1.1.1.41: isocitrate dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about isocitrate dehydrogenase (NAD+), go to the full flat file.

Reaction

Synonyms

At2g17130, At4g35260, At4g35650, At5g03290, AtIDH I, AtIDH II, AtIDH V, AtIDH VI, beta-decarboxylating dehydrogenase, beta-ketoglutaric-isocitric carboxylase, CaIDH, CcIDH, hNAD-IDHalpha, homodimeric NAD+-linked isocitrate dehydrogenase, Icd-2, ICDH, ICDH1, IDH, IDH I, IDH II, IDH III, IDH IV, IDH V, IDH-50, IDH-I, IDH-II, IDH-V, IDH1, IDH2, IDH3, IDH3A, IDH3alpha, IDH5, IDHa, isocitrate dehydrogenase, isocitrate dehydrogenase 2, isocitrate dehydrogenase 3alpha subunit, isocitrate-homoisocitrate dehydrogenase, isocitric acid dehydrogenase, isocitric dehydrogenase, McIDH, mIDH, MiIDH, mitochondrial NAD-dependent isocitrate dehydrogenase, monomeric NAD-IDH, NAD dependent isocitrate dehydrogenase, NAD isocitrate dehydrogenase, NAD isocitric dehydrogenase, NAD(P)+-dependent isocitrate dehydrogenase, NAD+-dependent ICDH, NAD+-dependent IDH, NAD+-dependent isocitrate dehydrogenase, NAD+-dependent isocitrate dehydrogenase 1, NAD+-dependent isocitrate dehydrogenase 3, NAD+-dependent type 1 IDH, NAD+-IDH, NAD+-specific ICDH, NAD+-specific IDH, NAD+-specific isocitrate dehydrogenase, NAD-Dependent IDH, NAD-dependent isocitrate dehydrogenase, NAD-ICDH, NAD-IDH, NAD-isocitrate dehydrogenase, NAD-linked isocitrate dehydrogenase, NAD-specific isocitrate dehydrogenase, NADH-IDH, OlIDH, OtIDH, PF0202, PH1722, Rv0066c, threo-DS-isocitrate:NAD+ oxidoreductase (decarboxylating), type 1 isocitrate dehydrogenase, type II homodimeric NAD-IDH, type II NAD+-specific isocitrate dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.41 isocitrate dehydrogenase (NAD+)

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Results	in table
31	Activating Compound
1745	AA Sequence
1	Application
1	CAS Registry Number
45	Cloned(Commentary)
108	Cofactor
10	Crystallization (Commentary)
4327	Disease/ Diagnostics
3	Expression
45	General Information
9	General Stability
3	IC50 Value
160	Inhibitors
63	kcat/KM [mM/s]
5	Ki Value [mM]
163	KM Value [mM]
40	Localization
90	Metals/Ions
71	Molecular Weight [Da]
101	Natural Substrates/ Products (Substrates)
357	Organism
9	Pathway
80	PDB ID
44	pH Optimum
9	pH Range
1	pH Stability
3	pI Value
2	Posttranslational Modification
124	Protein Variants
56	Purification (Commentary)
2	Reaction
5	Reaction Type
138	Reference
1	Renatured (Commentary)
127	Source Tissue
42	Specific Activity [micromol/min/mg]
5	Storage Stability
175	Substrates and Products (Substrate)
74	Subunits
231	Synonyms
1	Systematic Name
43	Temperature Optimum [°C]
8	Temperature Range [°C]
22	Temperature Stability [°C]
90	Turnover Number [1/s]

KM Value

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KM Value on EC 1.1.1.41 - isocitrate dehydrogenase (NAD+)

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.03 - 0.45

D,L-isocitrate

3 entries

0.09 - 62.2

D-isocitrate

20 entries

0.002 - 0.385

DL-isocitrate

6 entries

0.0183

homoisocitrate

Pyrococcus horikoshii

-

6fold His-tagged enzyme, at 70°C in 50 mM N-2-hydroxyethylpiperadine-N0-2-ethanesulfonate-NaOH (pH 7.8), 0.2 M KCl, 0.2 mM MnCl2, 1mM NAD+

