1.1.1.373: sulfolactaldehyde 3-reductase
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For detailed information about sulfolactaldehyde 3-reductase, go to the full flat file.
Reaction
Synonyms
3-sulfolactaldehyde reductase, 3-sulpholactaldehyde reductase, NADH-dependent SLA reductase, SLA reductase, sulfolactaldehyde reductase, yihU
ECTree
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Reaction
Reaction on EC 1.1.1.373 - sulfolactaldehyde 3-reductase
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2,3-dihydroxypropane-1-sulfonate + NAD+ = 2-hydroxy-3-oxopropane-1-sulfonate + NADH + H+
rapid equilibrium sequential Bi-Bi mechanism, dynamic domain movements occurs during catalysis. A conserved sulfonate pocket in SLA reductase recognizes the sulfonate oxygens through hydrogen bonding to Asn174, Ser178, and the backbone amide of Arg123, along with an ordered water molecule