1.1.1.3: homoserine dehydrogenase
This is an abbreviated version!
For detailed information about homoserine dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.3
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1.1.1.3
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l-threonine
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threonine-sensitive
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corynebacterium
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glutamicum
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l-lysine
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semialdehyde
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dihydrodipicolinate
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l-isoleucine
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brevibacterium
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aspartate-derived
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2.7.2.4
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i-homoserine
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rhodospirillum
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lysine-sensitive
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lactofermentum
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feedback-insensitive
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feedback-resistant
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synthesis
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drug development
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agriculture
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pharmacology
- 1.1.1.3
- l-threonine
-
threonine-sensitive
- corynebacterium
- glutamicum
- l-lysine
- semialdehyde
- dihydrodipicolinate
- l-isoleucine
- brevibacterium
-
aspartate-derived
-
2.7.2.4
-
i-homoserine
-
rhodospirillum
-
lysine-sensitive
- lactofermentum
-
feedback-insensitive
-
feedback-resistant
- synthesis
- drug development
- agriculture
- pharmacology
Reaction
Synonyms
AK-HDH, AK-HSD-1, AK-HSDH, AK-HseDH, aspartate kinase-homoserine dehydrogenase, aspartokinase-homoserine dehydrogenase I, bifunctional aspartate kinase-homoserine dehydrogenase, BsHSD, HDH, hom, hom-1, Hom6, homoserine dehydrogenase 1, homoserine dehydrogenase 2, HSD, HSDH, HseDH, More, orf19.2951, PbHSD, SACOL1362, StHSD, thrA, TM_0547, TTHA0489, TtHSD
ECTree
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Temperature Stability
Temperature Stability on EC 1.1.1.3 - homoserine dehydrogenase
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37
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half-life of mutant L200F/D215K is 4.16 h, of mutant L200F 3.71 h
50 - 100
purified recombinant enzyme, 10 min, completely stable at 50-90°C, loss of 40% activity at 100°C
75
purified recombinant His-tagged enzyme, 10 min, retains full activity
90
purified recombinant His-tagged enzyme, 10 min, retains 70% activity