1.1.1.146: 11beta-hydroxysteroid dehydrogenase
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For detailed information about 11beta-hydroxysteroid dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.146
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1.1.1.146
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glucocorticoid
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cortisone
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mineralocorticoid
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corticosterone
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hypertension
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obesity
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adipose
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fetal
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adrenal
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aldosterone
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11-dehydrocorticosterone
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pregnancy
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testosterone
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urinary
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progesterone
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carbenoxolone
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visceral
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dexamethasone
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leydig
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steroidogenic
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obese
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androgen
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adipocytes
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cushing
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hexose-6-phosphate
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tetrahydrocortisol
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hypothalamic-pituitary-adrenal
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steroidogenesis
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renin
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acth
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glycyrrhetinic
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21-hydroxylase
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hsd3b1
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hypercortisolism
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analysis
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pharmacology
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pregnenolone
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drug development
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spironolactone
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liquorice
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11beta-hydroxylase
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hsd17b3
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androstenedione
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omental
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5alpha
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medicine
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hypokalemia
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alpha-hydroxyprogesterone
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thf
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5alpha-reductase
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alpha-hydroxysteroid
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cyp11b1
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11-ketotestosterone
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low-renin
- 1.1.1.146
- glucocorticoid
- cortisone
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mineralocorticoid
- corticosterone
- hypertension
- obesity
- adipose
- fetal
- adrenal
- aldosterone
- 11-dehydrocorticosterone
- pregnancy
- testosterone
- urinary
- progesterone
- carbenoxolone
- visceral
- dexamethasone
- leydig
-
steroidogenic
-
obese
- androgen
- adipocytes
- cushing
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hexose-6-phosphate
- tetrahydrocortisol
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hypothalamic-pituitary-adrenal
-
steroidogenesis
- renin
- acth
-
glycyrrhetinic
- 21-hydroxylase
- hsd3b1
- hypercortisolism
- analysis
- pharmacology
- pregnenolone
- drug development
- spironolactone
-
liquorice
-
11beta-hydroxylase
- hsd17b3
- androstenedione
-
omental
-
5alpha
- medicine
- hypokalemia
-
alpha-hydroxyprogesterone
- thf
-
5alpha-reductase
-
alpha-hydroxysteroid
- cyp11b1
- 11-ketotestosterone
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low-renin
Reaction
Synonyms
11 beta-hydroxysteroid dehydrogenase type 1, 11-beta hydroxysteroid dehydrogenase type 1, 11-beta-HSD1, 11-beta-HSD1 (oxidase) NADP+, 11-beta-HSD2, 11-beta-hydroxysteroid dehydrogenase type1, 11-DH, 11-DH2, 11-oxoreductase, 11beta hydroxysteroid dehydrogenase type 1, 11beta-HSD, 11beta-HSD 1, 11beta-HSD type 1, 11beta-HSD-1, 11beta-HSD-2, 11beta-HSD1, 11beta-HSD1A, 11beta-HSD2, 11beta-hydroxy steroid dehydrogenase, 11beta-hydroxy steroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase, 11beta-hydroxysteroid dehydrogenase 1, 11beta-hydroxysteroid dehydrogenase 2, 11beta-hydroxysteroid dehydrogenase isoforms 1, 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase type I, 11beta-hydroxysteroid dehydrogenase type-1, 11beta-hydroxysteroid dehydrogenase-1, 11beta-hydroxysteroid dehydrogenases type 1, 11beta-hydroxysteroid type 1 dehydrogenase, 11beta-hydroxysteroid-dehydrogenase type I, 11betaHSD1, 11betaHSD2, 11HSD1, beta-hydroxysteroid dehydrogenase, corticosteroid 11-reductase, corticosteroid 11beta-dehydrogenase, dehydrogenase, 11beta-hydroxy steroid, HSD1, HSD11B, HSD11B1, Hsd11B2, HSD2, hydroxysteroid (11-beta) dehydrogenase, isozyme 11beta-HSD1, More, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, NADP(+)-dependent 11beta-dehydrogenase, NADP+-dependent 11beta-hydroxysteroid dehydrogenase 1, type 1 11beta-hydroxysteroid dehydrogenase
ECTree
1.1.1.146 11beta-hydroxysteroid dehydrogenaseAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 1.1.1.146 - 11beta-hydroxysteroid dehydrogenase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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11beta-HSD1 activity is increased in visceral adipose tissue in prepubertal children with normal weight
