1.1.1.197: 15-hydroxyprostaglandin dehydrogenase (NADP+)

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For detailed information about 15-hydroxyprostaglandin dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.1.1.197

1.1.1.197

swine

dehydrogenases

nadp+-dependent

15-ketoprostaglandin

nadph-linked

reductases

valine

monkey

medulla

Reaction

(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate

(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate

Synonyms

9-ketoprostaglandin reductase, carbonyl reductase, NADP-dependent 15-hydroxyprostaglandin dehydrogenase, NADP-linked 15-hydroxyprostglandin dehydrogenase, NADP-specific 15-hydroxyprostaglandin dehydrogenase, prostaglandin 9-ketoreductase, prostaglandin E 9-ketoreductase, type II 15-hydroxyprostaglandin dehydrogenase

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+)

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Results	in table
24	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
8	Cofactor
10	Inhibitors
11	KM Value [mM]
2	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
15	Organism
1	Pathway
5	PDB ID
6	Purification (Commentary)
1	Reaction
3	Reaction Type
15	Reference
18	Source Tissue
8	Specific Activity [micromol/min/mg]
30	Substrates and Products (Substrate)
3	Subunits
10	Synonyms
1	Systematic Name

Inhibitors

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Inhibitors on EC 1.1.1.197 - 15-hydroxyprostaglandin dehydrogenase (NADP+)

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1-glutathionyl-2-hydroxy-3(allyloxy)propane

Homo sapiens

competitive inhibition of prostaglandin B1 oxidation

beta-mercaptoacetate

beta-mercaptolactate

beta-Mercaptopyruvate

Homo sapiens

347833, 347835

glutathione-9-hydroxy-prostaglandin A1 thioether

Homo sapiens

inhibition of polycyclic aromatic hydrocarbon quinone reduction

GSSG

NADPH