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(R)-lactate + NAD(P)+
pyruvate + NAD(P)H + H+
(R)-lactate + NAD+
pyruvate + NADH
(R)-lactate + NAD+
pyruvate + NADH + H+
2-ketocaproate + NADH
2-hydroxycaproate + NAD+
-
-
-
-
?
2-ketoisocaproate + NADH
2-hydroxyisocaproate + NAD+
-
-
-
-
?
2-ketoisovalerate + NADH
2-hydroxyisovalerate + NAD+
-
-
-
-
?
2-ketovalerate + NADH
2-hydroxyvalerate + NAD+
-
-
-
-
?
2-oxo-4-phenyl-butyric acid + NADH + H+
(R)-2-hydroxy-4-phenyl-butyric acid + NAD+
-
-
-
-
?
2-oxo-4-phenylbutyric acid + NADH + H+
(R)-2-hydroxy-4-phenylbutyric acid + NAD+
2-oxo-4-phenylbutyric acid + reduced acceptor
(R)-2-hydroxy-4-phenylbutyric acid + acceptor
-
-
-
-
?
2-oxobutanoate + NADH + H+
(R)-2-hydroxybutanoate + NAD+
2-oxobutanoate + NADH + H+
2-hydroxybutanoate + NAD+
2-oxobutyrate + NADH
2-hydroxybutyrate + NAD+
2-oxobutyrate + NADH + H+
2-hydroxybutyrate + NAD+
2-oxobutyric acid + NADH + H+
(R)-2-hydroxybutyric acid + NAD+
-
-
-
-
ir
2-oxocaproate + NADH + H+
2-hydroxycaproate + NAD+
2-oxoglutarate + NADH + H+
2-hydroxypentanedioate + NAD+
-
-
-
-
?
2-oxoglutarate + NADPH + H+
(R)-2-hydroxyglutarate + NADP+
2-oxoisocaproate + NADH + H+
2-hydroxyisocaproate + NAD+
2-oxoisovalerate + NADH + H+
2-hydroxyisovalerate + NAD+
-
-
-
r
2-oxovalerate + NADH + H+
2-hydroxyvalerate + NAD+
3,4-dihydroxyphenylpyruvate + NADH + H+
(R)-3,4-dihydroxyphenyllactate + NAD+
3,4-dihydroxyphenylpyruvic acid + NADH + H+
(R)-3,4-dihydroxyphenyllactic acid + NAD+
-
-
-
-
?
3,4-dihydroxyphenylpyruvic acid + NADH + H+
D-3,4-dihydroxyphenyllactic acid + NAD+
3-methyl-2-oxobutanoate + NADH + H+
(R)-2-hydroxy-3-methylbutanoate + NAD+
3-methyl-2-oxobutanoate + NADH + H+
2-hydroxy-3-methylbutanoate + NAD+
4-methyl-2-oxopentanoate + NADH + H+
(R)-2-hydroxy-4-methylpentanoate + NAD+
alpha-ketobutyrate + NADH
2-hydroxybutyrate + NAD+
benzoylformate + NADH + H+
phenylglyoxylate + NAD+
-
-
-
-
?
bromopyruvate + NADH
3-bromo-2-hydroxypropanoate + NAD+
-
-
-
-
?
D-3-phenylpyruvate + NADH + H+
D-3-phenyllactate + NAD+
D-lactate + cytochrome c2ox
pyruvate + cytochrome c2red
-
-
-
-
?
D-lactate + NAD+
pyruvate + NADH
D-lactate + NAD+
pyruvate + NADH + H+
D-lactate + NAD+ + H+
pyruvate + NADH
-
-
-
?
D-lactate + nicotinamide cytosine dinucleotide
pyruvate + reduced nicotinamide cytosine dinucleotide
-
-
-
?
