1.1.1.267: 1-deoxy-D-xylulose-5-phosphate reductoisomerase

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For detailed information about 1-deoxy-D-xylulose-5-phosphate reductoisomerase, go to the full flat file.

Reaction

Synonyms

1-deoxy-D-xylulose 5-phosphate isomeroreductase, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 1-deoxy-D-xylulose-5-phosphate, 1-deoxy-D-xylulose-5-phosphate reductoisomerase, 1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose 5-phosphate reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase, 2C-methyl-D-erythritol 4-phosphate synthase, 2C-methyl-D-erythritol-4-phosphate synthase, AaDXR, CaDXR, deoxyxylulose 5-phosphate reductoisomerase, deoxyxylulosephosphate reductoisomerase, DOXP reductoisomerase, DOXP-reductoisomerase, DXP reductoisomerase, DXP-reductoisomerase, DXR, DXR1, DzDXR, EcDXR, FtIspC, IspC, MEP synthase, meps, methylerythritol phosphate synthase, MtbIspC, MtDXR, Os01g01710, OsDXR, PdDXR, PfDXR, PtDXR, Rv2870c, SaDXR, VvDxr, YpIspC

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.267 1-deoxy-D-xylulose-5-phosphate reductoisomerase

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Results	in table
7	Activating Compound
35608	AA Sequence
29	Application
1	CAS Registry Number
58	Cloned(Commentary)
106	Cofactor
16	Crystallization (Commentary)
10	Expression
64	General Information
162	IC50 Value
385	Inhibitors
14	kcat/KM [mM/s]
64	Ki Value [mM]
85	KM Value [mM]
21	Localization
76	Metals/Ions
24	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
540	Organism
7	Pathway
136	PDB ID
30	pH Optimum
1	pH Range
1	pH Stability
6	pI Value
4	Posttranslational Modification
47	Protein Variants
28	Purification (Commentary)
14	Reaction
3	Reaction Type
134	Reference
92	Source Tissue
8	Specific Activity [micromol/min/mg]
8	Storage Stability
141	Substrates and Products (Substrate)
29	Subunits
190	Synonyms
1	Systematic Name
29	Temperature Optimum [°C]
2	Temperature Range [°C]
4	Temperature Stability [°C]
36	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.1.1.267 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase

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SYSTEMATIC NAME

IUBMB Comments

2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing)

The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with the first being most effective. The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, {terp/nonMVA}). The mechanism has been shown to be a retroaldol/aldol reaction [2].