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expression of levels of isoform 11beta-HSD1, glucocorticoid receptor alpha and serum and glucocorticoid-regulated kinase 1 mRNA comparable to that expressed in occular ciliary body
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expression of levels of isoform 11beta-HSD1, glucocorticoid receptor alpha and serum and glucocorticoid-regulated kinase 1 mRNA comparable to that expressed in choroid plexus
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presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands
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expression of mRNA for 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2 and for glucocorticoid receptor during the estrous cycle. Level of 11beta-hydroxysteroid dehydrogenase type 1 mRNA is higher at the regressed state than at the other stages, whereas level of 11beta-hydroxysteroid dehydrogenase type 2 mRNA is lower at the regressed stage than at the other stages
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epididymal fat, presence of a functional glucose-6-phosphate-transporter hexose-6-phosphate dehydrogenase 11beta-hydroxysteroid dehydrogenase type 1 system
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of secretory choroid plexus, predominant expression of isoform 11beta-HSD1
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11beta-HSD1 is widely expressed in the eye, particularly ciliary epithelium
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isoform 11beta-HSD1 is highly expressed in freshly isolated omental adipose stromal vascular cells, predominantly in preadipocytes
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significant expression of isoform 11beta-HSD2 protein is found at single cell level in thymus parenchyma, at perivascular sites of capillaries and small vessels penetrating the thymus lobuli and within Hassall's bodies
additional information
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differentiation of cells causes a strong increase in 11beta-hydroxysteroid dehydrogenase protein levels, occuring late in the differentiation protocol. Reduction of 11beta-hydroxysteroid dehydrogenase activity in 3T3-L1 fibroblasts, achieved by pharmacological inhibition or adenovirally mediated delivery of short hairpin RNA constructs, specifically blocks the ability of inactive glucocorticoids to drive 3T3-L1 differentiation. Even modest increases in exogenous 11beta-hydroxysteroid dehydrogenase expression in 3T3-L1 fibroblasts, to levels comparable with endogenous 1 11beta-hydroxysteroid dehydrogenase in differentiated 3T3-L1 adipocytes, are sufficient to block adipogenesis
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methionine restriction induces isoform 11beta-HSD1 activity in all types of adipose tissue examined, correlating with increased tissue corticosterone. Inverse relationship between 11beta-HSD1 activity and adipocyte size is observed. Methionine restriction additionally increases adipose triglyceride lipase and acetyl-coenzyme A carboxylase protein levels
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epididymal fat, presence of a functional glucose-6-phosphate-transporter hexose-6-phosphate dehydrogenase 11beta-hydroxysteroid dehydrogenase type 1 system
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expression of isozyme 11beta-HSD1, in situ hybridization, overview
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11beta-hydroxysteroid dehydrogenase mRNA level together with the markers of late adipocyte differentiation are significantly lower in orbital adipose tissue than in subcutaneous tissue. In primary cultures of orbital preadipocytes, there is predominant 11beta-hydroxysteroid dehydrogenase 1 oxoreductase activity with minimal dehydrogenase activity. Orbital adipocytes are smaller, less differentiated and express low levels of 11beta-hydroxysteroid dehydrogenase, but abundant glucocorticoid receptor compared with subcutaneous omental depots
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in morbidly obese patients, 11beta-hydroxysteroid dehydrogenase 1 mRNA levlels are higher in subcutaneous adipose tissue than in visceral adipose tissue. Subcutaneous adipose tissue 11beta-hydroxysteroid dehydrogenase 1 levels increase parallel according to body mass index category. No correlation between subcutaneous adipose tissue or visceral adipose tissue with fasting glucose, total cholesterol, triglycerides, and high-density lipoprotein
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isoform 11beta-HSD1 is highly expressed in freshly isolated omental adipose stromal vascular cells, predominantly in preadipocytes. The enzxyme acts as an 11beta-reduxtase, reactivating glucocorticoids. Glucocorticoid reactivation is higher in intact mesenteric cells than in thigh and axillary depots
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sucrose can promote increased 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase message in mesenteric fat while concomitantly decreasing 11beta-dehydroxysteroid dehydrogenase message and increasing hexose-6-phosphate dehydrogenase message in liver
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the activity of 11beta-HSD1 is increased in adipose tissue of obese Zucker rats
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pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+
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pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+
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presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands
colonic tissue from inflammatory bowel disease patients and healthy controls
isoform 11beta-HSD1 is clearly expressed while isoform 11beta-HSD2 is much less prominent, 11beta-HSD1 protein expression predominates in endothelial cells and varies during periods of growth
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isoform 11beta-HSD1 is clearly expressed while isoform 11beta-HSD2 is much less prominent, 11beta-HSD1 protein expression predominates in endothelial cells and varies during periods of growth
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cortisol oxidation increases threefold with antral follicle diameter, accompanied by threefold increase in 11beta-hydroxysteroid dehydrogenase activity. Neither intact cells nor homogenates display net 11-ketosteroid reductase activities. Intact granulosa cells from ovarian cysts exhibit significantly lower enzyme activities than cells from large antral follicles