DL-2-hydroxybutyrate + NAD+
2-oxobutyrate + NADH
DL-2-hydroxybutyrate + NAD+
? + NADH
-
about 44% of activity against D-lactate
-
-
?
glyoxylate + NADH
hydroxyacetic acid + NAD+
-
-
-
-
?
glyoxylate + NADH + H+
glycolate + NAD+
-
best substrate of isoform LDHL1
-
-
?
glyoxylate + NADH + H+
hydroxyacetate + NAD+
glyoxylate + NADH + H+
hydroxyacetic acid + NAD+
-
-
-
-
?
hydroxypyruvate + NADH
glycerate + NAD+
-
-
-
-
?
hydroxypyruvate + NADH + H+
glycerate + NAD+
L-lactate + NAD+
pyruvate + NADH + H+
methylpyruvate + NADH
? + NAD+
oxaloacetate + NADH
malate + NAD+
oxaloacetate + NADH + H+
D-malate + NAD+
oxaloacetate + NADH + H+
malate + NAD+
oxaloacetic acid + NADH + H+
(R)-malate + NAD+
-
-
-
-
ir
phenylpyruvate + NADH
phenyllactate + NAD+
-
-
-
-
?
phenylpyruvate + NADH + H+
(R)-3-phenyllactate + NAD+
phenylpyruvate + NADH + H+
2-hydroxy-3-phenylpropanoate + NAD+
-
-
-
-
?
phenylpyruvate + NADH + H+
D-phenyllactate + NAD+
pyruvate + NAD(P)H + H+
(R)-lactate + NAD(P)+
pyruvate + NADH
(R)-lactate + NAD+
pyruvate + NADH + H+
(R)-lactate + NAD+
pyruvate + NADH + H+
D-lactate + NAD+
-
-
-
-
?
pyruvate + NADPH + H+
(R)-lactate + NADP+
-
-
-
-
r
additional information
?
-
(R)-lactate + NAD(P)+
pyruvate + NAD(P)H + H+
the enzyme is confirmed to be a typical D-lactate dehydrogenase based on the activity detected with substrate pyruvate and coenzyme NAD(P)H
-
-
r
(R)-lactate + NAD(P)+
pyruvate + NAD(P)H + H+
the enzyme is confirmed to be a typical D-lactate dehydrogenase based on the activity detected with substrate pyruvate and coenzyme NAD(P)H
-
-
r
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
Allomyces sp.
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
Lactobacillus jugurt-helveticus
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
(R)-lactate + NAD+
pyruvate + NADH + H+
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
-
no activity with L-lactate
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
-
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
development of an assay system of D-lactate with good precision, accuracy, and sensitivity for the determination of D-lactate concentrations in rat serum. D-Lactate dehydrogenase (D-LDH) is utilized to catalyze D-lactate and NAD+ to pyruvate and NADH, analysis of D-lactate by HPLC, respectively. Structure of the enzymatic assay system with a UV-LED fluorescent spectrometer, and method optimization and validation, overview
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
-
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
development of an assay system of D-lactate with good precision, accuracy, and sensitivity for the determination of D-lactate concentrations in rat serum. D-Lactate dehydrogenase (D-LDH) is utilized to catalyze D-lactate and NAD+ to pyruvate and NADH, analysis of D-lactate by HPLC, respectively. Structure of the enzymatic assay system with a UV-LED fluorescent spectrometer, and method optimization and validation, overview
-
-
r
(R)-lactate + NAD+
pyruvate + NADH + H+
-
-
-
?
2-oxo-4-phenylbutyric acid + NADH + H+
(R)-2-hydroxy-4-phenylbutyric acid + NAD+
-
-
-
-
?
2-oxo-4-phenylbutyric acid + NADH + H+
(R)-2-hydroxy-4-phenylbutyric acid + NAD+
-
-
-
-
?
2-oxobutanoate + NADH + H+
(R)-2-hydroxybutanoate + NAD+
-
12.6% of the activity with pyruvate
-
-
?
2-oxobutanoate + NADH + H+
(R)-2-hydroxybutanoate + NAD+
-
12.6% of the activity with pyruvate
-
-
?
2-oxobutanoate + NADH + H+
2-hydroxybutanoate + NAD+
-
-
-
-
?
2-oxobutanoate + NADH + H+
2-hydroxybutanoate + NAD+
-
-
-
-
?
2-oxobutanoate + NADH + H+
2-hydroxybutanoate + NAD+
-
-
-
?
2-oxobutanoate + NADH + H+
2-hydroxybutanoate + NAD+
-
-
-
?
2-oxobutanoate + NADH + H+
2-hydroxybutanoate + NAD+
-
-
-
-
?
