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1.1.1.42: isocitrate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about isocitrate dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.1.1.42

Reaction

isocitrate
+
NADP+
=
2-oxoglutarate
+
CO2
+
NADPH
+
H+

Synonyms

AbIDH1, AfIDH, CgIDH, cICDH, CtIDP1, CtIDP2, cytosolic isocitrate dehydrogenase 1, cytosolic NADP(+)-dependent isocitrate dehydrogenase, cytosolic NADP+-dependent isocitrate dehydrogenase, cytosolic NADP-dependent isocitrate dehydrogenase, cytosolic NADPH-dependent isocitrate dehydrogenase, DpIDH, EcIDH, HICDH, ICD, ICD1, ICD2, icdA, ICDH, ICDH-1, IDH, IDH-90, IDH-I, IDH-IIa, IDH-IIb, IDH1, IDH2, IDH3, IDHP, IDP, IDP1, IDP2, IDP3, IDPA, IDPc, IDPm, isocitrate dehydrogenase, isocitrate dehydrogenase (NADP), isocitrate dehydrogenase (NADP-dependent), isocitrate dehydrogenase (nicotinamide adenine dinucleotide phosphate), isocitrate dehydrogenase 1, isocitrate dehydrogenase 2, isocitrate dehydrogenase-1, isocytrate deyhdrogenase, mICDH, mitochondrial NADP+-dependent isocitrate dehydrogenase, NAD+-dependent isocitrate dehydrogenase, NADP isocitric dehydrogenase, NADP+ dependent isocitrate dehydrogenase, NADP+-dependent Ds-threo-isocitrate dehydrogenase, NADP+-dependent Ds-threo-isocitrate:NADP+ oxidoreductase, NADP+-dependent ICDH, NADP+-dependent IDH, NADP+-dependent isocitrate dehydrogenase, NADP+-ICDH, NADP+-IDH, NADP+-isocitrate dehydrogenase, NADP+-linked isocitrate dehydrogenase, NADP+-specific ICDH, NADP+-specific IDH, NADP+-specific isocitrate dehydrogenase, NADP-dependent IDH, NADP-dependent isocitrate dehydrogenase, NADP-dependent isocitric dehydrogenase, NADP-ICDH, NADP-IDH, NADP-IDH Idp1p, NADP-isocitrate dehydrogenase, NADP-linked isocitrate dehydrogenase, NADP-specific isocitrate dehydrogenase, NADPH-dependent isocitrate dehydrogenase, NADPH-IDH, oxalosuccinate decarboxylase, oxalsuccinic decarboxylase, perICDH, PS-NADP-IDH, TaIDH, TM1148, YlIDP

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.42 isocitrate dehydrogenase (NADP+)

Specific Activity

Specific Activity on EC 1.1.1.42 - isocitrate dehydrogenase (NADP+)

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.003
purified recombinant mutant K212Y, forward reaction
0.0046
-
purified chloroplastic isozyme ICDH1
0.038
0.065
purified recombinant mutant K212Q, forward reaction
0.072
-
mitochondria from green leaves, forward reaction at pH 7.5
0.08
purified recombinant mutant Y140E, forward reaction
0.083
purified recombinant mutant Y140T, forward reaction
0.102
purified recombinant mutant Y140F, forward reaction
0.179
purified recombinant mutant Y140K, forward reaction
0.24
-
enzyme extract of cells in stationary growth phase
0.26
-
enzyme extract of cells in growth phase with acid synthesis
0.28
-
purified enzyme, forward reaction
0.3
-
enzyme extract of cells in exponential growth phase
0.44
-
purified recombinant mutant N97D
0.75
-
cell free enzyme extracts of cells grown on glucose, best carbon source
108.2
-
transgenic mice liver
12.7
-
purified recombinant mutant T78A
136.03
-
His-tagged enzyme, at pH 8.0 and 35°C
162
-
purified recombinant enzyme
18.1
-
purified recombinant mutant R314Q
18.5
-
NAD+-linked reaction
20.1
-
purified recombinant mutant H319Q
219
purified recombinant N-terminally His6-tagged enzyme, pH and temperature not specified in the publication
23
-
NADP+-linked reaction
23.7
Q8X277
purified recombinant enzyme
27.2
-
purified enzyme
3.16
purified recombinant mutant K212R, forward reaction
33.5
-
-
34.6
-
purified enzyme
36
-
purified recombinant enzyme
37.8
-
purified recombinant wild-type enzyme
38.6
-
purified recombinant wild-type enzyme
38.7
-
purified recombinant mutant K323Q
39.6
-
purified recombinant mutant K321Q
4.1
-
purified recombinant mutant H315Q
40
-
pH 8.0, 30°C
40.3
-
purified recombinant mutant Y316F
5.29
-
purified recombinant mutant N97A
6.22
-
purified recombinant mutant T78D
67
purified recombinant N-terminally His6-tagged enzyme, pH and temperature not specified in the publication
7
-
purified recombinant mutant Y316L
7.18
-
purified recombinant mutant S95A
7.4
-
with NAD+ as cosubstrate, at pH 8.0 and 25°C
73.2
-
with NADP+ as cosubstrate, at pH 8.0 and 25°C
75
-
purified enzyme
77.4
-
wild-type liver
additional information