1.1.1.398: 2-glutathionyl-2-methylbut-3-en-1-ol dehydrogenase

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For detailed information about 2-glutathionyl-2-methylbut-3-en-1-ol dehydrogenase, go to the full flat file.

Reaction

2-(glutathion-S-yl)-2-methylbut-3-en-1-ol

+ 2 NAD⁺ +

2-(glutathion-S-yl)-2-methylbut-3-enoate

+ 2 NADH + 2 H+

Synonyms

4-hydroxy-3-glutathionyl-3-methylbut-1-ene dehydrogenase, isoH

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.398 2-glutathionyl-2-methylbut-3-en-1-ol dehydrogenase

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Results	in table
1	AA Sequence
1	Cofactor
2	KM Value [mM]
1	Molecular Weight [Da]
1	Organism
1	pH Optimum
1	Purification (Commentary)
3	Reaction
1	Reference
2	Specific Activity [micromol/min/mg]
3	Substrates and Products (Substrate)
1	Subunits
2	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 1.1.1.398 - 2-glutathionyl-2-methylbut-3-en-1-ol dehydrogenase

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1-hydroxy-2-glutathionyl-2-methyl-3-butene + NAD+

N-(2-methyl-1-oxobut-3-en-2-yl)-L-gamma-glutamyl-L-cysteinylglycine + NADH + H+

Rhodococcus sp. AD45

738510

2-glutathionyl-2-methyl-3-butenal + NAD+ + H2O

2-glutathionyl-2-methyl-3-butenoic acid + NADH + H+

Rhodococcus sp. AD45

738510

additional information

Rhodococcus sp. AD45

no NADH formation is observed when GSH, methanol, ethanol, glycerol, 2-methylbutanol, 3-methyl-butanol, 1-hydroxy-3-methyl-3-butene, or 1,2-dihydroxy-2-methyl-3-butene are used as a substrate. The conjugates of GSH with 1,2-epoxybutane and 1,2-epoxyhexane are also not substrates

738510