660907

0.009 - 41

isocitrate

37 entries

0.22 - 0.39

Mn2+

2 entries

0.004 - 20.65

NAD+

61 entries

0.0082 - 8.2

NADP+

27 entries

additional information

additional information

7 entries

-

0.03

D,L-isocitrate

Cupriavidus necator

-

-

286750

0.11

D,L-isocitrate

Saccharomyces cerevisiae

-

-

286749

0.45

D,L-isocitrate

Bos taurus

-

-

286749

0.09

D-isocitrate

Saccharomyces cerevisiae

-

octameric wild-type enzyme with AMP, without DTT, pH 7.4, 24°C

721650

0.1

D-isocitrate

Saccharomyces cerevisiae

-

octameric enzyme mutant IDH1/IDH2C150S with AMP, with or without DTT, pH 7.4, 24°C

721650

0.1

D-isocitrate

Saccharomyces cerevisiae

-

octameric wild-type enzyme with AMP and DTT, pH 7.4, 24°C

721650

0.17

D-isocitrate

Saccharomyces cerevisiae

-

octameric enzyme mutant IDH1/IDH2C56S/C150S/C242S with AMP, without DTT, pH 7.4, 24°C

721650

0.19

D-isocitrate

Saccharomyces cerevisiae

-

octameric enzyme mutant IDH1/IDH2C56S/C150S/C242S with AMP and DTT, pH 7.4, 24°C

721650

0.2

D-isocitrate

Saccharomyces cerevisiae

-

octameric enzyme mutant IDH1/IDH2C56S/C242S with AMP and DTT, pH 7.4, 24°C

721650

0.32

D-isocitrate

Saccharomyces cerevisiae

-

octameric enzyme mutant IDH1/IDH2C56S/C242S with AMP, without DTT, pH 7.4, 24°C

721650

0.48

D-isocitrate

Saccharomyces cerevisiae

-

octameric enzyme IDH1G15D/IDH2 with AMP and DTT, pH 7.4, 24°C

721650

0.5

D-isocitrate

Saccharomyces cerevisiae

-

octameric enzyme IDH1G15D/IDH2 with AMP, without DTT, pH 7.4, 24°C

721650

0.51

D-isocitrate

Saccharomyces cerevisiae

-

octameric wild-type enzyme without AMP, with DTT, pH 7.4, 24°C

721650

0.53

D-isocitrate

Saccharomyces cerevisiae

-

octameric enzyme mutant IDH1/IDH2C150S without AMP and DTT, pH 7.4, 24°C

721650

0.54

D-isocitrate

Saccharomyces cerevisiae

-

octameric enzyme mutant IDH1/IDH2C150S without AMP, with DTT, pH 7.4, 24°C

721650

0.56

D-isocitrate

Saccharomyces cerevisiae

-

octameric wild-type enzyme without AMP and DTT, pH 7.4, 24°C

721650

1.01

D-isocitrate

Saccharomyces cerevisiae

-

octameric enzyme mutant IDH1G15D/IDH2 without AMP and DTT, pH 7.4, 24°C

721650

1.03

D-isocitrate

Saccharomyces cerevisiae

-

octameric enzyme mutant IDH1/IDH2C56S/C150S/C242S without AMP, with or without DTT, pH 7.4, 24°C

721650

1.19

D-isocitrate

Saccharomyces cerevisiae

-

octameric enzyme IDH1G15D/IDH2 without AMP, with DTT, pH 7.4, 24°C

721650

1.3

D-isocitrate

Saccharomyces cerevisiae

-

octameric enzyme mutant IDH1/IDH2C56S/C242S without AMP, with DTT, pH 7.4, 24°C

721650

1.6

D-isocitrate

Saccharomyces cerevisiae

-

octameric enzyme mutant IDH1/IDH2C56S/C242S without AMP and DTT, pH 7.4, 24°C

721650

7.9

D-isocitrate

Azotobacter vinelandii

-

-

670158

62.2

D-isocitrate

Colwellia maris

-

-

670158

0.002

DL-isocitrate

Leishmania mexicana

-

at pH 7.4 and 37°C

761866

0.075

DL-isocitrate

Streptococcus mutans

-

pH 7.5, 37°C, recombinant wild-type enzyme

723607

0.143

DL-isocitrate

Streptococcus mutans

-

pH 7.5, 37°C, recombinant enzyme mutant S102G

723607

0.148

DL-isocitrate

Streptococcus mutans

-

pH 7.5, 37°C, recombinant enzyme mutant S102A

723607

0.15

DL-isocitrate

Streptococcus mutans

-

pH 7.5, 37°C, recombinant enzyme mutant S102T

723607

0.385

DL-isocitrate

Streptococcus mutans

-

pH 7.5, 37°C, recombinant enzyme mutant S102Y

723607

0.009

isocitrate

Methylobacillus flagellatus

-

at pH 8.5 and 42°C

762222

0.0164

isocitrate

Pyrococcus horikoshii

-

6fold His-tagged enzyme, at 70°C in 50 mM N-2-hydroxyethylpiperadine-N0-2-ethanesulfonate-NaOH (pH 7.8), 0.2 M KCl, 0.2 mM MnCl2, 1mM NAD+

