Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.1.1.146: 11beta-hydroxysteroid dehydrogenase

This is an abbreviated version!
For detailed information about 11beta-hydroxysteroid dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.146

Reaction

an 11beta-hydroxysteroid
+
NADP+
=
an 11-oxosteroid
 +
NADPH
 +
H+

Synonyms

11 beta-hydroxysteroid dehydrogenase type 1, 11-beta hydroxysteroid dehydrogenase type 1, 11-beta-HSD1, 11-beta-HSD1 (oxidase) NADP+, 11-beta-HSD2, 11-beta-hydroxysteroid dehydrogenase type1, 11-DH, 11-DH2, 11-oxoreductase, 11beta hydroxysteroid dehydrogenase type 1, 11beta-HSD, 11beta-HSD 1, 11beta-HSD type 1, 11beta-HSD-1, 11beta-HSD-2, 11beta-HSD1, 11beta-HSD1A, 11beta-HSD2, 11beta-hydroxy steroid dehydrogenase, 11beta-hydroxy steroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase, 11beta-hydroxysteroid dehydrogenase 1, 11beta-hydroxysteroid dehydrogenase 2, 11beta-hydroxysteroid dehydrogenase isoforms 1, 11beta-hydroxysteroid dehydrogenase type 1, 11beta-hydroxysteroid dehydrogenase type 2, 11beta-hydroxysteroid dehydrogenase type I, 11beta-hydroxysteroid dehydrogenase type-1, 11beta-hydroxysteroid dehydrogenase-1, 11beta-hydroxysteroid dehydrogenases type 1, 11beta-hydroxysteroid type 1 dehydrogenase, 11beta-hydroxysteroid-dehydrogenase type I, 11betaHSD1, 11betaHSD2, 11HSD1, beta-hydroxysteroid dehydrogenase, corticosteroid 11-reductase, corticosteroid 11beta-dehydrogenase, dehydrogenase, 11beta-hydroxy steroid, HSD1, HSD11B, HSD11B1, Hsd11B2, HSD2, hydroxysteroid (11-beta) dehydrogenase, isozyme 11beta-HSD1, More, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, NADP(+)-dependent 11beta-dehydrogenase, NADP+-dependent 11beta-hydroxysteroid dehydrogenase 1, type 1 11beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.146 11beta-hydroxysteroid dehydrogenase

IC50 Value

IC50 Value on EC 1.1.1.146 - 11beta-hydroxysteroid dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.05799 - 0.1312
(-)-epigallocatechin 3-gallate
0.0012
(1-[2-[(2-chloro-4-fluorobenzyl)amino]-2-oxoethyl]cyclopentyl)acetic acid
Homo sapiens
-
0.000018
(1-[6-[(5-hydroxytricyclo[3.3.1.1~3,7~]decan-2-yl)carbamoyl]pyridin-2-yl]piperidin-4-yl)acetic acid
Homo sapiens
at 37°C, pH not specified in the publication
0.003
(11beta)-11-hydroxyallopregnanolone
Homo sapiens
-
dehydrogenase reaction, pH 8.4, 37°C
0.0056
(11beta)-11-hydroxyprogesterone
Homo sapiens
-
dehydrogenase reaction, pH 8.4, 37°C
0.0000037
(1R)-4-(4'-fluoro[1,1'-biphenyl]-4-yl)-4-[(1H-tetrazol-5-yl)methyl]octahydro-2,5-methanopentalen-1-ol
Homo sapiens
pH and temperature not specified in the publication
0.001
(1r,4s)-4-[3-[(3-chloro-2-methylbenzene-1-sulfonyl)amino]-3-methylbutanamido]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
Homo sapiens
IC50 above 0.001 mM, pH and temperature not specified in the publication
0.001
(1r,4s)-4-[[5-(cyclopropylamino)-3,3-dimethyl-5-oxopentanoyl]amino]tricyclo[3.3.1.13,7]decane-1-carboxylic acid
Homo sapiens
IC50 above 0.001 mM, in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000015
(1S)-4-(4'-fluoro[1,1'-biphenyl]-4-yl)-4-[(1H-tetrazol-5-yl)methyl]octahydro-2,5-methanopentalen-1-ol
Homo sapiens
pH and temperature not specified in the publication
0.000002 - 0.000021
(1S,3R,4S,5S,7S)-4-(3-(2-fluorophenylsulfonamido)-3-methylbutanamido) adamantane-1-carboxamide
0.000001 - 0.000009
(1s,4r)-4-[3-[(2,3-dichlorobenzene-1-sulfonyl)amino]-3-methylbutanamido]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000001 - 0.000009
(1s,4r)-4-[3-[(2,3-difluorobenzene-1-sulfonyl)amino]-3-methylbutanamido]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000001 - 0.000022
(1s,4r)-4-[3-[(2,4-difluorobenzene-1-sulfonyl)amino]-3-methylbutanamido]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000001 - 0.000196
(1s,4r)-4-[3-[(2,6-difluorobenzene-1-sulfonyl)amino]-3-methylbutanamido]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000002 - 0.000021
(1s,4r)-4-[3-[(2-fluorobenzene-1-sulfonyl)amino]-3-methylbutanamido]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000007 - 0.000099
(1s,4r)-4-[3-[(3,5-difluorobenzene-1-sulfonyl)amino]-3-methylbutanamido]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000001 - 0.00001
(1s,4r)-4-[3-[(3-chloro-2-fluorobenzene-1-sulfonyl)amino]-3-methylbutanamido]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.00001 - 0.000012
(1s,4r)-4-[3-[(3-chloro-2-methylbenzene-1-sulfonyl)amino]-3-methylbutanamido]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000057 - 0.001
(1s,4r)-4-[3-[(3-chloro-2-methylbenzene-1-sulfonyl)amino]-3-methylbutanamido]tricyclo[3.3.1.1~3,7~]decane-1-carboxylic acid
0.000001 - 0.000046
(1s,4r)-4-[3-[(3-chlorobenzene-1-sulfonyl)amino]-3-methylbutanamido]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000002 - 0.000028
(1s,4r)-4-[3-[(3-fluorobenzene-1-sulfonyl)amino]-3-methylbutanamido]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000001 - 0.000024
(1s,4r)-4-[3-[(4-fluorobenzene-1-sulfonyl)amino]-3-methylbutanamido]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000254
(2-benzyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-3-yl)(phenyl)methanone
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.003 - 0.112
(2alpha,3beta,5xi,6beta,9xi,18xi)-2,3,6,23-tetrahydroxyurs-12-en-28-oate
0.005 - 0.2
(2alpha,3beta,5xi,9xi,18xi)-2,3,23-trihydroxyurs-12-en-28-oate
0.00001 - 0.000031
(2R)-1-(2-chloro-4-(2-methoxyethoxy)phenylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine
0.00001 - 0.000018
(2R)-1-(2-chloro-4-(difluoromethoxy)phenylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine
0.000012 - 0.000063
(2R)-1-(2-chloro-4-ethoxyphenylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine
0.00001 - 0.000017
(2R)-1-(3-chloro-4-(4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-ylsulfonyl)phenyl)piperidine-4-carboxamide
0.00001
(2R)-1-(3-chloro-4-(4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-ylsulfonyl)phenyl)piperidine-4-carboxylic acid
0.00001
(2R)-1-(3-chloro-4-([4-(4-fluoro-2-(trifluoromethyl)-phenyl)-2-methylpiperazin-1-yl]sulfonyl)phenyl)piperidin-4-ol
Homo sapiens
at 37°C
0.00001
(2R)-1-(4-bromo-2-chlorophenylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine
0.000028
(2R)-1-(4-bromophenylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)-phenyl)-2-methylpiperazine
Homo sapiens
at 37°C
0.000013 - 0.00004
(2R)-1-(4-tert-butoxy-2-chlorophenylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine
0.00001 - 0.000639
(2R)-1-([2-chloro-4-[(3S)-3-methylpiperazin-1-yl]phenyl]sulfonyl)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazine
0.000097
(2R)-1-[(2-chloro-4-piperidin-1-ylphenyl)sulfonyl]-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazine
Homo sapiens
at 37°C
0.000011 - 0.000012
(2R)-1-[(2-chloro-4-pyrrolidin-1-ylphenyl)sulfonyl]-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazine
0.000003
(2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-(4-nitrophenyl)piperazine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000113
(2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-(pyridin-4-ylmethyl)piperazine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000034
(2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-[1-(pyridin-4-yl)ethyl]piperazine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000053
(2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-[2-(pyridin-4-yl)ethyl]piperazine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000001
(2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-[3-(pyridin-4-yl)propyl]piperazine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000094
(2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-[phenyl(pyridin-4-yl)methyl]piperazine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00001 - 0.000015
(2R)-1-[3-chloro-4-([(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl]sulfonyl)phenyl]-N,N-dimethylpiperidin-4-amine
0.000018
(2R)-1-[3-chloro-4-([(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl]sulfonyl)phenyl]piperazin-2-one
Homo sapiens
at 37°C
0.00001
(2R)-1-[[2-chloro-4-(1H-1,2,4-triazol-1-yl)phenyl]sulfonyl]-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazine
0.000017 - 0.000074
(2R)-1-[[2-chloro-4-(4,4-difluoropiperidin-1-yl)phenyl]sulfonyl]-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazine
0.000015 - 0.00005
(2R)-1-[[2-chloro-4-(4-fluoropiperidin-1-yl)phenyl]sulfonyl]-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazine
0.000128 - 0.000136
(2R)-1-[[2-chloro-4-(4-methylpiperazin-1-yl)phenyl]sulfonyl]-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazine
0.00003
(2R)-1-[[4-(1,1-difluoroethyl)phenyl]sulfonyl]-2-methyl-4-[2-(pyridin-4-yl)ethyl]piperazine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000016
(2R)-1-[[4-(1-fluoroethyl)phenyl]sulfonyl]-2-methyl-4-[2-(pyridin-4-yl)ethyl]piperazine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000036
(2R)-1-[[4-(2-fluoropropan-2-yl)phenyl]sulfonyl]-2-methyl-4-[2-(pyridin-4-yl)ethyl]piperazine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00001 - 0.000092
(2R)-2-(3-chloro-4-(4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-ylsulfonyl)phenoxy)-N,N-dimethylethanamine
0.000004
(2R)-2-methyl-4-[2-(pyridin-4-yl)ethyl]-1-[[4-(1,1,1,2-tetrafluoropropan-2-yl)phenyl]sulfonyl]piperazine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00001 - 0.000015
(2R)-3-chloro-4-(4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-ylsulfonyl)-N,N-dimethylaniline
0.00001 - 0.000016
(2R)-3-chloro-4-(4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-ylsulfonyl)benzonitrile
0.000012 - 0.00005
(2R)-3-chloro-4-(4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-ylsulfonyl)phenol
0.00001
(2R)-3-chloro-4-([(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl]sulfonyl)benzamide
0.00001 - 0.000011
(2R)-4-(3-fluoro-4-(4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-ylsulfonyl)phenyl)morpholine
0.00001 - 0.000063
(2R)-4-(4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-ylsulfonyl)benzamide
0.00001 - 0.000636
(2R)-4-(4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-ylsulfonyl)benzonitrile
0.00002
(2R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-1-(4-methoxyphenylsulfonyl)-2-methylpiperazine
Homo sapiens
at 37°C
0.000016 - 0.000023
(2R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methyl-1-(4-(trifluoromethoxy)-phenylsulfonyl)-piperazine
0.000088 - 0.000185
(2R)-4-[3-chloro-4-([(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl]sulfonyl)phenyl]-cis-2,6-dimethylmorpholine
0.00001
(2R)-4-[3-chloro-4-([(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl]sulfonyl)phenyl]morpholine
0.00001
(2R)-4-[3-chloro-4-([(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl]sulfonyl)phenyl]piperazin-2-one
0.00001
(2R)-4-[3-chloro-4-([(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl]sulfonyl)phenyl]thiomorpholine-1,1-dioxide
0.000019
(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-[(4-piperidin-1-ylphenyl)sulfonyl]piperazine
Homo sapiens
at 37°C
0.000674 - 0.002337
(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-[[4-(1H-tetrazol-5-yl)phenyl]sulfonyl]piperazine
0.0000012 - 0.000015
(2R)-N-(5-hydroxytricyclo[3.3.1.13,7]dec-2-yl)-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide
0.0000015 - 0.000013
(2R)-N-(tricyclo[3.3.1.13,7]dec-2-yl)-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide
0.0000037 - 0.000032
(2R)-N-cycloheptyl-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide
0.0000031 - 0.000024
(2R)-N-[(1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide
0.000071 - 0.000115
(2R)-N-[3-chloro-4-([4-[4-fluoro-2-(trifluoromethyl)phenyl]-piperazin-1-yl]sulfonyl)phenyl]morpholine-4-carboxamide
0.000056 - 0.012
(2R,4aR,6aS,6bR,10S,12aS)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-1,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,14b-octadecahydropicen-13(2H)-one
0.0000619
(3alpha,18beta,20beta)-3-methoxyamino-11-oxo-olean-12-en-29-oic acid
Homo sapiens
pH not specified in the publication, 37°C
0.0007 - 0.008
(3alpha,5alpha)-3,11,21-trihydroxypregn-11-en-20-one
0.007138
(3beta)-3-(acetyloxy)-11-oxoolean-12-en-30-oic acid
Homo sapiens
pH not specified in the publication, 37°C
0.000049
(3beta)-3-hydroxy-18,29-epoxyolean-12-ene-11,29-dione
Homo sapiens
pH 7.4, 37°C
0.000025
(3beta)-3-[(3-carboxypropanoyl)oxy]urs-12-en-28-oic acid
Homo sapiens
pH 7.4, 37°C
0.001157
(3beta)-N,3-dihydroxy-11-oxoolean-12-en-30-amide
Homo sapiens
pH not specified in the publication, 37°C
0.000825
(3beta,18beta,20beta)-3-(acetylamino)-11-oxo-olean-12-en-29-oic acid
Homo sapiens
pH not specified in the publication, 37°C
0.000626
(3beta,18beta,20beta)-3-acetoxy-N-hydroxy-11-oxo-olean-12-en-29-amide
Homo sapiens
pH not specified in the publication, 37°C
0.001012
(3beta,18beta,20beta)-3-acetoxy-N-methyl-N-hydroxy-11-oxoolean-12-en-29-amide
Homo sapiens
pH not specified in the publication, 37°C
0.000929
(3beta,18beta,20beta)-3-hydroxy-N-methoxy-11-oxo-olean-12-en-29-amide
Homo sapiens
pH not specified in the publication, 37°C
0.0000427
(3beta,18beta,20beta)-3-methoxyamino-11-oxo-olean-12-en-29-oic acid
Homo sapiens
pH not specified in the publication, 37°C
0.002 - 0.2
(3beta,5xi,18xi)-oleana-9(11),12-diene-3,30-diol
0.002 - 0.2
