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1.1.1.315: 11-cis-retinol dehydrogenase

This is an abbreviated version!
For detailed information about 11-cis-retinol dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.315

Reaction

11-cis-retinol-[retinal-binding-protein]
+
NAD+
=
11-cis-retinal-[retinol-binding-protein]
+
NADH
+
H+

Synonyms

11-cis RD, 11-cis-RDH, 11-cis-retinol dehydrogenase, 11-cis-Ro-DH, atRDH, cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase, CRAD, CRAD2, cRDH, EC 5.2.1.3, RDH10, RDH5, retinol dehydrogenase 10

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.315 11-cis-retinol dehydrogenase

Reference

Reference on EC 1.1.1.315 - 11-cis-retinol dehydrogenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mata, N.L.; Tsin, A.T.C.
Distribution of 11-cis LRAT, 11-cis RD and 11-cis REH in bovine retinal pigment epithelium membranes
Biochim. Biophys. Acta
1394
16-22
1998
Bos taurus
Manually annotated by BRENDA team
Belyaeva, O.V.; Johnson, M.P.; Kedishvili, N.Y.
Kinetic analysis of human enzyme RDH10 defines the characteristics of a physiologically relevant retinol dehydrogenase
J. Biol. Chem.
283
20299-20308
2008
Homo sapiens, Homo sapiens (Q8IZV5)
Manually annotated by BRENDA team
Wang, J.; Chai, X.; Eriksson, U.; Napoli, J.L.
Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue.
Biochem. J.
338
23-27
1999
Homo sapiens, Homo sapiens (Q92781)
Manually annotated by BRENDA team
Takahashi, Y.; Moiseyev, G.; Farjo, K.; Ma, J.X.
Characterization of key residues and membrane association domains in retinol dehydrogenase 10
Biochem. J.
419
113-122
2009
Homo sapiens (Q8IZV5)
Manually annotated by BRENDA team
Picozzi, P.; Marozzi, A.; Fornasari, D.; Benfante, R.; Barisani, D.; Meneveri, R.; Ginelli, E.
Genomic organization and transcription of the human retinol dehydrogenase 10 (RDH10) gene
FEBS Lett.
554
59-66
2003
Homo sapiens (Q8IZV5)
Manually annotated by BRENDA team
Wu, B.X.; Chen, Y.; Chen, Y.; Fan, J.; Rohrer, B.; Crouch, R.K.; Ma, J.X.
Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE
Invest. Ophthalmol. Vis. Sci.
43
3365-3372
2002
Bos taurus (Q8HZT6), Bos taurus, Homo sapiens (Q8IZV5), Homo sapiens, Mus musculus (Q8VCH7), Mus musculus
Manually annotated by BRENDA team
Farjo, K.M.; Moiseyev, G.; Takahashi, Y.; Crouch, R.K.; Ma, J.X.
RDH10 has 11-cis-retinol dehydrogenase activity and interacts with visual cycle proteins.
Invest. Ophthalmol. Vis. Sci.
50
5089-5097
2009
Bos taurus (Q8HZT6), Bos taurus, Homo sapiens (Q8IZV5), Homo sapiens
Manually annotated by BRENDA team
Chai, X.; Zhai, Y.; Napoli, J.L.
cDNA cloning and characterization of a cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase
J. Biol. Chem.
272
33125-33131
1997
Mus musculus (O54909), Mus musculus
Manually annotated by BRENDA team
Su, J.; Chai, X.; Kahn, B.; Napoli, J.L.
cDNA cloning, tissue distribution, and substrate characteristics of a cis-Retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme.
J. Biol. Chem.
273
17910-17916
1998
Mus musculus (O88451), Mus musculus
Manually annotated by BRENDA team
Tsigelny, I.; Baker, M.E.
Structures important in NAD(P)(H) specificity for mammalian retinol and 11-cis-retinol dehydrogenases
Biochem. Biophys. Res. Commun.
226
118-127
1996
Bos taurus
Manually annotated by BRENDA team
Simon, A.; Hellman, U.; Wernstedt, C.; Eriksson, U.
The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases
J. Biol. Chem.
270
1107-1112
1995
Bos taurus (Q27979)
Manually annotated by BRENDA team
Chen, P.; Lee, T.D.; Fong, H.K.
Interaction of 11-cis-retinol dehydrogenase with the chromophore of retinal G protein-coupled receptor opsin
J. Biol. Chem.
276
21098-21104
2001
Bos taurus
Manually annotated by BRENDA team
Liden, M.; Romert, A.; Tryggvason, K.; Persson, B.; Eriksson, U.
Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus
J. Biol. Chem.
276
49251-49257
2001
Homo sapiens (Q92781), Homo sapiens
Manually annotated by BRENDA team
Wu, Z.; Yang, Y.; Shaw, N.; Bhattacharya, S.; Yan, L.; West, K.; Roth, K.; Noy, N.; Qin, J.; Crabb, J.W.
Mapping the ligand binding pocket in the cellular retinaldehyde binding protein
J. Biol. Chem.
278
12390-12396
2003
Homo sapiens (Q92781), Homo sapiens
Manually annotated by BRENDA team
Simon, A.; Romert, A.; Gustafson, A.; McCaffery, J.; Eriksson, U.
Intracellular localization and membrane topology of 11-cis retinol dehydrogenase in the retinal pigment epithelium suggest a compartmentalized synthesis of 11-cis retinaldehyde
J. Cell Sci.
112
549-558
1999
Bos taurus (Q27979)
Manually annotated by BRENDA team
Huang, X.F.; Luu-The, V.
Modulation of the androgenic response by recombinant human 11-cis retinol dehydrogenase
J. Steroid Biochem. Mol. Biol.
77
129-133
2001
Homo sapiens
Manually annotated by BRENDA team
Gonzalez-Fernandez, F.; Kurz, D.; Bao, Y.; Newman, S.; Conway, B.; Young, J.; Han, D.; Khani, S.
11-cis Retinol dehydrogenase mutations as a major cause of the congenital night-blindness disorder known as fundus albipunctatus
Mol. Vis.
5
XI-XII
1999
Homo sapiens (Q92781)
-
Manually annotated by BRENDA team
Yamamoto, H.; Simon, A.; Eriksson, U.; Harris, E.; Berson, E.L.; Dryja, T.P.
Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus
Nat. Genet.
22
188-191
1999
Homo sapiens (Q92781)
Manually annotated by BRENDA team
Parker, R.O.; Crouch, R.K.
Retinol dehydrogenases (RDHs) in the visual cycle
Exp. Eye Res.
91
788-792
2010
Mus musculus
Manually annotated by BRENDA team
Sahu, B.; Sun, W.; Perusek, L.; Parmar, V.; Le, Y.Z.; Griswold, M.D.; Palczewski, K.; Maeda, A.
Conditional ablation of retinol dehydrogenase 10 in the retinal pigmented epithelium causes delayed dark adaption in mice
J. Biol. Chem.
290
27239-27247
2015
Homo sapiens, Mus musculus (Q8VCH7)
Manually annotated by BRENDA team
Xue, Y.; Sato, S.; Razafsky, D.; Sahu, B.; Shen, S.Q.; Potter, C.; Sandell, L.L.; Corbo, J.C.; Palczewski, K.; Maeda, A.; Hodzic, D.; Kefalov, V.J.
The role of retinol dehydrogenase 10 in the cone visual cycle
Sci. Rep.
7
2390
2017
Mus musculus
Manually annotated by BRENDA team