1.1.1.229: diethyl 2-methyl-3-oxosuccinate reductase

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For detailed information about diethyl 2-methyl-3-oxosuccinate reductase, go to the full flat file.

Reaction

Synonyms

diethyl-2-methyl-3-oxosuccinate reductase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.229 diethyl 2-methyl-3-oxosuccinate reductase

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Results	in table
1	CAS Registry Number
6	Inhibitors
2	KM Value [mM]
6	Metals/Ions
2	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
1	Organism
1	pH Optimum
1	pH Range
1	pH Stability
1	Purification (Commentary)
1	Reaction
3	Reaction Type
1	Reference
2	Specific Activity [micromol/min/mg]
4	Substrates and Products (Substrate)
1	Subunits
1	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 1.1.1.229 - diethyl 2-methyl-3-oxosuccinate reductase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

diethyl 2-methyl-3-oxosuccinate + NADPH

diethyl 2-methyl-3-hydroxysuccinate + NADP+

2 entries

dimethyl 2-methyl-3-oxosuccinate + NADPH

dimethyl 2-methyl-3-hydroxysuccinate + NADP+

Torulaspora delbrueckii

-

poor substrate

389504

-

-

?

additional information

?

-

Torulaspora delbrueckii

-

no aldehydes or several synthetic substrates are reduced, such as: acetaldehyde, formaldehyde, isobutanal, n-pentanal, n-hexanal, n-heptanal, 4-hydroxybenzaldehyde, 4-dimethylaminobenzaldehyde, benzaldehyde, furfural, 2-methyl-3-oxobutanoic acid benzyl ester, 2-chloro-3-oxobutanoic acid ethyl ester, 3-phenyl-2-oxobutanoic acid methyl ester, 2-methyl-3-oxobutanoic acid ethyl ester, 3-(2'-furyl)-2-methyl-3-oxopropionic acid methyl ester, none of the following alcohols or other substrates is oxidized: methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, n-pentanol, isopentanol, benzyl alcohol, glycerin, shikimic acid, 2-deoxy-D-glucose, glucose 6-phosphate, in the presence of NAD+ or NADP+

389504

-

-

?

diethyl 2-methyl-3-oxosuccinate + NADPH

diethyl 2-methyl-3-hydroxysuccinate + NADP+

Torulaspora delbrueckii

-

the reduction is strongly preferred, the catalyzed reaction is an asymmetric reduction, best substrate

389504

alpha-methyl-beta-hydroxy ester, the enzyme catalyzes an asymmetric reduction, the product is a mixture of the (2R,3R)-syn- and (2S,3R)-anti-beta-hydroxyester

389504

r

diethyl 2-methyl-3-oxosuccinate + NADPH

diethyl 2-methyl-3-hydroxysuccinate + NADP+

Torulaspora delbrueckii

-

asymmetric reduction in yeast, the reduction is strongly preferred over the weak oxidation activity

389504

-

-

r