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1.1.1.35: 3-hydroxyacyl-CoA dehydrogenase

This is an abbreviated version!
For detailed information about 3-hydroxyacyl-CoA dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.35

Reaction

(S)-3-hydroxyacyl-CoA
+
NAD+
=
3-oxoacyl-CoA
 +
NADH
 +
H+

Synonyms

(S)-3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase, (S)-3-hydroxybutyryl-CoA dehydrogenase, (S)-stereospecific 3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase, 1-specific DPN-linked beta-hydroxybutyric dehydrogenase, 17beta-HSD10, 3-HADH, 3-hydroxyacetyl-coenzyme A dehydrogenase, 3-hydroxyacyl coenzyme A dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase II, 3-hydroxyacyl-coenzyme A dehydrogenase, 3-hydroxyadipyl-CoA dehydrogenase, 3-hydroxyadipyl-CoA dehydrogenase (NAD+) (probably (S)-3-specific), 3-hydroxybutyryl-CoA dehydrogenase, 3-hydroxyisobutyryl-CoA dehydrogenase, 3-keto reductase, 3-ketoacyl-CoA reductase, 3-L-hydroxyacyl-CoA dehydrogenase, 3-L-hydroxybutyryl-CoA dehydrogenase, 3beta-hydroxyacyl coenzyme A dehydrogenase, 3HA-CoA dehydrogenase, beta hydroxyacyl dehydrogenase, beta-hydroxy acid dehydrogenase, beta-hydroxyacyl CoA dehydrogenase, beta-hydroxyacyl-coenzyme A synthetase, beta-hydroxybutyrylcoenzyme A dehydrogenase, beta-keto-reductase, beta-ketoacyl reductase, beta-ketoacyl-CoA reductase, beta-ketoacyl-coenzyme A reductase, betahydroxyacylcoenzyme A dehydrogenase, CbHBD, endoplasmic reticulum-associated amyloid beta-peptide binding protein, F54C8.1, FadB, FadB', FadB2, Ferp_1035, Fum13p, H16_A0461, HAD, HADH, HADH2, HADHSC, HBD, HCDH, KCR1, KCR2, L-3-hydroxyacyl CoA dehydrogenase, L-3-hydroxyacyl-CoA dehydrogenase, L-3-hydroxyacyl-CoA dehydrogenase, short chain, L-3-hydroxyacylcoenzyme A dehydrogenase, L-3-hydroxybutyryl CoA dehydrogenase, L-specific 3-hydroxyacyl-CoA dehydrogenase, LIC13300, medium- and short-chain-3-hydroxyacyl-CoA dehydrogenase, medium- and short-chain-3-hydroxyacyl-coenzyme A dehydrogenase, More, Msed_0399, multifunctional beta-oxidation enzyme, NADH-3HB-CoA dehydrogenase, NADH-dependent (S)-3-hydroxyacyl-CoA dehydrogenase, NADH-dependent 3-hydroxyacyl-CoA dehydrogenase, PaaH, PaaH1, RePaaH1, SCHAD, SCHAD I, SCHAD II, SCHSD, Scully protein, short chain L-3-hydroxyacyl-CoA dehydrogenase, short-chain 3-hydroxyacyl-CoA dehydrogenase, short-chain 3-hydroxyacyl-coenzyme A dehydrogenase, short-chain hydroxyacyl CoA dehydrogenase, short-chain L-3-hydroxyacyl-CoA dehydrogenase, TFP, type 10 17beta-hydroxysteroid dehydrogenase, type II HADH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.35 3-hydroxyacyl-CoA dehydrogenase

KM Value

KM Value on EC 1.1.1.35 - 3-hydroxyacyl-CoA dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.034
(3beta,5alpha,17beta)-androstane-3,17-diol
-
enzyme from brain
0.0505 - 0.1157
(R)-3-hydroxyacyl-CoA
0.06 - 0.2
(S)-3-hydroxybutanoyl-CoA
0.000058 - 43.5
(S)-3-hydroxybutyryl-CoA
0.088
(S)-3-hydroxydecanoyl-CoA
-
mitochondrial enzyme, oxidation of (S)-3-hydroxydecanoyl-CoA
0.0286 - 0.34
(S)-3-hydroxyhexanoyl-CoA
0.1
(S)-3-hydroxylauryl-CoA
-
-
0.0163 - 0.35
(S)-3-hydroxyoctanoyl-CoA
0.043
17beta-estradiol
-
enzyme from brain
0.0096 - 65.6
3-acetoacetyl-CoA
0.0094 - 0.0175
3-acetoacyl-CoA
-
0.0083 - 0.016
3-oxohexanoyl-CoA
0.0065 - 0.0125
3-oxooctanoyl-CoA
0.003 - 0.263
acetoacetyl-CoA
44.4
acetoacetyl-N-acetyl-cysteamine
-
-
10
acetoacetyl-N-acetylcysteamine
-
-
1.4
acetoacetyl-N-beta-alanylcysteamine
-
-
10
acetoacetyl-Nacetylcysteamine
-
-
0.08 - 1.19
acetoacetyl-pantetheine
0.045
androsterone
-
enzyme from brain
0.00009 - 29.5
NAD+
0.0009 - 50
NADH
11
NADP+
-
-
0.435
NADPH
-
-
additional information
additional information
-