
?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
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-
-
-
?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
-
-
-
?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
-
-
-
-
?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
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?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
NADP+ is the highly preferred cofactor
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?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
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-
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?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
NADP+ is the highly preferred cofactor
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?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
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ir
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
carboxylation of 2-oxoglutarate to produce isocitrate
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ir
isocitrate + APADP+
2-oxoglutarate + CO2 + APADPH
60% activity compared to NAD+
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r
isocitrate + APADP+
2-oxoglutarate + CO2 + APADPH
60% activity compared to NAD+
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r
isocitrate + NAD+
2-oxoglutarate + CO2 + NADH + H+
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r
isocitrate + NAD+
2-oxoglutarate + CO2 + NADH + H+
engineered enzyme mutant D253A/S257K/K260Q/R314D/H315I/T327A, cf. EC 1.1.1.41
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r
isocitrate + NAD+
2-oxoglutarate + CO2 + NADH + H+
engineered enzyme mutant D253A/S257K/K260Q/R314D/H315I/T327A, cf. EC 1.1.1.41
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r
isocitrate + NAD+
2-oxoglutarate + CO2 + NADH + H+
the reaction is catalyzed by mutant enzymes H590L/R601D/R650S and H590L/R601D
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?
isocitrate + NAD+
2-oxoglutarate + CO2 + NADH + H+
the reaction is catalyzed by mutant enzymes H590L/R601D/R650S and H590L/R601D
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?
isocitrate + NAD+
2-oxoglutarate + CO2 + NADH + H+
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-
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-
r
isocitrate + NAD+
2-oxoglutarate + CO2 + NADH + H+
Km-value for NAD+ is 34fold higher compared to KM-value for NADP+
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?
isocitrate + NAD+
2-oxoglutarate + CO2 + NADH + H+
Km-value for NAD+ is 34fold higher compared to KM-value for NADP+
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?
isocitrate + NAD+
2-oxoglutarate + CO2 + NADH + H+
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-
-
-
?
isocitrate + NAD+
2-oxoglutarate + CO2 + NADH + H+
low activity with mutant enzyme R322D, no activity with the wild-type enzyme
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-
r
isocitrate + NAD+
2-oxoglutarate + CO2 + NADH + H+
low activity with mutant enzyme R322D, no activity with the wild-type enzyme
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-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
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-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
overall reaction
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?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
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?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
strict substrate and coenzyme specificity
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?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
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-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
carbon dioxide-fixing enzyme in the reductive tricarboxylic acid cycle, preference for carboxylation reaction direction
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r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
metabolic regulation, involved in the tricarboxylic acid cycle
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-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
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-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
the enzyme shows high substrate specificity
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?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
key enzyme of the tricarboxylic acid cycle
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?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
enzyme has a self-regulatory mechanism of activity mimicking the phosphorylation mechanism of bacterial enzymes
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?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
100% actiivty
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-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
100% actiivty
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
cytosolic enzyme is critical in fat and cholesterol biosynthesis, enzyme content correlates with adipogenesis in wild-type adipocytes and in transgenic cells
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?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
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-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
the cytosolic isozyme supplies 2-oxoglutarate for the photorespiratory ammonia fixation, pyridine nucleotide contents in mitochondria and cytosol, regulation, overview
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r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
the enzyme could have a protective antioxidant role against certain environmental stresses in plants
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?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
isocitrate dehydrogenase is an important NADPH-generating enzyme in the endoplasmic reticulum
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?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
metabolic regulation, involved in the tricarboxylic acid cycle
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-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
metabolic regulation, involved in the tricarboxylic acid cycle
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-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
Km-value for NAD+ is 34fold higher compared to KM-value for NADP+
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-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
Km-value for NAD+ is 34fold higher compared to KM-value for NADP+
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-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
isozymes are compartment interchangeable for glutamate synthesis, although mitochondrial localization has a positive impact on this function during fermentative growth
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?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
reaction is reversible for isozymes IDP1 and IDP2
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-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
metabolic regulation of the isozymes
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-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
Ser95, Asn97, and Thr78 are involved in substrate binding
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-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
low activity with NAD+. Km-value for NAD+ is about 140fold higher than the KM-value for NADP+
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
low activity with NAD+. Km-value for NAD+ is about 140fold higher than the KM-value for NADP+
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-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
IDH1 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate utilizing either NAD+ or NADP+ as cosubstrates
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
Pinus spp.
