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1.1.1.28: D-lactate dehydrogenase

This is an abbreviated version!
For detailed information about D-lactate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.28

Reaction

(R)-lactate
+
NAD+
=
pyruvate
+
NADH
+
H+

Synonyms

D-(-)-lactate dehydrogenase, D-(-)-lactate dehydrogenase (NAD), D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein, D-lactate dehydrogenase, D-lactic acid dehydrogenase, D-lactic dehydrogenase, D-LDH, D-LDH-like enzyme, D-LDH0653, D-LDH1, D-LDH2, D-LDH3, D-LDH82319, D-nLDH, D-specific lactic dehydrogenase, dehydrogenase, D-lactate, DLD1, DLDH, DLDH744, ECBD_2243, ECLDH, FD35_GL001981, Fermentative lactate dehydrogenase, FN0511, FNLDH, lactic acid dehydrogenase, ldb0101, Ldb1010, LDH, LdhA, ldhd, LDHD1, LDHD2, LDHD3, LdhTi, Ljd-LDH, MGG_01202, NAD-dependent D-lactate dehydrogenase, PA0927, PALDH, Respiratory D-lactate dehydrogenase, SO_0968, tp0037, WP_013906894

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.28 D-lactate dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.28 - D-lactate dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-lactate + NAD(P)+
pyruvate + NAD(P)H + H+
show the reaction diagram
(R)-lactate + NAD+
pyruvate + NADH
show the reaction diagram
(R)-lactate + NAD+
pyruvate + NADH + H+
show the reaction diagram
2-ketocaproate + NADH
2-hydroxycaproate + NAD+
show the reaction diagram
-
-
-
-
?
2-ketoisocaproate + NADH
2-hydroxyisocaproate + NAD+
show the reaction diagram
-
-
-
-
?
2-ketoisovalerate + NADH
2-hydroxyisovalerate + NAD+
show the reaction diagram
-
-
-
-
?
2-ketovalerate + NADH
2-hydroxyvalerate + NAD+
show the reaction diagram
-
-
-
-
?
2-oxo-4-phenyl-butyric acid + NADH + H+
(R)-2-hydroxy-4-phenyl-butyric acid + NAD+
show the reaction diagram
-
-
-
-
?
2-oxo-4-phenylbutyric acid + NADH + H+
(R)-2-hydroxy-4-phenylbutyric acid + NAD+
show the reaction diagram
2-oxo-4-phenylbutyric acid + reduced acceptor
(R)-2-hydroxy-4-phenylbutyric acid + acceptor
show the reaction diagram
-
-
-
-
?
2-oxobutanoate + NADH + H+
(R)-2-hydroxybutanoate + NAD+
show the reaction diagram
2-oxobutanoate + NADH + H+
2-hydroxybutanoate + NAD+
show the reaction diagram
2-oxobutyrate + NADH
2-hydroxybutyrate + NAD+
show the reaction diagram
2-oxobutyrate + NADH + H+
2-hydroxybutyrate + NAD+
show the reaction diagram
2-oxobutyric acid + NADH + H+
(R)-2-hydroxybutyric acid + NAD+
show the reaction diagram
-
-
-
-
ir
2-oxocaproate + NADH + H+
2-hydroxycaproate + NAD+
show the reaction diagram
2-oxoglutarate + NADH + H+
2-hydroxypentanedioate + NAD+
show the reaction diagram
-
-
-
-
?
2-oxoglutarate + NADPH + H+
(R)-2-hydroxyglutarate + NADP+
show the reaction diagram
2-oxoisocaproate + NADH + H+
2-hydroxyisocaproate + NAD+
show the reaction diagram
2-oxoisovalerate + NADH + H+
2-hydroxyisovalerate + NAD+
show the reaction diagram
-
-
-
r
2-oxovalerate + NADH + H+
2-hydroxyvalerate + NAD+
show the reaction diagram
3,4-dihydroxyphenylpyruvate + NADH + H+
(R)-3,4-dihydroxyphenyllactate + NAD+
show the reaction diagram