2-oxobutyrate + NADH
2-hydroxybutyrate + NAD+
-
11% of activity with pyruvate
-
-
r
2-oxobutyrate + NADH
2-hydroxybutyrate + NAD+
-
11% of activity with pyruvate
-
-
r
2-oxobutyrate + NADH + H+
2-hydroxybutyrate + NAD+
-
-
-
r
2-oxobutyrate + NADH + H+
2-hydroxybutyrate + NAD+
-
-
-
r
2-oxobutyrate + NADH + H+
2-hydroxybutyrate + NAD+
-
-
-
r
2-oxobutyrate + NADH + H+
2-hydroxybutyrate + NAD+
-
-
-
-
?
2-oxobutyrate + NADH + H+
2-hydroxybutyrate + NAD+
-
-
-
-
?
2-oxobutyrate + NADH + H+
2-hydroxybutyrate + NAD+
-
-
-
-
?
2-oxobutyrate + NADH + H+
2-hydroxybutyrate + NAD+
-
-
-
r
2-oxocaproate + NADH + H+
2-hydroxycaproate + NAD+
-
-
-
r
2-oxocaproate + NADH + H+
2-hydroxycaproate + NAD+
-
-
-
r
2-oxocaproate + NADH + H+
2-hydroxycaproate + NAD+
-
-
-
r
2-oxoglutarate + NADPH + H+
(R)-2-hydroxyglutarate + NADP+
-
-
-
-
?
2-oxoglutarate + NADPH + H+
(R)-2-hydroxyglutarate + NADP+
-
-
-
-
?
2-oxoisocaproate + NADH + H+
2-hydroxyisocaproate + NAD+
-
-
-
r
2-oxoisocaproate + NADH + H+
2-hydroxyisocaproate + NAD+
-
-
-
r
2-oxovalerate + NADH + H+
2-hydroxyvalerate + NAD+
-
-
-
r
2-oxovalerate + NADH + H+
2-hydroxyvalerate + NAD+
-
-
-
-
?
2-oxovalerate + NADH + H+
2-hydroxyvalerate + NAD+
-
-
-
-
?
2-oxovalerate + NADH + H+
2-hydroxyvalerate + NAD+
-
-
-
r
2-oxovalerate + NADH + H+
2-hydroxyvalerate + NAD+
-
-
-
-
?
3,4-dihydroxyphenylpyruvate + NADH + H+
(R)-3,4-dihydroxyphenyllactate + NAD+
-
43.1% of the activity with pyruvate
-
-
?
3,4-dihydroxyphenylpyruvate + NADH + H+
(R)-3,4-dihydroxyphenyllactate + NAD+
-
43.1% of the activity with pyruvate
-
-
?
3,4-dihydroxyphenylpyruvic acid + NADH + H+
D-3,4-dihydroxyphenyllactic acid + NAD+
-
-
-
-
?
3,4-dihydroxyphenylpyruvic acid + NADH + H+
D-3,4-dihydroxyphenyllactic acid + NAD+
-
-
-
-
?
3-methyl-2-oxobutanoate + NADH + H+
(R)-2-hydroxy-3-methylbutanoate + NAD+
-
19.4% of the activity with pyruvate
-
-
?
3-methyl-2-oxobutanoate + NADH + H+
(R)-2-hydroxy-3-methylbutanoate + NAD+
-
-
-
-
?
3-methyl-2-oxobutanoate + NADH + H+
(R)-2-hydroxy-3-methylbutanoate + NAD+
-
-
-
-
?
3-methyl-2-oxobutanoate + NADH + H+
2-hydroxy-3-methylbutanoate + NAD+
-
-
-
?
3-methyl-2-oxobutanoate + NADH + H+
2-hydroxy-3-methylbutanoate + NAD+
-
-
-
?
4-methyl-2-oxopentanoate + NADH + H+
(R)-2-hydroxy-4-methylpentanoate + NAD+
-
-
-
-
?
4-methyl-2-oxopentanoate + NADH + H+
(R)-2-hydroxy-4-methylpentanoate + NAD+
-
-
-
-
?
alpha-ketobutyrate + NADH
2-hydroxybutyrate + NAD+
-
-
-
-
?
alpha-ketobutyrate + NADH
2-hydroxybutyrate + NAD+
-
-
-
-
?
