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6.5
(3-acetamidopropyl)phosphonic acid
pH and temperature not specified in the publication
-
0.0041
(pyridin-2-ylmethyl)phosphonic acid
-
pH 7.6, 30°C, recombinant enzyme
2
1,1,1-trifluoro-1-deoxy-D-xylulose 5-phosphoric acid
-
pH 7.6, 37°C, recombinant enzyme
3.4
1,1-difluoro-1-deoxy-D-xylulose 5-phosphoric acid
-
pH 7.6, 37°C, recombinant enzyme
6.2
1,2-dideoxy-D-hexulose 6-phosphate
-
pH 7.6, 37°C, recombinant enzyme
0.63
1,2-dideoxy-D-threo-3-hexulose 6-phosphate
-
pH 7.8, 37°C, recombinant wild-type enzyme
1.1
1-deoxy-D-xylulose 5-phosphate
-
pH 7.9, 30°C, recombinant His-tagged enzyme
0.0014 - 0.0256
1-hydroxy-5-phenylpyridin-2(1H)-one
0.444
3-fluoro-1-deoxy-D-xylulose-5-phosphate
-
-
0.24
4-(N-formyl-N-hydroxy-amino)-butyric acid
-
pH 7.5, 37°C
0.0224
4-benzylbenzene-1,2-diol
-
pH not specified in the publication, temperature not specified in the publication
0.733
4-fluoro-1-deoxy-D-xylulose-5-phosphate
-
-
0.0447
biphenyl-3,4-diol
-
pH not specified in the publication, temperature not specified in the publication
0.1483 - 0.1794
epigallocatechin gallate
0.000019
fosfoxacin
-
pH 7.5, 37°C
0.0000021 - 0.00097
fosmidomycin
0.000048 - 0.0009
FR900098
0.0234 - 0.0252
gallocatechin gallate
0.000002
phosphoric acid mono-[2-(N-acetyl-N-hydroxy-amino)-ethyl]-ester
-
pH 7.5, 37°C
2.8
sulfamic acid 2-(N-formyl-N-hydroxy-amino)-ethyl ester
-
pH 7.5, 37°C
0.0222 - 0.0224
theaflavin-3'-gallate
0.0133 - 0.0182
theaflavin-3,3'-digallate
0.0247 - 0.03
theaflavin-3-gallate
0.0021
[(5-phenylpyridin-2-yl)methyl]phosphonic acid
-
pH 7.6, 30°C, recombinant enzyme
0.000077
[1-(3,4-dichlorophenyl)-3-[formyl(hydroxy)amino]propyl]phosphonic acid
-
pH 7.6, 30°C, recombinant enzyme
3.6
[3-(N-acetyl-N-methyl-amino)propyl]-phosphonic acid
-
pH 7.5, 37°C
5
[3-(N-formyl-N-methyl-amino)-propyl]-phosphonic acid
-
pH 7.5, 37°C
0.00022
[3-[acetyl(hydroxy)amino]-1-(3,4-dichlorophenyl)propyl]phosphonic acid
-
pH 7.6, 30°C, recombinant enzyme
0.0000019 - 0.00097
[3-[acetyl(hydroxy)amino]-1-(pyridin-3-yl)propyl]phosphonic acid
0.000013 - 0.00053
[3-[acetyl(hydroxy)amino]-1-(pyridin-4-yl)propyl]phosphonic acid
0.000085 - 0.00093
[3-[acetyl(hydroxy)amino]-1-phenylpropyl]phosphonic acid
0.000013 - 0.000087
[3-[formyl(hydroxy)amino]-1-(pyridin-3-yl)propyl]phosphonic acid
0.0000089 - 0.000079
[3-[formyl(hydroxy)amino]-1-(pyridin-4-yl)propyl]phosphonic acid
0.00048 - 0.0015
[3-[formyl(hydroxy)amino]-1-phenylpropyl]phosphonic acid
2.4
[4-(hydroxyamino)-4-oxobutyl]phosphonic acid
-
pH 7.5, 37°C
additional information
additional information
inhibition kinetics
-
0.0014
1-hydroxy-5-phenylpyridin-2(1H)-one
-
pH not specified in the publication, temperature not specified in the publication
0.0256
1-hydroxy-5-phenylpyridin-2(1H)-one
-
pH 7.6, 30°C, recombinant enzyme
0.1483
epigallocatechin gallate
pH 7.0, 37°C, recombinant enzyme, competitive versus 1-deoxy-D-xylulose 5-phosphate
0.1794
epigallocatechin gallate
pH 7.0, 37°C, recombinant enzyme, uncompetitive versus NADPH
0.0000021
fosmidomycin
-
-
0.000014
fosmidomycin