(3beta,5xi,9xi)-oleana-11,13(18)-diene-3,30-diol
0.000049 - 0.016
(3beta,5xi,9xi,18xi)-3,30-dihydroxyolean-12-en-11-one
0.011 - 0.074
(3beta,5xi,9xi,18xi)-3-(acetyloxy)-11-oxours-12-en-24-oate
0.009 - 0.2
(3beta,5xi,9xi,18xi)-3-(acetyloxy)urs-12-en-24-oate
0.000122 - 0.025
(3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-al
0.000008 - 0.000012
(3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-oate
0.001 - 0.068
(3beta,5xi,9xi,18xi)-3-hydroxy-11-oxours-12-en-28-oate
0.2
(3beta,5xi,9xi,18xi)-3-hydroxyolean-12-en-28-oate
0.001508
(3E)-3-(methoxyimino)-11-oxoolean-12-en-30-oic acid
Homo sapiens
pH not specified in the publication, 37°C
0.000053
(3R)-3-[(3-chloro-2-methylbenzene-1-sulfonyl)amino]-N-(tricyclo[3.3.1.1~3,7~]decan-2-yl)butanamide
Homo sapiens
pH and temperature not specified in the publication
0.000089
(3S)-3-[(3-chloro-2-methylbenzene-1-sulfonyl)amino]-N-(tricyclo[3.3.1.1~3,7~]decan-2-yl)butanamide
Homo sapiens
pH and temperature not specified in the publication
0.0148
(4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-3-yl)(phenyl)methanone
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000388
(4-hydroxy-2-methyl-1,1-dioxido-2H-1,2-benzothiazin-3-yl)(phenyl)methanone
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.001
(4-[[N-(2-fluorobenzene-1-sulfonyl)-2-methylalanyl]amino]tricyclo[3.3.1.1~3,7~]decan-1-yl)acetic acid
0.000116
(4R,7S)-1,7,8,8-tetramethyl-2-phenyl-1,2,4,5,6,7-hexahydro-4,7-methanoindazol-3-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000138
(4S,7R)-1,7,8,8-tetramethyl-2-phenyl-1,2,4,5,6,7-hexahydro-4,7-methanoindazol-3-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000074 - 0.016
(5xi,9xi,18xi)-3,11-dioxoolean-12-en-30-al
0.0000008
(6S)-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-3-[1-(2',4'-difluorobiphenyl-4-yl)ethyl]-1,3-oxazinan-2-one
Homo sapiens
pH 7.4, 22°C, microsomal assay
0.0000005
(6S)-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-3-[1-(4'-fluorobiphenyl-4-yl)ethyl]-1,3-oxazinan-2-one
Homo sapiens
pH 7.4, 22°C, microsomal assay
0.000197
(R)-1-((S)-2-acetamido-3-(4-cyanophenyl)propanoyl)-N-(adamantan-2-yl)pyrrolidine-2-carboxamide
Homo sapiens
at pH 7.4 and 37°C
0.000266
(R)-1-((S)-2-acetamido-3-(4-fluorophenyl)propanoyl)-N-(adamantan-2-yl)pyrrolidine-2-carboxamide
Homo sapiens
at pH 7.4 and 37°C
0.000902
(R)-1-(L-tyrosyl)-N-(adamantan-2-yl)pyrrolidine-2-carboxamide
Homo sapiens
at pH 7.4 and 37°C
0.000062
(R)-2-((1R,2R,4S)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.001505
(R)-2-((1R,2R,4S)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropylthiazol-4(5H)-one
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.0000568
(R)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.000885
(R)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropylthiazol-4(5H)-one
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.000373
(R)-N-(adamantan-2-yl)-1-((S)-2-amino-3-(4-ethoxyphenyl)propanoyl)pyrrolidine-2-carboxamide
Homo sapiens
at pH 7.4 and 37°C
0.0000286
(S)-2-((1R,2R,4S)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.000931
(S)-2-((1R,2R,4S)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropylthiazol-4(5H)-one
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.0000101
(S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.0000153
(S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropylthiazol-4(5H)-one
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.000094
1'-[[1-(4-chlorophenyl)cyclopropyl]carbonyl]-2,3-dihydrospiro[indene-1,3'-piperidine]
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000025
1'-[[1-(4-chlorophenyl)cyclopropyl]carbonyl]-2,3-dihydrospiro[indene-1,3'-pyrrolidine]
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000022
1'-[[1-(4-chlorophenyl)cyclopropyl]carbonyl]-3,4-dihydro-2H-spiro[naphthalene-1,3'-pyrrolidine]
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.0021
1'-[[1-(4-chlorophenyl)cyclopropyl]carbonyl]spiro[indene-1,4'-piperidine]
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.0000005
1,1,1-trifluoro-2-(4-[[(2R)-2-methyl-4-[[1-(pyridin-3-yl)cyclobutyl]methyl]piperazin-1-yl]sulfonyl]phenyl)propan-2-ol
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000006
1,1,1-trifluoro-2-(4-[[(2R)-2-methyl-4-[[1-(pyridin-3-yl)cyclopentyl]methyl]piperazin-1-yl]sulfonyl]phenyl)propan-2-ol
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000005
1,1,1-trifluoro-2-(4-[[(2R)-2-methyl-4-[[1-(pyridin-3-yl)cyclopropyl]methyl]piperazin-1-yl]sulfonyl]phenyl)propan-2-ol
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000006
1,1,1-trifluoro-2-(4-[[(2R)-2-methyl-4-[[1-(pyridin-4-yl)cyclobutyl]methyl]piperazin-1-yl]sulfonyl]phenyl)propan-2-ol
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000008
1,1,1-trifluoro-2-(4-[[(2R)-2-methyl-4-[[1-(pyridin-4-yl)cyclopentyl]methyl]piperazin-1-yl]sulfonyl]phenyl)propan-2-ol
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000004
1,1,1-trifluoro-2-(4-[[(2R)-2-methyl-4-[[1-(pyridin-4-yl)cyclopropyl]methyl]piperazin-1-yl]sulfonyl]phenyl)propan-2-ol
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00001
1,1,1-trifluoro-2-[4-([(2R)-2-methyl-4-[2-(pyridin-2-yl)ethyl]piperazin-1-yl]sulfonyl)phenyl]propan-2-ol
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000013
1,1,1-trifluoro-2-[4-([(2R)-2-methyl-4-[2-(pyridin-3-yl)ethyl]piperazin-1-yl]sulfonyl)phenyl]propan-2-ol
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000022
1,1,1-trifluoro-2-[4-([(2R)-2-methyl-4-[2-(pyridin-4-yl)ethyl]piperazin-1-yl]sulfonyl)phenyl]propan-2-ol
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000012
1-(((R)-3-methyl-4-(4-((S)-1,1,1-trifluoro-2-hydroxypropan-2-yl)phenylsulfonyl)-piperazin-1-yl)methyl)-cyclopropanecarboxamide
Homo sapiens
in PBS buffer, at 37°C
0.0058
1-(2,4-dichlorophenyl)-2-(2-methylbenzo[d]thiazol-5-ylamino)-ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.000116
1-(3,4-dimethoxyphenyl)-2-[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]ethanone
Homo sapiens
pH 7.0, 22°C, cellular assay
0.000012 - 0.000057
1-(3-chloro-4-[5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazol-3-yl]phenyl)-2-methyl-1H-benzimidazole
0.0064
1-(4-chlorophenyl)-2-(2-methylbenzo[d]thiazol-5-ylamino)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.000008
1-([1,1'-biphenyl]-4-yl)-1-[(1H-tetrazol-5-yl)methyl]hexahydro-2,5-methanopentalen-3a(1H)-ol
Homo sapiens
pH and temperature not specified in the publication
0.002975
1-adamantan-1-yl-2-(2,4-dichloro-benzylsulfanyl)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.000171
1-adamantan-1-yl-2-(2,4-dichloro-phenylmethanesulfonyl)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.000122
1-adamantan-1-yl-2-(2-chloro-phenylmethanesulfinyl)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.000128
1-adamantan-1-yl-2-(2-chloro-phenylmethanesulfonyl)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.000302
1-adamantan-1-yl-2-(2-methylbenzothiazol-5-ylamino)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.004755
1-adamantan-1-yl-2-(2-methylbenzothiazol-5-yloxy)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.000339
1-adamantan-1-yl-2-(3,4-dimethoxy-benzyloxy)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.009379
1-adamantan-1-yl-2-(3,4-dimethoxy-phenoxy)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.001438
1-adamantan-1-yl-2-(4-chloro-benzenesulfinyl)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.001
1-adamantan-1-yl-2-(4-chloro-phenoxy)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.000231
1-adamantan-1-yl-2-(4-chloro-phenylmethanesulfinyl)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.00135
1-adamantan-1-yl-2-(4-chloro-phenylmethanesulfonyl)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.00081
1-adamantan-1-yl-2-(4-chloro-phenylsulfanyl)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.000296
1-adamantan-1-yl-2-(4-methoxy-benzyloxy)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.002069
1-adamantan-1-yl-2-(4-methylbenzyloxy)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.002017
1-adamantan-1-yl-2-(4-tert-butyl-phenylmethanesulfonyl)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.005236
1-adamantan-1-yl-2-(4-trifluoromethyl-phenoxy)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.0049
1-adamantan-1-yl-2-(biphenyl-4-yloxy)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.000443
1-adamantan-1-yl-2-(toluene-4-sulfinyl)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.000668
1-adamantan-1-yl-2-(toluene-4-sulfonyl)ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.00251
1-adamantan-1-yl-2-p-tolyloxy-ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.00672
1-adamantan-1-yl-2-p-tolylsulfanyl-ethanone
Homo sapiens
pH not specified in the publication, 37°C
0.0007
1-methyl-2-[4-(4-methylbenzene-1-sulfonyl)piperazin-1-yl]-1H-benzimidazole
Homo sapiens
pH and temperature not specified in the publication
0.000012 - 0.000091
1-methyl-4-(4-methyl-5-phenyl-4H-1,2,4-triazol-3-yl)-1H-indole
0.00000098 - 0.0000013
1-methyl-4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]-1H-indole
0.000346 - 0.000963
1-methyl-5-(4-methyl-5-phenyl-4H-1,2,4-triazol-3-yl)-1H-indole
0.000257
1-phenyl-2-[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]ethanone
Homo sapiens
pH 7.0, 22°C, cellular assay
0.000007
1-[(2,4-dichlorophenyl)sulfonyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine
Homo sapiens
-
pH and temperature not specified in the publication
0.000008 - 0.000021
1-[(2-chlorobenzyl)oxy]-7-fluoro-3-hydroxyisoquinoline-4-carbonitrile
0.000005
1-[(2-chlorobenzyl)sulfanyl]-3-hydroxy-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
0.000002 - 0.000007
1-[(2-chlorobenzyl)sulfanyl]-7-fluoro-3-hydroxyisoquinoline-4-carbonitrile
0.000013
1-[(2-naphthylphenyl)sulfonyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine
Homo sapiens
-
pH and temperature not specified in the publication
0.00000003 - 0.000123
1-[(3-chloro-2-methylcyclohexyl)sulfonyl]-N-[(+)-bornyl]piperidine-3-carboxamide
0.0000004 - 0.000018
1-[(3-chloro-2-methylcyclohexyl)sulfonyl]-N-[(+)-isopinocampheyl]piperidine-3-carboxamide
0.000016
1-[(4-methylphenyl)sulfonyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine
0.00001
1-[(4-nitrophenyl)sulfonyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine
Homo sapiens
-
pH and temperature not specified in the publication
0.000003
1-[(4-tert-butylphenyl)sulfonyl]-(2R)-2-methyl-4-(4-nitrophenyl)piperazine
Homo sapiens
-
pH and temperature not specified in the publication
0.000011
1-[(4-tert-butylphenyl)sulfonyl]-(2R)-2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine
Homo sapiens
-
pH and temperature not specified in the publication
0.000009
1-[(4-tert-butylphenyl)sulfonyl]-(2S)-2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine
Homo sapiens
-
pH and temperature not specified in the publication
0.000009
1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine
Homo sapiens
-
pH and temperature not specified in the publication
0.00001
1-[(4-tert-butylphenyl)sulfonyl]-4-(4-nitrophenyl)piperazine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000004
1-[(4-tert-butylphenyl)sulfonyl]-4-(5-nitropyridin-2-yl)piperazine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000004
1-[(4-tert-butylphenyl)sulfonyl]-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine
Homo sapiens
-
pH and temperature not specified in the publication
0.000003
1-[(4-tert-butylphenyl)sulfonyl]-5-[3-(trifluoromethyl)pyridin-2-yl]-1,5-diazocane
Homo sapiens
-
pH and temperature not specified in the publication
0.0001
1-[1-(3,4-dimethylbenzoyl)piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00011
1-[1-(3-methoxy-4-methylbenzoyl)piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0001
1-[1-[(3,4-dimethylphenyl)carbonyl]piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00018
1-[1-[(3-amino-4-methoxyphenyl)carbonyl]piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0003
1-[1-[(3-methoxyphenyl)carbonyl]piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00011
1-[1-[(4-methoxy-3-methylphenyl)carbonyl]piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000012
1-[4-([(2R)-2-methyl-4-[2-(pyridin-4-yl)ethyl]piperazin-1-yl]sulfonyl)phenyl]ethanol
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000079
1-[[(3R)-3-methyl-4-([4-[(2R)-1,1,1-trifluoro-2-hydroxypropan-2-yl]phenyl]sulfonyl)piperazin-1-yl]methyl]cyclopropanecarboxamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000007
1-[[(3R)-3-methyl-4-([4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]phenyl]sulfonyl)piperazin-1-yl]methyl]cyclopropanecarboxamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000003
1-[[(3R)-3-methyl-4-[[4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl]sulfonyl]piperazin-1-yl]methyl]cyclobutanecarboxamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000017
1-[[(3R)-3-methyl-4-[[4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl]sulfonyl]piperazin-1-yl]methyl]cyclopropanecarboxamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000002
1-[[6-(4-nitrophenyl)pyridin-2-yl]carbonyl]decahydroquinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.00047
11-dehydrocortisterone
Ovis aries
-
pH 8.4, 37°C
0.031
11-deoxycorticosterone
Rattus sp.