D-3-phenylpyruvate + NADH + H+
D-3-phenyllactate + NAD+
-
-
i.e. 2-hydroxy-3-phenylpropanoic acid
-
r
D-3-phenylpyruvate + NADH + H+
D-3-phenyllactate + NAD+
-
i.e. 2-hydroxy-3-phenylpropanoic acid
-
r
D-lactate + NAD+
pyruvate + NADH
-
-
-
r
D-lactate + NAD+
pyruvate + NADH
during oxidation of NADH to NAD+, NADH transfers a hydride ion to pyruvate, in the reverse reaction NAD+ receives a hydride ion from lactate, D-lactate binding structure, overview
pyruvate binding structure, overview
-
r
D-lactate + NAD+
pyruvate + NADH
-
-
-
-
?
D-lactate + NAD+
pyruvate + NADH + H+
-
-
-
?
D-lactate + NAD+
pyruvate + NADH + H+
-
-
-
?
DL-2-hydroxybutyrate + NAD+
2-oxobutyrate + NADH
-
3% of activity with (R)-lactate
-
-
r
DL-2-hydroxybutyrate + NAD+
2-oxobutyrate + NADH
-
3% of activity with (R)-lactate
-
-
r
glyoxylate + NADH + H+
hydroxyacetate + NAD+
-
-
-
r
glyoxylate + NADH + H+
hydroxyacetate + NAD+
-
-
-
r
glyoxylate + NADH + H+
hydroxyacetate + NAD+
-
-
-
r
glyoxylate + NADH + H+
hydroxyacetate + NAD+
-
-
-
r
hydroxypyruvate + NADH + H+
glycerate + NAD+
-
-
-
r
hydroxypyruvate + NADH + H+
glycerate + NAD+
-
-
-
r
hydroxypyruvate + NADH + H+
glycerate + NAD+
-
-
-
r
hydroxypyruvate + NADH + H+
glycerate + NAD+
-
-
-
-
?
hydroxypyruvate + NADH + H+
glycerate + NAD+
-
-
-
r
L-lactate + NAD+
pyruvate + NADH + H+
very poor substrate
-
-
?
L-lactate + NAD+
pyruvate + NADH + H+
very poor substrate
-
-
?
methylpyruvate + NADH
? + NAD+
-
84% of activity with pyruvate
-
-
r
methylpyruvate + NADH
? + NAD+
-
84% of activity with pyruvate
-
-
r
oxaloacetate + NADH
malate + NAD+
-
-
-
-
?
oxaloacetate + NADH
malate + NAD+
-
-
-
-
?
oxaloacetate + NADH + H+
D-malate + NAD+
-
-
-
-
?
oxaloacetate + NADH + H+
D-malate + NAD+
-
-
-
-
?
oxaloacetate + NADH + H+
D-malate + NAD+
-
-
-
r
oxaloacetate + NADH + H+
malate + NAD+
-
-
-
r
oxaloacetate + NADH + H+
malate + NAD+
-
-
-
r
oxaloacetate + NADH + H+
malate + NAD+
-
-
-
r
phenylpyruvate + NADH + H+
(R)-3-phenyllactate + NAD+
-
70.4% of the activity with pyruvate
-
-
?
phenylpyruvate + NADH + H+
(R)-3-phenyllactate + NAD+
-
70.4% of the activity with pyruvate
-
-
?
phenylpyruvate + NADH + H+
(R)-3-phenyllactate + NAD+
-
-
-
-
?
phenylpyruvate + NADH + H+
(R)-3-phenyllactate + NAD+
-
-
-
?
phenylpyruvate + NADH + H+
(R)-3-phenyllactate + NAD+
-
-
-
-
?
phenylpyruvate + NADH + H+
(R)-3-phenyllactate + NAD+
-
-
-
?
phenylpyruvate + NADH + H+
(R)-3-phenyllactate + NAD+
-
-
-
-
?
phenylpyruvate + NADH + H+
(R)-3-phenyllactate + NAD+
-
-
-
-
?
phenylpyruvate + NADH + H+
D-phenyllactate + NAD+
-
-
-
?
phenylpyruvate + NADH + H+
D-phenyllactate + NAD+
-
-
-
?
phenylpyruvate + NADH + H+
D-phenyllactate + NAD+
-
-
-
r
phenylpyruvate + NADH + H+
D-phenyllactate + NAD+
-
-
-
-
?
phenylpyruvate + NADH + H+
D-phenyllactate + NAD+
-
-
-
-
ir
phenylpyruvate + NADH + H+
D-phenyllactate + NAD+
-
-
-
r
phenylpyruvate + NADH + H+
D-phenyllactate + NAD+
-
-
-
r
phenylpyruvate + NADH + H+
D-phenyllactate + NAD+
-
-
-
r
phenylpyruvate + NADH + H+
D-phenyllactate + NAD+
-
-
-
r
pyruvate + NAD(P)H + H+
(R)-lactate + NAD(P)+
-
-
-
r
pyruvate + NAD(P)H + H+
(R)-lactate + NAD(P)+
-
-
-
r
pyruvate + NADH
(R)-lactate + NAD+
-
-
-
-
r
pyruvate + NADH
(R)-lactate + NAD+
-
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
a highly stereospecific reaction leading to 98-99%optical purity of the product
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
-
?
