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1.1.1.247: codeinone reductase (NADPH)

This is an abbreviated version!
For detailed information about codeinone reductase (NADPH), go to the full flat file.

Word Map on EC 1.1.1.247

Reaction

codeine
+
NADP+
=
codeinone
+
NADPH
+
H+

Synonyms

codeine oxidase, codeine: NADP oxidoreductase, codeine:NADP oxidoreductase, codeinone reductase, codeinone reductase (NADPH), CodR, COR, COR-B, COR1.1, COR1.2, COR1.3, COR1.4, PsCor1.1, reductase, codeinone (reduced nicotinamide adenine dinucleotide phosphate)

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.247 codeinone reductase (NADPH)

Cloned

Cloned on EC 1.1.1.247 - codeinone reductase (NADPH)

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
factors involved in transcriptional regulation, overview
gene codR, expression in Papaver bracteatum in cultured hairy roots, subcloning in Escherichia coli strain DH5alpha. The T-DNA of the vector contains a neomycin phosphoteransferase gene and CodR cDNA with CaMV35S promoter and nos terminator
isozyme COR-B, DNA and amino acid sequence determination and analysis, sequence comparison with codeinone reductase isoforms COR1.2, COR1.3, COR1.4, and COR1.1, quantitative real-time PCR expression analysis, recombinant coexpression of isozyme COR-B with thebaine 6-O-demethylase (T6ODM) in Saccharomyces cerevisiae strain CEN.PK fed with thebaine
isozyme COR1.1, DNA and amino acid sequence determination and analysis, sequence comparison with codeinone reductase isoforms COR1.2, COR1.3, COR1.4, and COR-B, quantitative real-time PCR expression analysis
isozyme COR1.2, DNA and amino acid sequence determination and analysis, sequence comparison with codeinone reductase isoforms COR1.1, COR1.3, COR1.4, and COR-B, quantitative real-time PCR expression analysis. Isozyme COR1.2 exhibits lower expression levels compared to the other isozymes
isozyme COR1.3, DNA and amino acid sequence determination and analysis, sequence comparison with codeinone reductase isoforms COR1.2, COR1.1, COR1.4, and COR-B, quantitative real-time PCR expression analysis, recombinant coexpression of isozyme COR1.3 with thebaine 6-O-demethylase (T6ODM) in Saccharomyces cerevisiae strain CEN.PK fed with thebaine
isozyme COR1.4, DNA and amino acid sequence determination and analysis, sequence comparison with codeinone reductase isoforms COR1.2, COR1.3, COR1.1, and COR-B, quantitative real-time PCR expression analysis
overexpression of the enzyme in transgenic Papaver somnniferum plants leading to increased enzyme content and capsule alkaloid, morphine and total alkaloid, content without significant alterations of the alkaloid profile, overview
-
quantitative RT-PCR enzyme expression analysis, the gene expression levels of COR in tetraploids are not remarkably changed compared to diploid plants. In the roots both genes COR and CODM, downstream of thebaine in the alkaloid pathway, are downregulated in tetraploids