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1.1.1.312: 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

This is an abbreviated version!
For detailed information about 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.312

Reaction

4-carboxy-2-hydroxymuconate semialdehyde hemiacetal
+
NADP+
=
2-oxo-2H-pyran-4,6-dicarboxylate
+
NADPH
+
H+

Synonyms

2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 2-hydroxy-4-carboxymuconate-6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase, 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase, CHMS dehydrogenase, CHMS hydrolase, dehydrogenase, 2-hydroxy-4-carboxymuconate 6-semialdehyde, EC 1.2.1.45, PmdC

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

Natural Substrates Products

Natural Substrates Products on EC 1.1.1.312 - 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + NADP+ + H2O
4-carboxy-2-hydroxy-cis,cis-muconate + NADPH + 2 H+
show the reaction diagram
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP+
2-oxo-2H-pyran-4,6-dicarboxylate + NADPH + H+
show the reaction diagram
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-
?
additional information
?
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2-pyrone-4,6-dicarboxylic acid may be a metabolic intermediate in the bacterial metabolism of protocatechuic acid
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