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1.1.1.333: decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase

This is an abbreviated version!
For detailed information about decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase, go to the full flat file.

Word Map on EC 1.1.1.333

Reaction

trans,octacis-decaprenylphospho-beta-D-arabinofuranose
+
NAD+
=
trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose
+
NADH
+
H+

Synonyms

decaprenylphospho-beta-D-ribofuranose 2'-epimerase, DprE2, MSMEG_6385, Rv3791

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.333 decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase

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Resultsin table
730AA Sequence
2Application
1Cloned(Commentary)
1Cofactor
3General Information
2Inhibitors
7Organism
1Pathway
1Reaction
5Reference
4Substrates and Products (Substrate)
7Synonyms
1Systematic Name

Reference

Reference on EC 1.1.1.333 - decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Trefzer, C.; Skovierova, H.; Buroni, S.; Bobovska, A.; Nenci, S.; Molteni, E.; Pojer, F.; Pasca, M.; Makarov, V.; Cole, S.; Riccardi, G.; Mikusova, K.; Johnsson, K.
Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase DprE1
J. Am. Chem. Soc.
134
912-915
2012
Mycolicibacterium smegmatis (A0R610)
Manually annotated by BRENDA team
Mikusova, K.; Huang, H.; Yagi, T.; Holsters, M.; Vereecke, D.; DHaeze, W.; Scherman, M.S.; Brennan, P.J.; McNeil, M.R.; Crick, D.C.
Decaprenylphosphoryl arabinofuranose, the donor of the D-arabinofuranosyl residues of mycobacterial arabinan, is formed via a two-step epimerization of decaprenylphosphoryl ribose
J. Bacteriol.
187
8020-8025
2005
Mycobacterium tuberculosis (P9WGS9), Mycobacterium tuberculosis H37Rv (P9WGS9)
Manually annotated by BRENDA team
Christophe, T.; Jackson, M.; Hee, K.; Fenistein, D.; Contreras-Dominguez, M.; Kim, J.; Genovesio, A.; Carralot, J.; Ewann, F.; Kim, E.; Lee, S.; Kang, S.; Seo, M.; Eun, J.; Skovierova, H.; Pham, H.; Riccardi, G.; Youn, N.; Marsollier, L.; Kempf, M.; Jol
High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors.
PLoS Pathog.
5
e1000645
2009
Mycobacterium tuberculosis (P9WGS9), Mycobacterium tuberculosis H37Rv (P9WGS9)
Manually annotated by BRENDA team