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of normotensive and hypertensive rats, the latter are hyperthrophied and fibrotic and have structural alterations in the coronary circulation, expression of isozymes 11beta-HSD1 and 11beta-HSD2, overview
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of animals that received betamethasone as a fetus, or whose mothers received betamethasone during pregnancy. Adult animals demonstrate increased mineralocorticoid and 11beta-HSD2 mRNA levels
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similar amounts of protein for both isoform 11beta-HSD1 and 11beta-HSD2. 11beta-HSD1 functions as a dehydrogenase with no significant reverse reductase activity and colocalizes with cyclooxygenase COX-2 in proximal tubule cells. No colocalization of COX-2 with isoform 11beta-HSD2 in cortical collecting duct
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renal cortex, 1.5fold higher enzyme activity in hypertensive NISAG rats, i.e. rat strain with hereditary stress-induced arterial hypertension, compared to WAG rats
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kidney medullary interstitial cells, 11beta-HSD1 is expressed without significant expression of hexose-6-phosphate dehydrogenase
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11betaHSD2 mRNA and protein expression increases significantly after treatment with estradiol, renal 11beta-HSD1 mRNA and protein expression decrease to very low levels after estradiol treatment
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species-specific reaction profiles of 11beta-hydroxysteroid dehydrogenase, with a five times higher conversion rate in dog than in human and monkey liver microsome
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hepatic artery, portal vein, and hepatic vein, local cortisol concentrations, overview
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654637, 655216, 656215, 657253, 657396, 668432, 670258, 670264, 697498, 699841, 700178, 701324, 711383, 711387, 711800
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species-specific reaction profiles of 11beta-hydroxysteroid dehydrogenase, with a five times higher conversion rate in dog than in human and monkey liver microsome
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sucrose can promote increased 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase message in mesenteric fat while concomitantly decreasing 11beta-dehydroxysteroid dehydrogenase message and increasing hexose-6-phosphate dehydrogenase message in liver
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the activity of 11beta-HSD1 is decreased in the liver of obese Zucker rats
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activity occurs after differentiation of neutrophils to macrophages
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derived from bone-marrow, peritoneal macrophages, expression of isozyme 11beta-HSD1, not isozyme 11beta-HSD2
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11beta-HSD1 co-localises with glucagon in the periphery of pancreatic islets, but not with insulin or somatostatin
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11beta-HSD1 co-localises with glucagon in the periphery of pancreatic islets, but not with insulin or somatostatin
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constitutes an important barrier for 11-OH steroids during pregnancy between maternal and fetal organism, presence of two isoforms
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the 11beta-HSD2 expression and activity is 7-8fold higher compared to 11beta-HSD1 in the chorionic plate of small gestational age placentas
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presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands
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at baseline, mRNA levels are similar in diabetic and control sugjects for 11beta-HSD1, 11beta-HSD2, and hexose-6-phosphate dehydrogenase. 11beta-HSD1 activity is reduced in diabetic subjects, while 11beta-HSD2 activity is increased. After application of dexamethasone, 11beta-HSD1 mRNA increases in both groups, whereas 11beta-HSD2 mRNA decreases. 11beta-HSD1 activity increases in diabetic subjects, but not in controls, whereas 11beta-HSD2 activity does not change in either group; mRNA levels are similar in diabetic and control subjects for 11beta-hydroxysteroid dehydrogenase 1 and 11beta-hydroxysteroid dehydrogenase 2. 11beta-Hydroxysteroid dehydrogenase 2-activity is higher in diabetic patients. After treatment with dexamethasone, 11beta-hydroxysteroid dehydrogenase 1-mRNA increases in both groups, whereas 11beta-hydroxysteroid dehydrogenase 2-mRNA decreases. 11beta-Hydroxysteroid dehydrogenase 1-activity increases in diabetic patients, but not in control, whereas 11beta-hydroxysteroid dehydrogenase 2-activity does not change in either group
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prominent expression in testis, anterior kidney, liver and gills. Expression of isoform 11beta-HSD2 in testis and serum levels of 11-ketotestosterone are high in the prespawning phase
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pronounced 11beta-hydroxysteroid dehydrogenase activity in presence of NADP+ and NAD+
isoform 11beta-HSD1 is clearly expressed while isoform 11beta-HSD2 is much less prominent, 11beta-HSD1 protein expression predominates in endothelial cells and varies during periods of growth
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presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands
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presence of 11beta-hydroxysteroid dehydrogenase mRNA transcripts and protein in all tissues of the reproductive tract examined, but cortison-cortisol interconversion is undetectable in the corpus and cauda epididymides, vas deferens, vesicular and prostate glands
additional information
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11beta-HSD2, but not 11beta-HSD1, is strongly expressed in LbetaT2 cells
additional information
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LbetaT2 cell of 11beta-HSD2, but not 11beta-HSD1, is strongly expressed in LbetaT2 cells
additional information
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isozyme 11beta-HSD1 expression is about 30% reduced in castrated male rats, while expression of isozyme 11beta-HSD2 is increased, overview
