1.1.1.305: UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)

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For detailed information about UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating), go to the full flat file.

Reaction

Synonyms

ArnA, ArnA dehydrogenase, ArnADH, RsU4kpxs, UDP-alpha-D-xylose synthase, UDP-GlcUA dehydrogenase, UGA decarboxylase, UXS

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.305 UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)

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Results	in table
1	Activating Compound
2511	AA Sequence
2	Application
5	Cloned(Commentary)
9	Cofactor
6	Crystallization (Commentary)
3	General Information
2	kcat/KM [mM/s]
14	KM Value [mM]
1	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
10	Organism
3	Pathway
16	PDB ID
6	pH Optimum
1	pH Range
6	Protein Variants
3	Purification (Commentary)
1	Reaction
10	Reference
15	Substrates and Products (Substrate)
12	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Turnover Number [1/s]

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Application on EC 1.1.1.305 - UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)

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medicine

Escherichia coli

P77398

modification of the lipid A moiety of lipopolysaccharide by the addition of the sugar 4-amino-4-deoxy-L-arabinose is a strategy adopted by pathogenic Gram-negative bacteria to evade cationic antimicrobial peptides produced by the innate immune system. L-Ara4N biosynthesis is therefore a potential anti-infective target

698732

synthesis

Escherichia coli

A0A140N587

engineering of Escherichia coli to ynthesize the plant-specific flavonoid O-pentosides quercetin 3-O-xyloside and quercetin 3-O-arabinoside. For UDP-xylose biosynthesis, genes UXS (UDP-xylose synthase) from Arabidopsis thaliana and ugd (UDP-glucose dehydrogenase) from E.scherichia coli, are overexpressed. The gene encoding ArnA, which competes with UXS for UDP-glucuronic acid, is deleted. For UDP-arabinose biosynthesis, UXE (UDP-xylose epimerase) is overexpressed. UDP-dependent glycosyltransferases are engineered to ensure specificity for UDP-xylose and UDP-arabinose. The srains thus obtained synthesize approximately 160 mg/liter of quercetin 3-O-xyloside and quercetin 3-O-arabinoside

739902