1.1.1.289: sorbose reductase
This is an abbreviated version!
For detailed information about sorbose reductase, go to the full flat file.
Word Map on EC 1.1.1.289
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1.1.1.289
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gluconobacter
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albicans
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frateurii
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s-4-chloro-3-hydroxybutanoate
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mannitol
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4-chloro-3-oxobutanoate
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xylitol
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biocatalytic
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suboxydans
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substrate-coupled
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d-fructose
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s-chbe
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co-substrates
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nadp-dependent
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enantiomeric
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synthesis
- 1.1.1.289
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gluconobacter
- albicans
- frateurii
-
s-4-chloro-3-hydroxybutanoate
- mannitol
- 4-chloro-3-oxobutanoate
- xylitol
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biocatalytic
- suboxydans
-
substrate-coupled
- d-fructose
-
s-chbe
-
co-substrates
-
nadp-dependent
-
enantiomeric
- synthesis
Reaction
Synonyms
FAD-dependent D-sorbitol dehydrogenase, flavin adenine dinucleotide-dependent D-sorbitol dehydrogenase, L-sorbose reductase, NADPH-dependent L-sorbose reductase, NADPH-dependent sorbose reductase, NADPH-SR, SboA, SLDH, SOU1
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Substrates Products
Substrates Products on EC 1.1.1.289 - sorbose reductase
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REACTION DIAGRAM
4-chloro-3-oxobutanoate + NADPH + H+
(S)-4-chloro-3-hydroxybutanoate + NADP+
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?
L-fructose + NADPH
D-mannitol + NADP+
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142% of the rate with L-sorbose
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r
? + NADP+
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86.8% of the rate with L-sorbose
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r
5-keto-D-fructose + NADPH
? + NADP+
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86.8% of the rate with L-sorbose
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r
D-mannitol + NADP+
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less effective than reaction with L-sorbose
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-
?
L-fructose + NADPH + H+
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134% of the rate with L-sorbose
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r
D-mannitol + NADP+
L-fructose + NADPH + H+
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134% of the rate with L-sorbose
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r
D-sorbitol + NADP+
L-sorbose + NADPH + H+
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134% of the rate with L-sorbose
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r
D-sorbitol + NADP+
L-sorbose + NADPH + H+
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134% of the rate with L-sorbose
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r
erythritol + NADP+
? + NADPH
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65.3% of the rate with L-sorbose
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r
?
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development of a substrate-coupled biocatalytic process driven by NADPH-dependent sorbose reductase for the asymmetric reduction of ethyl 4-chloro-3-oxobutanoate, overview. Ethyl 4-chloro-3-oxobutanoate is reduced to (S)-4-chloro-3-hydroxybutanoate, while NADPH is regenerated by the enzyme via oxidation of sorbitol, mannitol, or xylitol in crude extract of recombinant Escherichia coli cells, overview
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additional information
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the enzyme catalyzes the asymmetric reduction of ethyl 4-chloro-3-oxobutanoate, reaction of (S)-specific secondary alcohol dehydrogenase, with an optical purity of 99% (e.e.) and an activity of 6.2 U/mg towards ethyl 4-chloro-3-oxobutanoate
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?
additional information
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the enzyme catalyzes the asymmetric reduction of ethyl 4-chloro-3-oxobutanoate, reaction of (S)-specific secondary alcohol dehydrogenase, with an optical purity of 99% (e.e.) and an activity of 6.2 U/mg towards ethyl 4-chloro-3-oxobutanoate
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?
additional information
?
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the enzyme catalyzes the asymmetric reduction of ethyl 4-chloro-3-oxobutanoate, reaction of (S)-specific secondary alcohol dehydrogenase, with an optical purity of 99% (e.e.) and an activity of 6.2 U/mg towards ethyl 4-chloro-3-oxobutanoate
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additional information
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highly specific for D-sorbitol and L-sorbose. Reaction rate in L-sorbose reduction highly predominates over L-sorbitol oxidation over a wide pH range
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additional information
?
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highly specific for D-sorbitol and L-sorbose. Reaction rate in L-sorbose reduction highly predominates over L-sorbitol oxidation over a wide pH range
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?