1.1.1.149: 20alpha-hydroxysteroid dehydrogenase
This is an abbreviated version!
For detailed information about 20alpha-hydroxysteroid dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.149
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1.1.1.149
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progesterone
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androgen
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prostate
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reductases
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testosterone
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prostaglandin
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akr1cs
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steroidogenic
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luteal
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castration-resistant
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srd5a1
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androstenedione
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5alpha-reductase
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cyp17a1
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dihydrotestosterone
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progestin
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akr1b10
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17beta-hydroxysteroid
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3alpha-hsds
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abiraterone
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neurosteroids
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luteolysis
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hsd3b1
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5alpha-dihydrotestosterone
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17beta-hsds
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enzalutamide
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flufenamic
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17beta
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ketosteroid
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allopregnanolone
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3beta-hsd
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17alpha
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17alpha-hydroxyprogesterone
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hydrogenans
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pgf2alpha
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hsd17b3
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pre-receptor
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intracrine
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3-ketosteroids
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dihydrodiol
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scarb1
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analysis
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biotechnology
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food industry
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medicine
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environmental protection
- 1.1.1.149
- progesterone
- androgen
- prostate
- reductases
- testosterone
- prostaglandin
- akr1cs
-
steroidogenic
- luteal
-
castration-resistant
- srd5a1
- androstenedione
-
5alpha-reductase
- cyp17a1
- dihydrotestosterone
- progestin
- akr1b10
-
17beta-hydroxysteroid
- 3alpha-hsds
- abiraterone
-
neurosteroids
-
luteolysis
- hsd3b1
- 5alpha-dihydrotestosterone
- 17beta-hsds
-
enzalutamide
-
flufenamic
-
17beta
- ketosteroid
- allopregnanolone
- 3beta-hsd
-
17alpha
- 17alpha-hydroxyprogesterone
-
hydrogenans
-
pgf2alpha
- hsd17b3
-
pre-receptor
-
intracrine
- 3-ketosteroids
- dihydrodiol
-
scarb1
- analysis
- biotechnology
- food industry
- medicine
- environmental protection
Reaction
Synonyms
20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 20alpha-HSD, 20alpha-HSDH, 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxysteroid dehydrogenase, 20alpha-hydroxysteroid oxidoreductase, 20alpha-OH-SDH, 20beta-HSDH, 20beta-hydroxysteroid dehydrogenase, 3alpha-HSOR, 3alpha-hydroxysteroid oxidoreductase, AKR1C1, AKR1C14, AKR1C23, AKR1C3, AKR1C5, AKR1C9, aldo-keto reductase family 1 member C1, HSD1, More
ECTree
1.1.1.149 20alpha-hydroxysteroid dehydrogenaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 1.1.1.149 - 20alpha-hydroxysteroid dehydrogenase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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abdominal subcutaneous and omental adipose tissue, the enzyme activity is highest in women with visceral obesity, expression analysis
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breast cancer cells: tumorgenic strains MCF-7, MDA-MB-231, T-47D, nontumorgenic strain MCF-10A
preovulatory, very high expression rate, expression analysis of AKR1C23, activity during follicular luteinization, overview
the enzyme is specifically localized in the seminiferous tubule at 8 week
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the enzyme is mainly localized in the trophoblast villus in the placenta on day 30 of pregnancy
additional information
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high expression level, expression is restricted to the X-zone, adrenal 20alpha-HSD activity in male mice peaks at 3 weeks of age and disappears thereafter, whereas 20alpha-HSD enzyme activity is maintained in adrenals from nulliparous female animals
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high expression level, expression is restricted to the X-zone, adrenal 20alpha-HSD activity in male mice peaks at 3 weeks of age and disappears thereafter, whereas 20alpha-HSD enzyme activity is maintained in adrenals from nulliparous female animals
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analysis of 3alpha-HSOR mRNA distribution in the mouse brain by in situ hybridization has shown that this enzyme is co-localized with 5alpha-R type 1 in neurons of the cerebral cortex, hippocampus, olfactory bulb, amygdala and thalamus. And 3alpha-HSOR immunoreactivity is largely distributed in both white and gray matters
transcripts of galectin-3 are restricted to corpus luteum and always coincident to the expression of 20alpha-hydroxysteroid dehydrogenase. In the nonpregnant ovary, signals for both galectin-1 and -3 are intense in the old, regressing corpora lutea formed at previous estrous cycles. In the newly formed corpora lutea, the signal intensity of galectin-1 first increases at the starting point of regression followed by increasing galectin-3/20alpha-hydroxysteroid dehydrogenase expressions. Under gestation with active progesterone production, signals for both galectin-1 and -3 in corpora lutea completely disappear. At the perinatal stage, intense expressions of galectin-3/20alpha-hydroxysteroid dehydrogenase recover in the remaining corpora lutea of gestation with the temporal expression of galectin-1 and continue until weaning
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the enzyme catalyzing renal NADPH-dependent 20alpha-hydroxysteroid dehydrogenase activity is distinct from enzyme(s) catalyzing hepatic NADPH- and NADH-dependent 20alpha-hydroxysteroid dehydrogenase activities
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the enzyme catalyzing renal NADPH-dependent 20alpha-hydroxysteroid dehydrogenase activity is distinct from enzyme(s) catalyzing hepatic NADPH- and NADH-dependent 20alpha-hydroxysteroid dehydrogenase activities
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immunohistochemical analysis shows that bovine 20alpha-HSD protein is intensively localized in the large luteal cells during the late estrous cycle
the protein is strongly detected in the placenta on days 14, 16, and 18 of pregnancy
additional information
the expression of AKR1C1 is elevated in lung, uterine cervix, and colon cancers
additional information
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the expression of AKR1C1 is elevated in lung, uterine cervix, and colon cancers
additional information
in addition to neurons, 3alpha-HSOR activity appears to be highly localized in glial cells, such as type 1 astrocytes in culture and oligodendrocytes, although, 3alpa-HSOR activity has not been detected in myelin membranes of the CNS
