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1.1.1.209: 3(or 17)alpha-hydroxysteroid dehydrogenase

This is an abbreviated version!
For detailed information about 3(or 17)alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.209

Reaction

androsterone
+
NAD(P)+
=
5alpha-androstane-3,17-dione
+
NAD(P)H
+
H+

Synonyms

3(17)alpha-hydroxysteroid dehydrogenase, 3beta- and 17beta-hydroxysteroid dehydrogenase, AKR1C21, dehydrogenase, 3(17)alpha-hydroxy steroid, More

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase

Reference

Reference on EC 1.1.1.209 - 3(or 17)alpha-hydroxysteroid dehydrogenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lau, P.C.K.; Layne, D.S.; Williamson, D.G.
A 3(17) alpha-hydroxysteroid dehydrogenase of female rabbit kidney cytosol. Purification and characterization of multiple forms of the enzyme
J. Biol. Chem.
257
9444-9449
1982
Oryctolagus cuniculus
Manually annotated by BRENDA team
Lau, P.C.K.; Layne, D.S.; Williamson, D.G.
Comparison of the multiple forms of the soluble 3(17)alpha-hydroxysteroid dehydrogenases of female rabbit kidney and liver
J. Biol. Chem.
257
9450-9456
1982
Oryctolagus cuniculus
Manually annotated by BRENDA team
Nakagawa, M.; Tsukuda, F.; Nakayama, T.; Matsuura, K.; Hara, A.; Sawada, H.
Identification of two dihydrodiol dehydrogenases associated with 3(17)alpha-hydoxysteroid dehydrogenase activity in mouse kidney
J. Biochem.
106
633-638
1989
Mus musculus
Manually annotated by BRENDA team
Lin, H.K.; Jez, J.M.; Schlegel, B.P.; Peehl, D.M.; Pachter, J.A.; Penning, T.M.
Expression and characterization of recombinant type 2: 3alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3alpha/17beta-HSD activity and cellular distribution
Mol. Endocrinol.
11
1971-1984
1997
Homo sapiens
Manually annotated by BRENDA team
El-Kabbani, O.; Ishikura, S.; Wagner, A.; Schulze-Briese, C.; Hara, A.
Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase
Acta crystallogr. Sect. F
61
688-690
2005
Mus musculus
Manually annotated by BRENDA team
Dhagat, U.; Carbone, V.; Chung, R.P.; Schulze-Briese, C.; Endo, S.; Hara, A.; El-Kabbani, O.
Structure of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme
Acta Crystallogr. Sect. F
63
825-830
2007
Mus musculus (Q91WR5), Mus musculus
Manually annotated by BRENDA team
Dhagat, U.; Endo, S.; Hara, A.; El-Kabbani, O.
Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors
Bioorg. Med. Chem.
16
3245-3254
2008
Mus musculus
Manually annotated by BRENDA team
Dhagat, U.; Endo, S.; Mamiya, H.; Hara, A.; El-Kabbani, O.
Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate
Acta Crystallogr. Sect. D
65
257-265
2009
Mus musculus (Q91WR5), Mus musculus
Manually annotated by BRENDA team
Dhagat, U.; Endo, S.; Mamiya, H.; Hara, A.; El-Kabbani, O.
Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme
Acta Crystallogr. Sect. D
66
198-204
2010
Mus musculus (Q91WR5), Mus musculus
Manually annotated by BRENDA team
Gajecka, M.; Otrocka-Domagala, I.
Immunocytochemical expression of 3beta- and 17beta-hydroxysteroid dehydrogenase in bitch ovaries exposed to low doses of zearalenone
Pol. J. Vet. Sci.
16
55-62
2013
Canis lupus familiaris, Canis lupus familiaris Beagle
Manually annotated by BRENDA team