1.1.1.315: 11-cis-retinol dehydrogenase
This is an abbreviated version!
For detailed information about 11-cis-retinol dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.315
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1.1.1.315
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retinal
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retinoids
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11-cis-retinal
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chromophore
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fundus
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photoreceptors
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all-trans-retinol
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albipunctatus
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cralbp
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retinaldehyde-binding
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3alpha-hydroxysteroids
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retinaldehyde
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9-cis-retinol
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androsterone
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photoisomerization
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cis-retinols
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electroretinography
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11-cis-retinaldehyde
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17beta-hydroxysteroid
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17beta
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medicine
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punctata
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interphotoreceptor
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11-cis-retinoids
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retinoid-binding
- 1.1.1.315
- retinal
-
retinoids
- 11-cis-retinal
- chromophore
-
fundus
-
photoreceptors
- all-trans-retinol
-
albipunctatus
-
cralbp
-
retinaldehyde-binding
-
3alpha-hydroxysteroids
- retinaldehyde
- 9-cis-retinol
- androsterone
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photoisomerization
- cis-retinols
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electroretinography
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11-cis-retinaldehyde
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17beta-hydroxysteroid
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17beta
- medicine
-
punctata
-
interphotoreceptor
-
11-cis-retinoids
-
retinoid-binding
Reaction
Synonyms
11-cis RD, 11-cis-RDH, 11-cis-retinol dehydrogenase, 11-cis-Ro-DH, atRDH, cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase, CRAD, CRAD2, cRDH, EC 5.2.1.3, RDH10, RDH5, retinol dehydrogenase 10
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General Information
General Information on EC 1.1.1.315 - 11-cis-retinol dehydrogenase
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malfunction
metabolism
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RDH11, which can can utilize both cis and trans-retinoid substrates, plays a minor but complementary role to RDH5 in the flow of retinoids during dark adaptation
physiological function
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11-cis retinol oxidation occurs at a reduced rate in retinal pigment epithelium membranes from Rdh5-/- mice
malfunction
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RDH10 is not required for the function of the retina visual cycle. Transgenic mice expressing RDH10 ectopically in rod cells show, that rod dark adaptation is unaffected by the expression of RDH10 and transgenic rods were unable to use cis-retinol for pigment regeneration
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cRDH is involved in the processing of 11-cis-retinal after irradiation of retinal G protein-coupled receptor RGR opsin and plays a role in the visual cycle
physiological function
reconstitution of the visual cycle in HEK-293A cells by co-expressing RDH10, cellular retinaldehyde-binding protein CRALBP, RPE-specific 65-kDa protein RPE65 and lecithin retinol acyltransferase LRAT leads to generation of 11-cis-retinol from all-trans-retinal
physiological function
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isomerization of 11-cis retinal to all-trans retinal in photoreceptors is the first step in vision. In the retinal pigment epithelium, all-trans retinol is converted to 11-cis retinol, and in the final enzymatic step, 11-cis-retinol is oxidized to 11-cis retinal, catalyzed by the enzyme RDH5. RDH5 does play a significant role in 11-cis retinol oxidation in the retinal pigment epithelium
physiological function
mice with a conditional knock-out of isoform Rdh10 in retinal pigmented epithelium cells display delayed 11-cis-retinal regeneration and dark adaption after bright light illumination. Retinal function after light exposure is also delayed in Rdh10 KO mice as compared with controls. Double deletion of isoforms Rdh5 and Rdh10 in mice causes elevated 11/13-cis-retinyl ester content also seen in Rdh5-/- Rdh11-/- mice as compared with Rdh5-/- mice. Normal retinal morphology is observed in 6-month-old Rdh10 KO and Rdh5 and Rdh10 KO mice
physiological function
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cone-specific 11-cis-RDH is likely to be important in regulating access to the retina visual cycle. Retinol dehydrogenase 10, RDH10 (UniProt ID Q8VCH7), is not the dominant retina 11-cis-RDH, it catalyzes the all-transretinol convertion, cf. EC 1.1.1.300