1.1.1.37: malate dehydrogenase
This is an abbreviated version!
For detailed information about malate dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.37
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1.1.1.37
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succinate
-
isocitrate
-
citrate
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isoenzymes
-
oxaloacetate
-
isozyme
-
glucose-6-phosphate
-
tricarboxylic
-
aminotransferase
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phosphoenolpyruvate
-
carboxylase
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hexokinase
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dismutase
-
esterase
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tca
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alpha-ketoglutarate
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creatine
-
fumarase
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aldolase
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carboxykinase
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transaminase
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krebs
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phosphoglucomutase
-
aconitase
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gpi
-
horn
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citric
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medullary
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phosphofructokinase
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6-phosphogluconate
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nadp-dependent
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trigeminal
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1.1.1.27
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allozyme
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meloidogyne
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glyoxysomal
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groes
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nadp-malate
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alpha-glycerophosphate
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watermelon
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phosphoglucose
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pqq
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monomorphic
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second-stage
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isoenzymatic
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root-knot
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perineal
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diagnostics
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drug development
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biotechnology
-
analysis
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subnucleus
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quinoproteins
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medicine
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agriculture
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shsps
- 1.1.1.37
- succinate
- isocitrate
- citrate
- isoenzymes
- oxaloacetate
- isozyme
- glucose-6-phosphate
-
tricarboxylic
- aminotransferase
- phosphoenolpyruvate
- carboxylase
- hexokinase
- dismutase
- esterase
- tca
- alpha-ketoglutarate
- creatine
- fumarase
- aldolase
-
carboxykinase
- transaminase
-
krebs
- phosphoglucomutase
- aconitase
- gpi
-
horn
-
citric
-
medullary
-
phosphofructokinase
- 6-phosphogluconate
-
nadp-dependent
-
trigeminal
-
1.1.1.27
-
allozyme
- meloidogyne
- glyoxysomal
- groes
-
nadp-malate
- alpha-glycerophosphate
- watermelon
-
phosphoglucose
- pqq
-
monomorphic
-
second-stage
-
isoenzymatic
-
root-knot
-
perineal
- diagnostics
- drug development
- biotechnology
- analysis
-
subnucleus