mutant W203Y, pH 7.5, 25°C
0.000021
fosmidomycin
pH 7.5, 22°C
0.000034
fosmidomycin
-
pH 7.5, 22°C, IC50 versus proliferation of Plasmodium falciparum strain Dd2
0.000057
fosmidomycin
-
pH 7.5, 37°C
0.00006
fosmidomycin
mutant W203F, pH 7.5, 25°C
0.000085
fosmidomycin
pH 8.0, 37°C, recombinant pseudomature enzyme
0.00009
fosmidomycin
-
pH 7.6, 30°C, recombinant enzyme
0.000093
fosmidomycin
wild-type, pH 7.5, 25°C
0.0000989
fosmidomycin
-
pH 7.8, 22°C
0.00097
fosmidomycin
pH 7.8, 37°C
0.000048
FR900098
-
pH 7.6, 30°C, recombinant enzyme
0.00017
FR900098
pH 7.8, 37°C
0.0009
FR900098
-
pH 7.5, 37°C
0.0234
gallocatechin gallate
pH 7.0, 37°C, recombinant enzyme, uncompetitive versus NADPH
0.0252
gallocatechin gallate
pH 7.0, 37°C, recombinant enzyme, competitive versus 1-deoxy-D-xylulose 5-phosphate
0.0222
theaflavin-3'-gallate
-
substrate 1-deoxy-D-xylulose 5-phosphate, pH 7.4, 37°C
0.0224
theaflavin-3'-gallate
-
substrate NADPH, pH 7.4, 37°C
0.0133
theaflavin-3,3'-digallate
-
substrate 1-deoxy-D-xylulose 5-phosphate, pH 7.4, 37°C
0.0182
theaflavin-3,3'-digallate
-
substrate NADPH, pH 7.4, 37°C
0.0247
theaflavin-3-gallate
-
substrate NADPH, pH 7.4, 37°C
0.03
theaflavin-3-gallate
-
substrate 1-deoxy-D-xylulose 5-phosphate , pH 7.4, 37°C
0.0000019
[3-[acetyl(hydroxy)amino]-1-(pyridin-3-yl)propyl]phosphonic acid
pH 7.5, 22°C
0.000042
[3-[acetyl(hydroxy)amino]-1-(pyridin-3-yl)propyl]phosphonic acid
-
pH 7.5, 22°C, IC50 versus proliferation of Plasmodium falciparum strain Dd5
0.00097
[3-[acetyl(hydroxy)amino]-1-(pyridin-3-yl)propyl]phosphonic acid
-
pH 7.6, 30°C, recombinant enzyme
0.000013
[3-[acetyl(hydroxy)amino]-1-(pyridin-4-yl)propyl]phosphonic acid
pH 7.5, 22°C
0.000082
[3-[acetyl(hydroxy)amino]-1-(pyridin-4-yl)propyl]phosphonic acid
-
pH 7.5, 22°C, IC50 versus proliferation of Plasmodium falciparum strain Dd6
0.00053
[3-[acetyl(hydroxy)amino]-1-(pyridin-4-yl)propyl]phosphonic acid
-
pH 7.6, 30°C, recombinant enzyme
0.000085
[3-[acetyl(hydroxy)amino]-1-phenylpropyl]phosphonic acid
pH 7.5, 22°C
0.00093
[3-[acetyl(hydroxy)amino]-1-phenylpropyl]phosphonic acid
-
pH 7.5, 22°C, IC50 versus proliferation of Plasmodium falciparum strain Dd8
0.000013
[3-[formyl(hydroxy)amino]-1-(pyridin-3-yl)propyl]phosphonic acid
pH 7.5, 22°C
0.000055
[3-[formyl(hydroxy)amino]-1-(pyridin-3-yl)propyl]phosphonic acid
-
pH 7.6, 30°C, recombinant enzyme
0.000087
[3-[formyl(hydroxy)amino]-1-(pyridin-3-yl)propyl]phosphonic acid
-
pH 7.5, 22°C, IC50 versus proliferation of Plasmodium falciparum strain Dd3
0.0000089
[3-[formyl(hydroxy)amino]-1-(pyridin-4-yl)propyl]phosphonic acid
pH 7.5, 22°C
0.000035
[3-[formyl(hydroxy)amino]-1-(pyridin-4-yl)propyl]phosphonic acid
-
pH 7.5, 22°C, IC50 versus proliferation of Plasmodium falciparum strain Dd4
0.000079
[3-[formyl(hydroxy)amino]-1-(pyridin-4-yl)propyl]phosphonic acid
-
pH 7.6, 30°C, recombinant enzyme
0.00048
[3-[formyl(hydroxy)amino]-1-phenylpropyl]phosphonic acid
pH 7.5, 22°C
0.0015
[3-[formyl(hydroxy)amino]-1-phenylpropyl]phosphonic acid
-
pH 7.5, 22°C, IC50 versus proliferation of Plasmodium falciparum strain Dd7