-
IC50: 0.031 mM
0.00065 - 0.05
11-oxo-3alpha,5alpha-tetrahydrotestosterone
0.008
11-oxo-3beta,5alpha-tetrathydrotestosterone
Ovis aries
-
pH 8.4, 37°C
0.0008 - 0.0015
11-oxo-allopregnanolone
0.021
11-oxo-androstenedione
Homo sapiens
-
reductase reaction, pH 8.4, 37°C
0.0004 - 0.0095
11-oxo-progesterone
0.00135 - 0.018
11-oxo-testosterone
0.00012
11beta-hydroxy-allopregnanolone
Ovis aries
-
pH 8.4, 37°C
0.005 - 0.0115
11beta-hydroxy-androstanediol
0.009
11beta-hydroxy-testosterone
Homo sapiens
-
dehydrogenase reaction, pH 8.4, 37°C
0.0045
11beta-hydroxyandrostanediol
Ovis aries
-
pH 8.4, 37°C
0.0078
11beta-hydroxyandrostenedione
Ovis aries
-
pH 8.4, 37°C
0.00005
11beta-hydroxyprogesterone
Ovis aries
-
pH 8.4, 37°C
0.00035
11beta-hydroxytestosterone
Ovis aries
-
pH 8.4, 37°C
0.002214
18alpha-glycyrrhetinic acid
Homo sapiens
37°C, pH not specified in the publication
0.000779
18beta-glycyrrhetinic acid
Homo sapiens
37°C, pH not specified in the publication
0.000027 - 0.00049
2,3-dihydro-4H-1,4-benzoxazin-4-yl[3-(1H-pyrazol-4-yl)pyrrolidin-1-yl]methanone
0.0032
2,5-dichloro-N-(2-methyl-1,3-benzothiazol-5-yl)benzenesulfonamide
Homo sapiens
-
at 37°C
0.000016
2-(1-[2-oxo-2-[(pyridin-2-ylmethyl)amino]ethyl]cyclopentyl)-N-tricyclo[3.3.1.13,7]dec-2-ylacetamide
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000009
2-(1-[2-[(2-methoxyphenyl)amino]-2-oxoethyl]cyclopentyl)-N-tricyclo[3.3.1.13,7]dec-2-ylacetamide
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000009
2-(1-[2-[(2-methylpropyl)amino]-2-oxoethyl]cyclopentyl)-N-tricyclo[3.3.1.13,7]dec-2-ylacetamide
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000018
2-(1-[2-[(4-fluorobenzyl)amino]-2-oxoethyl]cyclopentyl)-N-tricyclo[3.3.1.13,7]dec-2-ylacetamide
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000017
2-(1-[2-[(4-fluorophenyl)amino]-2-oxoethyl]cyclopentyl)-N-tricyclo[3.3.1.13,7]dec-2-ylacetamide
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000048
2-(1-[2-[(4-methoxyphenyl)amino]-2-oxoethyl]cyclopentyl)-N-tricyclo[3.3.1.13,7]dec-2-ylacetamide
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.0000029
2-(2-chlorophenyl)-6-[(3,3-dimethylpiperidin-1-yl)carbonyl]pyridine
Homo sapiens
-
pH and temperature not specified in the publication
0.01
2-(2-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000015
2-(2-methyl-2-phenylpropanoyl)-2-azaspiro[4.5]decane
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000052
2-(2-[[(3-chloro-2-methylphenyl)sulfonyl]amino]-1,3-thiazol-4-yl)-N,N-diethylacetamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00003
2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)-1-(4-nitrophenyl)ethanone
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000028
2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)-1-(biphenyl-4-yl)ethanone
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000031 - 0.0078
2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)-1-phenylethanone
0.000001 - 0.0000014
2-(3-chloro-4-[5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazol-3-yl]phenyl)pyridine
0.0000011
2-(4-chlorophenyl)-6-[(3,3-dimethylpiperidin-1-yl)carbonyl]pyridine
Homo sapiens
-
pH and temperature not specified in the publication
0.034
2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00026
2-(4-methylphenyl)-2-oxoethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoate
Homo sapiens
-
pH and temperature not specified in the publication
0.00035
2-(adamantan-1-yl)-N-methyl-N-(thiophen-3-ylmethyl)acetamide
Homo sapiens
-
-
0.036
2-(allylamino)-1-thia-3-azaspiro[4.3]oct-2-en-4-one
Homo sapiens
isoform 11beta-HSD1, at pH 7.4 and 37°C
0.0025
2-(allylamino)-1-thia-3-azaspiro[4.5]dec-2-en-4-one
Homo sapiens
isoform 11beta-HSD1, at pH 7.4 and 37°C
0.05
2-(allylamino)-5-(4-bromophenyl)thiazol-4(5H)-one
Homo sapiens
IC50 above 0.05 mM, isoform 11beta-HSD1, at pH 7.4 and 37°C
0.000308
2-adamantan-1-yl-N-methyl-N-thiophen-2-ylmethyl-acetamide
Homo sapiens
-
-
0.00888 - 0.00915
2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane
0.01296 - 0.05557
2-bis-(4-hydroxyphenyl)-1,1,1-trichloroethane
0.00357
2-bromo-N-[2-([2-oxo-2-[(2-phenylethyl)amino]ethyl]sulfanyl)-2,3-dihydro-1,3-benzothiazol-6-yl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00113 - 0.005843
2-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
0.0000005
2-[(1-phenylcyclopropyl)carbonyl]-2-azaspiro[4.5]decane
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000092
2-[(1-pyridin-2-ylcyclopropyl)carbonyl]-2-azaspiro[4.5]decane
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000252
2-[(1-pyridin-4-ylcyclopropyl)carbonyl]-2-azaspiro[4.5]decane
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.0000126
2-[(1S,2S,4R)-bicyclo[2.2.1]hept-2-ylamino]-5-methyl-5-(propan-2-yl)-1,3-thiazol-4(5H)-one
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.000027 - 0.000058
2-[(2-chlorobenzyl)sulfanyl]-4-hydroxy-6-phenylpyrimidine-5-carbonitrile
0.0000001
2-[(3,3-dimethylpiperidin-1-yl)carbonyl]-6-(3-fluoro-4-methylphenyl)pyridine
Homo sapiens
-
pH and temperature not specified in the publication
0.0000011
2-[(3,3-dimethylpiperidin-1-yl)carbonyl]-6-[4-(trifluoromethoxy)phenyl]pyridine
Homo sapiens
-
pH and temperature not specified in the publication
0.000547
2-[(3-benzoyl-2-methyl-1,1-dioxido-2H-1,2-benzothiazin-4-yl)oxy]-1-phenylethanone
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000006 - 0.000307
2-[(3-chlorophenylsulfonamido)methyl]-N-cycloheptyl-N-methylthiazole-4-carboxamide
0.000078 - 0.000279
2-[(3-chlorophenylsulfonamido)methyl]-N-cycloheptyl-N-propylthiazole-4-carboxamide
0.000222 - 0.001055
2-[(3-chlorophenylsulfonamido)methyl]-N-cycloheptylthiazole-4-carboxamide
0.00045
2-[(4-chlorophenyl)acetyl]-2-azaspiro[4.5]decane
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.00141
2-[(4-fluorophenyl)acetyl]-2-azaspiro[4.5]decane
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000019
2-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-1-(tricyclo[3.3.1.13,7]dec-1-yl)ethanone
Homo sapiens
37°C, pH not specified in the publication, cellular assay
0.000031
2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfonyl]-1-(tricyclo[3.3.1.13,7]dec-1-yl)ethanone
Homo sapiens
37°C, pH not specified in the publication, cellular assay
0.000048
2-[1-(2-oxo-2-pyrrolidin-1-ylethyl)cyclopentyl]-N-tricyclo[3.3.1.13,7]dec-2-ylacetamide
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000012 - 0.000094
2-[1-[(3-chloro-2-methylbenzene-1-sulfonyl)amino]cyclopropyl]-N-(tricyclo[3.3.1.1~3,7~]decan-2-yl)acetamide
0.00016
2-[1-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]cyclopentyl]-N-tricyclo[3.3.1.13,7]dec-2-ylacetamide
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000019
2-[1-[2-(benzylamino)-2-oxoethyl]cyclopentyl]-N-tricyclo[3.3.1.13,7]dec-2-ylacetamide
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.00034
2-[1-[2-(cyclopropylamino)-2-oxoethyl]cyclohexyl]-N-tricyclo[3.3.1.13,7]dec-2-ylacetamide
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.00006
2-[1-[2-(cyclopropylamino)-2-oxoethyl]cyclopentyl]-N-tricyclo[3.3.1.13,7]dec-2-ylacetamide
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.003
2-[2-(4,5-dicyclopropyl-4H-1,2,4-triazol-3-yl)propan-2-yl]pyrazine
Homo sapiens
IC50 above 0.003 mM, isoform 11beta-HSD1, at pH 6.6 and 25°C
0.000591
2-[2-(4,5-dicyclopropyl-4H-1,2,4-triazol-3-yl)propan-2-yl]pyridine
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.000017
2-[4-(2,6-difluorobenzenesulfonyl)-[1,4]diazepan-1-yl]-1-(octahydroquinolin-1-yl)-ethanone
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000058
2-[4-(2-adamantan-1-yl-2-oxoethoxy)phenyl]-N,N-dimethyl-acetamide
Homo sapiens
pH not specified in the publication, 37°C
0.000472
2-[4-(2-adamantan-1-yl-2-oxoethoxy)phenyl]-N-benzyl-acetamide
Homo sapiens
pH not specified in the publication, 37°C
0.000912
2-[4-(2-adamantan-1-yl-2-oxoethoxy)phenyl]-N-ethyl-acetamide
Homo sapiens
pH not specified in the publication, 37°C
0.000094
2-[4-(2-adamantan-1-yl-2-oxoethoxy)phenyl]-N-methyl-acetamide
Homo sapiens
pH not specified in the publication, 37°C
0.002194
2-[4-(2-adamantan-1-yl-2-oxoethoxy)phenyl]-N-phenyl-acetamide
Homo sapiens
pH not specified in the publication, 37°C
0.000204
2-[4-(2-adamantan-1-yl-2-oxoethoxy)phenyl]acetamide
Homo sapiens
pH not specified in the publication, 37°C
0.0185
2-[4-(3,4-dimethoxybenzene-1-sulfonyl)piperazin-1-yl]-1-methyl-1H-benzimidazole
Homo sapiens
pH and temperature not specified in the publication
0.0272
2-[4-(4-methoxy-3-nitrobenzene-1-sulfonyl)piperazin-1-yl]-1-methyl-1H-benzimidazole
Homo sapiens
pH and temperature not specified in the publication
0.0042
2-[4-(4-methoxybenzene-1-sulfonyl)piperazin-1-yl]-1-methyl-1H-benzimidazole
Homo sapiens
pH and temperature not specified in the publication
0.02
2-[4-(4-methylbenzene-1-sulfonyl)piperazin-1-yl]-1H-benzimidazole
Homo sapiens
pH and temperature not specified in the publication
0.0048
2-[4-(4-tert-butylphenyl)sulfonylpiperazin-1-yl]-1-methyl-benzimidazole
Homo sapiens
pH and temperature not specified in the publication
0.0064
2-[4-(benzenesulfonyl)piperazin-1-yl]-1-methyl-1H-benzimidazole
Homo sapiens
pH and temperature not specified in the publication
0.000005
2-[4-([(2R)-2-methyl-4-[2-(pyridin-4-yl)ethyl]piperazin-1-yl]sulfonyl)phenyl]propan-2-ol
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000011
2-[4-([(2R)-4-[2,2-difluoro-2-(pyridin-3-yl)ethyl]-2-methylpiperazin-1-yl]sulfonyl)phenyl]-1,1,1-trifluoropropan-2-ol
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000009
2-[4-([(2R)-4-[2,2-difluoro-2-(pyridin-4-yl)ethyl]-2-methylpiperazin-1-yl]sulfonyl)phenyl]-1,1,1-trifluoropropan-2-ol
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000018 - 0.000017
2-[5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazol-3-yl]phenol
0.000006
2-[[1-(4-chlorophenyl)cyclopropyl]carbonyl]-2-azaspiro[4.5]decane
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000003
2-[[1-(4-fluorophenyl)cyclopropyl]carbonyl]-2-azaspiro[4.5]decane
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000619
3,11-dioxoolean-12-en-30-oic acid
Homo sapiens
pH not specified in the publication, 37°C
0.000057
3,3-dimethyl-4-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)-N-tricyclo[3.3.1.13,7]dec-2-ylbutanamide
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000008
3,3-dimethyl-4-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-N-tricyclo[3.3.1.13,7]dec-2-ylbutanamide
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000134
3,4-dicyclopropyl-5-[2-(1H-pyrrol-1-yl)propan-2-yl]-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.000013
3,4-dicyclopropyl-5-[2-(3,5-dichlorothiophen-2-yl)propan-2-yl]-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.000012