-
quinoproteins
- medicine
- agriculture
-
shsps
Reaction
Synonyms
(R)-2-hydroxyacid dehydrogenase, (S)-malate dehydrogenase, A8B73_11505, CaMDH, cMDH, cMDH -S, cMDH-L, cyMDH, cyMDH1, cyMDH2, cyMDH3, cytMDH, cytMDH1, cytosolic malate dehydrogenase, cytosolic malate dehydrogenase 1, cytosolic MDH, cytosolic NAD-dependent malate dehydrogenase, flo16, floury endosperm16, halophilic malate dehydrogenase, HmMalDH, L-malate dehydrogenase, L-malate dehydrogenases, L-malate-NAD oxidoreductase, L-malate-NAD-oxidoreductase, L-malate: NAD oxidoreductase, L-malate: NAD+ oxidoreductase, L-malate:NAD oxidoreductase, L-malate:NAD-oxidoreductase, L-MDH, LDH-like malate dehydrogenase, ldh0076, LEUM_0076, m-MDH, malate (NAD) dehydrogenase, malate dehydrogenase, malate dehydrogenase (NAD), malate dehydrogenase 1, malate dehydrogenase 2, malate: NAD oxidoreductase, MalDH, malic acid dehydrogenase, malic dehydrogenase, mbNAD-MDH, MDH, MDH A, MDH B1, MDH B2, Mdh1, MDH2, Mdh2a, Mdh2b, Mdh3, mitochondrial malate dehydrogenase, mitochondrial MDH, mMDH, mNAD-MDH, More, NAD+ malate dehydrogenase, NAD+-dependent malate dehydrogenase, NAD+-dependent MDH, NAD+-MDH enzymes, NAD-dependent cytosolic malate dehydrogenase, NAD-dependent malate dehydrogenase, NAD-dependent MalDH, NAD-dependent malic dehydrogenase, NAD-dependent MDH, NAD-L-malate dehydrogenase, NAD-linked malate dehydrogenase, NAD-malate dehydrogenase, NAD-malic dehydrogenase, NAD-MDH, NAD-specific malate dehydrogenase, NADP+-dependent malate dehydrogenase, Pcal_1699, pdNAD-MDH, peroxisomal malate dehydrogenase, peroxisomal NAD+-malate dehydrogenase 1, peroxisomal NAD+-malate dehydrogenase 2, plastid-localized NAD-dependent MDH, plastidial NAD+-dependent malate dehydrogenase, plastidial NAD-dependent malate dehydrogenase, plastidial NAD-dependent malate dehydrogenase 1, plNAD-MDH, PMDH, PMDH1, PMDH2, regulatory subunit of nucleic acid-conducting channel, s-MDH, SrMalDH, TaMDH, VEG69, Vegetative protein 69, YlMdh2p, [LDH-like] MDH
ECTree
1.1.1.37 malate dehydrogenaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.1.1.37 - malate dehydrogenase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(S)-malate + 3-acetylpyridine-adenine dinucleotide
oxaloacetate + reduced 3-acetylpyridine-adenine dinucleotide + H+
-
can also use 3-acetylpyridine-adenine as cofactor
-
-
r
oxaloacetate + NADH
(S)-malate + NAD+
cytosolic enzyme and glycosomal enzyme
-
-
r
(S)-malate + NAD+
oxaloacetate + NADH + H+
-
the peroxisomal malate dehydrogenase functions in beta-oxidation, serving to reoxidize NADH, but not in the glyoxylate cycle
-
-
r
(S)-malate + NAD+
oxaloacetate + NADH + H+
the NAD-dependent mitochondrial malate dehydrogenase plays pivotal roles in tricarboxylic acid and is crucial for the survival and pathogenecity of parasites
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-
r
(S)-malate + NAD+
oxaloacetate + NADH + H+
-
-
-
r
(S)-malate + NAD+
oxaloacetate + NADH + H+
malate dehydrogenase is an oligomeric enzyme that catalyzes the reversible oxidation of malate to oxaloacetate in the presence of NAD+, MDH is an essential metabolic enzyme in the citric acid cycle
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-
r
(S)-malate + NAD+
oxaloacetate + NADH + H+
malate dehydrogenase is an oligomeric enzyme that catalyzes the reversible oxidation of malate to oxaloacetate in the presence of NAD+, MDH is an essential metabolic enzyme in the citric acid cycle
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-
r
(S)-malate + NAD+
oxaloacetate + NADH + H+
-
-
-
r
(S)-malate + NAD+
oxaloacetate + NADH + H+
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highly specific for oxaloacetate and malate
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-
r
(S)-malate + NAD+
oxaloacetate + NADH + H+
mitochondrial enzyme form mMDH functions in citric acid cycle and in the malate-aspartate shuttle
-
-
?
