Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
AKR1B3 mRNA 9 is expressed in preadipocytes, and its level increases about 4fold at day 1 after initiation of adipocyte differentiation, and then quickly decreases the following day to a level lower than that in the preadipocytes
brenda
-
expression of genes for PGE2 synthesis, with low levels of prostaglandin transporters and dehydrogenase
brenda
-
endothel, isozymes PGF synthase I and II
brenda
normal breast expresses very high levels of AKR1C3 relative to other tissues
brenda
-
brenda
-
brenda
-
low activity
brenda
-
-
brenda
-
production of PGE2, PGF2 and PGD2 and high prostaglandin turnover
brenda
-
peri- and postimplantation conceptus. Prostaglandin H synthase and prostaglandin E synthase are down-regulated, and prostaglandin G synthase, prostaglandin F synthase and carbonyl reductase/prostaglandin 9-reductase are down-regulated in conceptuses during trophoblasic elongation. After initiation of implantation, expression of prostaglandin G synthase, prostaglandin F synthase and carbonyl reductase/prostaglandin 9-reductase in conceptuses increases and remains higher until days 24-25 of pregnancy
brenda
-
brenda
-
brenda
isoform AKR1B1 is expressed at a high level during the menstrual cycle during the secretory phase and in both epithelial and stromal cells
brenda
-
isozyme PGF synthase II
brenda
isoform AKR1B1 is expressed at a high level during the menstrual cycle during the secretory phase and in both epithelial and stromal cells
brenda
-
brenda
-
brenda
-
glioblastoma cell
brenda
-
embryonic kidney cell, isozyme PGFS-I
brenda
-
-
brenda
-
-
brenda
keloid fibroblasts
brenda
-
brenda
-
low activity
brenda
-
-
brenda
-
co-localization of cyclooxygenase-1, prostaglandin F receptor and prostaglandin F synthase
brenda
-
peritoneal
brenda
high expression level
brenda
-
brenda
-
low activity
brenda
-
enzyme co-localizes with myelin basic protein in myelin sheaths but not in axons
brenda
-
brenda
-
dendrites and somata, isozyme PGF synthase I
brenda
-
cultured oligodendrocytes at 7 days in vitro express the enzyme in cytoplasmic processes where the enzyme is co-localized with myelin basic protein
brenda
-
-
brenda
-
brenda
-
brenda
low expression level
brenda
-
the enzyme is associated with the cyclooxygenase-II, COX-II
brenda
-
-
brenda
-
brenda
AKR1C3 is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism
brenda
high expression level
brenda
-
brenda
-
isozyme PGF synthase II
brenda
-
glioblastoma cell
brenda
-
brenda
-
low activity
brenda
-
lung fibroblast cell
brenda
-
-
brenda
abundant expression
brenda
-
-
brenda
-
brenda
-
-
-
brenda
-
-
brenda
-
high activity
brenda
low expression level
brenda
-
enzyme is expressed preferentially in the white matter bundles of the entire central nervous system of adult mice with less marked expression inneuronal cell bodies. The enzyme co-localizes with myelin basic protein in myelin sheaths but not in axons
brenda
-
brenda
highest activity
brenda
18fold increase in the median AKR1C3 mRNA levels in breast cancer patients as compared to those without disease
brenda
of invasive ductal carcinoma of the breast, immunohistochemical analysis
brenda
no or very low expression of prostaglandin F2alpha synthase synthase
brenda
high expression level of the lung-type and the microsomal endometrium-type isozymes
brenda
-
at days 12-14 of pregnancy and the estrous cycle, the expression of prostaglandin E2 synthase, prostaglandin F synthase, and carbonyl reductase/prostaglandin 9-ketoreductase genes and prostaglandin E2 synthase/prostaglandin F synthase ratio are significantly higher in corpora lutea of the pregnant gilts compared to the corpora lutea from the parallel ovaries of the cyclic gilts. There is no difference in expression of prostaglandin E2 synthase, prostaglandin F synthase, and carbonyl reductase/prostaglandin 9-ketoreductase genes and prostaglandin E2 synthase/prostaglandin F synthase ratio between corpora lutea ipsi- and contralateral to the uterine horn with the developing embryos