3,4-dihydroxyphenylpyruvic acid + NADH + H+
(R)-3,4-dihydroxyphenyllactic acid + NAD+
show the reaction diagram
-
-
-
-
?
3,4-dihydroxyphenylpyruvic acid + NADH + H+
D-3,4-dihydroxyphenyllactic acid + NAD+
show the reaction diagram
3-methyl-2-oxobutanoate + NADH + H+
(R)-2-hydroxy-3-methylbutanoate + NAD+
show the reaction diagram
3-methyl-2-oxobutanoate + NADH + H+
2-hydroxy-3-methylbutanoate + NAD+
show the reaction diagram
4-methyl-2-oxopentanoate + NADH + H+
(R)-2-hydroxy-4-methylpentanoate + NAD+
show the reaction diagram
alpha-ketobutyrate + NADH
2-hydroxybutyrate + NAD+
show the reaction diagram
benzoylformate + NADH + H+
phenylglyoxylate + NAD+
show the reaction diagram
-
-
-
-
?
bromopyruvate + NADH
3-bromo-2-hydroxypropanoate + NAD+
show the reaction diagram
-
-
-
-
?
D-3-phenylpyruvate + NADH + H+
D-3-phenyllactate + NAD+
show the reaction diagram
D-lactate + cytochrome c2ox
pyruvate + cytochrome c2red
show the reaction diagram
-
-
-
-
?
D-lactate + NAD+
pyruvate + NADH
show the reaction diagram
D-lactate + NAD+
pyruvate + NADH + H+
show the reaction diagram
D-lactate + NAD+ + H+
pyruvate + NADH
show the reaction diagram
-
-
-
?
D-lactate + nicotinamide cytosine dinucleotide
pyruvate + reduced nicotinamide cytosine dinucleotide
show the reaction diagram
-
-
-
?
DL-2-hydroxybutyrate + NAD+
2-oxobutyrate + NADH
show the reaction diagram
DL-2-hydroxybutyrate + NAD+
? + NADH
show the reaction diagram
-
about 44% of activity against D-lactate
-
-
?
glyoxylate + NADH
hydroxyacetic acid + NAD+
show the reaction diagram
-
-
-
-
?
glyoxylate + NADH + H+
glycolate + NAD+
show the reaction diagram
-
best substrate of isoform LDHL1
-
-
?
glyoxylate + NADH + H+
hydroxyacetate + NAD+
show the reaction diagram
glyoxylate + NADH + H+
hydroxyacetic acid + NAD+
show the reaction diagram
-
-
-
-
?
hydroxypyruvate + NADH
glycerate + NAD+
show the reaction diagram
-
-
-
-
?
hydroxypyruvate + NADH + H+
glycerate + NAD+
show the reaction diagram
L-lactate + NAD+
pyruvate + NADH + H+
show the reaction diagram
methylpyruvate + NADH
? + NAD+
show the reaction diagram
oxaloacetate + NADH
malate + NAD+
show the reaction diagram
oxaloacetate + NADH + H+
D-malate + NAD+
show the reaction diagram
oxaloacetate + NADH + H+
malate + NAD+
show the reaction diagram
oxaloacetic acid + NADH + H+
(R)-malate + NAD+
show the reaction diagram
-
-
-
-
ir
phenylpyruvate + NADH
phenyllactate + NAD+
show the reaction diagram
-
-
-
-
?
phenylpyruvate + NADH + H+
(R)-3-phenyllactate + NAD+
show the reaction diagram
phenylpyruvate + NADH + H+
2-hydroxy-3-phenylpropanoate + NAD+
show the reaction diagram
-
-
-
-
?
phenylpyruvate + NADH + H+
D-phenyllactate + NAD+
show the reaction diagram
pyruvate + NAD(P)H + H+
(R)-lactate + NAD(P)+
show the reaction diagram
pyruvate + NADH
(R)-lactate + NAD+
show the reaction diagram
pyruvate + NADH + H+
(R)-lactate + NAD+
show the reaction diagram
pyruvate + NADH + H+
D-lactate + NAD+
show the reaction diagram
-
-
-
-
?
pyruvate + NADPH + H+
(R)-lactate + NADP+
show the reaction diagram
-
-
-
-
r
additional information
?
-