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1.1.1.267: 1-deoxy-D-xylulose-5-phosphate reductoisomerase

This is an abbreviated version!
For detailed information about 1-deoxy-D-xylulose-5-phosphate reductoisomerase, go to the full flat file.

Word Map on EC 1.1.1.267

Reaction

2-C-methyl-D-erythritol 4-phosphate
+
NADP+
=
1-deoxy-D-xylulose 5-phosphate
+
NADPH
+
H+

Synonyms

1-deoxy-D-xylulose 5-phosphate isomeroreductase, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 1-deoxy-D-xylulose-5-phosphate, 1-deoxy-D-xylulose-5-phosphate reductoisomerase, 1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose 5-phosphate reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase, 2C-methyl-D-erythritol 4-phosphate synthase, 2C-methyl-D-erythritol-4-phosphate synthase, AaDXR, CaDXR, deoxyxylulose 5-phosphate reductoisomerase, deoxyxylulosephosphate reductoisomerase, DOXP reductoisomerase, DOXP-reductoisomerase, DXP reductoisomerase, DXP-reductoisomerase, DXR, DXR1, DzDXR, EcDXR, FtIspC, IspC, MEP synthase, meps, methylerythritol phosphate synthase, MtbIspC, MtDXR, Os01g01710, OsDXR, PdDXR, PfDXR, PtDXR, Rv2870c, SaDXR, VvDxr, YpIspC

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.267 1-deoxy-D-xylulose-5-phosphate reductoisomerase

KI Value

KI Value on EC 1.1.1.267 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6.5
(3-acetamidopropyl)phosphonic acid
pH and temperature not specified in the publication
-
0.0041
(pyridin-2-ylmethyl)phosphonic acid
-
pH 7.6, 30°C, recombinant enzyme
2
1,1,1-trifluoro-1-deoxy-D-xylulose 5-phosphoric acid
-
pH 7.6, 37°C, recombinant enzyme
3.4
1,1-difluoro-1-deoxy-D-xylulose 5-phosphoric acid
-
pH 7.6, 37°C, recombinant enzyme
6.2
1,2-dideoxy-D-hexulose 6-phosphate
-
pH 7.6, 37°C, recombinant enzyme
0.63
1,2-dideoxy-D-threo-3-hexulose 6-phosphate
-
pH 7.8, 37°C, recombinant wild-type enzyme
1.1
1-deoxy-D-xylulose 5-phosphate
-
pH 7.9, 30°C, recombinant His-tagged enzyme
0.0014 - 0.0256
1-hydroxy-5-phenylpyridin-2(1H)-one
0.444
3-fluoro-1-deoxy-D-xylulose-5-phosphate
-
-
0.24
4-(N-formyl-N-hydroxy-amino)-butyric acid
-
pH 7.5, 37°C
0.0224
4-benzylbenzene-1,2-diol
-
pH not specified in the publication, temperature not specified in the publication
0.733
4-fluoro-1-deoxy-D-xylulose-5-phosphate
-
-
0.0447
biphenyl-3,4-diol
-
pH not specified in the publication, temperature not specified in the publication
0.1483 - 0.1794
epigallocatechin gallate
0.000019
fosfoxacin
-
pH 7.5, 37°C
0.0000021 - 0.00097
fosmidomycin
0.000048 - 0.0009
FR900098
0.0234 - 0.0252
gallocatechin gallate
0.000002
phosphoric acid mono-[2-(N-acetyl-N-hydroxy-amino)-ethyl]-ester
-
pH 7.5, 37°C
2.8
sulfamic acid 2-(N-formyl-N-hydroxy-amino)-ethyl ester
-
pH 7.5, 37°C
0.0222 - 0.0224
theaflavin-3'-gallate
0.0133 - 0.0182
theaflavin-3,3'-digallate
0.0247 - 0.03
theaflavin-3-gallate
0.0021
[(5-phenylpyridin-2-yl)methyl]phosphonic acid
-
pH 7.6, 30°C, recombinant enzyme
0.000077
[1-(3,4-dichlorophenyl)-3-[formyl(hydroxy)amino]propyl]phosphonic acid
-
pH 7.6, 30°C, recombinant enzyme
3.6
[3-(N-acetyl-N-methyl-amino)propyl]-phosphonic acid
-
pH 7.5, 37°C
5
[3-(N-formyl-N-methyl-amino)-propyl]-phosphonic acid
-
pH 7.5, 37°C
0.00022
[3-[acetyl(hydroxy)amino]-1-(3,4-dichlorophenyl)propyl]phosphonic acid
-
pH 7.6, 30°C, recombinant enzyme
0.0000019 - 0.00097
[3-[acetyl(hydroxy)amino]-1-(pyridin-3-yl)propyl]phosphonic acid
0.000013 - 0.00053
[3-[acetyl(hydroxy)amino]-1-(pyridin-4-yl)propyl]phosphonic acid
0.000085 - 0.00093
[3-[acetyl(hydroxy)amino]-1-phenylpropyl]phosphonic acid
0.000013 - 0.000087
[3-[formyl(hydroxy)amino]-1-(pyridin-3-yl)propyl]phosphonic acid
0.0000089 - 0.000079
[3-[formyl(hydroxy)amino]-1-(pyridin-4-yl)propyl]phosphonic acid
0.00048 - 0.0015
[3-[formyl(hydroxy)amino]-1-phenylpropyl]phosphonic acid
2.4
[4-(hydroxyamino)-4-oxobutyl]phosphonic acid
-
pH 7.5, 37°C
additional information
additional information
inhibition kinetics
-