brenda
-
-
brenda
-
during luteolysis, activity of 20alpha-hydroxysteroid dehydrogenase synthesizing prostaglandin F2alpha
brenda
from cyclic and pregnant animals, high expression level of the microsomal endometrium-type isozyme, spatiotemporal expression during estrous cycle and early pregnancy
brenda
-
liver-type isozyme, sinusoidal endothelial cells in the liver
brenda
-
brenda
-
isozyme PGF synthase I in endothelial cells of the whole area of the spinal cord, and isozyme PGF synthase II in endothelial cells of the blood vessels only
brenda
-
brenda
-
-
-
brenda
-
low activity
brenda
-
anterior uveal and scleral complex
brenda
-
brenda
both activities of enzymes AKR1C1/AKR1C2 and AKR1C3 are present in the periovuatory granulosa cell
brenda
-
both activities of enzymes AKR1C1/AKR1C2 and AKR1C3 are present in the periovuatory granulosa cell
-
brenda
-
both activities of enzymes AKR1C1/AKR1C2 and AKR1C3 are present in the periovuatory granulosa cell. Prostaglandin F synthase mRNA and protein levels are low before treatment with gonadotropin and peak 24-36 h after gonadotropin administration
brenda
-
both activities of enzymes AKR1C1/AKR1C2 and AKR1C3 are present in the periovuatory granulosa cell. Prostaglandin F synthase mRNA and protein levels are low before treatment with gonadotropin and peak 24-36 h after gonadotropin administration
-
brenda
-
-
brenda
-
high activity
brenda
-
-
brenda
-
brenda
-
brenda
-
proximal tubule, the enzyme is associated with the cyclooxygenase-I, COX-I
brenda
-
-
brenda
-
low activity
brenda
-
AKR1B3
brenda
-
brenda
-
-
brenda
-
two different active sites
brenda
-
liver-type isozyme
brenda
-
liver-type isozyme, sinusoidal endothelial cells
brenda
-
-
brenda
-
-
brenda
-
low activity
brenda
-
PGFS-II, liver-type isozyme
brenda
-
liver-type isozyme
brenda
-
-
brenda
high expression level of the lung-type and the liver-type isozymes
brenda
-
-
brenda
-
contractile interstitial cells
brenda
-
two different active sites
brenda
-
lung-type isozyme
brenda
-
PGH2 9-,11-endoperoxide reductase activity lung-type isozyme
brenda
-
-
brenda
-
brenda
-
-
brenda
-
brenda
-
lung-type isozyme
brenda
-
-
brenda
-
low activity
brenda
low expression level
brenda
-
PGFS-I, lung-type isozyme
brenda
-
-
brenda
-
brenda
-
brenda
-
-
brenda
-
-
-
brenda
-
brenda
-
brenda
-
in pregnant myometrium, PGI2, PGD2 and PGF2 synthases are highly expressed while prostaglandin dehydrogenase is underexpressed. Myometrium from non-pregnant women has lower levels of prostaglandin synthases and higher levels of prostaglandin dehydrogenase than pregnant myometrium
brenda
-
brenda
-
PGH2 9-,11-endoperoxide reductase activity is expressed and active at early pregnant sows, probably also in cyclic sows
brenda
-
brenda
-
-
-
brenda
-
-
brenda
-
-
-
brenda
-
brenda
-
-
-
brenda
-
-
brenda
-
-
-
brenda
-
high activity
brenda
abundant expression
brenda
-
-
brenda
-
brenda
-
expression levels in uninucleated trophoblasts of the placentome of pregnant cows, especially chorionic plate and apical tertiary villi, overview
brenda
-
utero/placental expression of isoform AKR1C3 is found in the superficial uterine glands throughout gestation and in the trophoblast cells within the feto-maternal contact zone during placentation
brenda
-
brenda
-
brenda
-
the prostaglandin synthase expression profile favours production of PGD2, PGE2 and PGF2, with high levels of prostaglandin transporters and catabolic prostaglandin dehydrogenase suggesting rapid prostaglandin turnover
brenda
