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1.1.1.21: aldose reductase

This is an abbreviated version!
For detailed information about aldose reductase, go to the full flat file.

Word Map on EC 1.1.1.21

Reaction

alditol
+
NAD(P)+
=
aldose
 +
NAD(P)H
 +
H+

Synonyms

17betaHSD5, 20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, AdhA, AKR1B, AKR1B1, AKR1B10, AKR1B13, AKR1B14, AKR1B3, AKR1C3, AKR4C7, aldehyde reductase, alditol/NADP+ oxidoreductase, alditol: NADP+ 1-oxidoreductase, alditol:NAD(P)+1oxidoreductase, alditol:NADP 1-oxidoreductase, alditol:NADP oxidoreductase, aldo-keto reductase, aldo-keto reductase family 1 member B1, aldo-keto reductase family 1 member B7, aldoketo reductase 1C3, aldose reductase, aldose reductase 2, aldose reductase-like, aldose reductase-like protein, aldose xylose reductase, ALDRXV4, ALR, ALR1, ALR2, AR, ARI, BAR, EC 1.1.1.139, Fibroblast growth factor regulated protein, FR-1 protein, GRE3, HAR, HRAR, isobutyraldehyde reductase, More, MVDP, NADPH dependent xylose reductase, NADPH-aldopentose reductase, NADPH-aldose reductase, polyol dehydrogenase (NADP2), RLAR, small intestine reductase, TPN-polyol dehydrogenase, VAS deferens androgen-dependent protein, YqhD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.21 aldose reductase

Turnover Number

Turnover Number on EC 1.1.1.21 - aldose reductase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.333
(1S)-Camphorquinone
-
in 0.1 M potassium phosphate, pH 7.4
0.007
(S)-1-indanol
-
in 0.1 M potassium phosphate, pH 7.4
0.003
(S)-1-tetralol
-
in 0.1 M potassium phosphate, pH 7.4
0.67 - 1.3
1-butanal
0.137
1-butanol
-
in 0.1 M potassium phosphate, pH 7.4
0.35
1-decanal
-
in 0.1 M potassium phosphate, pH 7.4
0.023 - 0.05
1-Decanol
1.25
1-Dodecanal
in 0.1 M potassium phosphate, pH 7.4, at 25°C
2
1-heptanal
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.75 - 2.37
1-hexanal
0.068 - 0.158
1-Hexanol
0.57 - 1.38
1-nonanal
0.062 - 0.065
1-nonanol
0.7 - 1.37
1-octanal
0.61
1-palmitoyl-2-(5-oxovaleryl)sn-glycero-3-phosphocholine
-
pH 6.0, 30°C
0.13
1-propanal
-
in 0.1 M potassium phosphate, pH 7.4
0.017
1-Tetradecanol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.183
16-ketoestrone
-
in 0.1 M potassium phosphate, pH 7.4
0.333
2,3-Butanedione
-
in 0.1 M potassium phosphate, pH 7.4
0.6
2,3-heptanedione
-
in 0.1 M potassium phosphate, pH 7.4
0.25 - 1.32
2,3-Hexanedione
0.383
2,3-Pentanedione
-
in 0.1 M potassium phosphate, pH 7.4
0.2
2,4-decadienal
-
in 0.1 M potassium phosphate, pH 7.4
0.2
2,4-nonadienal
-
in 0.1 M potassium phosphate, pH 7.4
0.145
2-decenal
-
in 0.1 M potassium phosphate, pH 7.4
0.183
2-deoxy-2-fluoro-galactose
-
-
0.67
2-hexenal
-
in 0.1 M potassium phosphate, pH 7.4
0.155
2-nonenal
-
in 0.1 M potassium phosphate, pH 7.4
0.012
2-phenyl-1-propanol
-
in 0.1 M potassium phosphate, pH 7.4
0.43
2-phenyl-2-propenal
-
in 0.1 M potassium phosphate, pH 7.4
0.004
20alpha-hydroxyprogesterone
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.64
20alpha-Isocorticosterone
-
20alpha-isocortisol
0.2 - 0.48
21-Dehydrocortisol
0.233
3,4-hexanedione
-
in 0.1 M potassium phosphate, pH 7.4
0.2 - 0.75
3-deoxyglucosone
40
3-Nitrobenzaldehyde
pH 7.0, 45°C
0.183
4-hydroxynonenal
-
in 0.1 M potassium phosphate, pH 7.4
0.57
4-nitrobenzaldehyde
-
in 0.1 M potassium phosphate, pH 7.4
0.006
5-Pregnene-3beta,20alpha-diol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.008
5alpha-pregnan-20alpha-ol-3-one
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.012
5alpha-pregnane-3beta,20alpha-diol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
27.6
acetaldehyde
-
in 50 mM MOPS buffer, pH 7.0, at 37°C
0.27 - 2.4
acrolein
0.42 - 11
benzaldehyde
0.0383 - 0.167
benzyl alcohol
163
D-arabinose
pH 7.0, 45°C
0.233 - 106
D-galactose
0.183 - 126
D-glucose
0.418 - 2.3
D-glucuronate
0.55
D-glyceraldehyde
-
-
0.283 - 1.87
D-lactoaldehyde
92
D-ribose
pH 7.0, 45°C
0.283 - 108
D-xylose
0.09 - 155
DL-glyceraldehyde
0.567
geraniol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.078 - 0.165
geranylgeraniol
0.2
glycoaldehyde
-
in 0.1 M potassium phosphate, pH 7.4
0.58
glycolaldehyde
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.2 - 41
Glyoxal
0.283 - 1.12
isatin
1.8
Isobutyraldehyde
-
in 50 mM MOPS buffer, pH 7.0, at 37°C
1.43
isocaproaldehyde
in 0.1 M potassium phosphate, pH 7.4, at 25°C
2 - 8
isophthalaldehyde
pH 7.0, 45°C
30 - 143
L-idose
0.43 - 266
methylglyoxal
0.117
nerol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.383
phenyl-1,2-propanedione
-
in 0.1 M potassium phosphate, pH 7.4
0.42 - 0.76
Phenylglyoxal
13
propanal
-
-
0.52 - 7
Pyridine-3-aldehyde
0.002 - 0.042
Pyridine-3-methanol
0.63
Pyridine-4-aldehyde
-
in 0.1 M potassium phosphate, pH 7.4
0.155 - 0.5
trans,trans-farnesol
0.78
trans-2-buten-1-al
in 0.1 M potassium phosphate, pH 7.4, at 25°C
1.83
trans-2-decen-1-al
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.82
trans-2-hexen-1-al
in 0.1 M potassium phosphate, pH 7.4, at 25°C
1.34
trans-2-nonen-1-al
in 0.1 M potassium phosphate, pH 7.4, at 25°C
additional information
DL-glyceraldehyde
-
turnover number in mol per seconds for several mutants