1.1.1.197: 15-hydroxyprostaglandin dehydrogenase (NADP+)

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For detailed information about 15-hydroxyprostaglandin dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

9-ketoprostaglandin reductase, carbonyl reductase, NADP-dependent 15-hydroxyprostaglandin dehydrogenase, NADP-linked 15-hydroxyprostglandin dehydrogenase, NADP-specific 15-hydroxyprostaglandin dehydrogenase, prostaglandin 9-ketoreductase, prostaglandin E 9-ketoreductase, type II 15-hydroxyprostaglandin dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+)

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Results	in table
24	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
8	Cofactor
10	Inhibitors
11	KM Value [mM]
2	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
15	Organism
1	Pathway
5	PDB ID
6	Purification (Commentary)
1	Reaction
3	Reaction Type
15	Reference
18	Source Tissue
8	Specific Activity [micromol/min/mg]
30	Substrates and Products (Substrate)
3	Subunits
10	Synonyms
1	Systematic Name

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Reaction on EC 1.1.1.197 - 15-hydroxyprostaglandin dehydrogenase (NADP+)

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP+ = (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH + H+

Acts on prostaglandins E2, F2alpha and B1, but not on prostaglandin D2[cf. EC1.1.1.141 (NADP)]. May be identical with EC1.1.1.189 prostaglandin-E2 9-reductase

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