3,4-dicyclopropyl-5-[2-(3-fluorothiophen-2-yl)propan-2-yl]-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.000011
3,4-dicyclopropyl-5-[2-(5-fluorothiophen-2-yl)propan-2-yl]-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.000019
3,4-dicyclopropyl-5-[2-(5-methylthiophen-2-yl)propan-2-yl]-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.000023
3,4-dicyclopropyl-5-[2-(thiophen-2-yl)propan-2-yl]-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.000024
3,4-dicyclopropyl-5-[2-[5-(trifluoromethyl)thiophen-2-yl] -propan-2-yl]-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.000007 - 0.000055
3,4-dihydroquinoxalin-1(2H)-yl[3-(1H-pyrazol-4-yl)pyrrolidin-1-yl]methanone
0.000021 - 0.000089
3,5-bis(2,4-dichlorophenyl)-4-methyl-4H-1,2,4-triazole
0.0000029 - 0.000022
3,5-bis(2-chlorophenyl)-4-methyl-4H-1,2,4-triazole
0.0032
3,5-dichloro-N-(2-methyl-1,3-benzothiazol-5-yl)benzamide
Homo sapiens
-
at 37°C
0.0000016
3-(1-(4-fluorophenyl)cyclopropyl)-4-isopropyl-5-(4-(trifluoromethoxy)phenyl)-4H-1,2,4-triazole
Homo sapiens
in PBS buffer, at 37°C
0.0000028 - 0.0000043
3-(1-fluoronaphthalen-2-yl)-4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.000001
3-(1-methoxynaphthalen-2-yl)-4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.000001 - 0.000008
3-(1-phenylcyclobutyl)-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000013 - 0.0001
3-(1-phenylcyclohexyl)-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000002 - 0.000012
3-(1-phenylcyclopentyl)-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000008 - 0.000172
3-(1-phenylcyclopropyl)-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.0000087
3-(1-[6-[(5-hydroxytricyclo[3.3.1.1~3,7~]decan-2-yl)carbamoyl]pyridin-2-yl]piperidin-4-yl)propanoic acid
Homo sapiens
at 37°C, pH not specified in the publication
0.000032 - 0.00026
3-(2,3-difluorophenyl)-4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.000013 - 0.00014
3-(2,4-dichlorophenyl)-4-methyl-5-(2-nitrophenyl)-4H-1,2,4-triazole
0.00009 - 0.00085
3-(2,4-dichlorophenyl)-4-methyl-5-phenyl-4H-1,2,4-triazole
0.00002 - 0.00018
3-(2,4-dichlorophenyl)-5-(2-fluorophenyl)-4-methyl-4H-1,2,4-triazole
0.000057
3-(2-adamantan-1-yl-2-oxoethanesulfinyl)-N,N-dimethylbenzamide
Homo sapiens
pH not specified in the publication, 37°C
0.000069
3-(2-adamantan-1-yl-2-oxoethanesulfonyl)-N,N-dimethylbenzamide
Homo sapiens
pH not specified in the publication, 37°C
0.000527
3-(2-adamantan-1-yl-2-oxoethoxy)-N-benzylbenzamide
Homo sapiens
pH not specified in the publication, 37°C
0.000343
3-(2-adamantan-1-yl-2-oxoethoxy)-N-ethylbenzamide
Homo sapiens
pH not specified in the publication, 37°C
0.000229
3-(2-adamantan-1-yl-2-oxoethoxy)-N-furan-2-ylmethylbenzamide
Homo sapiens
pH not specified in the publication, 37°C
0.001222
3-(2-adamantan-1-yl-2-oxoethoxy)-N-isopropylbenzamide
Homo sapiens
pH not specified in the publication, 37°C
0.000068
3-(2-adamantan-1-yl-2-oxoethoxy)-N-methylbenzamide
Homo sapiens
pH not specified in the publication, 37°C
0.000876
3-(2-adamantan-1-yl-2-oxoethoxy)-N-phenylbenzamide
Homo sapiens
pH not specified in the publication, 37°C
0.001047
3-(2-adamantan-1-yl-2-oxoethoxy)benzamide
Homo sapiens
pH not specified in the publication, 37°C
0.000153
3-(2-adamantan-1-yl-2-oxoethoxy)benzoic acid
Homo sapiens
pH not specified in the publication, 37°C
0.000078
3-(2-adamantan-1-yl-2-oxoethoxy)benzoic acid methyl ester
Homo sapiens
pH not specified in the publication, 37°C
0.000002 - 0.000012
3-(2-bromophenyl)-5-(2-chlorophenyl)-4-methyl-4H-1,2,4-triazole
0.000001 - 0.000008
3-(2-bromophenyl)-5-[4-chloro-2-(trifluoromethyl)phenyl]-4-methyl-4H-1,2,4-triazole
0.0000026 - 0.000042
3-(2-chloro-4-fluorophenyl)-4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.0000058 - 0.000071
3-(2-chloro-4-fluorophenyl)-5-(2-chlorophenyl)-4-methyl-4H-1,2,4-triazole
0.0000077 - 0.00001
3-(2-chlorophenyl)-4-methyl-5-(4-pentylphenyl)-4H-1,2,4-triazole
0.000043 - 0.00019
3-(2-chlorophenyl)-4-methyl-5-phenyl-4H-1,2,4-triazole
0.0000031 - 0.0000086
3-(2-chlorophenyl)-4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.0002 - 0.00041
3-(2-chlorophenyl)-5-(3,4-dichlorophenyl)-4-methyl-4H-1,2,4-triazole
0.00000028 - 0.0000035
3-(2-chlorophenyl)-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.000088 - 0.00014
3-(2-chlorophenyl)-5-[2-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-4H-1,2,4-triazole
0.000118 - 0.004
3-(3,5,7-trimethyladamantyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
0.000089 - 0.0013
3-(3,5-dichlorophenyl)-4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.000104 - 0.01
3-(3,5-dimethyladamantyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
0.00005 - 0.004
3-(3,5-dimethyladamantyl)methyl-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
0.000292 - 0.004
3-(3-bromoadamantyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
0.000001 - 0.0000013
3-(3-chloro-4-[5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazol-3-yl]phenyl)pyridine
0.000001 - 0.0000014
3-(3-chlorobiphenyl-4-yl)-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.0000029 - 0.0000098
3-(3-chloronaphthalen-2-yl)-4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.000001 - 0.000034
3-(3-chlorophenyl)-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.000417 - 0.004
3-(3-fluoroadamantyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
0.001674 - 0.004
3-(3-hydroxyadamantyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
0.000365 - 0.004
3-(3-phenyladamantyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
0.000018 - 0.000068
3-(4-benzylphenyl)-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.000001
3-(4-butyl-2-methylphenyl)-4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.000068 - 0.00026
3-(4-butylphenyl)-4-methyl-5-phenyl-4H-1,2,4-triazole
0.0000023
3-(4-chloro-1-methoxynaphthalen-2-yl)-4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.000015 - 0.0001
3-(4-chloro-2-fluorophenyl)-4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.0000027 - 0.00002
3-(4-chloro-3-methoxynaphthalen-2-yl)-4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.00063 - 0.0015
3-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-4-methyl-4H-1,2,4-triazole
0.0000027 - 0.000043
3-(4-chlorophenyl)-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.0000018 - 0.000014
3-(4-tert-butylphenyl)-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.000001
3-(7-chloro-1-methoxynaphthalen-2-yl)-4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.000035 - 0.004
3-adamant-2-yl-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
0.0000092 - 0.004
3-adamantyl-5,6,7,8,9,10,11,12,13,14-decahydro[1,2,4]triazolo[4,3-a]azacyclododecine
0.0000046 - 0.004
3-adamantyl-5,6,7,8,9,10,11,12-octahydro[1,2,4]triazolo[4,3-a]azecine
0.000016 - 0.01
3-adamantyl-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.001112 - 0.01
3-adamantyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine
0.0000022 - 0.01165
3-adamantyl-6,7,8,9,10,11,12,13-octahydro-5H-[1,2,4]triazolo[4,3-a]azacycloundecine
0.000008 - 0.004563
3-adamantyl-6,7,8,9,10,11-hexahydro-5H-[1,2,4]triazolo[4,3-a]azonine
0.000098 - 0.004
3-adamantyl-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
0.00682 - 0.01
3-adamantyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole
0.000587 - 0.004
3-adamantylmethy-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.00074
3-benzoyl-1,1-dioxido-2-(2-oxo-2-phenylethyl)-2H-1,2-benzothiazin-4-yl trifluoromethanesulfonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000043 - 0.000056
3-biphenyl-3-yl-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.000004 - 0.000011
3-biphenyl-4-yl-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.001024 - 0.002631
3-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)-4-fluorobenzenesulfonamide
0.000576 - 0.001672
3-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
0.003379 - 0.01449
3-chloro-N-[4-(morpholin-4-ylcarbonyl)benzyl]benzenesulfonamide
0.000131 - 0.000647
3-chloro-N-[4-(piperidin-1-ylcarbonyl)benzyl]benzenesulfonamide
0.00048 - 0.001733
3-chloro-N-[4-(pyrrolidin-1-ylcarbonyl)benzyl]benzenesulfonamide
0.001319 - 0.0159
3-chloro-N-[4-[(4-methylpiperazin-1-yl)carbonyl]benzyl]benzenesulfonamide
0.000013
3-cyclobutyl-4-cyclopropyl-5-[2-(thiophen-2-yl)propan-2-yl]-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.00001
3-cyclohexyl-4-cyclopropyl-5-[2-(thiophen-2-yl)propan-2-yl]-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.000014
3-cyclopentyl-4-cyclopropyl-5-[2-(thiophen-2-yl)propan-2-yl]-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.0004 - 0.00354
3-methylchrysazin
0.000016
3-tert-butyl-4-cyclopropyl-5-[2-(thiophen-2-yl)propan-2-yl]-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.0000078 - 0.000098
3-tricyclo[3.3.1.13,7]dec-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine
0.00008 - 0.00064
3-[(3-chloro-2-methylbenzene-1-sulfonyl)amino]-3-methyl-N-(tricyclo[3.3.1.1~3,7~]decan-1-yl)butanamide
0.000004 - 0.00013
3-[(3-chloro-2-methylbenzene-1-sulfonyl)amino]-3-methyl-N-(tricyclo[3.3.1.1~3,7~]decan-2-yl)butanamide
0.00019
3-[(3-chloro-2-methylbenzene-1-sulfonyl)amino]-N-cycloheptyl-3-methylbutanamide
Homo sapiens
pH and temperature not specified in the publication
0.00039
3-[(3-chloro-2-methylbenzene-1-sulfonyl)amino]-N-cyclohexyl-3-methylbutanamide
Homo sapiens
pH and temperature not specified in the publication
0.000054 - 0.001
3-[(3-chloro-2-methylbenzene-1-sulfonyl)amino]-N-[(2s,5r)-5-(methanesulfonyl)tricyclo[3.3.1.1~3,7~]decan-2-yl]-3-methylbutanamide
0.000004 - 0.00007
3-[(3-chloro-2-methylbenzene-1-sulfonyl)amino]-N-[(2s,5r)-5-hydroxytricyclo[3.3.1.1~3,7~]decan-2-yl]-3-methylbutanamide
0.12 - 0.82
3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate
0.000002 - 0.000199
3-[1-(2,4-dichlorophenyl)cyclopropyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000001 - 0.000016
3-[1-(2-fluorophenyl)cyclobutyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000001 - 0.000027
3-[1-(2-fluorophenyl)cyclopentyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000001 - 0.000078
3-[1-(2-methylphenyl)cyclobutyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000114
3-[1-(3-chlorophenyl)-1H-tetrazol-5-yl]-1-phenylpropan-1-one
Homo sapiens
pH 7.0, 22°C, cellular assay
0.000002 - 0.000019
3-[1-(3-fluorophenyl)cyclobutyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000002 - 0.000052
3-[1-(3-methylphenyl)cyclobutyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.00001 - 0.000057
3-[1-(3-methylphenyl)cyclopentyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000035 - 0.000107
3-[1-(4-chlorophenyl)-3,3-difluorocyclobutyl]-4,5-dicyclopropyl-4H-1,2,4-triazole
0.000005 - 0.000021
3-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-5-(2-methylphenyl)-4H-1,2,4-triazole
0.0000037 - 0.000026