660907

0.031

isocitrate

Campylobacter concisus

-

mutant enzyme L580H/L591R/A640R, at pH 7.5 and 25°C

760649

0.038

isocitrate

Campylobacter concisus

-

wild type enzyme, at pH 7.5 and 25°C

760649

0.0517

isocitrate

Methylococcus capsulatus

-

-

684749

0.09

isocitrate

Homo sapiens

-

pH 7.2, 25°C, recombinant mutant betaY137E, in presence of 1 mM ADP

712440

0.12

isocitrate

Pisum sativum

-

pH 7.5

654843

0.28

isocitrate

Homo sapiens

-

pH 7.2, 25°C, recombinant mutant betaY137F, in presence of 1 mM ADP

712440

0.32

isocitrate

Homo sapiens

-

purified recombinant wild-type enzyme, pH 7.2, 25°C, in presence of 1 mM ADP

656189

0.5

isocitrate

Homo sapiens

-

pH 7.2, 25°C, recombinant wild-type enzyme, in presence of 1 mM ADP

712440

0.581

isocitrate

Yarrowia lipolytica

-

pH 7.4, 25°C

654783

0.77

isocitrate

Homo sapiens

-

purified recombinant mutant beta-R99Q, pH 7.2, 25°C, in presence of 1 mM ADP

656189

0.9

isocitrate

Homo sapiens

-

purified recombinant mutant beta-R99Q, pH 7.2, 25°C

656189

0.92

isocitrate

Homo sapiens

-

pH 7.2, 25°C, recombinant mutant betaY137S, in presence of 1 mM ADP

712440

1.2

isocitrate

Homo sapiens

-

pH 7.2, 25°C, recombinant mutant betaY137S

712440

1.8

isocitrate

Homo sapiens

-

purified recombinant mutant gamma-R97Q, pH 7.2, 25°C, in presence of 1 mM ADP

656189

1.8

isocitrate

Homo sapiens

-

pH 7.2, 25°C, recombinant mutant betaY137F

712440

2

isocitrate

Homo sapiens

-

purified recombinant mutant gamma-R97Q, pH 7.2, 25°C

656189

2

isocitrate

Homo sapiens

-

pH 7.2, 25°C, recombinant wild-type enzyme

712440

2.2

isocitrate

Homo sapiens

-

purified recombinant wild-type enzyme, pH 7.2, 25°C

656189

2.2

isocitrate

Homo sapiens

-

wild type enzyme in 20 mM isocitrate and 1mM MnSO4

669477

2.2

isocitrate

Homo sapiens

-

25°C, pH 7.2, wild-type enzyme

669477

2.4

isocitrate

Homo sapiens

-

pH 7.2, wild-type enzyme

685154

2.9

isocitrate

Homo sapiens

-

pH 7.2, beta-subunit mutant enzyme D192N

685154

3.4

isocitrate

Homo sapiens

-

D234C, alpha-subunit mutant, in 20 mM isocitrate and 1mM MnSO4

669477

3.4

isocitrate

Homo sapiens

-

25°C, pH 7.2, alpha-subunit mutant enzyme D234C

669477

3.4

isocitrate

Homo sapiens

-

pH 7.2, 25°C, recombinant mutant betaY137E

712440

3.5

isocitrate

Homo sapiens

-

D206N, alpha-subunit mutant, in 20 mM isocitrate and 1mM MnSO4

669477

3.5

isocitrate

Homo sapiens

-

25°C, pH 7.2, alpha-subunit mutant enzyme D206N

669477

5.1

isocitrate

Homo sapiens

-

D217N, beta-subunit mutant, in 20 mM isocitrate and 1mM MnSO4

669477

5.1

isocitrate

Homo sapiens

-

25°C, pH 7.2, beta-subunit mutant enzyme D217N

669477

9.1

isocitrate

Homo sapiens

-

pH 7.2, alpha-subunit mutant enzyme D181N

685154

13

isocitrate

Homo sapiens

-

pH 7.2, gamma-subunit mutant enzyme D190N

685154

20

isocitrate

Homo sapiens

-

D230C, alpha-subunit mutant, in 20 mM isocitrate and 1mM MnSO4

669477

20

isocitrate

Homo sapiens

-

25°C, pH 7.2, alpha-subunit mutant enzyme D230C

669477

41

isocitrate

Homo sapiens

-

