1.1.1.213: 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)

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For detailed information about 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific), go to the full flat file.

Word Map on EC 1.1.1.213

1.1.1.213

aldo-keto

androgen

5alpha-reductase

polycyclic

17beta-hydroxysteroid

5alpha-dihydrotestosterone

alpha-hydroxysteroids

dihydrotestosterone

androsterone

17beta-hsd

trans-dihydrodiols

hydroxysteroids

20alpha-hydroxysteroid

5alpha-dht

neurosteroids

allopregnanolone

20alpha-hsds

akr1c9

3alpha-diol

o-quinones

5alpha-androstane-3alpha,17beta-diol

3alpha-androstanediol

i-babp

1.1.1.50

testosteroni

17beta

5alpha-reduced

alicyclic

5alpha-dihydroprogesterone

20alpha-hydroxyprogesterone

neurosteroidogenic

drug development

diagnostics

medicine

synthesis

Reaction

Synonyms

17beta-HSD type 5, 17beta-hydroxysteroid dehydrogenase type 5, 3-alpha hydroxysteroid oxidoreductase, 3-alpha-HSO, 3alpha-HSD, 3alpha-HSD type 2, 3alpha-HSD type 3, 3alpha-HSD/CR, 3alpha-HSD3, 3alpha-HSDH, 3alpha-HSOR, 3alpha-hydroxysteroid dehydrogenase, 3alpha-hydroxysteroid dehydrogenase (B-specific), 3alpha-hydroxysteroid dehydrogenase type 2, 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase, 3alpha-hydroxysteroid oxido-reductase, 3alpha-hydroxysteroid oxidoreductase, 3alpha-hydroxysteroid:NAD(P) oxidoreductase, 3alphaHSD, A-specific 3alpha-hydroxysteroid dehydrogenase, AKR1C17, AKR1C2, AKR1C3, AKR1C4, AKR1C9, alpha-HSD/CR, B-specific 3alpha-hydroxysteroid dehydrogenase, bile acid-binding protein, CDD59474, DD2, dihydrodiol dehydrogenase, HSDH, More, NAD+-dependent 3alpha-HSD, NADP(H)-dependent 3alpha-HSD, type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 3 3-alpha-hydroxysteroid dehydrogenase, type 3 3alpha-HSD, type 3 3alpha-hydroxysteroid dehydrogenase, type 5 beta-hydroxysteroid dehydrogenase

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.213 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)

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Results	in table
5	Activating Compound
8	AA Sequence
7	Application
1	CAS Registry Number
23	Cloned(Commentary)
78	Cofactor
8	Crystallization (Commentary)
194	Disease/ Diagnostics
2	Expression
5	General Information
33	IC50 Value
118	Inhibitors
7	kcat/KM [mM/s]
31	Ki Value [mM]
86	KM Value [mM]
23	Localization
2	Metals/Ions
19	Molecular Weight [Da]
51	Natural Substrates/ Products (Substrates)
76	Organism
9	Pathway
58	PDB ID
15	pH Optimum
2	pH Range
59	Protein Variants
20	Purification (Commentary)
24	Reaction
4	Reaction Type
58	Reference
73	Source Tissue
37	Specific Activity [micromol/min/mg]
9	Storage Stability
216	Substrates and Products (Substrate)
24	Subunits
94	Synonyms
1	Systematic Name
19	Temperature Optimum [°C]
2	Temperature Stability [°C]
65	Turnover Number [1/s]

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Turnover Number on EC 1.1.1.213 - 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)

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0.00063 - 0.85

(2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide

4 entries

0.115

(5beta,20R)-20-hydroxypregnan-3-one

Rattus norvegicus

pH 7.4, 25°C, recombinant wild-type AKR1C17

684676

54.5

3-oxo-deoxycholic acid

Eggerthella sp. CAG:298

R7B6R4

coenzyme: NADPH, pH 7.0, temperature not specified in the publication

760397

0.008

3alpha-androstanediol

Homo sapiens

pH 7.0, 25°C, recombinant enzyme

672088

1.13 - 1.25

3alpha-hydroxy-5alpha-androstan-17-one

2 entries

0.148

4-oxo-2-nonenal

Homo sapiens

P42330

pH 7.4, 25°C

724719

0.35

5alpha-androstan-17beta-ol-3-one