1.1.1.159: 7alpha-hydroxysteroid dehydrogenase
This is an abbreviated version!
For detailed information about 7alpha-hydroxysteroid dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.159
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1.1.1.159
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chenodeoxycholic
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cholic
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testosteroni
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bacteroides
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thin-layer
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3alpha-hydroxysteroid
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synthesis
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fragilis
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7alpha-oh
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glycochenodeoxycholic
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nadp-dependent
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ursodeoxycholic
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perfringens
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degradation
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analysis
- 1.1.1.159
-
chenodeoxycholic
-
cholic
- testosteroni
- bacteroides
-
thin-layer
-
3alpha-hydroxysteroid
- synthesis
- fragilis
-
7alpha-oh
-
glycochenodeoxycholic
-
nadp-dependent
-
ursodeoxycholic
- perfringens
- degradation
- analysis
Reaction
Synonyms
7-alpha-HSDH, 7-HSDH, 7alpha-HSD, 7alpha-HSDH, 7alpha-hydroxy steroid dehydrogenase, 7alpha-hydroxysteroid dehydrogenase, Bile acid-inducible protein, CA 7alpha-HSDH, Ca7alpha-HSDH, dehydrogenase, 7alpha-hydroxy steroid, J-1-1, NADP(H)-dependent 7alpha-HSDH, NADP(H)-dependent 7alpha-hydroxysteroid dehydrogenase, NADP+-dependent 7alpha-HSDH, nicotinamide adenine dinucleotide phosphate-dependent 7alpha-hydroxysteroid dehydrogenase
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Natural Substrates Products
Natural Substrates Products on EC 1.1.1.159 - 7alpha-hydroxysteroid dehydrogenase
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REACTION DIAGRAM
7-keto-lithocholic acid + NADH
cheno-deoxycholic acid + NAD+
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in the gastrointestinal tract of host organisms
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?
taurochenodeoxycholic acid + NADP+
tauro-7-ketolithocholic acid + NADPH + H+
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?
?
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serve as energy sources in absence of glucose
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bile acids + NAD(P)+
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dehydrogenation of hydroxyl group at position 7, wide variety of substrate binding specificities in short-chain dehydrogenase enzyme family
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3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + NADH + H+
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r
cholate + NAD+
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + NADH + H+
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r
cholate + NAD+
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + NADH + H+
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-
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r
cholate + NAD+
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + NADH + H+
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r
cholate + NAD+
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + NADH + H+
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r
cholate + NAD+
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + NADH + H+
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r
cholate + NAD+
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + NADH + H+
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r
cholate + NAD+
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + NADH + H+
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r
?
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bile acid-induction, e.g. deoxycholate and chenodeoxycholate, is necessary for measurable activity, induction is inhibited by ursodeoxycholate
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additional information
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bile acid-inducible to 10fold higher activity on substrate compared to uninduced cells
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additional information
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substrate specificity and cycles in bile acid pathways, overview
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