D215N, gamma-subunit mutant, in 20 mM isocitrate and 1mM MnSO4

669477

41

isocitrate

Homo sapiens

-

25°C, pH 7.2, gamma-subunit mutant enzyme D215N

669477

0.22

Mn2+

Homo sapiens

-

purified recombinant wild-type enzyme and mutant beta-R99Q, pH 7.2, 25°C

656189

0.39

Mn2+

Homo sapiens

-

purified recombinant mutant gamma-R97Q, pH 7.2, 25°C

656189

0.004

NAD+

Homo sapiens

-

purified recombinant mutant gamma-R97Q, pH 7.2, 25°C

656189

0.014

NAD+

Homo sapiens

-

purified recombinant mutant beta-R99Q, pH 7.2, 25°C

656189

0.0289

NAD+

Campylobacter sp.

J4X756

pH 75, 25°C, recombinant His6-tagged enzyme

741414

0.04

NAD+

Homo sapiens

-

25°C, pH 7.2, alpha-subunit mutant enzyme D234C

669477

0.05

NAD+

Leishmania mexicana

-

at pH 7.4 and 37°C

761866

0.06

NAD+

Homo sapiens

-

pH 7.2, 25°C, recombinant wild-type enzyme

712440

0.06 - 0.09

NAD+

Bos taurus

-

-

286760

0.066

NAD+

Pyrococcus furiosus

Q8U488

pH 8.0, 70°C, mutant enzyme D328K

721450

0.068

NAD+

Pyrococcus furiosus

Q8U488

pH 8.0, 70°C, wild-type enzyme

721450

0.0683

NAD+

Pyrococcus furiosus

Q8U488

pH 8.0, 70°C, the Km-value for NADP+ is about 65fold higher than the KM-value for NAD+

727835

0.07

NAD+

Homo sapiens

-

25°C, pH 7.2, wild-type enzyme

669477

0.073

NAD+

Homo sapiens

-

purified recombinant wild-type enzyme, pH 7.2, 25°C

656189

0.0742

NAD+

Campylobacter curvus

A0A0M4S9Q1

pH 75, 25°C, recombinant His6-tagged enzyme

741414

0.0771

NAD+

Pyrococcus horikoshii

-

6fold His-tagged enzyme, at 70°C in 50 mM N-2-hydroxyethylpiperadine-N0-2-ethanesulfonate-NaOH (pH 7.8), 0.2 M KCl, 0.2 mM MnCl2

660907

0.08

NAD+

Homo sapiens

-

pH 7.2, wild-type enzyme

685154

0.088

NAD+

Campylobacter concisus

-

wild type enzyme, at pH 7.5 and 25°C

760649

0.09

NAD+

Homo sapiens

-

pH 7.2, 25°C, recombinant mutant betaY137E

712440

0.099

NAD+

Escherichia coli

-

7-fold mutant

286777

0.113

NAD+

Methylobacillus flagellatus

-

at pH 8.5 and 42°C

762222

0.12

NAD+

Homo sapiens

-

pH 7.2, 25°C, recombinant mutant betaY137F

712440

0.121

NAD+

Xylella fastidiosa

-

wild type enzyme, at pH 8.0 and 25°C

760747

0.126

NAD+

Micromonas commoda

C1E5X2

pH 75, 25°C, recombinant His6-tagged enzyme

741414

0.136

NAD+

Yarrowia lipolytica

-

pH 7.4, 25°C

654783

0.136

NAD+

Ostreococcus sp. 'lucimarinus'

A4SBK5

pH 75, 25°C, recombinant His6-tagged enzyme

741414

0.14

NAD+

Homo sapiens

-

25°C, pH 7.2, alpha-subunit mutant enzyme D206N

669477

0.154

NAD+

Streptococcus mutans

-

pH 7.5, 37°C, recombinant enzyme

723607

0.18

NAD+

Acidithiobacillus thiooxidans

Q8GAX0

pH 9.0, 30°C, native enzyme

655607

0.19

NAD+

Homo sapiens

-

25°C, pH 7.2, gamma-subunit mutant enzyme D215N

669477

0.2

NAD+

Pisum sativum

-

pH 7.5

654843

0.226

NAD+

Ostreococcus tauri

-

pH 7.6, temperature not specified in the publication, His6-tagged recombinant wild-type enzyme, with Mn2+

740425

0.245

NAD+

Zymomonas mobilis

-

pH 7.5, 37°C, with Mn2+, recombinant enzyme

722295

0.246

NAD+

Streptococcus mutans

-

pH 7.5, 37°C, recombinant enzyme mutant S102A

723607

0.25

NAD+

Pseudomonas sp.