(S)-malate + NAD+
oxaloacetate + NADH + H+
mitochondrial enzyme, Krebs cycle
-
-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
286629, 286630, 286633, 286635, 286640, 286641, 286645, 286648, 286653, 286655, 286659, 286661, 286662, 286669
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-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
286629, 286630, 286633, 286635, 286639, 286640, 286641, 286645, 286648, 286655, 286660, 286661, 286662, 286666, 286669, 286672, 286673, 286674
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-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
286626, 286629, 286630, 286632, 286633, 286636, 286637, 286638, 286639, 286640, 286641, 286645, 286646, 286647, 286650, 286651, 286656, 286658, 286660, 286661, 286662, 286664, 286665, 286668, 286672, 286673, 286674, 286675
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-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
malate + NAD+
oxaloacetate + NADH + H+
-
-
-
-
r
oxaloacetate + NADH + H+
(S)-malate + NAD+
-
-
-
r
oxaloacetate + NADH + H+
(S)-malate + NAD+
-
-
-
r
oxaloacetate + NADH + H+
(S)-malate + NAD+
-
the enzyme is more efficient in the reductive reaction in the tricarboxylic acid cycle
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-
r
oxaloacetate + NADH + H+
L-malate + NAD+
-
-
-
ir
oxaloacetate + NADH + H+
L-malate + NAD+
-
-
-
ir
oxaloacetate + NADH + H+
L-malate + NAD+
-
-
-
ir
oxaloacetate + NADH + H+
L-malate + NAD+
-
-
-
ir
oxaloacetate + NADH + H+
L-malate + NAD+
-
-
-
r
oxaloacetate + NADH + H+
L-malate + NAD+
-
-
-
r
oxaloacetate + NADH + H+
L-malate + NAD+
-
-
-
r
oxaloacetate + NADH + H+
L-malate + NAD+
-
-
-
r
oxaloacetate + NADH + H+
L-malate + NAD+
-
-
-
r
oxaloacetate + NADH + H+
L-malate + NAD+
-
-
-
r
oxaloacetate + NADH + H+
L-malate + NAD+
-
-
-
r
oxaloacetate + NADH + H+
L-malate + NAD+
-
-
-
r
oxaloacetate + NADH + H+
L-malate + NAD+
-
-
-
r
oxaloacetate + NADH + H+
L-malate + NAD+
-
-
-
r
oxaloacetate + NADH + H+
L-malate + NAD+
-
-
-
r
oxaloacetate + NADH + H+
L-malate + NAD+
-
-
-
r
additional information
?
-
-
PMDH activity is not essential for photosynthesis in air in Arabidopsis
-
-
?
additional information
?
-
-
the enzyme is involved in the tricarboxylic acid cycle supplying organic acids as the main source of carbon but not energy
-
-
?
additional information
?
-
-
the enzyme is involved in the tricarboxylic acid cycle supplying organic acids as the main source of carbon but not energy
-
-
?
additional information
?
-
-
the dimeric 74-kDa isozyme is involved in tricarboxylic acid cycle, while the tetrameric 148-kDa isozyme takes part in the citramalate pathway
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-
?
additional information
?
-
-
the dimeric 74-kDa isozyme is involved in tricarboxylic acid cycle, while the tetrameric 148-kDa isozyme takes part in the citramalate pathway
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-
?
additional information
?
-
-
MDH1 stabilizes and transactivates p53 protein by binding to p53-responsive elements in the promotor of downstream genes, MDH1 directly regulates p53-dependent apoptosis upon glucose deprivation
-
-
?
additional information
?
-
the enzyme plays a central role in Crassulacean acid metabolism
-
-
?
additional information
?
-
the PknD phosphorylated MDH can bind to Rv1827 and Rv0020c, i.e. glycogen accumulation regulator GarA and protein Fha, two proteins containing a FHA domain. The FHA domain recognizes phosphothreonine on proteins
-
-
?
additional information
?
-
-
the PknD phosphorylated MDH can bind to Rv1827 and Rv0020c, i.e. glycogen accumulation regulator GarA and protein Fha, two proteins containing a FHA domain. The FHA domain recognizes phosphothreonine on proteins
-
-
?
additional information
?
-
the PknD phosphorylated MDH can bind to Rv1827 and Rv0020c, i.e. glycogen accumulation regulator GarA and protein Fha, two proteins containing a FHA domain. The FHA domain recognizes phosphothreonine on proteins
-
-
?
additional information
?
-
-
the dimeric isoform of the enzyme is responsible for Krebs cycle function and the tetrameric isoform is involved in functioning of the glyoxylate cycle
-
-
?
additional information
?
-
-
the dimeric isoform of the enzyme is responsible for Krebs cycle function and the tetrameric isoform is involved in functioning of the glyoxylate cycle
-
-
?
additional information
?
-
-
the malate-aspartate NADH shuttle components are metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast, the shuttle plays a major role in the activation of the downstream targets of calorie restriction such as Sir2, mechanism and regulation, detailed overview
-
-
?
additional information
?
-
the malate-aspartate NADH shuttle components are metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast, the shuttle plays a major role in the activation of the downstream targets of calorie restriction such as Sir2, mechanism and regulation, detailed overview
-
-
?
