1.1.1.312: 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

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For detailed information about 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase, go to the full flat file.

Reaction

Synonyms

2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 2-hydroxy-4-carboxymuconate-6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase, 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase, CHMS dehydrogenase, CHMS hydrolase, dehydrogenase, 2-hydroxy-4-carboxymuconate 6-semialdehyde, EC 1.2.1.45, PmdC

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

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Results	in table
1	Activating Compound
508	AA Sequence
5	Application
1	CAS Registry Number
5	Cloned(Commentary)
9	Cofactor
15	Inhibitors
5	Ki Value [mM]
11	KM Value [mM]
6	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
18	Organism
6	Pathway
3	pH Optimum
1	pH Range
1	pH Stability
1	Protein Variants
3	Purification (Commentary)
2	Reaction
5	Reaction Type
10	Reference
2	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
23	Substrates and Products (Substrate)
6	Subunits
17	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]

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Cloned on EC 1.1.1.312 - 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

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Pseudomonas straminea

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655061

4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase gene ligC expressed in Escherichia coli

Sphingomonas paucimobilis

-

288244

coexpression with protocatechuate 4,5-dioxygenase in Pseudomonas putida PpY1100

Sphingomonas paucimobilis

-

671526

gene pmdC, transient recombinant expression of the enzyme in Nicotiana benthamiana, coexpression with PmdA and, PmdB from Comamonas testosteroni, stable expression of enzymes PmdA, PmdB, and PmdC from Comamonas testosteroni in Arabidopsis thaliana, coexpression with 3-dehydroshikimate dehydratase (QsuB). The metabolic pathway is implemented in the Arabidopsis thaliana ecotype Columbia plastids to produce 2-pyrone-4,6-dicarboxylic acid (PDC), overview

Comamonas testosteroni

Q93PS4

763427

into the pKT230MC vector for expression in Pseudomonas putida PpY1100 and into pUC119 for DNA amplification in Escherichia coli DH5alpha

Sphingomonas paucimobilis

-

671526