-

-

286756

0.263

NAD+

Congregibacter litoralis

A4ADB8

wild-type enzyme, with Mg2+, pH 7.5, 35°C

741236

0.265

NAD+

Ostreococcus tauri

-

pH 7.6, temperature not specified in the publication, His6-tagged recombinant wild-type enzyme, with Mg2+

740425

0.295

NAD+

Streptococcus mutans

-

pH 7.5, 37°C, recombinant enzyme mutant S102G

723607

0.3

NAD+

Cupriavidus necator

-

-

286750

0.309

NAD+

Congregibacter litoralis

A4ADB8

wild-type enzyme, with Mn2+, pH 7.5, 35°C

741236

0.312

NAD+

Zymomonas mobilis

-

pH 7.5, 37°C, with Mg2+, recombinant enzyme

722295

0.33

NAD+

Pisum sativum

-

membrane-associated ICDH

286774

0.336

NAD+

Pyrococcus furiosus

Q8U488

pH 8.0, 70°C, mutant enzyme D328K/I329Y

721450

0.35

NAD+

Streptococcus mutans

-

pH 7.5, 37°C, recombinant enzyme mutant S102T

723607

0.384

NAD+

Xylella fastidiosa

-

mutant enzyme D268K, at pH 8.0 and 25°C

760747

0.493

NAD+

Campylobacter sp.

J4X756

pH 75, 25°C, recombinant His6-tagged mutant L584H/D595R

741414

0.63

NAD+

Homo sapiens

-

pH 7.2, 25°C, recombinant mutant betaY137S

712440

0.664

NAD+

Congregibacter litoralis

A4ADB8

mutant D487R/L488H, with Mn2+, pH 7.5, 35°C

741236

0.68

NAD+

Homo sapiens

-

25°C, pH 7.2, beta-subunit mutant enzyme D217N

669477

0.71

NAD+

Homo sapiens

-

pH 7.2, beta-subunit mutant enzyme D192N

685154

0.738

NAD+

Ostreococcus tauri

-

pH 7.6, temperature not specified in the publication, His6-tagged recombinant mutant D344R, with Mn2+

740425

0.903

NAD+

Phaeodactylum tricornutum

-

in the presence of Mg2+, at pH 8.0 and 25°C

761311

1.1

NAD+

Homo sapiens

-

25°C, pH 7.2, alpha-subunit mutant enzyme D230C

669477

1.1325

NAD+

Phaeodactylum tricornutum

-

in the presence of Mn2+, at pH 8.0 and 25°C

761311

1.2

NAD+

Homo sapiens

-

pH 7.2, alpha-subunit mutant enzyme D181N

685154

1.5

NAD+

Homo sapiens

-

pH 7.2, gamma-subunit mutant enzyme D190N

685154

1.56

NAD+

Streptococcus mutans

-

pH 7.5, 37°C, recombinant enzyme mutant S102Y

723607

2.948

NAD+

Ostreococcus sp. 'lucimarinus'

A4SBK5

pH 75, 25°C, recombinant His6-tagged mutant D326R/M327H

741414

3.15

NAD+

Xylella fastidiosa

-

mutant enzymeD268K/I269Y/A275V, at pH 8.0 and 25°C

760747

4.413

NAD+

Xylella fastidiosa

-

mutant enzyme D268K/I269Y, at pH 8.0 and 25°C

760747

4.5

NAD+

Campylobacter concisus

-

mutant enzyme L580H/L591R/A640R, at pH 7.5 and 25°C

760649

4.7

NAD+

Escherichia coli

-

wild type

286777

20.65

NAD+

Ostreococcus tauri

-

pH 7.6, temperature not specified in the publication, His6-tagged recombinant mutant D344R/M345H, with Mn2+

740425

0.0082

NADP+

Ostreococcus sp. 'lucimarinus'

A4SBK5

pH 75, 25°C, recombinant His6-tagged mutant D326R/M327H

741414

0.0114

NADP+

Campylobacter sp.