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
oxalosuccinate + NADPH + H+
-
-
-
r
isocitrate + NADP+
oxalosuccinate + NADPH + H+
-
-
-
r
isocitrate + NHDP+
2-oxoglutarate + CO2 + NHDPH
2.0% activity compared to NAD+
-
-
r
isocitrate + NHDP+
2-oxoglutarate + CO2 + NHDPH
2.0% activity compared to NAD+
-
-
r
oxalosuccinate
2-oxoglutarate + CO2
-
-
-
-
r
oxalosuccinate
2-oxoglutarate + CO2
-
-
-
r
additional information
?
-
-
the enzyme is a substrate for Escherichia coli isocitrate dehydrogenase kinase/phosphatase
-
-
-
additional information
?
-
the enzyme is a substrate for Escherichia coli isocitrate dehydrogenase kinase/phosphatase
-
-
-
additional information
?
-
does not use citrate as substrate
-
-
?
additional information
?
-
NADP+-dependent isocitrate dehydrogenase may play an important role in regulating the apoptosis induced by heat shock
-
-
?
additional information
?
-
-
NADP+-dependent isocitrate dehydrogenase may play an important role in regulating the apoptosis induced by TNF-alpha and anticancer drugs
-
-
?
additional information
?
-
the R132H mutant IDH1 directly converts 2-oxoglutarate to 2-hydroxyglutarate, that rapidly accumulates in the medium of cells expressing R132H mutant IDH1
-
-
?
additional information
?
-
-
the R132H mutant IDH1 directly converts 2-oxoglutarate to 2-hydroxyglutarate, that rapidly accumulates in the medium of cells expressing R132H mutant IDH1
-
-
?
additional information
?
-
the enzyme is highly specific to NADP+ and cannot utilize NAD+
-
-
-
additional information
?
-
the enzyme is highly specific to NADP+ and cannot utilize NAD+
-
-
-
additional information
?
-
-
enzyme plays an important regulatory role in cellular defense against oxidative stress and in senescence
-
-
?
additional information
?
-
-
NADP+-dependent isocitrate dehydrogenase plays an important protective role in apoptosis of HL-60 cells induced by singlet oxygen
-
-
?
additional information
?
-
-
IDPm expression in HepG2 cells regulates ethanol-induced toxicity
-
-
?
additional information
?
-
Mycobacterium tuberculosis ICDH-1 also catalyzes the formation of 2-hydroxyglutarate
-
-
?
additional information
?
-
-
Mycobacterium tuberculosis ICDH-1 also catalyzes the formation of 2-hydroxyglutarate
-
-
?
additional information
?
-
Mycobacterium tuberculosis ICDH-1 also catalyzes the formation of 2-hydroxyglutarate
-
-
?
additional information
?
-
-
no activity Is detected when 0.12 mM NAD+, instead of NADP+, is added to the reaction mixture
-
-
-
additional information
?
-
-
86% of total activity in the cell, main factor for synthesis of 2-oxoglutarate. Enzyme and cytoplasmic aspartate aminotransferase are regulated oppositely and the catalytic activity of one enzyme can be stimulated concurrently with a decrease in the activity of the other
-
-
?
additional information
?
-
suppression of enzyme activity by small interfering RNA results in impairment of glucose-stimulated insulin secretion, attenuates glucose-induced increments in pyruvate cycling activity and in NADPH levels, and causes increases in lactate production
-
-
?
additional information
?
-
-
His319 and His315 are not responsible for enzyme Fe2+-isocitrate cleavage
-
-
?
additional information
?
-
-
during oxidative stress, enzyme activity appears to be modulated through enzymatic glutathionylation and deglutathionylation
-
-
?
additional information
?
-
the isocitrate molecule is located at the active site, and interacts with residues at the cleft between the large and small domain. The catalytic triad residues Lys191, Asp248 and Tyr144 are conserved and interact with isocitrate
-
-
?
additional information
?
-
-
the isocitrate molecule is located at the active site, and interacts with residues at the cleft between the large and small domain. The catalytic triad residues Lys191, Asp248 and Tyr144 are conserved and interact with isocitrate
-
-
?