promastigotes synthesize prostaglandin F2alpha in the presence of arachidonic acid, with peak production in the stationary growth phase under heat stress
brenda
-
promastigotes synthesize prostaglandin F2alpha in the presence of arachidonic acid, with peak production in the stationary growth phase under heat stress
-
brenda
-
brenda
AKR1C3 is overexpressed in the fibrotic area of keloids (scarfs) while relatively weak staining is detected in normal skin
brenda
-
low activity
brenda
low expression level
brenda
-
-
brenda
-
neuronal dendrites and somata of gray matter
brenda
-
isozymes PGF synthase I and II
brenda
-
colocalization of prostaglandin F2alpha receptor FP and PGFS I
brenda
-
-
brenda
-
low activity
brenda
-
-
brenda
-
low activity
brenda
-
-
brenda
-
-
brenda
-
low activity
brenda
abundant expression
brenda
-
expression of both cyclooxygenase-1 and prostaglandin F synthase proteins in wild-type and prostaglandin F-receptor deficient strain
brenda
-
-
brenda
-
high activity
brenda
-
uninucleated cell
brenda
-
brenda
-
-
brenda
-
epithelial
brenda
the bovine endometrium produces huge amounts of PGF2alpha
brenda
at oestrus and mid and late phases of pseudopregnancy
brenda
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
-
brenda
-
endometrium of repeat-breeding cows
brenda
-
uterine expression of isoforms AKR1C3 is up-regulated postimplantation and declines prepartum. Enzyme co-localizes with 15-prostaglandin dehydrogenase
brenda
utero/placental expression of PGFS (AKR1C3) is identified in the superficial uterine glands throughout gestation and in the trophoblast cells within the feto-maternal contact zone during placentation. Colocalization of 15-hydroxyprostaglandin dehydrogenase (HPGD) with PGFS (AKR1C3) expression. Uterine PGFS (AKR1C3) is up-regulated postimplantation and declined prepartum
brenda
-
uterine tissues at delivery
brenda
the prostaglandin F synthase AKR1B1 is upregulated while prostaglandin transporter is downregulated during term labor. The amnion is more responsive than choriodecidua to stimulation with proinflammatory cytokines. The mechanisms of term and preterm labor are different, overview
brenda
-
high activity
brenda
-
PGFS mRNA and protein expression in the endometrium does not differ between pregnancy and oestrous cycle but PGFS mRNA in the myometrium increases during pregnancy both in the gravid and the non-gravid uterine horns
brenda
additional information
-
isoform AKR1C3 expression is weak or absent in luteal samples
brenda
additional information
quantitative enzyme expression analysis during pregnancy and prepartum
brenda
additional information
-
quantitative enzyme expression analysis during pregnancy and prepartum
brenda
additional information
-
enzyme tissue localization analysis
brenda
additional information
AKR1B1 shows decreased expression in neoplastic disease, with decreased AKR1B1 immunoreactivity in carcinoma cells compared with nonneoplastic ductal cells, suggesting that AKR1B1 activity might be suppressed in tumor cells in breast cancer tissues
brenda
additional information
AKR1B1 shows decreased expression in neoplastic disease, with decreased AKR1B1 immunoreactivity in carcinoma cells compared with nonneoplastic ductal cells, suggesting that AKR1B1 activity might be suppressed in tumor cells in breast cancer tissues
brenda
additional information
in situ enzyme immunohistochemic analysis
brenda
additional information
-
in situ enzyme immunohistochemic analysis
brenda
additional information
-
low activity in deferent duct and epididymidis
brenda
additional information
-
immunocytochemical localization study
brenda
additional information
isozyme expression levels and tissue distribution, overview
brenda
additional information
-
isozyme expression levels and tissue distribution, overview
brenda