1.1.1.189: prostaglandin-E2 9-reductase

This is an abbreviated version!
For detailed information about prostaglandin-E2 9-reductase, go to the full flat file.

Word Map on EC 1.1.1.189

1.1.1.189

pgf2alpha

luteal

indomethacin

corpora

pseudopregnancy

luteolysis

13,14-dihydro-15-keto

cyclooxygenases

furosemide

medicine

Reaction

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 9-keto-prostaglandin E2 reductase, 9-ketoprostaglandin reductase, 9-KPR, CBR1, More, mPGES, PG 9-ketoreductase/carbonyl reductase, PGE 9-ketoreductase, PGE2 9-ketoreductase, PGE2-9-K, PGE2-9-ketoreductase, PGE2-9-OR, prostaglandin 9-ketoreductase, prostaglandin 9-ketoreductase/carbonyl reductase, prostaglandin E 9-ketoreductase, prostaglandin E2 9-ketoreductase, prostaglandin E2-9-oxoreductase, prostaglandin-E2 9-keto reductase, reductase, 15-hydroxy9-oxoprostaglandin

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.189 prostaglandin-E2 9-reductase

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Results	in table
13	Activating Compound
30	AA Sequence
1	Application
1	CAS Registry Number
42	Cofactor
4	Disease/ Diagnostics
25	Inhibitors
4	Ki Value [mM]
21	KM Value [mM]
12	Localization
1	Metals/Ions
15	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
30	Organism
5	Pathway
9	PDB ID
14	pH Optimum
9	Purification (Commentary)
3	Reaction
3	Reaction Type
30	Reference
46	Source Tissue
8	Specific Activity [micromol/min/mg]
76	Substrates and Products (Substrate)
7	Subunits
35	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]

Inhibitors

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Inhibitors on EC 1.1.1.189 - prostaglandin-E2 9-reductase

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17beta-estradiol

3 entries

5,5'-dithiobis(2-nitrobenzoate)

Gallus gallus

complete inhibition at 1 mM concentration

389477

aspirin

Homo sapiens

equimolar to substrate inhibits 65% of enzyme activity

cortisol

Cu2+

5 mM concentration

FAD

5 mM concentration

Fentiazac

non competitive

indomethacin

interferon tau

recombinant ovine interferon tau inhibits 25% prostaglandin E2 and prostaglandin F2alpha production at a concentration of 1 ng per ml

389447

lonazolac

Homo sapiens

equimolar to substrate inhibits 78% of enzyme activity

389473

NAD+

Rattus norvegicus

5 mM concentration 60% inhibition, competitive

389474

NADP+

Rattus norvegicus

5 mM concentration 60% inhibition, non-competitive

389474

nitric oxide

Homo sapiens

inhibition e.g. by NOC-18, a NO donor

670733

p-chloromercuribenzoate

Gallus gallus

complete inhibition at 1 mM concentration

389477

palmitic acid

Homo sapiens

inhibits enzyme in dose-dependent manner

389469

progesterone

2 entries

prostaglandin E2

Oryctolagus cuniculus

inhibits the reduction of 20alpha-hydroxy-pregn-4-en-3-one to progesterone competitively

Substance P

vitamin D3

equimolar to substrate inhibits 38% of enzyme activity

389473

additional information

Rattus norvegicus

no effect: Mg2+, Ca2+, EDTA, EGTA, cAMP and cGMP

389474