J4X756

pH 75, 25°C, recombinant His6-tagged mutant L584H/D595R

741414

0.0139

NADP+

Ostreococcus tauri

-

pH 7.6, temperature not specified in the publication, His6-tagged recombinant mutant D344R/M345H, with Mn2+

740425

0.017

NADP+

Escherichia coli

-

wild type

286777

0.031

NADP+

Xylella fastidiosa

-

mutant enzymeD268K/I269Y/A275V, at pH 8.0 and 25°C

760747

0.067

NADP+

Ostreococcus tauri

-

pH 7.6, temperature not specified in the publication, His6-tagged recombinant mutant D344R, with Mn2+

740425

0.087

NADP+

Xylella fastidiosa

-

mutant enzyme D268K/I269Y, at pH 8.0 and 25°C

760747

0.101

NADP+

Xylella fastidiosa

-

mutant enzyme D268K, at pH 8.0 and 25°C

760747

0.157

NADP+

Congregibacter litoralis

A4ADB8

mutant D487R/L488H, with Mn2+, pH 7.5, 35°C

741236

0.162

NADP+

Pyrococcus furiosus

Q8U488

pH 8.0, 70°C, mutant enzyme D328K

721450

0.207

NADP+

Campylobacter concisus

-

mutant enzyme L580H/L591R/A640R, at pH 7.5 and 25°C

760649

0.211

NADP+

Pyrococcus furiosus

Q8U488

pH 8.0, 70°C, mutant enzyme D328K/I329Y

721450

0.476

NADP+

Campylobacter curvus

A0A0M4S9Q1

pH 75, 25°C, recombinant His6-tagged enzyme

741414

0.513

NADP+

Campylobacter sp.

J4X756

pH 75, 25°C, recombinant His6-tagged enzyme

741414

1.827

NADP+

Micromonas commoda

C1E5X2

pH 75, 25°C, recombinant His6-tagged enzyme

741414

2.211

NADP+

Ostreococcus sp. 'lucimarinus'

A4SBK5

pH 75, 25°C, recombinant His6-tagged enzyme

741414

2.339

NADP+

Xylella fastidiosa

-

wild type enzyme, at pH 8.0 and 25°C

760747

3.354

NADP+

Ostreococcus tauri

-

pH 7.6, temperature not specified in the publication, His6-tagged recombinant wild-type enzyme, with Mg2+

740425

4.3

NADP+

Campylobacter concisus

-

wild type enzyme, at pH 7.5 and 25°C

760649

4.314

NADP+

Ostreococcus tauri

-

pH 7.6, temperature not specified in the publication, His6-tagged recombinant wild-type enzyme, with Mn2+

740425

4.44

NADP+

Pyrococcus furiosus

Q8U488

pH 8.0, 70°C, wild-type enzyme

721450

5.8

NADP+

Azotobacter vinelandii

-

-

670158

5.8

NADP+

Escherichia coli

-

7-fold mutant

286777

6.57

NADP+

Acidithiobacillus thiooxidans

Q8GAX0

pH 9.0, 30°C, native enzyme

655607

6.9

NADP+

Colwellia maris

-

-

670158

7.7

NADP+

Zymomonas mobilis

-

pH 7.5, 37°C, with Mn2+, recombinant enzyme

722295

8.2

NADP+

Zymomonas mobilis

-

pH 7.5, 37°C, with Mg2+, recombinant enzyme

722295

additional information

additional information

Acidithiobacillus thiooxidans

Q8GAX0

kinetic properties of the native and the recombinant enzyme are similar

655607

-

additional information

additional information

Acidithiobacillus thiooxidans

-

kinetic properties of the native and the recombinant enzyme are similar

655607

-

additional information

additional information

Saccharomyces cerevisiae

-

kinetics and ligand binding

656052

-

additional information

additional information

Saccharomyces cerevisiae

-

kinetics and ligand binding

656118

-

additional information

additional information

Saccharomyces cerevisiae

-

NAD+-specific D-isocitrate dehydrogenase is an allosterically regulated. AMP and NAD+ binding kinetics of enzyme mutants in presence or absence of DTT, overview

721650

-

additional information

additional information

Saccharomyces cerevisiae

-

yeast NAD+-specific isocitrate dehydrogenase is an allosterically regulated

721650

-

additional information

additional information

Ostreococcus tauri

-

OtIDH exhibits a sigmoidal kinetic behavior in response to isocitrate unlike other homodimeric enzyme homologues, and a remarkably high affinity for isocitrate unlike other heterooligomeric enzyme homologues

740425

-