3-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-5-(4-phenoxyphenyl)-4H-1,2,4-triazole
0.0000017 - 0.000052
3-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-5-phenyl-4H-1,2,4-triazole
0.0000023 - 0.0000041
3-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-5-[2-(trifluoromethoxy)phenyl]-4H-1,2,4-triazole
0.000002 - 0.000004
3-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.0000022 - 0.000036
3-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-5-[3-(trifluoromethoxy)phenyl]-4H-1,2,4-triazole
0.0000031 - 0.000044
3-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-5-[4-(1,3-thiazol-2-yl)phenyl]-4H-1,2,4-triazole
0.000003 - 0.0000054
3-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-5-[4-(1H-pyrrol-1-yl)phenyl]-4H-1,2,4-triazole
0.0000069 - 0.000013
3-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-5-[4-(trifluoromethoxy)phenyl]-4H-1,2,4-triazole
0.0000093 - 0.000026
3-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-5-[4-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.000001 - 0.000014
3-[1-(4-chlorophenyl)cyclobutyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000001 - 0.000013
3-[1-(4-chlorophenyl)cyclobutyl]-5-(2,4-dichlorophenyl)-4-methyl-4H-1,2,4-triazole
0.000002 - 0.000021
3-[1-(4-chlorophenyl)cyclobutyl]-5-(2-fluorophenyl)-4-methyl-4H-1,2,4-triazole
0.0000027 - 0.0000078
3-[1-(4-chlorophenyl)cyclobutyl]-5-(2-methoxyphenyl)-4-methyl-4H-1,2,4-triazole
0.000003 - 0.000042
3-[1-(4-chlorophenyl)cyclobutyl]-5-(3-fluoro-4-methoxyphenyl)-4-methyl-4H-1,2,4-triazole
0.0000022 - 0.000163
3-[1-(4-chlorophenyl)cyclobutyl]-5-(3-fluorophenyl)-4-methyl-4H-1,2,4-triazole
0.0000091 - 0.000011
3-[1-(4-chlorophenyl)cyclobutyl]-5-(4'-fluorobiphenyl-4-yl)-4-methyl-4H-1,2,4-triazole
0.0000015 - 0.000101
3-[1-(4-chlorophenyl)cyclobutyl]-5-(4-fluorophenyl)-4-methyl-4H-1,2,4-triazole
0.0000038 - 0.0000082
3-[1-(4-chlorophenyl)cyclobutyl]-5-(4-iodophenyl)-4-methyl-4H-1,2,4-triazole
0.00000096 - 0.00000098
3-[1-(4-chlorophenyl)cyclobutyl]-5-[2-chloro-4-[2-(trifluoromethyl)-1H-imidazol-1-yl]phenyl]-4-methyl-4H-1,2,4-triazole
0.0000035 - 0.000046
3-[1-(4-chlorophenyl)cyclobutyl]-5-[4-(1H-imidazol-1-yl)phenyl]-4-methyl-4H-1,2,4-triazole
0.0000022
3-[1-(4-chlorophenyl)cyclobutyl]-5-[4-(cyclopropyloxy)phenyl]-4-methyl-4H-1,2,4-triazole
0.000032 - 0.000454
3-[1-(4-chlorophenyl)cyclohexyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000002 - 0.000041
3-[1-(4-chlorophenyl)cyclopentyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000002 - 0.00023
3-[1-(4-chlorophenyl)cyclopropyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000003 - 0.000037
3-[1-(4-fluorophenyl)cyclobutyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000027 - 0.000494
3-[1-(4-fluorophenyl)cyclohexyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000008 - 0.000018
3-[1-(4-fluorophenyl)cyclopentyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000002 - 0.000019
3-[1-(4-methylphenyl)cyclobutyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000015 - 0.000374
3-[1-(4-methylphenyl)cyclohexyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000002 - 0.000025
3-[1-(4-methylphenyl)cyclopentyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000001 - 0.000332
3-[1-(4-methylphenyl)cyclopropyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000043 - 0.000061
3-[1-(5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocin-3-yl)cyclopentyl]phenol
0.00017
3-[1-[(4-methoxy-3-methylphenyl)carbonyl]piperidin-4-yl]-1,3-benzothiazol-2(3H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00027
3-[1-[(4-methoxy-3-methylphenyl)carbonyl]piperidin-4-yl]-1,3-benzoxazol-2(3H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00024
3-[1-[(4-methoxy-3-methylphenyl)carbonyl]piperidin-4-yl]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00018
3-[1-[(4-methoxy-3-methylphenyl)carbonyl]piperidin-4-yl]-1-methyl-1,3-dihydro-2H-benzimidazol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00014
3-[1-[(4-methoxy-3-methylphenyl)carbonyl]piperidin-4-yl]-4-methyl-1,3-dihydro-2H-benzimidazol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000005 - 0.000355
3-[1-[2-(trifluoromethyl)phenyl]cyclobutyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.000002 - 0.000115
3-[1-[4-(trifluoromethyl)phenyl]cyclobutyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine
0.0000036 - 0.000022
3-[2,3-bis(trifluoromethyl)phenyl]-4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.000014
3-[2-(3-chlorothiophen-2-yl)propan-2-yl]-4,5-dicyclopropyl-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.000012
3-[2-(4-bromothiophen-2-yl)propan-2-yl]-4,5-dicyclopropyl-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.0000079
3-[2-(5-bromothiophen-2-yl)propan-2-yl]-4,5-dicyclopropyl-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.000043
3-[2-(5-bromothiophen-2-yl)propan-2-yl]-5-cyclopropyl-4-(2-phenylethyl)-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.000012
3-[2-(5-bromothiophen-2-yl)propan-2-yl]-5-cyclopropyl-4-(cyclopropylmethyl)-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.000014
3-[2-(5-bromothiophen-2-yl)propan-2-yl]-5-cyclopropyl-4-(propan-2-yl)-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.0000096
3-[2-(5-bromothiophen-2-yl)propan-2-yl]-5-cyclopropyl-4-ethyl-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.0000048
3-[2-(5-bromothiophen-2-yl)propan-2-yl]-5-cyclopropyl-4-methyl-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.0000086
3-[2-(5-bromothiophen-2-yl)propan-2-yl]-5-cyclopropyl-4-propyl-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.0000087
3-[2-(5-chloro-3-fluorothiophen-2-yl)propan-2-yl]-4,5-dicyclopropyl-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.000015
3-[2-(5-chlorothiophen-2-yl)propan-2-yl]-4,5-dicyclopropyl-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.000001 - 0.0000028
3-[2-chloro-4-(1H-imidazol-1-yl)phenyl]-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.0000069 - 0.0000072
3-[2-chloro-4-(2,4-dimethyl-1H-imidazol-1-yl)phenyl]-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.000006 - 0.0000098
3-[2-chloro-4-(2-cyclopropyl-4-methyl-1H-imidazol-1-yl)phenyl]-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.0000026 - 0.0000096
3-[2-chloro-4-(2-methyl-1H-imidazol-1-yl)phenyl]-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.0000039
3-[2-chloro-4-[2-(methylsulfanyl)-1H-imidazol-1-yl]phenyl]-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.0000094 - 0.000014
3-[2-chloro-4-[2-(methylsulfonyl)-1H-imidazol-1-yl]phenyl]-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.0000084 - 0.000028
3-[2-chloro-4-[3-(ethylsulfonyl)propyl]phenyl]-4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.0000047 - 0.000011
3-[3-chloro-2'-(ethylsulfanyl)biphenyl-4-yl]-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.00000098 - 0.0000012
3-[3-chloro-2'-(ethylsulfonyl)biphenyl-4-yl]-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.00000098
3-[3-chloro-3'-(ethylsulfonyl)biphenyl-4-yl]-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.00000098
3-[3-chloro-3'-(methylsulfonyl)biphenyl-4-yl]-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.00000098 - 0.0000021
3-[3-chloro-4'-(ethylsulfonyl)biphenyl-4-yl]-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.0000012 - 0.0000017
3-[3-chloro-4'-(methylsulfonyl)biphenyl-4-yl]-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazole
0.00000098 - 0.0000071
3-[4-chloro-2-(trifluoromethyl)phenyl]-4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.0000013 - 0.000011
3-[4-chloro-2-(trifluoromethyl)phenyl]-5-(2,4-dichlorophenyl)-4-methyl-4H-1,2,4-triazole
0.0000064 - 0.000028
3-[4-[2-(ethylsulfonyl)ethyl]-2-methylphenyl]-4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.000011 - 0.000034
3-[4-[3-(ethylsulfonyl)propyl]-2-methylphenyl]-4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.000001 - 0.000019
3-[5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazol-3-yl]phenol
0.000005 - 0.000016
3-[cis-1-(4-chlorophenyl)-3-fluorocyclobutyl]-4,5-dicyclopropyl-4H-1,2,4-triazole
0.000022 - 0.000038
3-[trans-1-(4-chlorophenyl)-3-fluorocyclobutyl]-4,5-dicyclopropyl-4H-1,2,4-triazole
0.000146
3-[[2-(adamantan-1-yl)-2-oxoethyl]sulfanyl]-N,N-dimethyl benzamide
Homo sapiens
pH not specified in the publication, 37°C
0.000124
3-[[2-(adamantan-1-yl)-2-oxoethyl]sulfanyl]-N-methylbenzamide
Homo sapiens
pH not specified in the publication, 37°C
0.0008
3alpha,5alpha-tetrahydro-dehydrocortisterone
Ovis aries
-
pH 8.4, 37°C
0.0005
3alpha,5alpha-tetrahydroaldosterone
Ovis aries
-
pH 8.4, 37°C
0.00026 - 0.05
3alpha,5alpha-tetrahydrocorticosterone
0.008
3alpha,5alpha-tetrahydrocortisol
Ovis aries
-
pH 8.4, 37°C
0.0003
3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000496
4-((S)-2-acetamido-3-((R)-2-((adamantan-2-yl)carbamoyl)pyrrolidin-1-yl)-3-oxopropyl)phenyl acetate
Homo sapiens
at pH 7.4 and 37°C
0.0000012
4-(1-[[(3R)-3-methyl-4-[[4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl]sulfonyl]piperazin-1-yl]methyl]cyclopropyl)benzamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000002 - 0.0000026
4-(2'-fluoro[1,1'-biphenyl]-4-yl)-4-[(1H-tetrazol-5-yl)methyl]octahydro-2,5-methanopentalen-1-ol
0.000798
4-(2-adamantan-1-yl-2-oxoethoxy)-N,N-diethylbenzamide
Homo sapiens
pH not specified in the publication, 37°C
0.001959
4-(2-adamantan-1-yl-2-oxoethoxy)-N-benzylbenzamide
Homo sapiens
pH not specified in the publication, 37°C
0.000382
4-(2-adamantan-1-yl-2-oxoethoxy)-N-ethylbenzamide
Homo sapiens
pH not specified in the publication, 37°C
0.000594
4-(2-adamantan-1-yl-2-oxoethoxy)-N-isopropylbenzamide
Homo sapiens
pH not specified in the publication, 37°C
0.000283
4-(2-adamantan-1-yl-2-oxoethoxy)-N-phenylbenzamide
Homo sapiens
pH not specified in the publication, 37°C
0.00114
4-(2-adamantan-1-yl-2-oxoethoxy)-N-tert-butylbenzamide
Homo sapiens
pH not specified in the publication, 37°C
0.000117
4-(2-adamantan-1-yl-2-oxoethoxy)benzamide
Homo sapiens
pH not specified in the publication, 37°C
0.000074
4-(2-adamantan-1-yl-2-oxoethoxy)benzoic acid
Homo sapiens
pH not specified in the publication, 37°C
0.000056
4-(2-adamantan-1-yl-2-oxoethoxymethyl)-N,N-dimethylbenzamide
Homo sapiens
pH not specified in the publication, 37°C
0.00025
4-(2-adamantan-1-yl-2-oxoethoxymethyl)-N-methylbenzamide
Homo sapiens
pH not specified in the publication, 37°C
0.000359
4-(2-adamantan-1-yl-2-oxoethoxymethyl)benzoic acid
Homo sapiens
pH not specified in the publication, 37°C
0.000025 - 0.000193
4-(2-[1-[(2-fluorobenzene-1-sulfonyl)amino]cyclopropyl]-2-methylpropanamido)tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000006
4-(3'-fluoro[1,1'-biphenyl]-4-yl)-4-[(1H-tetrazol-5-yl)methyl]octahydro-2,5-methanopentalen-1-ol
Homo sapiens
pH and temperature not specified in the publication
