1.1.1.268: 2-(R)-hydroxypropyl-CoM dehydrogenase

This is an abbreviated version!
For detailed information about 2-(R)-hydroxypropyl-CoM dehydrogenase, go to the full flat file.

Reaction

Synonyms

(R)-hydroxypropyl-coenzyme M dehydrogenase, (R)-hydroxypropylthioethanesulfonate dehydrogenase, 2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase, 2-(R)-hydroxypropyl-coenzyme M dehydrogenase, R-HPCDH, xecD

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.268 2-(R)-hydroxypropyl-CoM dehydrogenase

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Results	in table
4	Activating Compound
508	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
11	Cofactor
2	Crystallization (Commentary)
10	General Information
12	Inhibitors
16	kcat/KM [mM/s]
11	Ki Value [mM]
36	KM Value [mM]
1	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
40	Organism
1	Pathway
4	PDB ID
25	Protein Variants
2	Purification (Commentary)
4	Reaction
3	Reaction Type
13	Reference
4	Source Tissue
49	Substrates and Products (Substrate)
3	Subunits
15	Synonyms
1	Systematic Name
41	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.1.1.268 - 2-(R)-hydroxypropyl-CoM dehydrogenase

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(2S)-2-hydroxypropyl-CoM

Xanthobacter autotrophicus

Q56840

competitive inhibition

762714

2-(2-methyl-2-hydroxypropylthio)-ethanesulfonate

Xanthobacter autotrophicus

Q56840

M-HPC, competitive inhibition

762714

2-(2-methyl-2-hydroxypropylthio)ethanesulfonate

2 entries

2-(S)-hydroxypropyl-CoM

Xanthobacter sp.

389507

2-bromoethanesulfonate

Xanthobacter autotrophicus

Q56840

CoM-analogue, mixed type inhibitor. 32.7% residual activity at 5 mM, reversible inhibition

712458

2-oxopropyl-CoM

Xanthobacter sp.

mixed-type inhibitor with respect to 2-(R)-hydroxypropyl-CoM

389507

CoM

Xanthobacter autotrophicus

mixed inhibition

ethanesulfonate

mercaptoethanesulfonate

methanesulfonate

NADH

mixed-type inhibitor with respect to 2-(R)-hydroxypropyl-CoM, competitive inhibition with respect to 2-oxopropyl-CoM

389507