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
a highly stereospecific reaction leading to 98-99%optical purity of the product
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
-
?
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
-
?
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
-
?
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
-
?
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
-
?
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
-
?
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
?
pyruvate + NADH + H+
(R)-lactate + NAD+
preferred subtrate
-
-
?
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
r
pyruvate + NADH + H+
(R)-lactate + NAD+
-
-
-
r
additional information
?
-
each subunit of the homodimer in a closed conformation binds NADH to the coenzyme-binding domain and a lactate or pyruvate molecule at the interdomain active-site cleft, structure, overview
-
-
?
additional information
?
-
-
each subunit of the homodimer in a closed conformation binds NADH to the coenzyme-binding domain and a lactate or pyruvate molecule at the interdomain active-site cleft, structure, overview
-
-
?
additional information
?
-
-
effect of a single-gene knockout on the metabolic regulation in Escherichia coli for D-lactate production under microaerobic condition
-
-
?
additional information
?
-
the enzyme ECLDH exhibits high substrate specificity toward pyruvate. No or poor activity with 2-oxovalerate, 2-oxoisovalerate, 2-oxocaproate, 2-oxoisocaproate, phenylpyruvate, and hydroxyphenylpyruvate
-
-
?
additional information
?
-
-
the enzyme ECLDH exhibits high substrate specificity toward pyruvate. No or poor activity with 2-oxovalerate, 2-oxoisovalerate, 2-oxocaproate, 2-oxoisocaproate, phenylpyruvate, and hydroxyphenylpyruvate
-
-
?
additional information
?
-
the enzyme FNLDH exhibits a broad substrate specificity toward hydrophobic 2-oxoacids such as 2-oxobutyrate and 2-oxovalerate. Poor activity with hydroxyphenylpyruvate and 2-oxoisovalerate
-
-
?
additional information
?
-
the enzyme FNLDH exhibits a broad substrate specificity toward hydrophobic 2-oxoacids such as 2-oxobutyrate and 2-oxovalerate. Poor activity with hydroxyphenylpyruvate and 2-oxoisovalerate
-
-
?
additional information
?
-
-
D-LDH is an NADH-dependent reductase, substrate reduction is accompanied by the oxidation of NADH to NAD?
-
-
?
additional information
?
-
-
strain NCIMB 8826 produces optically pure D-lactic acid
-
-
?
additional information
?
-
-
strain NCIMB 8826 produces optically pure D-lactic acid
-
-
?
additional information
?
-
Lactiplantibacillus plantarum NCIMB 8826 delta ldhL1 -xpk1::tkt-delta xpk
-
strain NCIMB 8826 produces optically pure D-lactic acid
-
-
?
additional information
?
-
-
residues Tyr52 and Phe299 are mainly responsible for hindering larger substrates because of their short distance from the side chain of 2-oxocarboxylic acids and their steric orientation in the wild-type enzyme. Substrate specificity and enantioselectivity of D-nLDH and DnLDH mutants, overview
-
-
?
additional information
?
-
-
residues Tyr52 and Phe299 are mainly responsible for hindering larger substrates because of their short distance from the side chain of 2-oxocarboxylic acids and their steric orientation in the wild-type enzyme. Substrate specificity and enantioselectivity of D-nLDH and DnLDH mutants, overview
-
-
?
additional information
?
-
-
substrate specificities of the D-LDH isozymes, overview. (R)-2-Hydroxybutyric acid, D-(+)-malic acid, and D-(+)-3-phenyllactic acid are no substrates
-
-
?
additional information
?
-
-
no substrate: phenylpyruvate
-
-
-
additional information
?
-
-
no substrate: phenylpyruvate
-
-
-
additional information
?