0.000001 - 0.000002
4-(3-chloro-4-[5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazol-3-yl]phenyl)pyridine
0.000012
4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-3,3-dimethyl-N-tricyclo[3.3.1.13,7]dec-2-ylbutanamide
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.00001
4-(4'-fluoro[1,1'-biphenyl]-4-yl)-4-[(1H-tetrazol-5-yl)methyl]octahydro-2,5-methanopentalen-1-ol
Homo sapiens
pH and temperature not specified in the publication
0.000008
4-(4'-methoxy[1,1'-biphenyl]-4-yl)-4-[(1H-tetrazol-5-yl)methyl]octahydro-2,5-methanopentalen-1-ol
Homo sapiens
pH and temperature not specified in the publication
0.000026
4-(4-phenoxyphenyl)-4-[(1H-tetrazol-5-yl)methyl]octahydro-2,5-methanopentalen-1-ol
Homo sapiens
pH and temperature not specified in the publication
0.000107
4-(phenylethynyl)-4-[(1H-tetrazol-5-yl)methyl]octahydro-2,5-methanopentalen-1-ol
Homo sapiens
pH and temperature not specified in the publication
0.001
4-([(3R)-3-[(2-fluorobenzene-1-sulfonyl)amino]-4-hydroxy-2,2-dimethylbutanoyl]amino)tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.0000073
4-([(3R)-4-[(4-tert-butylphenyl)sulfonyl]-3-methylpiperazin-1-yl]methyl)-5,8-dihydroquinoline
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.001
4-([(3S)-3-[(2-fluorobenzene-1-sulfonyl)amino]-4-hydroxy-2,2-dimethylbutanoyl]amino)tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.00064
4-([1,1'-biphenyl]-3-yl)-4-[(1H-tetrazol-5-yl)methyl]octahydro-2,5-methanopentalen-1-ol
Homo sapiens
pH and temperature not specified in the publication
0.000152
4-([1,1'-biphenyl]-4-yl)-4-[(1H-tetrazol-5-yl)methyl]hexahydro-2,5-methanopentalen-2(1H)-ol
Homo sapiens
pH and temperature not specified in the publication
0.000008
4-([1-[4-([(2R)-2-methyl-4-[2-(pyridin-4-yl)ethyl]piperazin-1-yl]sulfonyl)phenyl]cyclopropyl]methyl)morpholine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000395 - 0.002106
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N,N-diethylbenzamide
0.00001 - 0.000014
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-(tricyclo[3.3.1.13,7]dec-1-yl)benzamide
0.000002 - 0.000638
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptyl-N-methylbenzamide
0.000002
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptyl-N-propylbenzamide
0.000015 - 0.000049
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptylbenzamide
0.000302 - 0.000411
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cyclohexylbenzamide
0.000732 - 0.008512
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cyclopentylbenzamide
0.000022
4-benzyl-3-[2-(5-bromothiophen-2-yl)propan-2-yl]-5-cyclopropyl-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.00408
4-benzyl-4-[(1H-tetrazol-5-yl)methyl]octahydro-2,5-methanopentalen-1-ol
Homo sapiens
pH and temperature not specified in the publication
0.001404 - 0.002698
4-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
0.000051
4-cyclopropyl-3-(cyclopropylmethyl)-5-[2-(thiophen-2-yl)propan-2-yl]-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.000051
4-cyclopropyl-3-propyl-5-[2-(thiophen-2-yl)propan-2-yl]-4H-1,2,4-triazole
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.003
4-cyclopropyl-3-[2-(thiophen-2-yl)propan-2-yl]-4H-1,2,4-triazole
Homo sapiens
IC50 above 0.003 mM, isoform 11beta-HSD1, at pH 6.6 and 25°C
0.0000046 - 0.000046
4-methyl-3-(2-methylnaphthalen-1-yl)-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.000054 - 0.00025
4-methyl-3-(4-pentylphenyl)-5-phenyl-4H-1,2,4-triazole
0.0000029 - 0.0000052
4-methyl-3-(4-pentylphenyl)-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.000009 - 0.00001
4-methyl-3-(7-methylnaphthalen-2-yl)-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.000015 - 0.000026
4-methyl-3-naphthalen-2-yl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.0000078 - 0.000098
4-methyl-3-phenyl-5-(tricyclo[3.3.1.13,7]dec-1-yl)-4H-1,2,4-triazole
0.000037 - 0.000109
4-methyl-3-phenyl-5-tricyclo[3.3.1.13,7]dec-1-yl-4H-1,2,4-triazole
0.000027 - 0.00012
4-methyl-3-phenyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
0.0000013 - 0.0000045
4-methyl-3-[2-(trifluoromethoxy)phenyl]-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole
49.3
4-nonylphenol
Homo sapiens
-
inhibition of liver isozyme 11beta-HSD1, pH 7.4, 37°C
0.00019
4-phenyl-4-[(1H-tetrazol-5-yl)methyl]octahydro-2,5-methanopentalen-1-ol
Homo sapiens
pH and temperature not specified in the publication
0.1
4-pregnen-11,17-diol-3,20-dione
Rattus sp.
-
IC50: 0.1 mM
0.0095
4-pregnen-11alpha-ol-3,20-dione
Rattus sp.
-
IC50: 0.0095 mM
0.011
4-pregnen-11beta-ol-3,20-dione
Rattus sp.
-
IC50: 0.011 mM
0.9
4-pregnen-16alpha-ol-3,20-dione
Rattus sp.
-
IC50: 0.9 mM
0.07
4-pregnen-17,21-diol-3,20-dione
Rattus sp.
-
IC50: 0.07 mM
0.115
4-pregnen-17alpha,20alpha-diol-3-one
Rattus sp.
-
IC50: 0.115 mM
0.19
4-pregnen-17alpha-ol-3,20-dione
Rattus sp.
-
IC50: 0.19 mM
0.022
4-pregnen-20alpha-ol-3-one
Rattus sp.
-
IC50: 0.022 mM
0.031
4-pregnen-20beta-ol-3-one
Rattus sp.
-
IC50: 0.031 mM
0.031
4-pregnen-21-ol-3,20-dione
Rattus sp.
-
IC50: 0.031 mM
0.19
4-pregnen-3,11,20-trione
Rattus sp.
-
IC50: 0.19 mM
0.015
4-pregnen-3,20-dione
Rattus sp.
-
IC50: 0.015 mM
0.000008
4-[(1H-tetrazol-5-yl)methyl]-4-[3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]octahydro-2,5-methanopentalen-1-ol
Homo sapiens
pH and temperature not specified in the publication
0.0000023
4-[(1H-tetrazol-5-yl)methyl]-4-[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]octahydro-2,5-methanopentalen-1-ol
Homo sapiens
pH and temperature not specified in the publication
0.00072
4-[(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)acetyl]benzoic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00004 - 0.009
4-[(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)acetyl]benzonitrile
0.00195
4-[(E)-[(2Z)-2-[(2-chlorophenyl)imino]-4-oxo-1,3-thiazolidin-5-ylidene]methyl]-2-methoxyphenyl benzoate
Homo sapiens
-
pH and temperature not specified in the publication
0.00013 - 0.001
4-[(N-[4-[(dimethylamino)methoxy]benzene-1-sulfonyl]-2-methylalanyl)amino]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000282
4-[([1,1'-biphenyl]-4-yl)methyl]-4-[(1H-tetrazol-5-yl)methyl]octahydro-2,5-methanopentalen-1-ol
Homo sapiens
pH and temperature not specified in the publication
0.000006 - 0.000013
4-[2-(1-[[(2-fluorobenzene-1-sulfonyl)amino]methyl]cyclopropyl)-2-methylpropanamido]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000343
4-[2-(4,5-dicyclopropyl-4H-1,2,4-triazol-3-yl)propan-2-yl]pyridine
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.0002
4-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]-3,3-dimethyl-N-tricyclo[3.3.1.13,7]dec-2-ylbutanamide
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.001
4-[3-[(2-fluorobenzene-1-sulfonyl)amino]-2,2-dimethylpropanamido]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000102
4-[4-(pyridin-3-yl)phenyl]-4-[(1H-tetrazol-5-yl)methyl]octahydro-2,5-methanopentalen-1-ol
Homo sapiens
pH and temperature not specified in the publication
0.000014
4-[4-(pyridin-4-yl)phenyl]-4-[(1H-tetrazol-5-yl)methyl]octahydro-2,5-methanopentalen-1-ol
Homo sapiens
pH and temperature not specified in the publication
0.00001 - 0.000069
4-[4-([(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl]sulfonyl)phenyl]morpholine
0.0000039 - 0.0000066
4-[4-methyl-5-(1-methyl-1H-indol-4-yl)-4H-1,2,4-triazol-3-yl]phenol
0.000009 - 0.000204
4-[4-[(2-fluorobenzene-1-sulfonyl)amino]-2,2,3,3-tetramethylbutanamido]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.001
4-[4-[(2-fluorobenzene-1-sulfonyl)amino]-2,2-dimethylbutanamido]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000037 - 0.000075
4-[4-[[3-(1H-pyrazol-4-yl)pyrrolidin-1-yl]carbonyl]-3,4-dihydroquinoxalin-1(2H)-yl]benzonitrile
0.00000098 - 0.0000012
4-[5-(2-chlorophenyl)-4-methyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole
0.000002 - 0.000061
4-[5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazol-3-yl]-2-fluorophenol
0.00000034 - 0.000019
4-[5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-4H-1,2,4-triazol-3-yl]phenol
0.000014 - 0.000207
4-[[2-methyl-N-(2,4,5-trifluorobenzene-1-sulfonyl)alanyl]amino]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.0000003 - 0.000172
4-[[N-(2,5-dichlorobenzene-1-sulfonyl)-2-methylalanyl]amino]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.0000004 - 0.000012
4-[[N-(2,6-difluorobenzene-1-sulfonyl)-2-methylalanyl]amino]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.0000001 - 0.00001
4-[[N-(2-chloro-4-fluorobenzene-1-sulfonyl)-2-methylalanyl]amino]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.0000006 - 0.000026
4-[[N-(2-fluorobenzene-1-sulfonyl)-2-methylalanyl]amino]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.001
4-[[N-(2-fluorobenzene-1-sulfonyl)-2-methylalanyl]amino]tricyclo[3.3.1.1~3,7~]decane-1-carboxylic acid
0.0000002 - 0.000008
4-[[N-(3,5-dichlorobenzene-1-sulfonyl)-2-methylalanyl]amino]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.00001 - 0.000018
4-[[N-(3,5-difluorobenzene-1-sulfonyl)-2-methylalanyl]amino]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000013 - 0.001
4-[[N-(3-chloro-2-fluorobenzene-1-sulfonyl)-2-methylalanyl]amino]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000001 - 0.000012
4-[[N-(3-chlorobenzene-1-sulfonyl)-2-methylalanyl]amino]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000034 - 0.00013
4-[[N-(4-chlorobenzene-1-sulfonyl)-2-methylalanyl]amino]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000044 - 0.000084
4-[[N-(4-hydroxybenzene-1-sulfonyl)-2-methylalanyl]amino]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000002 - 0.000056
4-[[N-(4-tert-butylbenzene-1-sulfonyl)-2-methylalanyl]amino]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000002 - 0.000028
4-[[N-(benzenesulfonyl)-2-methylalanyl]amino]tricyclo[3.3.1.1~3,7~]decane-1-carboxamide
0.000449
5-(2-[1-[(3-chlorophenyl)methyl]octahydro-2,5-methanopentalen-1-yl]ethyl)-1H-tetrazole
Homo sapiens
pH and temperature not specified in the publication
0.000012 - 0.00103
5-(3-chloro-2-methylphenoxy)-3-(4-hydroxybicyclo[2.2.2]oct-1-yl)-[1,2,4]triazolo[4,3-a]pyridine
0.000435
5-(adamantan-1-ylcarbonyl)-4H,5H,6H,7H-thieno[3,2-c]pyridine
Homo sapiens
-
-
0.000014 - 0.004
5-adamantyl-3-benzyl-4-methyl-4H-1,2,4-triazole
0.000091 - 0.004
5-adamantyl-3-butyl-4-methyl-4H-1,2,4-triazole
0.000023 - 0.00005
5-adamantyl-3-ethyl-4-propyl-4H-1,2,4-triazole
0.00027 - 0.004
5-adamantyl-3-methyl-4-butyl-4H-1,2,4-triazole
0.000109 - 0.004
5-adamantyl-3-phenyl-4-methyl-4H-1,2,4-triazole
0.00005 - 0.004
5-adamantyl-3-propyl-4-ethyl-4H-1,2,4-triazole
0.0002
5-fluoro-1-[1-[(4-methoxy-3-methylphenyl)carbonyl]piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0095
5-pregnen-3beta,11beta-diol-20-one
Rattus sp.
