1.1.1.22: UDP-glucose 6-dehydrogenase
This is an abbreviated version!
For detailed information about UDP-glucose 6-dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.22
-
1.1.1.22
-
udp-glucuronic
-
polysaccharide
-
ugdhs
-
glycosaminoglycans
-
hyaluronan
-
pyrophosphorylase
-
udp-xylose
-
glucuronic
-
glucuronidation
-
udp-glca
-
exopolysaccharide
-
udp-sugars
-
medicine
-
glca
-
udpga
-
udp-d-glucuronate
-
udp-glucuronyltransferase
-
hasas
-
pharmacology
-
agriculture
-
molecular biology
-
synthesis
- 1.1.1.22
-
udp-glucuronic
- polysaccharide
-
ugdhs
- glycosaminoglycans
- hyaluronan
-
pyrophosphorylase
- udp-xylose
-
glucuronic
-
glucuronidation
- udp-glca
- exopolysaccharide
- udp-sugars
- medicine
-
glca
-
udpga
- udp-d-glucuronate
-
udp-glucuronyltransferase
-
hasas
- pharmacology
- agriculture
- molecular biology
- synthesis
Reaction
Synonyms
ADH-like UDP-glucose dehydrogenase, AglM, BceC, Cj1441c, dehydrogenase, uridine diphosphoglucose, dual specificity UDP-glucose dehydrogenase, GbUGD, GH_D12G1806, HasB, HasB2, HVO_1531, jekyll m151, kfiD, PA2022, PA3559, PH02Gene21682, sqv-4, Sugarless protein, UDG1, UDP-alpha-D-glucose:NAD oxidoreductase, UDP-D-glucose dehydrogenase, UDP-GDH, UDP-Glc dehydrogenase, UDP-Glc DH, UDP-GlcDH, UDP-GlcDHase, UDP-glucose dehydrogenase, UDPDH, UDPG dehydrogenase, UDPG-DH, UDPG:NAD oxidoreductase, UDPGD, UDPGDH, UDPGDH-A, UDPGDH-B, UDPGlc dehydrogenase, UDPglucose dehydrogenase, UDPglucose:NAD+ oxidoreductase, Ugd, UGD1, Ugd2, UgdG, UGDH, UGDH4, uridine diphosphate D-glucose dehydrogenase, uridine diphosphate glucose dehydrogenase, uridine diphosphate glucose-6-dehydrogenase, uridine diphosphate-glucose dehydrogenase, uridine diphosphoglucose dehydrogenase, uridine-5'-diphosphoglucose dehydrogenase, uridyl phosphate dehydrogenase, VNG1048G, VNG_1048G
ECTree
1.1.1.22 UDP-glucose 6-dehydrogenaseAdvanced search results
results (
results (Application
Application on EC 1.1.1.22 - UDP-glucose 6-dehydrogenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
agriculture
changes in the mRNA level during peach fruit development correspond to changes in the amount of cell wall material and the cell wall uronic acid content. These are greater in the fruits of the commercial cultivars compared with the Japanese native peach cultivars, and the expression of enzyme is higher in the fruits of the commercial cultivars
medicine
molecular biology
-
the high activity combined with the simple purification procedure used make GbUGD a valuable alternative biocatalyst for the synthesis of UDP-glucuronic acid or the development of NAD+ regeneration systems
synthesis
medicine
-
possibility that gallic acid and quercetin may modulate human breast cancer cell proliferation by inhibiting UGDH
medicine
-
UGDH content in prostatic acini is a novel candidate biomarker that may complement the development of a multi-biomarker panel for detecting prostate cancer within the tumor adjacent field on a histologically normal biopsy specimen
medicine
manipulation of UGDH activity by hexamer stabilization may offer therapeutic options in cancer and other pathologies
medicine
biallelic mutations in UGDH cause developmental epileptic encephalopathy. In 36 cases from 25 families presenting with epileptic encephalopathy with developmental delay and hypotonia, mutations either impair UGDH stability, oligomerization, or enzymatic activity. In vitro, patient-derived cerebral organoids are smaller with a reduced number of proliferating neuronal progenitors
medicine
epirubicin accumulation increases and apoptosis decreases during UGDH knockdown. Hyaluronan-coated matrix increases and a positive modulation of autophagy is detected. Higher levels of UGDH are correlated with worse prognosis in triple-negative breast cancer patients that receive chemotherapy. High expression of UGDH is found in tumoral tissue from HER2--patients. UGDH knockdown contributes to epirubicin resistance
medicine
expression of UDP-glucose dehydrogenase is up-regulated in highly metastatic ovarian cancer TOV-21G cells, but not in normal adjacent tissue. RNAi-mediated silencing results in a significant decrease in metastatic ability in transwell migration, transwell invasion and wound healing assays. The knockdown of UGDH causes cell cycle arrest in the G0/G1 phase and induces a massive decrease of tumour formation rate in vivo. UGDH-depletion leads to the down-regulation of epithelial-mesenchymal transition-related markers as well as MMP2, and inactivation of the ERK/MAPK pathway
medicine
high UGDH expression is associated with decreased patient survival in poor-prognosis breast cancer subsets
medicine
knocking out UGDH in highly metastatic 6DT-1 breast cancer cells impairs migration ability without affecting in vitro proliferation. UGDH-KO results in significantly decreased metastatic capacity in vivo when the cells are orthotopically injected in syngeneic mice
medicine
shRNA-mediated knockdown of UGDH inhibits breast cancer invasion, colony formation, and tumor growth
synthesis
-
the high activity combined with the simple purification procedure used make GbUGD a valuable alternative biocatalyst for the synthesis of UDP-glucuronic acid or the development of NAD+ regeneration systems
synthesis
use of recombinant Triton-permeabilized cells of Schizosaccharomyces pombe to synthesize UDP-glucuronic acid with 100 % yield and selectivity. 5 mM UDP-glucose are converted into 5 mM UDP-glucuronic acid within 3 h