-
-
enzyme displays more than 99% enantioselectivity. No substrates: 3-methyl-2-oxopentanoate, 4-methyl-2-oxopentanoate, indole-3-pyruvate
-
-
-
additional information
?
-
-
enzyme displays more than 99% enantioselectivity. No substrates: 3-methyl-2-oxopentanoate, 4-methyl-2-oxopentanoate, indole-3-pyruvate
-
-
-
additional information
?
-
-
no or poor substrates: 2-oxobutanoate, phenylpyruvate, 4-hydroxyphenylpyruvate
-
-
-
additional information
?
-
-
no or poor substrates: 2-oxobutanoate, phenylpyruvate, 4-hydroxyphenylpyruvate
-
-
-
additional information
?
-
enzymatic production of D-3-phenyllactic acid by recombinant Pediococcus pentosaceus D-lactate dehydrogenase with NADH regeneration by recombinant Ogataea parapolymorpha formate dehydrogenase, EC 1.2.1.2
-
-
?
additional information
?
-
-
enzymatic production of D-3-phenyllactic acid by recombinant Pediococcus pentosaceus D-lactate dehydrogenase with NADH regeneration by recombinant Ogataea parapolymorpha formate dehydrogenase, EC 1.2.1.2
-
-
?
additional information
?
-
the enzyme PALDH exhibits high substrate specificity toward pyruvate. Poor activity with hydroxyphenylpyruvate and 2-oxoisovalerate
-
-
?
additional information
?
-
-
the enzyme PALDH exhibits high substrate specificity toward pyruvate. Poor activity with hydroxyphenylpyruvate and 2-oxoisovalerate
-
-
?
additional information
?
-
-
interactin of enzyme with F-actin in vivo, playing an important role in the yeast cell morphology
-
-
?
additional information
?
-
the bifunctional enzyme from Sporolactobacillus inulinus has both the D-LDH and NAD(P)+/NAD(P)H-utilizing glutamate dehydrogenase (GDH, EC 1.4.1.3) activities, the latter with reversible deamination. Identification of key residues from the crystal structure analysis and site-directed mutagenesis, enzyme reidues Arg234 and Gly79 residues play a significant role in both D-LDH and GDH activities. Residues His295 and Phe298 in DLDH744 are identified to be key residues for lactate dehydrogenase (LDH) activity only, whereas Tyr101 is a unique residue that is critical for GDH activity. DLDH744 is a strict D-2-hydroxyacid dehydrogenase, no formation of L-isomers
-
-
?
additional information
?
-
-
the bifunctional enzyme from Sporolactobacillus inulinus has both the D-LDH and NAD(P)+/NAD(P)H-utilizing glutamate dehydrogenase (GDH, EC 1.4.1.3) activities, the latter with reversible deamination. Identification of key residues from the crystal structure analysis and site-directed mutagenesis, enzyme reidues Arg234 and Gly79 residues play a significant role in both D-LDH and GDH activities. Residues His295 and Phe298 in DLDH744 are identified to be key residues for lactate dehydrogenase (LDH) activity only, whereas Tyr101 is a unique residue that is critical for GDH activity. DLDH744 is a strict D-2-hydroxyacid dehydrogenase, no formation of L-isomers
-
-
?
additional information
?
-
the bifunctional enzyme from Sporolactobacillus inulinus has both the D-LDH and NAD(P)+/NAD(P)H-utilizing glutamate dehydrogenase (GDH, EC 1.4.1.3) activities, the latter with reversible deamination. Identification of key residues from the crystal structure analysis and site-directed mutagenesis, enzyme reidues Arg234 and Gly79 residues play a significant role in both D-LDH and GDH activities. Residues His295 and Phe298 in DLDH744 are identified to be key residues for lactate dehydrogenase (LDH) activity only, whereas Tyr101 is a unique residue that is critical for GDH activity. DLDH744 is a strict D-2-hydroxyacid dehydrogenase, no formation of L-isomers
-
-
?
additional information
?
-
-
specific for NAD+/NADH
-
-
?
additional information
?
-
-
specific for NAD+/NADH
-
-
?
additional information
?
-
no activity towards L-lactate
-
-
?
additional information
?
-
the enzyme shows very low in vivo activity
-
-
?
additional information
?
-
-
the enzyme shows very low in vivo activity
-
-
?
additional information
?
-
the enzyme shows very low in vivo activity
-
-
?
additional information
?
-
-
the enzyme shows very low in vivo activity
-
-
?