-
IC50: 0.0095 mM
0.000085
5-[2-(1-phenyloctahydro-2,5-methanopentalen-1-yl)ethyl]-1H-tetrazole
Homo sapiens
pH and temperature not specified in the publication
0.000095
5-[2-(4,5-dicyclopropyl-4H-1,2,4-triazol-3-yl)propan-2-yl]thiophene-2-carbonitrile
Homo sapiens
isoform 11beta-HSD1, at pH 6.6 and 25°C
0.000052
5-[2-[1-(4-fluorophenyl)octahydro-2,5-methanopentalen-1-yl]ethyl]-1H-tetrazole
Homo sapiens
pH and temperature not specified in the publication
0.0000048
5-[2-[1-([1,1'-biphenyl]-4-yl)octahydro-2,5-methanopentalen-1-yl]ethyl]-1H-tetrazole
Homo sapiens
pH and temperature not specified in the publication
0.000002
5-[[1-([1,1'-biphenyl]-4-yl)-3a-methoxyoctahydro-2,5-methanopentalen-1-yl]methyl]-1H-tetrazole
Homo sapiens
pH and temperature not specified in the publication
0.00015 - 0.0063
5alpha-dihydrocorticosterone
0.0027
5alpha-pregnan-11alpha-ol-3,20-dione
Rattus sp.
-
IC50: 0.0027 mM
0.04
5alpha-pregnan-11beta,17alpha,21-triol-3,20-dione
Rattus sp.
-
IC50: 0.04 mM
0.0075
5alpha-pregnan-11beta,21-diol-3,20-dione
Rattus sp.
-
IC50: 0.0075 mM
0.18
5alpha-pregnan-3alpha,11beta,17alpha,21-tetrol-20-one
Rattus sp.
-
IC50: 0.18 mM
0.008
5alpha-pregnan-3alpha,11beta,21-triol-20-one
Rattus sp.
-
IC50: 0.008 mM
0.016
5alpha-pregnan-3alpha,11beta-diol-20-one
Rattus sp.
-
IC50: 0.016 mM
0.24
5alpha-pregnan-3alpha,17alpha,21-triol-11,20-dione
Rattus sp.
-
IC50: 0.24 mM
0.029
5alpha-pregnan-3alpha,21-diol-11,20-dione
Rattus sp.
-
IC50: 0.029 mM
0.031
5alpha-Pregnan-3alpha,21-diol-20-one
Rattus sp.
-
IC50: 0.031 mM
0.014
5alpha-pregnan-3alpha-ol-20-one
Rattus sp.
-
IC50: 0.014 mM
0.08
5beta-pregnan-3alpha,11alpha-diol-20-one
Rattus sp.
-
IC50: 0.08 mM
0.12
5beta-pregnan-3alpha,11beta,17alpha,21-tetrol-20-one
Rattus sp.
-
IC50: 0.12 mM
0.14
5beta-pregnan-3alpha,11beta,21-triol-20-one
Rattus sp.
-
IC50: 0.14 mM
0.003
5beta-Pregnan-3alpha,21-diol-20-one
Rattus sp.
-
IC50: 0.003 mM
0.012
5beta-Pregnan-3alpha-ol-20-one
Rattus sp.
-
IC50: 0.012 mM
0.0000068
6-(4-benzylpiperazin-1-yl)-N-(5-hydroxytricyclo[3.3.1.1~3,7~]decan-2-yl)pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.0000039
6-(4-hydroxy-4-methylpiperidin-1-yl)-N-(5-hydroxytricyclo[3.3.1.1~3,7~]decan-2-yl)pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.0000032
6-(4-hydroxy-4-phenylpiperidin-1-yl)-N-(5-hydroxytricyclo[3.3.1.1~3,7~]decan-2-yl)pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.0000032
6-(4-hydroxy-4-propylpiperidin-1-yl)-N-(5-hydroxytricyclo[3.3.1.1~3,7~]decan-2-yl)pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.001929
6-([1,1'-biphenyl]-4-yl)-6-[(1H-tetrazol-5-yl)methyl]tetrahydro-2,5-methanopentalene-2,3a(1H,3H)-diol
Homo sapiens
pH and temperature not specified in the publication
0.0025
6-fluoro-4'-[(1-phenylcyclopropyl)methyl]spiro[chromene-2,1'-cyclohexan]-4(3H)-one
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000045 - 0.000057
6-[(3-chlorophenylsulfonamido)methyl]-N-cycloheptyl-N-methylnicotinamide
0.00008 - 0.000375
6-[(3-chlorophenylsulfonamido)methyl]-N-cycloheptyl-N-propylnicotinamide
0.000849
6-[(3-chlorophenylsulfonamido)methyl]-N-cycloheptylnicotinamide
Mus musculus
pH 7.4, 37°C
0.0000066
6-[4-(2-amino-2-oxoethyl)piperidin-1-yl]-N-(5-hydroxytricyclo[3.3.1.1~3,7~]decan-2-yl)pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.0000041
6-[4-(3-amino-3-oxopropyl)piperidin-1-yl]-N-(5-hydroxytricyclo[3.3.1.1~3,7~]decan-2-yl)pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.0000028
6-[4-(4-cyanophenyl)piperazin-1-yl]-N-(5-hydroxytricyclo[3.3.1.1~3,7~]decan-2-yl)pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.0000031
6-[4-(4-hydroxyphenyl)piperazin-1-yl]-N-(5-hydroxytricyclo[3.3.1.1~3,7~]decan-2-yl)pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.0000019
6-[4-(hydroxymethyl)piperidin-1-yl]-N-(5-hydroxytricyclo[3.3.1.1~3,7~]decan-2-yl)pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.0069
7-(cyclohexylmethyl)-2-iodomethyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-5-one
Homo sapiens
isoform 11beta-HSD1, at pH 7.4 and 37°C
0.000019 - 0.000089
7-chloro-2-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]naphthalen-1-ol
0.00024
7-hydroxy-2-(2-hydroxyethyl)-6-(3-methylbut-2-en-1-yl)-3-oxo-2,3-dihydro-1H-isoindol-5-yl 2,4-dihydroxy-6-methylbenzoate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00023
7-hydroxy-6-(3-methylbut-2-en-1-yl)-3-oxo-2,3-dihydro-1H-isoindol-5-yl 2,4-dihydroxy-6-methylbenzoate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000049 - 0.002
7-keto,25-hydroxycholesterol
0.000015 - 0.000357
7-keto,27-hydroxycholesterol
0.0194
7-oxo-cholesterol
Mus musculus
-
recombinant enzyme, at pH 7.4 and 37°C
0.000091 - 0.003
7beta,25-dihydroxycholesterol
0.000011 - 0.003
7beta,27-dihydroxycholesterol
0.0022
7beta-hydroxycholesterol
Mus musculus
-
recombinant enzyme, at pH 7.4 and 37°C
0.000003 - 0.000035
8,8-dimethyl-5-(1-hydroxytricyclo[3.3.1.13,7]dec-3-yl)-1-(4-chlorophenyl)-5,6,7,8-tetrahydropyrazolo[4,3-c]azepin-4(1H)-one
0.0000089 - 0.0000098
8,8-dimethyl-5-(1-hydroxytricyclo[3.3.1.13,7]dec-3-yl)-1-phenyl-5,6,7,8-tetrahydropyrazolo[4,3-c]azepin-4(1H)-one
0.000012 - 0.000105
8-[[(2-cyanopyridin-3-yl)methyl]sulfanyl]-6-hydroxy-3,4-dihydro-1H-pyrano[3,4-c]pyridine-5-carbonitrile
0.000098 - 0.000879
Aloe-emodin
0.000042
alpha-glycyrrhetinic acid
Rattus sp.
-
oxidase, IC50: 14 nmol, reductase, IC50: 42 nmol
0.000007 - 0.00047
AMG-221
0.0000025
azonan-1-yl(6-[[(2,6-dichlorophenyl)sulfonyl]methyl]pyridin-2-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.01197
BDE-100
Homo sapiens
-
pH and temperature not specified in the publication
0.00441
BDE-153
Homo sapiens
-
pH and temperature not specified in the publication
0.01242
BDE-3
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00595
BDE-47
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000013
beta-glycyrrhetinic acid
Rattus sp.
-
oxidase, IC50: 2.9 nmol, reductase, IC50: 13 nmol
0.01481 - 0.01939
bisphenol A
0.01399 - 0.06925
butylated hydroxyanisole
0.000052
BVT-14225
Homo sapiens
-
isozyme 11beta-HSD1 IC50: 52 nM, 1000fold less potent against isozyme 11beta-HSD2, pH and temperature not specified in the publication
0.000281 - 0.0005
carbenoxolone
0.00074
danazol
Homo sapiens
pH and temperature not specified in the publication
0.00195
dibutyltin
Homo sapiens
pH and temperature not specified in the publication
0.0017
diethyldithiocarbamate
Homo sapiens
pH and temperature not specified in the publication
49.4
diethylhexyl adipate
Homo sapiens
-
inhibition of liver isozyme 11beta-HSD1, pH 7.4, 37°C
0.00142
diphenyltin
Homo sapiens
pH and temperature not specified in the publication
0.000128
Disulfiram
Homo sapiens
pH and temperature not specified in the publication
0.000086 - 0.000186
emodin
0.000068 - 0.2
ethyl (3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-oate
0.003
ethyl 4-hydroxy-2-(2-oxo-2-phenylethyl)-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0045
ethyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00006
fluoxymesterone
Homo sapiens
pH and temperature not specified in the publication
0.000256 - 0.000778
glycyrrhetinic acid
0.000008 - 1.994
glycyrrhizic acid
0.0000186 - 0.0000295
glycyrrhizinic acid
0.0000186 - 0.0000295
glycyrrhizininc acid
0.297
gossypol acetic acid
Cavia porcellus
-
dose-dependent competitive inhibition, IC50: 0.297 mM, (+)-isomer more potent inhibitor than (-)-isomer, mutant hairless strain more sensitive to inhibition than haired strain due to pharmacogenetic differences between the strains
0.000187 - 0.0119
hydroxyitraconazole
0.000122 - 0.0098
itraconazole
0.0017
lanosterol
Rattus sp.
-
oxidase IC50: 0.00065 mM, reductase IC50: 0.0017 mM
0.000753
maneb
Homo sapiens
pH and temperature not specified in the publication
0.00191
methoxychlor
Homo sapiens
37°C, pH not specified in the publication, microsomal assay
0.000061 - 0.2
methyl (3beta,5xi,9xi,18xi)-3-hydroxy-11-oxoolean-12-en-30-oate
0.000038 - 0.0015
methyl 2-[5-(2-chlorophenyl)-4-methyl-4H-1,2,4-triazol-3-yl]benzenesulfinate
0.0000019
methyl 2-[5-(7-chloro-1-methoxynaphthalen-2-yl)-4-methyl-4H-1,2,4-triazol-3-yl]benzenesulfinate
0.000005 - 0.00002
methyl 4'-[4-hydroxy-1-[(1H-tetrazol-5-yl)methyl]octahydro-2,5-methanopentalen-1-yl][1,1'-biphenyl]-4-sulfinate
0.000031
methyl 4-[(3-benzoyl-4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-2-yl)acetyl]benzoate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00005 - 0.003
methyl 4-[5-(2-chlorophenyl)-4-methyl-4H-1,2,4-triazol-3-yl]benzenesulfinate
0.0058
N,N-bis(3-D-gluconamidopropyl)cholamide
Rattus sp.
-
oxidase IC50: 0.0026 mM, reductase IC50: 0.0058 mM
0.58
N,N-bis(3-D-gluconamidopropyl)deoxycholamide
Rattus sp.
