1.1.1.231: 15-hydroxyprostaglandin-I dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about 15-hydroxyprostaglandin-I dehydrogenase (NADP+), go to the full flat file.
Reaction
Synonyms
dehydrogenase, prostacyclin, NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase, NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase, PG I2 dehydrogenase, prostacyclin dehydrogenase
ECTree
1.1.1.231 15-hydroxyprostaglandin-I dehydrogenase (NADP+)Advanced search results
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results (Substrates Products
Substrates Products on EC 1.1.1.231 - 15-hydroxyprostaglandin-I dehydrogenase (NADP+)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH
6-keto-prostaglandin F1alpha + NADP+
6,15-diketoprostaglandin F2alpha + NADPH
-
at 1.8% the reaction rate of prostaglandin I2
-
-
?
phenanthrene quinone + NADP+
?
-
more rapid reaction than with prostacyclin
-
-
?
prostaglandin B1 + NADP+
15-ketoprostaglandin B1 + NADPH + H+
-
at 8% the reaction rate of prostaglandin I2
-
-
?
prostaglandin F2alpha + NAD+
15-ketoprostaglandin F2alpha + NADH + H+
-
-
-
-
?
pyridine-4-carboxaldehyde + NADP+
?
-
recombinant forms CHCR1, CHCR2
-
-
?
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH
-
-
-
-
?
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH
-
i.e. prostaglandin I2, prostacyclin
the product is not stable and not available for analysis of the reverse reaction
?
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH
-
i.e. prostaglandin I2, prostacyclin
i.e. 15-keto prostaglandin I2
?
4-nitrobenzaldehyde + NADP+
4-nitrobenzoate + NADPH
-
recombinant forms CHCR1, CHCR2
-
-
?
4-nitrobenzaldehyde + NADP+
4-nitrobenzoate + NADPH
-
more rapid reaction than with prostacyclin
-
-
?
prostaglandin E2 + NADP+
15-ketoprostaglandin E2 + NADPH + H+
-
at 4% the reaction rate of prostaglandin I2
-
-
?
prostaglandin F2alpha + NADP+
15-ketoprostaglandin F2alpha + NADPH + H+
-
-
-
-
?
prostaglandin F2alpha + NADP+
15-ketoprostaglandin F2alpha + NADPH + H+
-
at 2.2% the reaction rate of prostaglandin I2
-
-
?
additional information
?
-
-
comparison of 3 15-hydroxyproastaglandin dehydrogenases with varying amounts of 9-ketoprostaglandin reductase activity
-
-
?
additional information
?
-
-
enzyme catalyzes reduction of 9-keto group in prostaglandin E2 at less than 1% the rate of prostaglandin I2 oxidation
-
-
?
