1.1.1.189: prostaglandin-E2 9-reductase
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For detailed information about prostaglandin-E2 9-reductase, go to the full flat file.
Word Map on EC 1.1.1.189
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1.1.1.189
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pgf2alpha
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luteal
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indomethacin
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corpora
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pseudopregnancy
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luteolysis
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13,14-dihydro-15-keto
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cyclooxygenases
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furosemide
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medicine
- 1.1.1.189
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pgf2alpha
- luteal
- indomethacin
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corpora
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pseudopregnancy
-
luteolysis
-
13,14-dihydro-15-keto
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cyclooxygenases
- furosemide
- medicine
Reaction
Synonyms
20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 9-keto-prostaglandin E2 reductase, 9-ketoprostaglandin reductase, 9-KPR, CBR1, More, mPGES, PG 9-ketoreductase/carbonyl reductase, PGE 9-ketoreductase, PGE2 9-ketoreductase, PGE2-9-K, PGE2-9-ketoreductase, PGE2-9-OR, prostaglandin 9-ketoreductase, prostaglandin 9-ketoreductase/carbonyl reductase, prostaglandin E 9-ketoreductase, prostaglandin E2 9-ketoreductase, prostaglandin E2-9-oxoreductase, prostaglandin-E2 9-keto reductase, reductase, 15-hydroxy9-oxoprostaglandin
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Source Tissue
Source Tissue on EC 1.1.1.189 - prostaglandin-E2 9-reductase
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peri- and postimplantation conceptus. Prostaglandin H synthase and prostaglandin E synthase are down-regulated, and prostaglandin G synthase, prostaglandin F synthase and carbonyl reductase/prostaglandin 9-reductase are down-regulated in conceptuses during trophoblasic elongation. After initiation of implantation, expression of prostaglandin G synthase, prostaglandin F synthase and carbonyl reductase/prostaglandin 9-reductase in conceptuses increases and remains higher until days 24-25 of pregnancy
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detection of immunosignals in all luteal cells. Enzymic activity is higher in late corpus luteum. Results support the idea that cyclooxygenase, nitric oxide synthase, and prostaglandin E2 9-ketoreductase regulate buffalo corpus luteum life span
at days 12-14 of pregnancy and the estrous cycle, the expression of prostaglandin E2 synthase, prostaglandin F synthase, and carbonyl reductase/prostaglandin 9-ketoreductase genes and prostaglandin E2 synthase/prostaglandin F synthase ratio are significantly higher in corpora lutea of the pregnant gilts compared to the corpora lutea from the parallel ovaries of the cyclic gilts. There is no difference in expression of prostaglandin E2 synthase, prostaglandin F synthase, and carbonyl reductase/prostaglandin 9-ketoreductase genes and prostaglandin E2 synthase/prostaglandin F synthase ratio between corpora lutea ipsi- and contralateral to the uterine horn with the developing embryos
expression of CBR1 mRNA and protein is constant during the cycle and pregnancy
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with and without retained fetal membranes, retained and not retained tissue, activity increases with parturition, activity is higher in the maternal than in the fetal part, overview
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high expression of conceptus and endometrial terminal CBR1 after initiation of blastocyst attachment suggest its involvement in early placentation