-
oxidase IC50: 0.055 mM, reductase IC50: 0.58 mM
0.00528
N-(4-chloro-2-methyl-1,3-benzothiazol-5-yl)adamantane-1-carboxamide
Homo sapiens
-
-
0.001208 - 0.005614
N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)-3-(trifluoromethyl)benzenesulfonamide
0.001
N-(5-cyanotricyclo[3.3.1.1~3,7~]decan-2-yl)-N2-(2-fluorobenzene-1-sulfonyl)-2-methylalaninamide
0.0000038 - 0.0000072
N-(5-hydroxytricyclo[3.3.1.1~3,7~]decan-2-yl)-6-(4-phenylpiperazin-1-yl)pyridine-2-carboxamide
0.0000017
N-(5-hydroxytricyclo[3.3.1.1~3,7~]decan-2-yl)-6-(piperidin-1-yl)pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.0000037
N-(5-hydroxytricyclo[3.3.1.1~3,7~]decan-2-yl)-6-[4-(pyridin-2-yl)piperazin-1-yl]pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.0000027
N-(5-hydroxytricyclo[3.3.1.1~3,7~]decan-2-yl)-6-[4-hydroxy-4-(trifluoromethyl)piperidin-1-yl]pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.0000095
N-(5-hydroxytricyclo[3.3.1.1~3,7~]decan-2-yl)-6-[4-[(pyridin-3-yl)methyl]piperazin-1-yl]pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.000249
N-(furan-2-ylmethyl)-N-methyladamantane-1-carboxamide
Homo sapiens
-
-
0.000403
N-(thiophen-2-ylmethyl)adamantane-1-carboxamide
Homo sapiens
-
-
0.000027
N-(trans-4-hydroxycyclohexyl)-6-(piperidin-1-yl)pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.000084 - 0.00021
N-butyl-2-[(3-chlorophenylsulfonamido)methyl]-N-cycloheptylthiazole-4-carboxamide
0.000002 - 0.000047
N-butyl-4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptylbenzamide
0.000024 - 0.000143
N-butyl-6-[(3-chlorophenylsulfonamido)methyl]-N-cycloheptylnicotinamide
0.000058
N-cyclohexyl-6-(piperidin-1-yl)picolinamide
Homo sapiens
at 37°C, pH not specified in the publication
0.0000008
N-cyclohexyl-N-cyclopropyl-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0000017
N-cyclohexyl-N-ethyl-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide
Homo sapiens
pH and temperature not specified in the publication
0.00015
N-cyclopropyl-3,3-dimethyl-N'-tricyclo[3.3.1.13,7]dec-2-ylpentanediamide
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.001
N-cyclopropyl-N'-tricyclo[3.3.1.13,7]dec-2-ylpentanediamide
Homo sapiens
IC50 above 0.001 mM, in 30 mM HEPES buffer, pH 7.4, at 37°C
0.00055
N-cyclopropyl-N'-[(2R)-1-hydroxytricyclo[3.3.1.13,7]dec-2-yl]-3,3-dimethylpentanediamide
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000008
N-cyclopropyl-N'-[(2r,5s)-5-hydroxytricyclo[3.3.1.13,7]dec-2-yl]-3,3-dimethylpentanediamide
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.0000046
N-cyclopropyl-N-(cis-4-hydroxy-4-methylcyclohexyl)-6-(piperidin-1-yl)pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.0000018
N-cyclopropyl-N-(cis-4-hydroxycyclohexyl)-6-(piperidin-1-yl)pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.0000064
N-cyclopropyl-N-(trans-4-hydroxy-4-methylcyclohexyl)-6-(piperidin-1-yl)pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.000021
N-cyclopropyl-N-(trans-4-hydroxycyclohexyl)-6-(piperidin-1-yl)pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.0000014
N-cyclopropyl-N-(trans-4-pyridin-3-ylcyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide
Homo sapiens
-
0.000013
N-cyclopropyl-N-[cis-4-hydroxy-4-(trifluoromethyl)cyclohexyl]-6-(piperidin-1-yl)pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.0000037
N-cyclopropyl-N-[trans-4-hydroxy-4-(trifluoromethyl)cyclohexyl]-6-(piperidin-1-yl)pyridine-2-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.0000014 - 0.0000023
N-methyl-2-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]naphthalen-1-amine
0.000229
N-methyl-N-(thiophen-2-ylmethyl)adamantane-1-carboxamide
Homo sapiens
-
-
0.000125
N-methyl-N-(thiophen-3-ylmethyl)adamantane-1-carboxamide
Homo sapiens
-
-
0.000113
N-methyl-N-[(1-methyl-1H-pyrrol-2-yl)methyl]adamantane-1-carboxamide
Homo sapiens
-
-
0.000448
N-methyl-N-[2-(thiophen-2-yl)ethyl]adamantane-1-carboxamide
Homo sapiens
-
-
0.0017
N-[(1-methyl-1H-pyrrol-2-yl)methyl]adamantane-1-carboxamide
Homo sapiens
-
-
0.000008
N-[(2s,5r)-5-carbamoyltricyclo[3.3.1.13,7]dec-2-yl]-N'-cyclopropyl-3,3-dimethylpentanediamide
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000014
N-[1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl]-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide
Homo sapiens
-
0.000011
N-[1-[(1-cyanocyclopropyl)methyl]piperidin-4-yl]-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide
Homo sapiens
-
0.000679
N-[2-(thiophen-2-yl)ethyl]adamantane-1-carboxamide
Homo sapiens
-
-
0.000105
N-[3-(2-adamantan-1-yl-2-oxoethanesulfinyl)phenyl]acetamide
Homo sapiens
pH not specified in the publication, 37°C
0.000167
N-[3-(2-adamantan-1-yl-2-oxoethanesulfonyl)phenyl]acetamide
Homo sapiens
pH not specified in the publication, 37°C
0.000285
N-[3-(2-adamantan-1-yl-2-oxoethoxy)phenyl]acetamide
Homo sapiens
pH not specified in the publication, 37°C
0.002037
N-[3-(2-adamantan-1-yl-2-oxoethylsulfanyl)phenyl]acetamide
Homo sapiens
pH not specified in the publication, 37°C
0.0000007
N-[4(4-cyanophenyl)cyclohexyl]-N-cyclopropyl-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide
Homo sapiens
pH and temperature not specified in the publication
0.000151
N-[4-(2-adamantan-1-yl-2-oxoethanesulfinyl)phenyl]acetamide
Homo sapiens
pH not specified in the publication, 37°C
0.000058
N-[4-(2-adamantan-1-yl-2-oxoethanesulfonyl)phenyl]acetamide
Homo sapiens
pH not specified in the publication, 37°C
0.000894
N-[4-(2-adamantan-1-yl-2-oxoethoxy)-2-fluoro-phenyl]acetamide
Homo sapiens
pH not specified in the publication, 37°C
0.000897
N-[4-(2-adamantan-1-yl-2-oxoethoxy)-3-methyl-phenyl]acetamide
Homo sapiens
pH not specified in the publication, 37°C
0.000211
N-[4-(2-adamantan-1-yl-2-oxoethoxy)phenyl]acetamide
Homo sapiens
pH not specified in the publication, 37°C
0.00009
N-[4-(2-adamantan-1-yl-2-oxoethylamino)phenyl]acetamide
Homo sapiens
pH not specified in the publication, 37°C
0.000313
N-[4-(2-adamantan-1-yl-2-oxoethylsulfanyl)phenyl]acetamide
Homo sapiens
pH not specified in the publication, 37°C
0.000036
N-[4-(2-amino-2-oxoethyl)cyclohexyl]-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide
Homo sapiens
-
0.0000007
N-[4-(3-cyanopropyl)cyclohexyl]-N-cyclopropyl-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0000014
N-[4-(3-pyridyl)cyclohexyl]-N-cyclopropyl-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide
Homo sapiens
pH and temperature not specified in the publication
0.00069
N-[4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]phenyl]-4-[oxo(phenyl)acetyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000015 - 0.000301
N-[5-(2-amino-2-oxoethyl)tricyclo[3.3.1.1~3,7~]decan-2-yl]-N2-(2-fluorobenzene-1-sulfonyl)-2-methylalaninamide
0.000543 - 0.001
N-[5-(3-amino-3-oxopropyl)tricyclo[3.3.1.1~3,7~]decan-2-yl]-N2-(2-fluorobenzene-1-sulfonyl)-2-methylalaninamide
0.001
N-[5-(cyanomethyl)tricyclo[3.3.1.1~3,7~]decan-2-yl]-N2-(2-fluorobenzene-1-sulfonyl)-2-methylalaninamide
0.000002
N-[cis-4-(2-cyano-2-methylpropyl)cyclohexyl]-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide
Homo sapiens
-
0.0000028
N-[cis-4-(3-cyanopropyl)cyclohexyl]-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide
Homo sapiens
-
0.000011
N-[cis-4-(4-amino-4-oxobutyl)cyclohexyl]-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide
Homo sapiens
-
0.0000076
N-[cis-4-(cyanomethyl)cyclohexyl]-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide
Homo sapiens
-
0.0000006
N-[trans-4-(2-cyano-2-cyclopropylethyl)cyclohexyl]-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide
Homo sapiens
-
0.00000088
N-[trans-4-(2-cyano-2-methylpropyl)cyclohexyl]-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide
Homo sapiens
-
0.0000038
N-[trans-4-(3-amino-2,2-dimethyl-3-oxopropyl)cyclohexyl]-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide
Homo sapiens
-
0.0000007
N-[trans-4-(3-cyanopropyl)cyclohexyl]-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide
Homo sapiens
-
0.0000024
N-[trans-4-(4-amino-4-oxobutyl)cyclohexyl]-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide
Homo sapiens
-
0.0000055
N-[trans-4-(cyanomethyl)cyclohexyl]-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide
Homo sapiens
-
0.0000017
N-[trans-4-[(1-carbamoylcyclopropyl)methyl]cyclohexyl]-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide
Homo sapiens
-
0.001
N2-(2-fluorobenzene-1-sulfonyl)-N-[5-(hydrazinecarbonyl)tricyclo[3.3.1.1~3,7~]decan-2-yl]-2-methylalaninamide
0.000002 - 0.000021
N2-(2-fluorobenzene-1-sulfonyl)-N-[5-(hydroxymethyl)tricyclo[3.3.1.1~3,7~]decan-2-yl]-2-methylalaninamide
0.000055 - 0.001
N2-(2-fluorobenzene-1-sulfonyl)-N-[5-[(2-hydroxyhydrazinyl)methyl]tricyclo[3.3.1.1~3,7~]decan-2-yl]-2-methylalaninamide
0.00055
oleanolic acid
Rattus sp.
-
oxidase IC50: 0.00015 mM, reductase IC50: 0.00055 mM
0.00096
oxymesterone
Homo sapiens
pH and temperature not specified in the publication
0.00071
oxymetholone
Homo sapiens
pH and temperature not specified in the publication
0.00001897 - 0.00006287
perfluorohexane sulfonate
0.000000048 - 0.000000293
perfluorooctane sulfonate
0.0000038 - 0.00002441
Perfluorooctanoic acid
0.000512 - 0.0101
posaconazole
0.0063
pyrrolidine dithiocarbamate
Homo sapiens
pH and temperature not specified in the publication
0.0352
resveratrol
Rattus norvegicus
-
at pH 7.4 and 37°C
0.00284
Rhein
Mus musculus
-
pH 7.4, 37°C
0.000081 - 0.000542
rheochrysidin
0.00023
sterenin A
Homo sapiens
-
value above, pH not specified in the publication, 26°C
0.0066
sterenin B
Homo sapiens
-
value above, pH not specified in the publication, 26°C
0.00024
sterenin C
Homo sapiens
-
value above, pH not specified in the publication, 26°C
0.0026
sterenin D
Homo sapiens
-
value above, pH not specified in the publication, 26°C
0.00137
testosterone
Homo sapiens
pH and temperature not specified in the publication
0.000132
thiram
Homo sapiens
pH and temperature not specified in the publication
0.0019
tributyltin
Homo sapiens
pH and temperature not specified in the publication
0.00319
Triphenyltin
Homo sapiens
pH and temperature not specified in the publication
0.031
zineb
Homo sapiens
pH and temperature not specified in the publication
0.0018
[1-[2-oxo-2-(tricyclo[3.3.1.13,7]dec-2-ylamino)ethyl]cyclopentyl]acetic acid
Homo sapiens
in 30 mM HEPES buffer, pH 7.4, at 37°C
0.000004
[1-[4-([(2R)-2-methyl-4-[2-(pyridin-4-yl)ethyl]piperazin-1-yl]sulfonyl)phenyl]cyclopropyl]methanol
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000012 - 0.00012
[2-(4-fluorophenyl)tricyclo[3.3.1.13,7]dec-2-yl]acetic acid
0.00077 - 0.00185
[3-(5H-chromeno[4,3-b]pyridin-3-yl)-5-methyl-1-benzofuran-2-yl](phenyl)methanone
0.0004
[4-(2-adamantan-1-yl-2-oxoethoxy)phenyl]acetic acid
Homo sapiens
pH not specified in the publication, 37°C
0.00258
[4-(2-Adamantan-1-yl-2-oxoethoxy)phenyl]acetic acid methyl ester
Homo sapiens
pH not specified in the publication, 37°C
0.000234
[4-hydroxy-1,1-dioxido-2-(2-phenylethyl)-2H-1,2-benzothiazin-3-yl](phenyl)methanone
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000043 - 0.000049
[4-[5-(4-methoxyphenyl)pyrimidin-2-yl]-3,4-dihydroquinoxalin-1(2H)-yl][3-(1H-pyrazol-4-yl)pyrrolidin-1-yl]methanone
0.000013 - 0.001616
[5-fluoro-2-(4-fluorophenyl)tricyclo[3.3.1.13,7]dec-2-yl]acetic acid
0.0000017
[5-[(2,4-dichlorophenoxy)methyl]pyridin-3-yl][(1R,5S)-1,3,3-trimethyl-6-azabicyclo[3.2.1]oct-6-yl]methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.000002
[5-[(2,4-dichlorophenoxy)methyl]pyridin-3-yl][2-(pyridin-3-yl)piperidin-1-yl]methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.000003 - 0.000184
[9-(4-fluorophenyl)bicyclo[3.3.1]non-9-yl]acetic acid
additional information
(1S,2R,3S,5R,6R)-4-methylidene-1-([(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl)-7-oxabicyclo[4.1.0]heptane-2,3,5-triol